IE44708L - Esters of hydroxy alkoxyalkyl purines - Google Patents
Esters of hydroxy alkoxyalkyl purinesInfo
- Publication number
- IE44708L IE44708L IE770438A IE43877A IE44708L IE 44708 L IE44708 L IE 44708L IE 770438 A IE770438 A IE 770438A IE 43877 A IE43877 A IE 43877A IE 44708 L IE44708 L IE 44708L
- Authority
- IE
- Ireland
- Prior art keywords
- compounds
- formula
- purines
- esters
- carbon atoms
- Prior art date
Links
- 150000002148 esters Chemical class 0.000 title 1
- -1 hydroxy alkoxyalkyl purines Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000000840 anti-viral effect Effects 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
This invention relates to compounds of formula (1) (1) Wherein R1 is hydroxy or amino, R2 is hydrogen, straight or branched chain alkyl group having from 2 to 16 carbon atoms, an unsubstituted aryl group having 10 carbon atoms, or a substituted aryl group having 6 to 18 carbons atoms. Provided are pharmaceutical compositions comprising a compound of formula (1) together with an acceptable carrier therefor, and the use of the compounds in medicine. Also provided are methods for the synthesis of the novel compounds. Compounds of formula (1) have good antiviral activity against several types of virus, in particular those in the Herpes family.
[CA1086316A]
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7988/76A GB1561380A (en) | 1976-03-01 | 1976-03-01 | Esters of hydroxyalkoxyalkyl purines their preparation and pharmaceutical compositions containing them |
| US71810576A | 1976-08-27 | 1976-08-27 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE44708L true IE44708L (en) | 1977-09-01 |
| IE44708B1 IE44708B1 (en) | 1982-03-10 |
Family
ID=26241801
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE438/77A IE44708B1 (en) | 1976-03-01 | 1977-03-01 | Esters of hydroxyalkoxylkyl purines, their preparation, and pharmaceutical compositions containing them |
Country Status (25)
| Country | Link |
|---|---|
| JP (1) | JPS52106896A (en) |
| AR (4) | AR228232A1 (en) |
| AT (1) | AT361007B (en) |
| AU (1) | AU515553B2 (en) |
| BE (1) | BE851972R (en) |
| BG (2) | BG27750A3 (en) |
| CA (1) | CA1086316A (en) |
| CH (4) | CH629806A5 (en) |
| DD (1) | DD128611A5 (en) |
| DE (1) | DE2708827A1 (en) |
| DK (1) | DK147824C (en) |
| ES (1) | ES456432A2 (en) |
| FI (1) | FI60710C (en) |
| FR (1) | FR2342972A2 (en) |
| GR (1) | GR66070B (en) |
| HU (1) | HU176907B (en) |
| IE (1) | IE44708B1 (en) |
| IT (1) | IT8048953A0 (en) |
| LU (1) | LU76869A1 (en) |
| NL (2) | NL7702175A (en) |
| PL (2) | PL115267B1 (en) |
| RO (1) | RO76591A (en) |
| SE (1) | SE433216B (en) |
| SU (1) | SU637086A3 (en) |
| ZA (1) | ZA771220B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL8202626A (en) * | 1982-06-29 | 1984-01-16 | Stichting Rega V Z W | DERIVATIVES OF 9- (2-HYDROXYETHOXYMETHYL) GUANINE. |
| ES8403904A1 (en) * | 1983-02-25 | 1984-04-01 | Ind Farma Especial | Process for the preparation of acycloguanosine |
| GB8816760D0 (en) * | 1988-07-14 | 1988-08-17 | Wellcome Found | Therapeutic compounds |
| US6110923A (en) * | 1994-06-22 | 2000-08-29 | Biochem Pharma Inc. | Method for treating cancer using novel substituted purinyl derivatives with immunomodulating activity |
| JP4704223B2 (en) * | 2006-01-30 | 2011-06-15 | Ｈｏｙａ株式会社 | Lead screw mechanism |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5122049A (en) * | 1974-08-19 | 1976-02-21 | Sanwa Denki Kk | KAHENTEIKO SOCHI |
-
1977
- 1977-02-28 AU AU22759/77A patent/AU515553B2/en not_active Expired
- 1977-03-01 CA CA272,888A patent/CA1086316A/en not_active Expired
- 1977-03-01 BG BG035556A patent/BG27750A3/en unknown
- 1977-03-01 ES ES456432A patent/ES456432A2/en not_active Expired
- 1977-03-01 HU HU77WE550A patent/HU176907B/en not_active IP Right Cessation
- 1977-03-01 CH CH257177A patent/CH629806A5/en not_active IP Right Cessation
- 1977-03-01 GR GR52881A patent/GR66070B/el unknown
- 1977-03-01 NL NL7702175A patent/NL7702175A/en active Search and Examination
- 1977-03-01 DE DE19772708827 patent/DE2708827A1/en active Granted
- 1977-03-01 ZA ZA00771220A patent/ZA771220B/en unknown
- 1977-03-01 PL PL1977196356A patent/PL115267B1/en not_active IP Right Cessation
- 1977-03-01 BG BG036534A patent/BG28067A3/en unknown
- 1977-03-01 LU LU76869A patent/LU76869A1/xx unknown
- 1977-03-01 AR AR266728A patent/AR228232A1/en active
- 1977-03-01 AT AT134877A patent/AT361007B/en not_active IP Right Cessation
- 1977-03-01 SU SU772455681A patent/SU637086A3/en active
- 1977-03-01 IE IE438/77A patent/IE44708B1/en unknown
- 1977-03-01 RO RO7796630A patent/RO76591A/en unknown
- 1977-03-01 DD DD197619A patent/DD128611A5/en unknown
- 1977-03-01 SE SE7702233A patent/SE433216B/en not_active IP Right Cessation
- 1977-03-01 FI FI770655A patent/FI60710C/en not_active IP Right Cessation
- 1977-03-01 FR FR7705924A patent/FR2342972A2/en active Granted
- 1977-03-01 BE BE175383A patent/BE851972R/en not_active IP Right Cessation
- 1977-03-01 JP JP2211377A patent/JPS52106896A/en active Granted
- 1977-03-01 DK DK88677A patent/DK147824C/en not_active IP Right Cessation
- 1977-03-01 PL PL1977211568A patent/PL115242B1/en unknown
-
1980
- 1980-06-12 IT IT8048953A patent/IT8048953A0/en unknown
-
1981
- 1981-07-24 AR AR286219A patent/AR228282A1/en active
- 1981-07-24 AR AR286220A patent/AR228283A1/en active
- 1981-07-24 AR AR286218A patent/AR228281A1/en active
- 1981-08-31 CH CH558781A patent/CH632758A5/en not_active IP Right Cessation
- 1981-08-31 CH CH558681A patent/CH632757A5/en not_active IP Right Cessation
- 1981-08-31 CH CH558581A patent/CH631176A5/en not_active IP Right Cessation
-
1984
- 1984-03-21 NL NL8400896A patent/NL8400896A/en not_active Application Discontinuation
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