IE44588L - Benzopyran derivatives - Google Patents
Benzopyran derivativesInfo
- Publication number
- IE44588L IE44588L IE770161A IE16177A IE44588L IE 44588 L IE44588 L IE 44588L IE 770161 A IE770161 A IE 770161A IE 16177 A IE16177 A IE 16177A IE 44588 L IE44588 L IE 44588L
- Authority
- IE
- Ireland
- Prior art keywords
- antihypertensives
- piperidino
- ran
- benzo
- dihydro
- Prior art date
Links
- 150000001562 benzopyrans Chemical class 0.000 title 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 230000021736 acetylation Effects 0.000 abstract 1
- 238000006640 acetylation reaction Methods 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000004442 acylamino group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003302 alkenyloxy group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 230000003276 anti-hypertensive effect Effects 0.000 abstract 1
- 239000002220 antihypertensive agent Substances 0.000 abstract 1
- 229940030600 antihypertensive agent Drugs 0.000 abstract 1
- 239000002876 beta blocker Substances 0.000 abstract 1
- VZWXIQHBIQLMPN-UHFFFAOYSA-N chromane Chemical compound C1=CC=C2CCCOC2=C1 VZWXIQHBIQLMPN-UHFFFAOYSA-N 0.000 abstract 1
- 239000002934 diuretic Substances 0.000 abstract 1
- 229940030606 diuretics Drugs 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 229940097258 other antihypertensives in atc Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrane Compounds (AREA)
Abstract
Chroman derivs. of formula (I) and their salts are new: (R9 = CH3 or C2H5, R10 = H or CH3, R11 = H or CH3, R12 = H, halo, 1-6C alkyl, 2-6 C alkenyl, 1-6C alkoxy, 2-6C alkenyloxy, 1-6C alkylthio, NO2, CF3, 2-7C acylamino or CN). R13 = R14 or R14O. R 14 = 18C hydrocarbyl opt. substd. by halo. X = bond, CH2, CH2CH2, CH2CH2CHi, CH=CH or O). Also claimed is the intermediate trans-4-piperidino-3,4-dihydro-2,2-dimethyl-7-nitro-2H-benzo(b)py- ran-3-ol (II) and its pharmaceutically acceptable acid addition salts. (I) are antihypertensives. They are given generally at 1-250, e.g. 2-100 mg/day for a 70 kg person, opt. together with beta-adrenergic blockers, diuretics and/or other antihypertensives. (II) also has antihypertensive action with minimal side effects on the heart. In an example trans-4-piperidino-3,4-dihydro-2,2-dimethyl-6-nitro-2H-benzo(b)py- ran-3-yl acerate was prepd. by acetylation of the 3-ol.
[FR2339606A1]
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IE66/80A IE44589B1 (en) | 1976-01-27 | 1977-01-26 | Trans-4-heterocyclyl-3,4-dihydro-2h-benzo(b)pyran-3-ol derivatives |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3024/76A GB1548221A (en) | 1976-01-27 | 1976-01-27 | Trans-4-heterocycyl-3,4-dihydro-2h-benzo pyran-3-ol esters |
| GB1423976 | 1976-04-08 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE44588L true IE44588L (en) | 1977-07-27 |
| IE44588B1 IE44588B1 (en) | 1982-01-27 |
Family
ID=26237940
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE161/77A IE44588B1 (en) | 1976-01-27 | 1977-01-26 | Trans-4-heterocyclyl-3,4-dihidro-2h-benzo(b)pyran-3-ol esters |
Country Status (9)
| Country | Link |
|---|---|
| JP (1) | JPS5291866A (en) |
| AU (1) | AU505768B2 (en) |
| DE (1) | DE2702092A1 (en) |
| DK (1) | DK31977A (en) |
| ES (1) | ES454888A1 (en) |
| FR (1) | FR2339606A1 (en) |
| IE (1) | IE44588B1 (en) |
| NL (1) | NL7700819A (en) |
| SE (1) | SE7700824L (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5549371A (en) * | 1978-10-04 | 1980-04-09 | Beecham Group Ltd | Chromanol derivatives*their manufacture and their use of pharmaceutic composition |
| ZM7682A1 (en) * | 1981-09-25 | 1983-05-23 | Beecham Group Plc | Active compounds |
| GB8313679D0 (en) * | 1983-05-18 | 1983-06-22 | Beecham Group Plc | Active compounds |
| GB8419516D0 (en) * | 1984-07-31 | 1984-09-05 | Beecham Group Plc | Treatment |
| GB8625185D0 (en) * | 1986-10-21 | 1986-11-26 | Beecham Group Plc | Active compounds |
| US5352814A (en) * | 1991-08-30 | 1994-10-04 | Nissan Chemical Industries, Ltd. | Asymmetric epoxidation reaction |
| EP1214307B1 (en) | 1999-09-24 | 2004-04-07 | Nissan Chemical Industries, Ltd. | 4-oxybenzopyran derivative |
| US6677371B1 (en) | 1999-10-05 | 2004-01-13 | Nissan Chemical Industries, Ltd. | 4-oxybenzopyran derivative |
| EP1401823B1 (en) | 2001-06-25 | 2005-10-05 | Nissan Chemical Industries, Ltd. | Substituted benzopyran derivatives against arrhythmia |
-
1977
- 1977-01-07 ES ES454888A patent/ES454888A1/en not_active Expired
- 1977-01-19 DE DE19772702092 patent/DE2702092A1/en not_active Withdrawn
- 1977-01-21 FR FR7701699A patent/FR2339606A1/en active Granted
- 1977-01-25 AU AU21625/77A patent/AU505768B2/en not_active Expired
- 1977-01-26 JP JP761377A patent/JPS5291866A/en active Pending
- 1977-01-26 IE IE161/77A patent/IE44588B1/en unknown
- 1977-01-26 DK DK31977A patent/DK31977A/en not_active Application Discontinuation
- 1977-01-26 SE SE7700824A patent/SE7700824L/en unknown
- 1977-01-27 NL NL7700819A patent/NL7700819A/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| FR2339606A1 (en) | 1977-08-26 |
| AU2162577A (en) | 1978-08-03 |
| FR2339606B1 (en) | 1981-01-16 |
| ES454888A1 (en) | 1978-05-01 |
| DE2702092A1 (en) | 1977-07-28 |
| AU505768B2 (en) | 1979-11-29 |
| IE44588B1 (en) | 1982-01-27 |
| NL7700819A (en) | 1977-07-29 |
| DK31977A (en) | 1977-07-28 |
| JPS5291866A (en) | 1977-08-02 |
| SE7700824L (en) | 1977-07-28 |
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