IE43541L - 3-(heterocyclic) thiomethyl cephalosporin derivatives. - Google Patents
3-(heterocyclic) thiomethyl cephalosporin derivatives.Info
- Publication number
- IE43541L IE43541L IE760624A IE62476A IE43541L IE 43541 L IE43541 L IE 43541L IE 760624 A IE760624 A IE 760624A IE 62476 A IE62476 A IE 62476A IE 43541 L IE43541 L IE 43541L
- Authority
- IE
- Ireland
- Prior art keywords
- heterocyclic
- cephalosporin derivatives
- lower alkyl
- thiomethyl
- thiomethyl cephalosporin
- Prior art date
Links
- -1 thiomethyl cephalosporin Chemical class 0.000 title abstract 3
- 229930186147 Cephalosporin Natural products 0.000 title abstract 2
- 229940124587 cephalosporin Drugs 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 241000894006 Bacteria Species 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 150000001780 cephalosporins Chemical class 0.000 abstract 1
- 125000005633 phthalidyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/36—Methylene radicals, substituted by sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
Abstract
Cephalosporins of formula (I) and their salts are new (where R is H or OH; Y is NH2, OH or OR4, where R4 is lower alkanoyl, lower alkoxycarbonyl or benzoyl; X is O, S. NH or NMe; Z is H, lower alkyl, benzhydrylphenyl, indan-5-yl, R'OCOCH2 (R' = lower alkyl), R'OOCOCH(Me) or phthalidyl; R1 is CH2oCH2COOH, CH2OCH2COOR', CH2OCH2CONR2R3 or CONR2R3; R2 and r3 are H or lower alkyl). Cpds. (I) are antibacterials active against Gram-positive and -negative bacteria.
[FR2305186A1]
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7512813A GB1542397A (en) | 1975-03-27 | 1975-03-27 | Cephem compounds |
| GB4393575 | 1975-10-24 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE43541L true IE43541L (en) | 1976-09-27 |
| IE43541B1 IE43541B1 (en) | 1981-03-25 |
Family
ID=26249284
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE624/76A IE43541B1 (en) | 1975-03-27 | 1976-03-25 | Cephem compounds |
Country Status (15)
| Country | Link |
|---|---|
| JP (1) | JPS51138694A (en) |
| AU (1) | AU1244276A (en) |
| DD (1) | DD124601A5 (en) |
| DE (1) | DE2612760A1 (en) |
| DK (1) | DK132876A (en) |
| ES (1) | ES446353A1 (en) |
| FI (1) | FI760793A7 (en) |
| FR (1) | FR2305186A1 (en) |
| IE (1) | IE43541B1 (en) |
| IL (1) | IL49183A0 (en) |
| LU (1) | LU74651A1 (en) |
| NL (1) | NL7603116A (en) |
| NO (1) | NO761052L (en) |
| PT (1) | PT64951B (en) |
| SE (1) | SE7603699L (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR3149076A1 (en) | 2023-05-25 | 2024-11-29 | Psa Automobiles Sa | Automotive air treatment system with HEPA filter |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA999574A (en) * | 1972-06-14 | 1976-11-09 | Smith Kline And French Canada Ltd. | 7-hydroxyhalophenylacetamido-3-h heterocyclicthiomethyl cephalosporins |
| PH16419A (en) * | 1973-01-31 | 1983-09-29 | Bristol Myers Co | 7-(d-alpha-amino-alpha-(3'-methyl-4'-hydroxyphenyl)-acetamido)-3-(1,2,3-triazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid,pharmaceutically acceptable esters and salts thereof |
| US3989694A (en) * | 1974-12-27 | 1976-11-02 | Smithkline Corporation | 7-Acyl-3-(substituted triazolyl thiomethyl)cephalosporins |
-
1976
- 1976-03-09 IL IL49183A patent/IL49183A0/en unknown
- 1976-03-25 ES ES76446353A patent/ES446353A1/en not_active Expired
- 1976-03-25 FI FI760793A patent/FI760793A7/fi not_active Application Discontinuation
- 1976-03-25 IE IE624/76A patent/IE43541B1/en unknown
- 1976-03-25 NL NL7603116A patent/NL7603116A/en unknown
- 1976-03-25 DK DK132876A patent/DK132876A/en unknown
- 1976-03-25 DE DE19762612760 patent/DE2612760A1/en active Pending
- 1976-03-25 NO NO761052A patent/NO761052L/no unknown
- 1976-03-26 FR FR7608977A patent/FR2305186A1/en active Granted
- 1976-03-26 JP JP51033472A patent/JPS51138694A/en active Pending
- 1976-03-26 LU LU74651A patent/LU74651A1/xx unknown
- 1976-03-26 PT PT64951A patent/PT64951B/en unknown
- 1976-03-26 DD DD192069A patent/DD124601A5/xx unknown
- 1976-03-26 SE SE7603699A patent/SE7603699L/en unknown
- 1976-03-29 AU AU12442/76A patent/AU1244276A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| IL49183A0 (en) | 1976-05-31 |
| SE7603699L (en) | 1976-09-28 |
| JPS51138694A (en) | 1976-11-30 |
| AU1244276A (en) | 1977-10-06 |
| DK132876A (en) | 1976-09-28 |
| FR2305186B1 (en) | 1980-07-04 |
| FI760793A7 (en) | 1976-09-28 |
| LU74651A1 (en) | 1977-10-10 |
| FR2305186A1 (en) | 1976-10-22 |
| PT64951B (en) | 1977-08-26 |
| NO761052L (en) | 1976-09-28 |
| IE43541B1 (en) | 1981-03-25 |
| DD124601A5 (en) | 1977-03-02 |
| DE2612760A1 (en) | 1976-10-07 |
| PT64951A (en) | 1976-04-01 |
| ES446353A1 (en) | 1977-11-16 |
| NL7603116A (en) | 1976-09-29 |
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