IE44403L - CIS-4a-PHENYL-ISOQUINOLINES - Google Patents
CIS-4a-PHENYL-ISOQUINOLINESInfo
- Publication number
- IE44403L IE44403L IE762735A IE273576A IE44403L IE 44403 L IE44403 L IE 44403L IE 762735 A IE762735 A IE 762735A IE 273576 A IE273576 A IE 273576A IE 44403 L IE44403 L IE 44403L
- Authority
- IE
- Ireland
- Prior art keywords
- hydrogen
- carbon atoms
- cis
- isoquinolines
- phenyl
- Prior art date
Links
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 6
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 229940035676 analgesics Drugs 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 230000001430 anti-depressive effect Effects 0.000 abstract 1
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- 229940005513 antidepressants Drugs 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000411 inducer Substances 0.000 abstract 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
- 230000007958 sleep Effects 0.000 abstract 1
- 239000003204 tranquilizing agent Substances 0.000 abstract 1
- 230000002936 tranquilizing effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
Cis-4a-Phenylisoquinolines The compounds of formula I, I wherein (i) R1 is hydrogen or alkyl of 1 to 4 carbon atoms, R2 is hydrogen, R3 and R4 together are oxygen, and each of R5 and R6 is hydrogen, or (ii) R1 is hydrogen, alkyl of 1 to 4 carbon atoms, or alkanoyl of 1 to 4 carbon atoms, and R2 is an alkyl group of 1 to 4 carbon atoms, and (a) either R3 and R4, together, are oxygen, or methylene, and each of R5 and R6 is hydrogen, or (b) R3 and R6, together, form a bond, and each of R4 and R5 is hydrogen, are useful as analgesics, anti-depressants, tranquilizers and sleep inducers.
[CA1085854A]
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1628375A CH619937A5 (en) | 1975-12-16 | 1975-12-16 | Process for the preparation of novel cis-4a-phenyl- isoquinolines |
| CH1628475 | 1975-12-16 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE44403L true IE44403L (en) | 1977-06-16 |
| IE44403B1 IE44403B1 (en) | 1981-11-18 |
Family
ID=25717645
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE2735/76A IE44403B1 (en) | 1975-12-16 | 1976-12-14 | Cis-4a-phenyl-isoquinolines |
Country Status (10)
| Country | Link |
|---|---|
| JP (1) | JPS5273881A (en) |
| AU (1) | AU512799B2 (en) |
| CA (1) | CA1085854A (en) |
| DE (1) | DE2655150A1 (en) |
| FR (1) | FR2335225A1 (en) |
| GB (1) | GB1568976A (en) |
| IE (1) | IE44403B1 (en) |
| IL (1) | IL51104A (en) |
| NZ (1) | NZ182883A (en) |
| PH (1) | PH13335A (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2907461A1 (en) * | 1978-03-10 | 1979-09-20 | Sandoz Ag | ISOCHINOLINE DERIVATIVES, THEIR MANUFACTURING AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE |
| CN1163487C (en) * | 1995-07-20 | 2004-08-25 | 东丽株式会社 | 4α-Aryl decahydroisoquinoline compound and its medical application |
| US5939551A (en) * | 1996-05-15 | 1999-08-17 | Toray Industries, Inc. | Process for producing 4a-aryldecahydroisoquinoline derivatives |
| AU2014287471C1 (en) | 2013-07-10 | 2019-11-28 | Vertex Pharmaceuticals Incorporated | Fused piperidine amides as modulators of ion channels |
-
1976
- 1976-12-06 DE DE19762655150 patent/DE2655150A1/en not_active Withdrawn
- 1976-12-14 CA CA267,852A patent/CA1085854A/en not_active Expired
- 1976-12-14 NZ NZ182883A patent/NZ182883A/en unknown
- 1976-12-14 IL IL51104A patent/IL51104A/en unknown
- 1976-12-14 PH PH19247A patent/PH13335A/en unknown
- 1976-12-14 GB GB52073/76A patent/GB1568976A/en not_active Expired
- 1976-12-14 IE IE2735/76A patent/IE44403B1/en unknown
- 1976-12-15 JP JP51149925A patent/JPS5273881A/en active Pending
- 1976-12-16 FR FR7637860A patent/FR2335225A1/en active Granted
- 1976-12-16 AU AU20625/76A patent/AU512799B2/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| IL51104A (en) | 1981-12-31 |
| DE2655150A1 (en) | 1977-06-23 |
| AU2062576A (en) | 1978-06-22 |
| PH13335A (en) | 1980-03-13 |
| IE44403B1 (en) | 1981-11-18 |
| GB1568976A (en) | 1980-06-11 |
| AU512799B2 (en) | 1980-10-30 |
| NZ182883A (en) | 1979-06-08 |
| FR2335225B1 (en) | 1980-04-18 |
| JPS5273881A (en) | 1977-06-21 |
| IL51104A0 (en) | 1977-02-28 |
| CA1085854A (en) | 1980-09-16 |
| FR2335225A1 (en) | 1977-07-15 |
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