IE44265L - Amino-alcohols - Google Patents
Amino-alcoholsInfo
- Publication number
- IE44265L IE44265L IE762541A IE254176A IE44265L IE 44265 L IE44265 L IE 44265L IE 762541 A IE762541 A IE 762541A IE 254176 A IE254176 A IE 254176A IE 44265 L IE44265 L IE 44265L
- Authority
- IE
- Ireland
- Prior art keywords
- activity
- image
- reaction
- formula
- group
- Prior art date
Links
- 150000001414 amino alcohols Chemical class 0.000 title abstract 2
- 230000000694 effects Effects 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 2
- 206010002660 Anoxia Diseases 0.000 abstract 1
- 241000976983 Anoxia Species 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 206010021143 Hypoxia Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 150000008064 anhydrides Chemical class 0.000 abstract 1
- 230000007953 anoxia Effects 0.000 abstract 1
- 230000003276 anti-hypertensive effect Effects 0.000 abstract 1
- 230000002921 anti-spasmodic effect Effects 0.000 abstract 1
- 230000002785 anti-thrombosis Effects 0.000 abstract 1
- 210000000748 cardiovascular system Anatomy 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000002107 myocardial effect Effects 0.000 abstract 1
- 230000002093 peripheral effect Effects 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 abstract 1
- 230000000304 vasodilatating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
- C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
- C07D327/06—Six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
- C07D337/02—Seven-membered rings
- C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D337/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/08—Six-membered rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Aminoalcohol derivatives corresponding to the formula (I) <IMAGE> in which Q is a group <IMAGE> and the other substituents have the meaning shown in Claim 1 are prepared by reaction with a compound of formula I, in which Q represents a group <IMAGE> or <IMAGE>, with an amine of type R3R4NH, Z being a halogen. The alcohol can then be esterified by reaction with an acid or an anhydride as defined in Claim 1. The compounds obtained have activities on the cardiovascular system, for example antihypertensive and/or antispasmodic activities, peripheral vasodilative activity, protective activity against myocardial anoxia, hypolipidemiating activity, antithrombotic activity, beta -lytic activity or platelet aggregation inhibiting activity, and/or activity on the central nervous system, for example a tranquillising activity.
[GB1565080A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7535217A FR2332010A1 (en) | 1975-11-18 | 1975-11-18 | HETEROCYCLIC AMINO-ALCOHOL, ITS SALT AND ITS PREPARATION PROCESS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE44265L true IE44265L (en) | 1977-05-18 |
| IE44265B1 IE44265B1 (en) | 1981-09-23 |
Family
ID=9162563
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE2541/76A IE44265B1 (en) | 1975-11-18 | 1976-11-18 | Amino-alcohol derivatives and their preparation |
Country Status (21)
| Country | Link |
|---|---|
| JP (2) | JPS5297952A (en) |
| AT (1) | AT355566B (en) |
| AU (1) | AU510315B2 (en) |
| BE (1) | BE848496A (en) |
| CA (1) | CA1094088A (en) |
| CH (2) | CH623321A5 (en) |
| DE (1) | DE2651572C2 (en) |
| DK (1) | DK151330C (en) |
| ES (1) | ES453389A1 (en) |
| FI (1) | FI763265A7 (en) |
| FR (1) | FR2332010A1 (en) |
| GB (1) | GB1565080A (en) |
| GR (1) | GR62012B (en) |
| IE (1) | IE44265B1 (en) |
| IL (1) | IL50932A (en) |
| MX (1) | MX4881E (en) |
| NL (1) | NL180936C (en) |
| NZ (1) | NZ182665A (en) |
| PT (1) | PT65853B (en) |
| SE (1) | SE434744B (en) |
| ZA (1) | ZA766907B (en) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2512817A1 (en) * | 1981-09-17 | 1983-03-18 | Roussel Uclaf | NOVEL AMINOMETHYL 1H-INDOLE-4-METHANOL DERIVATIVES AND THEIR SALTS, PROCESS FOR PREPARING THEM, THEIR APPLICATION AS MEDICAMENTS, THE COMPOSITIONS COMPRISING THEM AND THEIR PREPARATION INTERMEDIATES |
| US4622399A (en) * | 1983-06-30 | 1986-11-11 | American Home Products Corporation | Bicyclo-heterocyclic nitrogen substituted aminoethanol derivatives |
| US4562200A (en) * | 1983-06-30 | 1985-12-31 | American Home Products Corporation | 5(Indolyl) and 5(2,3-dihydroindolyl) substituted aminoethanols and their use as anti-hypertensives |
| US4521606A (en) * | 1983-06-30 | 1985-06-04 | American Home Products Corp. | 5-Indolyl substituted aminoethanols |
| ATE194982T1 (en) | 1992-04-24 | 2000-08-15 | Takeda Chemical Industries Ltd | BENZOXAZEPINE DERIVATIVES AS CHOLINESTERASE INHIBITORS |
| US5561142A (en) * | 1994-04-26 | 1996-10-01 | Merck & Co., Inc. | Substituted sulfonamides as selective β3 agonists for the treatment of diabetes and obesity |
| US5705515A (en) * | 1994-04-26 | 1998-01-06 | Merck & Co., Inc. | Substituted sulfonamides as selective β-3 agonists for the treatment of diabetes and obesity |
| US5541197A (en) * | 1994-04-26 | 1996-07-30 | Merck & Co., Inc. | Substituted sulfonamides as selective β3 agonists for the treatment of diabetes and obesity |
| US5674891A (en) * | 1994-07-27 | 1997-10-07 | The Procter & Gamble Company | Dihydrobenzothiophene compounds useful as anti-inflammatory agents |
| US5684002A (en) * | 1994-09-07 | 1997-11-04 | The Procter & Gamble Company | Dihydorbenzofuran and related compounds useful as anti-inflammatory agents |
| WO1997025311A1 (en) * | 1996-01-10 | 1997-07-17 | Asahi Kasei Kogyo Kabushiki Kaisha | Novel tricyclic compounds and drug compositions containing the same |
| JP3124242B2 (en) | 1996-01-10 | 2001-01-15 | 旭化成工業株式会社 | New tricyclic compounds |
| US5684031A (en) * | 1996-02-01 | 1997-11-04 | The Procter & Gamble Company | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents |
| US5672620A (en) * | 1996-02-01 | 1997-09-30 | The Procter & Gamble Company | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents |
| FR2758820B1 (en) * | 1997-01-30 | 1999-02-26 | Synthelabo | ALPHA-AZACYCLOMETHYL-BENZOFURANE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
| AU6218598A (en) * | 1997-01-30 | 1998-08-25 | Synthelabo | Alpha-azacyclomethyl benzothiophene and alpha-azacyclomethyl benzofurane derivatives, preparation and therapeutic application |
| AU735249B2 (en) | 1997-07-03 | 2001-07-05 | Asahi Kasei Kabushiki Kaisha | Novel tricyclic compounds having saturated rings and medicinal compositions containing the same |
| WO2001083451A1 (en) | 2000-04-28 | 2001-11-08 | Asahi Kasei Kabushiki Kaisha | Novel bicyclic compounds |
| EP1447400B1 (en) | 2001-10-25 | 2008-09-17 | Asahi Kasei Pharma Corporation | Bicyclic compound |
| USD529397S1 (en) | 2004-08-18 | 2006-10-03 | Gabrielle Studio, Inc. | Cosmetic container |
| KR20110050733A (en) | 2008-10-09 | 2011-05-16 | 아사히 가세이 파마 가부시키가이샤 | Indazole derivatives |
| AU2009301798B2 (en) | 2008-10-09 | 2012-03-01 | Asahi Kasei Pharma Corporation | Indazole compound |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1013224A (en) * | 1962-06-21 | 1965-12-15 | Ici Ltd | Heterocyclic aminoethanols |
| US3255249A (en) * | 1963-04-26 | 1966-06-07 | Ici Ltd | 2-branched lower alkyl-amino-1-(indan-, hydrogenated indan- and hydrogenated naphth-2-yl) lower alkanols |
| CH442302A (en) * | 1964-04-17 | 1967-08-31 | Sandoz Ag | Process for the production of a new indole derivative |
| FR2138488A1 (en) * | 1971-05-27 | 1973-01-05 | Lipha | 1-(5-indanyl)-omega-aminoalkanes - with tranquillizing activity |
-
1975
- 1975-11-18 FR FR7535217A patent/FR2332010A1/en active Granted
-
1976
- 1976-11-11 SE SE7612554A patent/SE434744B/en not_active IP Right Cessation
- 1976-11-12 DE DE2651572A patent/DE2651572C2/en not_active Expired
- 1976-11-15 FI FI763265A patent/FI763265A7/fi not_active Application Discontinuation
- 1976-11-17 NL NLAANVRAGE7612794,A patent/NL180936C/en not_active IP Right Cessation
- 1976-11-17 PT PT65853A patent/PT65853B/en unknown
- 1976-11-17 DK DK517076A patent/DK151330C/en not_active IP Right Cessation
- 1976-11-17 IL IL50932A patent/IL50932A/en unknown
- 1976-11-17 AT AT854376A patent/AT355566B/en not_active IP Right Cessation
- 1976-11-17 MX MX765135U patent/MX4881E/en unknown
- 1976-11-17 ES ES453389A patent/ES453389A1/en not_active Expired
- 1976-11-18 JP JP13785976A patent/JPS5297952A/en active Granted
- 1976-11-18 BE BE172486A patent/BE848496A/en not_active IP Right Cessation
- 1976-11-18 GB GB48127/76A patent/GB1565080A/en not_active Expired
- 1976-11-18 CH CH1454276A patent/CH623321A5/en not_active IP Right Cessation
- 1976-11-18 ZA ZA766907A patent/ZA766907B/en unknown
- 1976-11-18 IE IE2541/76A patent/IE44265B1/en unknown
- 1976-11-18 CA CA266,041A patent/CA1094088A/en not_active Expired
- 1976-11-18 NZ NZ182665A patent/NZ182665A/en unknown
- 1976-11-18 GR GR52209A patent/GR62012B/en unknown
- 1976-11-18 AU AU19779/76A patent/AU510315B2/en not_active Expired
-
1980
- 1980-03-03 CH CH167280A patent/CH622770A5/en not_active IP Right Cessation
-
1982
- 1982-01-12 JP JP57002388A patent/JPS6017778B2/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| AU510315B2 (en) | 1980-06-19 |
| CH623321A5 (en) | 1981-05-29 |
| DK151330C (en) | 1988-04-25 |
| GR62012B (en) | 1979-02-15 |
| SE434744B (en) | 1984-08-13 |
| DE2651572A1 (en) | 1977-06-08 |
| ZA766907B (en) | 1977-10-26 |
| IE44265B1 (en) | 1981-09-23 |
| NL180936B (en) | 1986-12-16 |
| DK151330B (en) | 1987-11-23 |
| JPS5297952A (en) | 1977-08-17 |
| CH622770A5 (en) | 1981-04-30 |
| JPS6017778B2 (en) | 1985-05-07 |
| SE7612554L (en) | 1977-05-19 |
| DK517076A (en) | 1977-05-19 |
| FR2332010B1 (en) | 1979-06-29 |
| PT65853B (en) | 1978-05-15 |
| IL50932A (en) | 1984-01-31 |
| ATA854376A (en) | 1979-08-15 |
| DE2651572C2 (en) | 1982-05-19 |
| AU1977976A (en) | 1978-05-25 |
| FR2332010A1 (en) | 1977-06-17 |
| GB1565080A (en) | 1980-04-16 |
| BE848496A (en) | 1977-05-18 |
| JPS57145843A (en) | 1982-09-09 |
| FI763265A7 (en) | 1977-05-19 |
| NZ182665A (en) | 1978-11-13 |
| CA1094088A (en) | 1981-01-20 |
| AT355566B (en) | 1980-03-10 |
| NL180936C (en) | 1987-05-18 |
| JPS63435B2 (en) | 1988-01-07 |
| NL7612794A (en) | 1977-05-23 |
| ES453389A1 (en) | 1977-11-16 |
| PT65853A (en) | 1976-12-01 |
| IL50932A0 (en) | 1977-01-31 |
| MX4881E (en) | 1982-11-30 |
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