IE44704L - ß-LACTAM ANTIBIOTIC - Google Patents
ß-LACTAM ANTIBIOTICInfo
- Publication number
- IE44704L IE44704L IE770415A IE41577A IE44704L IE 44704 L IE44704 L IE 44704L IE 770415 A IE770415 A IE 770415A IE 41577 A IE41577 A IE 41577A IE 44704 L IE44704 L IE 44704L
- Authority
- IE
- Ireland
- Prior art keywords
- calcium
- salt
- diclavulanate
- resulting
- solution
- Prior art date
Links
- 239000003782 beta lactam antibiotic agent Substances 0.000 title 1
- 239000002132 β-lactam antibiotic Substances 0.000 title 1
- 229940124586 β-lactam antibiotics Drugs 0.000 title 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 3
- 229910052791 calcium Inorganic materials 0.000 abstract 3
- 239000011575 calcium Substances 0.000 abstract 3
- 159000000007 calcium salts Chemical class 0.000 abstract 2
- 150000001768 cations Chemical class 0.000 abstract 2
- 239000011347 resin Substances 0.000 abstract 2
- 229920005989 resin Polymers 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000000243 solution Substances 0.000 abstract 2
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 abstract 1
- HZZVJAQRINQKSD-UHFFFAOYSA-N Clavulanic acid Natural products OC(=O)C1C(=CCO)OC2CC(=O)N21 HZZVJAQRINQKSD-UHFFFAOYSA-N 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 229910001424 calcium ion Inorganic materials 0.000 abstract 1
- HZZVJAQRINQKSD-PBFISZAISA-N clavulanic acid Chemical compound OC(=O)[C@H]1C(=C/CO)/O[C@@H]2CC(=O)N21 HZZVJAQRINQKSD-PBFISZAISA-N 0.000 abstract 1
- 229960003324 clavulanic acid Drugs 0.000 abstract 1
- 150000004683 dihydrates Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
An aqueous solution of a salt of clavulanic acid with the exception of the calcium salt is treated with a cation exchanger resin in the form of the calcium salt. The calcium diclavulanate which is formed is eluted from the exchanger resin, resulting in a solution of calcium diclavulanate which is virtually free of cations other than calcium ions. Calcium diclavulanate dihydrate is allowed to crystallise out of the resulting solution and is isolated in crystalline form. The resulting salt is suitable as active component in pharmaceutical compositions, especially for oral administration.
[GB1561395A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7544/76A GB1561395A (en) | 1976-02-26 | 1976-02-26 | -lactam antibiotic |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE44704L true IE44704L (en) | 1977-08-26 |
| IE44704B1 IE44704B1 (en) | 1982-02-24 |
Family
ID=9835161
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE415/77A IE44704B1 (en) | 1976-02-26 | 1977-02-25 | Lactam antibiotic |
Country Status (13)
| Country | Link |
|---|---|
| JP (1) | JPS52105193A (en) |
| AU (1) | AU504721B2 (en) |
| BE (1) | BE851872A (en) |
| CA (1) | CA1079736A (en) |
| CH (1) | CH624957A5 (en) |
| DE (1) | DE2708046A1 (en) |
| DK (1) | DK86177A (en) |
| FR (1) | FR2342289A1 (en) |
| GB (1) | GB1561395A (en) |
| IE (1) | IE44704B1 (en) |
| NL (1) | NL7702036A (en) |
| SE (1) | SE7702078L (en) |
| ZA (1) | ZA771089B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU600655B2 (en) * | 1984-10-27 | 1990-08-23 | Beecham Group Plc | Preparation of clavulanic acid and its salts and esters |
| AT400033B (en) | 1992-03-10 | 1995-09-25 | Biochemie Gmbh | NEW METHOD FOR ISOLATING AND PURIFYING CLAVULANIC ACID AND FOR PRODUCING PHARMACOLOGICALLY COMPATIBLE SALTS THEREOF |
| AT399155B (en) * | 1992-03-26 | 1995-03-27 | Lek Tovarna Farmacevtskih | NEW ALKYLENE DIAMMONIUM DICLAVULANATE DERIVATIVES, METHOD FOR THE PRODUCTION AND USE THEREOF |
| US9433640B2 (en) | 2014-12-23 | 2016-09-06 | Ardelyx, Inc. | Compositions and methods for treating hyperkalemia |
| CA2971725C (en) * | 2014-12-23 | 2024-05-14 | Ardelyx, Inc. | Compositions and methods for treating hyperkalemia |
-
1976
- 1976-02-26 GB GB7544/76A patent/GB1561395A/en not_active Expired
-
1977
- 1977-02-23 FR FR7705257A patent/FR2342289A1/en active Granted
- 1977-02-23 ZA ZA00771089A patent/ZA771089B/en unknown
- 1977-02-24 AU AU22643/77A patent/AU504721B2/en not_active Expired
- 1977-02-24 DE DE19772708046 patent/DE2708046A1/en not_active Withdrawn
- 1977-02-24 SE SE7702078A patent/SE7702078L/en not_active Application Discontinuation
- 1977-02-25 BE BE175302A patent/BE851872A/en unknown
- 1977-02-25 CA CA272,740A patent/CA1079736A/en not_active Expired
- 1977-02-25 CH CH242177A patent/CH624957A5/en not_active IP Right Cessation
- 1977-02-25 NL NL7702036A patent/NL7702036A/en not_active Application Discontinuation
- 1977-02-25 DK DK86177A patent/DK86177A/en not_active Application Discontinuation
- 1977-02-25 IE IE415/77A patent/IE44704B1/en unknown
- 1977-02-26 JP JP2076577A patent/JPS52105193A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| IE44704B1 (en) | 1982-02-24 |
| DK86177A (en) | 1977-08-27 |
| GB1561395A (en) | 1980-02-20 |
| NL7702036A (en) | 1977-08-30 |
| BE851872A (en) | 1977-08-25 |
| ZA771089B (en) | 1978-01-25 |
| FR2342289B1 (en) | 1980-02-01 |
| SE7702078L (en) | 1977-08-27 |
| JPS52105193A (en) | 1977-09-03 |
| AU504721B2 (en) | 1979-10-25 |
| CH624957A5 (en) | 1981-08-31 |
| AU2264377A (en) | 1978-08-31 |
| CA1079736A (en) | 1980-06-17 |
| DE2708046A1 (en) | 1977-09-01 |
| FR2342289A1 (en) | 1977-09-23 |
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