IE45470L - Thiophene derivatives - Google Patents
Thiophene derivativesInfo
- Publication number
- IE45470L IE45470L IE771751A IE175177A IE45470L IE 45470 L IE45470 L IE 45470L IE 771751 A IE771751 A IE 771751A IE 175177 A IE175177 A IE 175177A IE 45470 L IE45470 L IE 45470L
- Authority
- IE
- Ireland
- Prior art keywords
- thiophene derivatives
- formula
- gb1587084a
- ketotetrahydrothiophene
- hypolipaemic
- Prior art date
Links
- 150000003577 thiophenes Chemical class 0.000 title 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001735 carboxylic acids Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000055 hyoplipidemic effect Effects 0.000 abstract 1
- DWWREQRWOXEVGY-UHFFFAOYSA-N n-(thiolan-3-ylidene)hydroxylamine Chemical class ON=C1CCSC1 DWWREQRWOXEVGY-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- DKGYESBFCGKOJC-UHFFFAOYSA-N thiophen-3-amine Chemical class NC=1C=CSC=1 DKGYESBFCGKOJC-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Hypolipaemic 3-aminothiophenes of the formula <IMAGE> in which R1 is lower alkyl, aryl or aralkyl and R2 is lower alkoxy, and salts thereof are prepared starting from the corresponding 3-ketotetrahydrothiophene oximes. The resulting compounds of the formula I can be converted into the corresponding carboxylic acids or N-alkylated or N-aralkylated.
[GB1587084A]
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71685476A | 1976-08-23 | 1976-08-23 | |
| US71685376A | 1976-08-23 | 1976-08-23 | |
| US82052177A | 1977-08-01 | 1977-08-01 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE45470L true IE45470L (en) | 1978-02-23 |
| IE45470B1 IE45470B1 (en) | 1982-09-08 |
Family
ID=27418961
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1751/77A IE45470B1 (en) | 1976-08-23 | 1977-08-22 | Thiophene derivatives |
Country Status (21)
| Country | Link |
|---|---|
| JP (1) | JPS5340755A (en) |
| AR (1) | AR222453A1 (en) |
| AT (1) | AT359486B (en) |
| AU (1) | AU509956B2 (en) |
| BE (1) | BE858012A (en) |
| CH (1) | CH628628A5 (en) |
| DE (1) | DE2737738C2 (en) |
| DK (1) | DK150484C (en) |
| ES (1) | ES461796A1 (en) |
| FI (1) | FI66859C (en) |
| FR (1) | FR2365566A1 (en) |
| GB (1) | GB1587084A (en) |
| HU (1) | HU179484B (en) |
| IE (1) | IE45470B1 (en) |
| IL (1) | IL52792A (en) |
| IT (1) | IT1143757B (en) |
| LU (1) | LU78003A1 (en) |
| MC (1) | MC1156A1 (en) |
| NL (1) | NL7709246A (en) |
| NO (1) | NO148673C (en) |
| NZ (1) | NZ184981A (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6232765Y2 (en) * | 1981-02-28 | 1987-08-21 | ||
| US6515009B1 (en) | 1991-09-27 | 2003-02-04 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| US5811447A (en) | 1993-01-28 | 1998-09-22 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| US6251920B1 (en) | 1993-05-13 | 2001-06-26 | Neorx Corporation | Prevention and treatment of cardiovascular pathologies |
| US6491938B2 (en) | 1993-05-13 | 2002-12-10 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| DE69435137D1 (en) | 1993-05-13 | 2008-10-16 | Poniard Pharmaceuticals Inc | PREVENTION AND TREATMENT OF PATHOLOGIES ASSOCIATED WITH AN ABNORMAL PROLIFERATION GLATTER MUSCLE CELLS |
| WO1998046588A2 (en) * | 1997-04-11 | 1998-10-22 | Neorx Corporation | Compounds and therapies for the prevention of vascular and non-vascular pathologies |
| US6613083B2 (en) | 2001-05-02 | 2003-09-02 | Eckhard Alt | Stent device and method |
| DE102004063191A1 (en) | 2004-12-29 | 2006-07-13 | Bayer Cropscience Ag | Process for the preparation of substituted 2-alkoxycarbonyl-3-aminothiophenes |
| NZ587261A (en) * | 2008-02-29 | 2012-05-25 | Nissan Chemical Ind Ltd | Process for producing thiophene compound and intermediate thereof |
| AR130733A1 (en) | 2022-10-14 | 2025-01-15 | Adama Agan Ltd | PROCESS FOR THE PREPARATION OF SUBSTITUTED AMINOTHIOPHENE |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2502421A (en) * | 1944-08-28 | 1950-04-04 | Parke Davis & Co | Tetrahydrothiophenes |
| US2502424A (en) * | 1944-12-23 | 1950-04-04 | Parke Davis & Co | 3-acylamino-4-carboalkoxy-2-omega-ralkylthiophenes |
| US2502423A (en) * | 1944-12-23 | 1950-04-04 | Parke Davis & Co | 4-carbalkoxy-3-keto-2-substituted tetrahydrothiophene oximes |
| US2443598A (en) * | 1944-12-23 | 1948-06-22 | Parke Davis & Co | 3-amino-4-carbethoxy-2-alkyl derivatives of thiophene |
-
1977
- 1977-08-03 CH CH954377A patent/CH628628A5/en not_active IP Right Cessation
- 1977-08-19 FR FR7725379A patent/FR2365566A1/en active Granted
- 1977-08-22 GB GB35098/77A patent/GB1587084A/en not_active Expired
- 1977-08-22 FI FI772494A patent/FI66859C/en not_active IP Right Cessation
- 1977-08-22 IL IL52792A patent/IL52792A/en unknown
- 1977-08-22 NZ NZ184981A patent/NZ184981A/en unknown
- 1977-08-22 AR AR268888A patent/AR222453A1/en active
- 1977-08-22 IE IE1751/77A patent/IE45470B1/en unknown
- 1977-08-22 MC MC771256A patent/MC1156A1/en unknown
- 1977-08-22 NO NO772917A patent/NO148673C/en unknown
- 1977-08-22 AT AT607477A patent/AT359486B/en not_active IP Right Cessation
- 1977-08-22 AU AU28092/77A patent/AU509956B2/en not_active Expired
- 1977-08-22 BE BE180354A patent/BE858012A/en not_active IP Right Cessation
- 1977-08-22 DE DE2737738A patent/DE2737738C2/en not_active Expired
- 1977-08-22 ES ES461796A patent/ES461796A1/en not_active Expired
- 1977-08-22 NL NL7709246A patent/NL7709246A/en not_active Application Discontinuation
- 1977-08-22 JP JP9963877A patent/JPS5340755A/en active Granted
- 1977-08-22 HU HU77HO2009A patent/HU179484B/en not_active IP Right Cessation
- 1977-08-22 IT IT26845/77A patent/IT1143757B/en active
- 1977-08-22 LU LU78003A patent/LU78003A1/xx unknown
- 1977-08-22 DK DK372177A patent/DK150484C/en active
Also Published As
| Publication number | Publication date |
|---|---|
| CH628628A5 (en) | 1982-03-15 |
| MC1156A1 (en) | 1978-04-17 |
| AU509956B2 (en) | 1980-06-05 |
| NO772917L (en) | 1978-02-24 |
| FI772494A7 (en) | 1978-02-24 |
| JPS6121235B2 (en) | 1986-05-26 |
| GB1587084A (en) | 1981-03-25 |
| ATA607477A (en) | 1980-04-15 |
| AR222453A1 (en) | 1981-05-29 |
| HU179484B (en) | 1982-10-28 |
| IL52792A (en) | 1981-06-29 |
| FI66859C (en) | 1984-12-10 |
| JPS5340755A (en) | 1978-04-13 |
| NZ184981A (en) | 1980-08-26 |
| NO148673B (en) | 1983-08-15 |
| AT359486B (en) | 1980-11-10 |
| ES461796A1 (en) | 1978-12-16 |
| FR2365566A1 (en) | 1978-04-21 |
| DE2737738C2 (en) | 1987-01-29 |
| NO148673C (en) | 1983-11-23 |
| LU78003A1 (en) | 1978-09-14 |
| BE858012A (en) | 1978-02-22 |
| FR2365566B1 (en) | 1980-12-26 |
| IE45470B1 (en) | 1982-09-08 |
| DK372177A (en) | 1978-02-24 |
| DK150484C (en) | 1987-10-05 |
| DK150484B (en) | 1987-03-09 |
| FI66859B (en) | 1984-08-31 |
| DE2737738A1 (en) | 1978-03-09 |
| AU2809277A (en) | 1979-03-01 |
| NL7709246A (en) | 1978-02-27 |
| IT1143757B (en) | 1986-10-22 |
| IL52792A0 (en) | 1977-10-31 |
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