IE43694L - Thieno-4,1-oxazepinones - Google Patents
Thieno-4,1-oxazepinonesInfo
- Publication number
- IE43694L IE43694L IE761583A IE158376A IE43694L IE 43694 L IE43694 L IE 43694L IE 761583 A IE761583 A IE 761583A IE 158376 A IE158376 A IE 158376A IE 43694 L IE43694 L IE 43694L
- Authority
- IE
- Ireland
- Prior art keywords
- formula vii
- resulting
- reacted
- compounds
- ammonia
- Prior art date
Links
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- 229910021529 ammonia Inorganic materials 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 239000005864 Sulphur Substances 0.000 abstract 1
- 230000001773 anti-convulsant effect Effects 0.000 abstract 1
- 230000002921 anti-spasmodic effect Effects 0.000 abstract 1
- 239000002249 anxiolytic agent Substances 0.000 abstract 1
- 230000000949 anxiolytic effect Effects 0.000 abstract 1
- 239000000812 cholinergic antagonist Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 235000021050 feed intake Nutrition 0.000 abstract 1
- BHEPBYXIRTUNPN-UHFFFAOYSA-N hydridophosphorus(.) (triplet) Chemical compound [PH] BHEPBYXIRTUNPN-UHFFFAOYSA-N 0.000 abstract 1
- 231100000053 low toxicity Toxicity 0.000 abstract 1
- 239000003158 myorelaxant agent Substances 0.000 abstract 1
- 125000003585 oxepinyl group Chemical group 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- -1 sulphur halide Chemical class 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/36—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
6-Aryl-4H-s-triazolo[3,4-c]thieno[2,3-e]-1,4-diazepines of the formula VII are prepared from compounds of the formula V. This entails using a strong hydrohalic acid to split open the bond on the oxygen atom of the oxepine ring. The resulting hydrohalide is extracted with a solvent which is immiscible with water, and the residue is reacted with a phosphorous or sulphur halide. The resulting dihalo compound is reacted with ammonia or a substance which provides ammonia, and the resulting product is dehydrogenated. The substituents in the formula VII and V have the meaning stated in Claim 1. The compounds of the formula VII and their acid addition salts have proved to have anxiolytic, antispasmodic and muscle-relaxant activity. In addition, they display a potent anticonvulsant action and extremely low toxicity. They furthermore increase the feed intake of mammals. <IMAGE>
[FR2318165A1]
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2531678A DE2531678C3 (en) | 1975-07-16 | 1975-07-16 | Thieno [2,3e] triazole [3,4c] 5,6-dihydro-1,4-diazepines and processes for their preparation |
| DE19752531677 DE2531677A1 (en) | 1975-07-16 | 1975-07-16 | Aryl- triazolo-thieno-diazephines - anticonvulsants anxiolytics and antiaagression prepn. from substd. thienyl acetamides |
| DE19752531679 DE2531679A1 (en) | 1975-07-16 | 1975-07-16 | Aryl- triazolo-thieno-diazephines - anticonvulsants anxiolytics and antiaagression prepn. from substd. thienyl acetamides |
| DE2533924A DE2533924C3 (en) | 1975-07-30 | 1975-07-30 | Process for the preparation of 6-aryl-4H-striazolo [3,4-c] thieno [2,3-e] 1,4-diazepines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE43694L true IE43694L (en) | 1977-01-16 |
| IE43694B1 IE43694B1 (en) | 1981-05-06 |
Family
ID=27432000
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1583/76A IE43694B1 (en) | 1975-07-16 | 1976-07-16 | Thieno-4,1-oxazepinones |
Country Status (17)
| Country | Link |
|---|---|
| AU (1) | AU506140B2 (en) |
| BG (1) | BG25227A3 (en) |
| CA (1) | CA1077475A (en) |
| CH (2) | CH627181A5 (en) |
| DD (1) | DD126744A5 (en) |
| ES (1) | ES449849A1 (en) |
| FR (1) | FR2318165A1 (en) |
| GR (1) | GR60819B (en) |
| HU (1) | HU172620B (en) |
| IE (1) | IE43694B1 (en) |
| IL (1) | IL50032A (en) |
| LU (1) | LU75384A1 (en) |
| MX (1) | MX4246E (en) |
| NL (1) | NL186008C (en) |
| PT (1) | PT65374B (en) |
| RO (1) | RO76083A (en) |
| YU (1) | YU40458B (en) |
-
1976
- 1976-07-09 RO RO7686908A patent/RO76083A/en unknown
- 1976-07-10 GR GR51234A patent/GR60819B/en unknown
- 1976-07-13 IL IL50032A patent/IL50032A/en unknown
- 1976-07-14 LU LU75384A patent/LU75384A1/xx unknown
- 1976-07-14 BG BG033745A patent/BG25227A3/en unknown
- 1976-07-14 DD DD193857A patent/DD126744A5/xx unknown
- 1976-07-14 CH CH901976A patent/CH627181A5/en not_active IP Right Cessation
- 1976-07-15 NL NLAANVRAGE7607871,A patent/NL186008C/en not_active IP Right Cessation
- 1976-07-15 ES ES449849A patent/ES449849A1/en not_active Expired
- 1976-07-15 CA CA257,092A patent/CA1077475A/en not_active Expired
- 1976-07-15 MX MX761774U patent/MX4246E/en unknown
- 1976-07-15 AU AU15913/76A patent/AU506140B2/en not_active Expired
- 1976-07-15 YU YU1753/76A patent/YU40458B/en unknown
- 1976-07-15 PT PT65374A patent/PT65374B/en unknown
- 1976-07-16 FR FR7621836A patent/FR2318165A1/en active Granted
- 1976-07-16 HU HU70CA00000291A patent/HU172620B/en unknown
- 1976-07-16 IE IE1583/76A patent/IE43694B1/en unknown
-
1981
- 1981-05-19 CH CH327381A patent/CH630630A5/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU506140B2 (en) | 1979-12-13 |
| RO76083A (en) | 1981-06-22 |
| BG25227A3 (en) | 1978-08-10 |
| NL7607871A (en) | 1977-01-18 |
| IL50032A (en) | 1981-03-31 |
| AU1591376A (en) | 1978-01-19 |
| GR60819B (en) | 1978-08-30 |
| YU175376A (en) | 1982-06-30 |
| PT65374B (en) | 1978-06-08 |
| HU172620B (en) | 1978-11-28 |
| YU40458B (en) | 1986-02-28 |
| MX4246E (en) | 1982-03-02 |
| CH630630A5 (en) | 1982-06-30 |
| LU75384A1 (en) | 1977-07-27 |
| NL186008C (en) | 1990-09-03 |
| NL186008B (en) | 1990-04-02 |
| CH627181A5 (en) | 1981-12-31 |
| ES449849A1 (en) | 1977-08-16 |
| IE43694B1 (en) | 1981-05-06 |
| FR2318165B1 (en) | 1980-02-01 |
| FR2318165A1 (en) | 1977-02-11 |
| CA1077475A (en) | 1980-05-13 |
| PT65374A (en) | 1976-08-01 |
| DD126744A5 (en) | 1977-08-10 |
| IL50032A0 (en) | 1976-09-30 |
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