IE44727L - Dibenzothiophene derivatives - Google Patents
Dibenzothiophene derivativesInfo
- Publication number
- IE44727L IE44727L IE770615A IE61577A IE44727L IE 44727 L IE44727 L IE 44727L IE 770615 A IE770615 A IE 770615A IE 61577 A IE61577 A IE 61577A IE 44727 L IE44727 L IE 44727L
- Authority
- IE
- Ireland
- Prior art keywords
- alkylamino
- alkoxy
- mono
- amino
- lower alkoxy
- Prior art date
Links
- IYYZUPMFVPLQIF-ALWQSETLSA-N dibenzothiophene Chemical class C1=CC=CC=2[34S]C3=C(C=21)C=CC=C3 IYYZUPMFVPLQIF-ALWQSETLSA-N 0.000 title abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 10
- -1 nitro, amino Chemical group 0.000 abstract 8
- 125000003282 alkyl amino group Chemical group 0.000 abstract 6
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000004414 alkyl thio group Chemical group 0.000 abstract 2
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- JCLPOPNXITXHOR-UHFFFAOYSA-N 1,2,3,4-tetrahydrodibenzothiophene Chemical class S1C2=CC=CC=C2C2=C1CCCC2 JCLPOPNXITXHOR-UHFFFAOYSA-N 0.000 abstract 1
- 125000005530 alkylenedioxy group Chemical group 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 238000005899 aromatization reaction Methods 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/76—Dibenzothiophenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Rheumatology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Dibenzothiophene derivatives which have anti-inflammatory activity and the formula <IMAGE> in which R is hydrogen, halogen, hydroxyl, cyano, lower alkyl, hydroxy-lower-alkyl, lower alkoxy, acyl, benzyloxy, lower alkylthio, trifluoromethyl, nitro, amino, mono-lower alkylamino, di-lower alkylamino, sulphamoyl, di-lower alkylsulphamoyl or difluoromethylsulphonyl; R1 is halogen, cyano, lower alkyl, hydroxy-lower alkyl, lower alkoxy, acyl, acylamido, benzyloxy, lower alkylthio, trifluoromethyl, hydroxyl, nitro, amino, mono-lower alkylamino, di-lower alkylamino, sulphamoyl, di-lower alkylsulphamoyl or difluoromethylsulphonyl, or R together with an adjacent R1 is alkylenedioxy, R2 is the group <IMAGE> where A is hydroxyl, lower alkoxy, amino-lower alkoxy, mono-lower alkylamino-lower alkoxy or di-lower alkylamino-lower alkoxy, X and Y are, independently of one another, hydrogen or lower alkyl, m is a number from 1 to 7, R2 is the group <IMAGE>, in which B is hydroxyl, carboxyl, lower alkoxy, amino, hydroxyamino, mono-lower alkylamino, di-lower alkylamino, amino-lower alkoxy, mono-lower alkylamino-lower alkoxy or di-lower alkylamino-lower alkoxy, Y and X are, independently of one another, hydrogen or lower alkyl, n is a number from 1 to 7, and pharmaceutically utilisable salts thereof are prepared by aromatisation starting from the corresponding 1,2,3,4-tetrahydrodibenzothiophene derivatives.
[GB1572358A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66994076A | 1976-03-24 | 1976-03-24 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE44727L true IE44727L (en) | 1977-09-24 |
| IE44727B1 IE44727B1 (en) | 1982-03-10 |
Family
ID=24688362
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE615/77A IE44727B1 (en) | 1976-03-24 | 1977-03-23 | Dibenzothiophene derivatives |
Country Status (24)
| Country | Link |
|---|---|
| JP (1) | JPS52116461A (en) |
| AT (1) | AT360003B (en) |
| AU (1) | AU508330B2 (en) |
| BE (1) | BE852778A (en) |
| CA (1) | CA1104144A (en) |
| CH (1) | CH628045A5 (en) |
| DE (1) | DE2712045A1 (en) |
| DK (1) | DK129277A (en) |
| ES (1) | ES457132A1 (en) |
| FI (1) | FI770930A7 (en) |
| FR (1) | FR2345443A1 (en) |
| GB (1) | GB1572358A (en) |
| GR (1) | GR62464B (en) |
| IE (1) | IE44727B1 (en) |
| IL (1) | IL51718A (en) |
| LU (1) | LU76997A1 (en) |
| MC (1) | MC1133A1 (en) |
| NL (1) | NL7703143A (en) |
| NO (1) | NO771032L (en) |
| NZ (1) | NZ183656A (en) |
| PH (1) | PH13274A (en) |
| PT (1) | PT66343B (en) |
| SE (1) | SE436496B (en) |
| ZA (1) | ZA771722B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8428930D0 (en) * | 1984-11-15 | 1984-12-27 | Wellcome Found | Polycyclic biocidal compounds |
| GB2380192B8 (en) * | 2001-02-09 | 2005-09-14 | Sumitomo Chemical Co | Phenylacetylene compounds liquid crystal compositions polymers optically anisotropic products & optical & liquid crystal elements derived therefrom |
| JP4824015B2 (en) * | 2004-04-14 | 2011-11-24 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | Benzofuran derivatives, dibenzothiophene derivatives, and fluorene derivatives |
| CN109715736B (en) * | 2016-09-27 | 2021-08-24 | 保土谷化学工业株式会社 | Sensitizing dye, sensitizing dye for photoelectric conversion, photoelectric conversion element using the same, and dye-sensitized solar cell |
-
1977
- 1977-03-11 CH CH310177A patent/CH628045A5/en not_active IP Right Cessation
- 1977-03-18 DE DE19772712045 patent/DE2712045A1/en not_active Ceased
- 1977-03-22 ZA ZA00771722A patent/ZA771722B/en unknown
- 1977-03-22 MC MC771236A patent/MC1133A1/en unknown
- 1977-03-22 FR FR7708489A patent/FR2345443A1/en active Granted
- 1977-03-22 IL IL51718A patent/IL51718A/en unknown
- 1977-03-22 NZ NZ183656A patent/NZ183656A/en unknown
- 1977-03-22 LU LU76997A patent/LU76997A1/xx unknown
- 1977-03-23 GR GR53069A patent/GR62464B/en unknown
- 1977-03-23 AT AT203577A patent/AT360003B/en not_active IP Right Cessation
- 1977-03-23 CA CA274,592A patent/CA1104144A/en not_active Expired
- 1977-03-23 SE SE7703353A patent/SE436496B/en unknown
- 1977-03-23 ES ES457132A patent/ES457132A1/en not_active Expired
- 1977-03-23 BE BE176030A patent/BE852778A/en not_active IP Right Cessation
- 1977-03-23 PT PT66343A patent/PT66343B/en unknown
- 1977-03-23 GB GB12224/77A patent/GB1572358A/en not_active Expired
- 1977-03-23 JP JP3121977A patent/JPS52116461A/en active Pending
- 1977-03-23 DK DK129277A patent/DK129277A/en not_active Application Discontinuation
- 1977-03-23 PH PH19581A patent/PH13274A/en unknown
- 1977-03-23 NO NO771032A patent/NO771032L/en unknown
- 1977-03-23 IE IE615/77A patent/IE44727B1/en unknown
- 1977-03-23 NL NL7703143A patent/NL7703143A/en not_active Application Discontinuation
- 1977-03-24 AU AU23572/77A patent/AU508330B2/en not_active Expired
- 1977-03-24 FI FI770930A patent/FI770930A7/fi not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| SE436496B (en) | 1984-12-17 |
| FI770930A7 (en) | 1977-09-25 |
| IE44727B1 (en) | 1982-03-10 |
| ES457132A1 (en) | 1978-08-16 |
| GB1572358A (en) | 1980-07-30 |
| ATA203577A (en) | 1980-05-15 |
| DK129277A (en) | 1977-09-25 |
| ZA771722B (en) | 1978-02-22 |
| LU76997A1 (en) | 1978-06-01 |
| BE852778A (en) | 1977-09-23 |
| NO771032L (en) | 1977-09-27 |
| GR62464B (en) | 1979-04-13 |
| IL51718A (en) | 1980-11-30 |
| JPS52116461A (en) | 1977-09-29 |
| AU508330B2 (en) | 1980-03-20 |
| MC1133A1 (en) | 1977-11-18 |
| PH13274A (en) | 1980-02-27 |
| CA1104144A (en) | 1981-06-30 |
| FR2345443A1 (en) | 1977-10-21 |
| CH628045A5 (en) | 1982-02-15 |
| AU2357277A (en) | 1978-09-28 |
| IL51718A0 (en) | 1977-05-31 |
| NL7703143A (en) | 1977-09-27 |
| PT66343B (en) | 1979-01-18 |
| NZ183656A (en) | 1979-01-11 |
| FR2345443B1 (en) | 1979-03-09 |
| DE2712045A1 (en) | 1977-09-29 |
| PT66343A (en) | 1977-04-01 |
| SE7703353L (en) | 1977-11-07 |
| AT360003B (en) | 1980-12-10 |
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