IE43375L - Benzamides - Google Patents
BenzamidesInfo
- Publication number
- IE43375L IE43375L IE761166A IE116676A IE43375L IE 43375 L IE43375 L IE 43375L IE 761166 A IE761166 A IE 761166A IE 116676 A IE116676 A IE 116676A IE 43375 L IE43375 L IE 43375L
- Authority
- IE
- Ireland
- Prior art keywords
- group
- alkyl
- alkoxy
- hydrogen
- formula
- Prior art date
Links
- 229940054066 benzamide antipsychotics Drugs 0.000 title abstract 2
- 150000003936 benzamides Chemical class 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000006556 (C1-C5) alkylsulphonyl group Chemical group 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000003302 alkenyloxy group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 230000003474 anti-emetic effect Effects 0.000 abstract 1
- 235000010233 benzoic acid Nutrition 0.000 abstract 1
- 150000001559 benzoic acids Chemical class 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
1500105 Benzamides SOC D'ETUDES SCIENTIFIQUES ET INDUSTRIELLES DE L'ILE-DE-FRANCE 8 June 1976 [10 June 1975] 23695/76 Heading C2C Novel compounds (I) (including salts and oxides thereof) in which A is a hydrogen atom or a C 1-5 alkyl or 6 2-5 alkenyl group; X is a hydrogen atom or a C 1-5 alkoxy, C 1-5 alkyl, C 2-5 alkenyloxy or C 2-5 alkenyl group; Y is a hydrogen or halogen atom or a nitro, C 1-5 alkyl, C 1-5 alkoxy, amino or substituted amino group; Z is a hydrogen or halogen atom, a C 1-5 alkoxy or C 1-5 alkylsulphonyl group or a group of formula SO 2 NR 1 R 2 in which each of R 1 and R 2 , which may be the same or different, is a hydrogen atom or a C 1-5 alkyl group, or -NR 1 R 2 is a heterocyclic ring optionally containing another hetero atom; W is a C 1-4 straight or branched-chain alkylene group; B is a group of formula NR 3 R 4 in which R 3 is a C 1-5 alkyl group and R 4 is a C 1-5 hydroxyalkyl group; or B is a nitrogen-attached heterocyclic ring optionally containing a second nitrogen and optionally having a substituent; or B is a racemic, dextrorotary or laevorotary heterocyclic radical of Formula (IV) in which R is a C 1-5 alkyl group containing a reactive function and m is 1, 2 or 3, including the dextrorotatory and laevorotatory forms of the compounds, are made by interacting H 2 N-W-B and appropriate benzoic acids or derivatives thereof. Pharmaceutical preparations having antiemetic action contain (I) as active ingredient. Administration is parenterally.
[GB1500105A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7518001A FR2313935A1 (en) | 1975-06-10 | 1975-06-10 | NEW BENZAMIDES SUBSTITUTES, THEIR DERIVATIVES AND THEIR PREPARATION PROCESS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE43375L true IE43375L (en) | 1976-12-10 |
| IE43375B1 IE43375B1 (en) | 1981-02-11 |
Family
ID=9156239
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1166/76A IE43375B1 (en) | 1975-06-10 | 1976-06-01 | Substituted benzamides, their preparation, and compositions containing them |
Country Status (37)
| Country | Link |
|---|---|
| JP (1) | JPS6055503B2 (en) |
| AR (1) | AR210888A1 (en) |
| AT (1) | AT358571B (en) |
| AU (1) | AU506001B2 (en) |
| BE (1) | BE842059A (en) |
| BG (1) | BG27360A3 (en) |
| CA (1) | CA1064930A (en) |
| CH (1) | CH596175A5 (en) |
| CS (1) | CS189007B2 (en) |
| DD (1) | DD124380A5 (en) |
| DE (1) | DE2623075A1 (en) |
| DK (1) | DK255276A (en) |
| EG (1) | EG12285A (en) |
| ES (1) | ES448643A1 (en) |
| FI (1) | FI761669A7 (en) |
| FR (1) | FR2313935A1 (en) |
| GB (1) | GB1500105A (en) |
| HK (1) | HK46979A (en) |
| HU (1) | HU172195B (en) |
| IE (1) | IE43375B1 (en) |
| IN (1) | IN142899B (en) |
| LU (1) | LU75104A1 (en) |
| MW (1) | MW1676A1 (en) |
| MX (1) | MX3580E (en) |
| NL (1) | NL186382C (en) |
| NO (1) | NO146058C (en) |
| NZ (1) | NZ181072A (en) |
| OA (1) | OA05350A (en) |
| PH (1) | PH13912A (en) |
| PL (2) | PL103075B1 (en) |
| PT (1) | PT65164B (en) |
| RO (1) | RO70265A (en) |
| SE (1) | SE415971B (en) |
| SU (2) | SU607551A3 (en) |
| YU (1) | YU39352B (en) |
| ZA (1) | ZA763042B (en) |
| ZM (1) | ZM6576A1 (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ186175A (en) * | 1977-01-27 | 1980-03-05 | Shionogi & Co | Meta-sulphonamidobenzamide derivatives |
| FR2415099A1 (en) * | 1978-01-20 | 1979-08-17 | Ile De France | NEW DERIVATIVES OF 4-AMINO-5-ALKYLSULFONYL ORTHO-ANISAMIDES, THEIR METHODS OF PREPARATION AND THEIR APPLICATION AS PSYCHOTROPES |
| FR2438650A1 (en) * | 1978-10-11 | 1980-05-09 | Ile De France | N- (1-METHYL 2-PYRROLIDINYL METHYL) 2,3-DIMETHOXY 5-METHYLSULFAMOYL BENZAMIDE AND DERIVATIVES THEREOF, THEIR PREPARATION METHODS AND THEIR APPLICATION IN THE TREATMENT OF LOWER URINARY DISORDERS |
| JPS597160A (en) * | 1982-06-28 | 1984-01-14 | ラボラトリーオス・デラグランヘ・エセ・ア | N-(1-propyl-2-pyrrolidinylmethyl)-2-methoxy-5- sulfamoylbenzamide, manufacture and antidepressive |
| US4808624A (en) * | 1984-06-28 | 1989-02-28 | Bristol-Myers Company | Pharmacologically active substituted benzamides |
| US5011992A (en) * | 1984-06-28 | 1991-04-30 | Bristol-Myers Squibb Company | Pharmacologically active substituted benzamides |
| US4820715A (en) * | 1984-06-28 | 1989-04-11 | Bristol-Myers Company | Anti-emetic quinuclidinyl benzamides |
| JP3026845B2 (en) * | 1991-02-20 | 2000-03-27 | 日清製粉株式会社 | Piperidine derivative |
| RU2205009C1 (en) * | 2002-03-27 | 2003-05-27 | Государственный научный центр - Институт биофизики | Antiemetic agent benzamide |
| EP2895457B1 (en) | 2012-09-17 | 2020-05-20 | Nektar Therapeutics | Oligomer-containing benzamide-based compounds |
-
1975
- 1975-06-10 FR FR7518001A patent/FR2313935A1/en active Granted
-
1976
- 1976-05-21 ZA ZA763042A patent/ZA763042B/en unknown
- 1976-05-21 BE BE1007404A patent/BE842059A/en not_active IP Right Cessation
- 1976-05-22 RO RO7686179A patent/RO70265A/en unknown
- 1976-05-22 DE DE19762623075 patent/DE2623075A1/en not_active Withdrawn
- 1976-05-24 AR AR263374A patent/AR210888A1/en active
- 1976-05-27 IN IN926/CAL/1976A patent/IN142899B/en unknown
- 1976-05-27 AU AU14360/76A patent/AU506001B2/en not_active Expired
- 1976-05-28 YU YU1318/76A patent/YU39352B/en unknown
- 1976-06-01 PT PT65164A patent/PT65164B/en unknown
- 1976-06-01 IE IE1166/76A patent/IE43375B1/en unknown
- 1976-06-01 AT AT400176A patent/AT358571B/en not_active IP Right Cessation
- 1976-06-02 EG EG326/76A patent/EG12285A/en active
- 1976-06-03 ZM ZM65/76A patent/ZM6576A1/en unknown
- 1976-06-04 NZ NZ181072A patent/NZ181072A/en unknown
- 1976-06-04 BG BG033362A patent/BG27360A3/en unknown
- 1976-06-04 CS CS763724A patent/CS189007B2/en unknown
- 1976-06-07 PH PH18542A patent/PH13912A/en unknown
- 1976-06-07 SU SU762362660A patent/SU607551A3/en active
- 1976-06-08 SE SE7606424A patent/SE415971B/en not_active IP Right Cessation
- 1976-06-08 LU LU75104A patent/LU75104A1/xx unknown
- 1976-06-08 DD DD193235A patent/DD124380A5/xx not_active IP Right Cessation
- 1976-06-08 ES ES448643A patent/ES448643A1/en not_active Expired
- 1976-06-08 GB GB23695/76A patent/GB1500105A/en not_active Expired
- 1976-06-08 JP JP51067553A patent/JPS6055503B2/en not_active Expired
- 1976-06-09 OA OA55847A patent/OA05350A/en unknown
- 1976-06-09 HU HU76SO00001171A patent/HU172195B/en unknown
- 1976-06-09 PL PL1976190247A patent/PL103075B1/en not_active IP Right Cessation
- 1976-06-09 MX MX76291U patent/MX3580E/en unknown
- 1976-06-09 DK DK255276A patent/DK255276A/en unknown
- 1976-06-09 SU SU762366253A patent/SU645557A3/en active
- 1976-06-09 CA CA254,480A patent/CA1064930A/en not_active Expired
- 1976-06-09 NO NO761977A patent/NO146058C/en unknown
- 1976-06-10 NL NLAANVRAGE7606284,A patent/NL186382C/en not_active IP Right Cessation
- 1976-06-10 PL PL1976190304A patent/PL102929B1/en unknown
- 1976-06-10 FI FI761669A patent/FI761669A7/fi not_active Application Discontinuation
- 1976-06-10 MW MW16/76A patent/MW1676A1/en unknown
- 1976-06-10 CH CH736076A patent/CH596175A5/xx not_active IP Right Cessation
-
1979
- 1979-07-12 HK HK469/79A patent/HK46979A/en unknown
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