IE44482L - N-(morpholinoethyl) benzamides - Google Patents
N-(morpholinoethyl) benzamidesInfo
- Publication number
- IE44482L IE44482L IE770296A IE29677A IE44482L IE 44482 L IE44482 L IE 44482L IE 770296 A IE770296 A IE 770296A IE 29677 A IE29677 A IE 29677A IE 44482 L IE44482 L IE 44482L
- Authority
- IE
- Ireland
- Prior art keywords
- benzamides
- halogen
- morpholinoethyl
- denotes
- gb1512194a
- Prior art date
Links
- VFQYQYRTIQWWPE-UHFFFAOYSA-N n-(2-morpholin-4-ylethyl)benzamide Chemical class C=1C=CC=CC=1C(=O)NCCN1CCOCC1 VFQYQYRTIQWWPE-UHFFFAOYSA-N 0.000 title 1
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 abstract 2
- 229940054066 benzamide antipsychotics Drugs 0.000 abstract 2
- 150000003936 benzamides Chemical class 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 208000020401 Depressive disease Diseases 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- HGBCPYMIZWPKMI-UHFFFAOYSA-N aziridin-1-yl(phenyl)methanone Chemical class C=1C=CC=CC=1C(=O)N1CC1 HGBCPYMIZWPKMI-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000005494 condensation Effects 0.000 abstract 1
- 238000009833 condensation Methods 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Benzamides of the formula <IMAGE> in which X denotes halogen, trifluoromethyl or C3-4-alkyl and Y denotes hydrogen, halogen or nitro, and N-oxides and acid addition salts thereof have useful MAO-inhibiting properties and are accordingly suitable in particular for the treatment of depressive states. These compounds are prepared by condensation of morpholine with appropriately substituted N-(2-haloethyl)benzamides or benzoylaziridines and optionally N-oxidation.
[GB1512194A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT107076A AT345842B (en) | 1976-02-16 | 1976-02-16 | METHOD FOR PRODUCING NEW MORPHOLINE DERIVATIVES, THEIR N-OXYDES AND SALTS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE44482L true IE44482L (en) | 1977-08-16 |
| IE44482B1 IE44482B1 (en) | 1981-12-16 |
Family
ID=3505951
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE296/77A IE44482B1 (en) | 1976-02-16 | 1977-02-11 | Benzamides |
Country Status (28)
| Country | Link |
|---|---|
| JP (1) | JPS52100476A (en) |
| AR (2) | AR214307A1 (en) |
| AT (5) | AT345842B (en) |
| AU (1) | AU506427B2 (en) |
| BE (1) | BE851422A (en) |
| CA (1) | CA1076112A (en) |
| CH (5) | CH623317A5 (en) |
| DE (1) | DE2706179C2 (en) |
| DK (1) | DK148824C (en) |
| ES (4) | ES455907A1 (en) |
| FI (1) | FI65426C (en) |
| FR (1) | FR2340940A1 (en) |
| GB (1) | GB1512194A (en) |
| GR (1) | GR62413B (en) |
| HR (1) | HRP930495B1 (en) |
| IE (1) | IE44482B1 (en) |
| IL (1) | IL51406A (en) |
| LU (2) | LU76771A1 (en) |
| MC (1) | MC1136A1 (en) |
| NL (2) | NL179382C (en) |
| NO (2) | NO148417C (en) |
| NZ (1) | NZ183316A (en) |
| PH (1) | PH12847A (en) |
| PT (1) | PT66195B (en) |
| SE (1) | SE426822B (en) |
| SI (1) | SI7710060A8 (en) |
| YU (1) | YU39983B (en) |
| ZA (1) | ZA77746B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005263787A (en) | 2004-02-17 | 2005-09-29 | Ishihara Sangyo Kaisha Ltd | Amide compound or its salt and cytokine production inhibitor containing the same |
| DE602006003756D1 (en) | 2005-05-03 | 2009-01-02 | Bayer Cropscience Sa | NEW HETEROCYCLYLETHYLBENZAMIDE DERIVATIVES |
| RU2414462C1 (en) * | 2009-11-16 | 2011-03-20 | Федеральное государственное унитарное предприятие "Государственный научный центр "Научно-исследовательский институт органических полупродуктов и красителей" (ФГУП "ГНЦ "НИОПИК") | Method for preparing 4-chlor-n-(2-morpholinoethyl)benzamide |
| RU2570898C2 (en) * | 2014-03-27 | 2015-12-20 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Российский химико-технологический университет имени Д.И. Менделеева (РХТУ им. Д.И. Менделеева)" | Method for obtaining n-[2-(morpholin-4-yl)ethyl]-4-chlorobenzamide (versions) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH451142A (en) * | 1965-01-19 | 1968-05-15 | Sandoz Ag | Process for the preparation of new basic substituted benzoic acid amides |
| FR1501846A (en) * | 1966-09-26 | 1967-11-18 | Bellon Labor Sa Roger | Improved process for the preparation of thioamides |
| US3787419A (en) * | 1971-07-01 | 1974-01-22 | American Home Prod | N-substituted-alpha,alpha,alpha-trifluoro-m-toluamides |
-
1976
- 1976-02-16 AT AT107076A patent/AT345842B/en not_active IP Right Cessation
- 1976-12-16 CH CH1581976A patent/CH623317A5/en not_active IP Right Cessation
-
1977
- 1977-01-06 AU AU21099/77A patent/AU506427B2/en not_active Expired
- 1977-01-12 YU YU60/77A patent/YU39983B/en unknown
- 1977-01-12 SI SI7710060A patent/SI7710060A8/en unknown
- 1977-01-27 AR AR266340A patent/AR214307A1/en active
- 1977-02-01 FI FI770356A patent/FI65426C/en not_active IP Right Cessation
- 1977-02-03 NL NLAANVRAGE7701144,A patent/NL179382C/en not_active IP Right Cessation
- 1977-02-08 DK DK51677A patent/DK148824C/en not_active IP Right Cessation
- 1977-02-09 ZA ZA770746A patent/ZA77746B/en unknown
- 1977-02-09 IL IL51406A patent/IL51406A/en unknown
- 1977-02-11 IE IE296/77A patent/IE44482B1/en not_active IP Right Cessation
- 1977-02-11 NZ NZ183316A patent/NZ183316A/en unknown
- 1977-02-11 CA CA271,635A patent/CA1076112A/en not_active Expired
- 1977-02-14 MC MC771233A patent/MC1136A1/en unknown
- 1977-02-14 JP JP1431377A patent/JPS52100476A/en active Granted
- 1977-02-14 PH PH19452A patent/PH12847A/en unknown
- 1977-02-14 DE DE2706179A patent/DE2706179C2/en not_active Expired
- 1977-02-14 LU LU76771A patent/LU76771A1/xx active Protection Beyond IP Right Term
- 1977-02-14 FR FR7704087A patent/FR2340940A1/en active Granted
- 1977-02-15 ES ES455907A patent/ES455907A1/en not_active Expired
- 1977-02-15 SE SE7701669A patent/SE426822B/en not_active IP Right Cessation
- 1977-02-15 NO NO770488A patent/NO148417C/en unknown
- 1977-02-15 GR GR52790A patent/GR62413B/en unknown
- 1977-02-15 PT PT66195A patent/PT66195B/en unknown
- 1977-02-15 BE BE174926A patent/BE851422A/en not_active IP Right Cessation
- 1977-02-15 GB GB6215/77A patent/GB1512194A/en not_active Expired
- 1977-08-15 AR AR268800A patent/AR212554A1/en active
-
1978
- 1978-01-13 AT AT25878A patent/AT349482B/en not_active IP Right Cessation
- 1978-01-13 AT AT25778A patent/AT349481B/en not_active IP Right Cessation
- 1978-01-13 AT AT25678A patent/AT349480B/en not_active IP Right Cessation
- 1978-01-13 AT AT25578A patent/AT349479B/en not_active IP Right Cessation
- 1978-03-01 ES ES467455A patent/ES467455A1/en not_active Expired
- 1978-03-01 ES ES467448A patent/ES467448A1/en not_active Expired
- 1978-03-01 ES ES467449A patent/ES467449A1/en not_active Expired
-
1980
- 1980-07-18 CH CH554380A patent/CH622786A5/en not_active IP Right Cessation
- 1980-07-18 CH CH554680A patent/CH623577A5/en not_active IP Right Cessation
- 1980-07-18 CH CH554480A patent/CH622787A5/en not_active IP Right Cessation
- 1980-07-18 CH CH554580A patent/CH623576A5/en not_active IP Right Cessation
-
1993
- 1993-03-24 HR HRP-60/77A patent/HRP930495B1/en not_active IP Right Cessation
- 1993-06-10 LU LU88300C patent/LU88300I2/en unknown
- 1993-06-17 NL NL930082C patent/NL930082I2/en unknown
-
1994
- 1994-08-03 NO NO1994008C patent/NO1994008I1/en unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| SPCF | Request for grant of supplementary protection certificate |
Free format text: SPC 42/93:19930610 |
|
| SPCG | Supplementary protection certificate granted |
Free format text: SPC 42/93 EXPIRES:20020210 |
|
| MK9A | Patent expired |