IE45604L - Prostacyclin derivatives - Google Patents

Prostacyclin derivatives

Info

Publication number
IE45604L
IE45604L IE771133A IE113377A IE45604L IE 45604 L IE45604 L IE 45604L IE 771133 A IE771133 A IE 771133A IE 113377 A IE113377 A IE 113377A IE 45604 L IE45604 L IE 45604L
Authority
IE
Ireland
Prior art keywords
compound
compounds
formula
image
reaction product
Prior art date
Application number
IE771133A
Other versions
IE45604B1 (en
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of IE45604L publication Critical patent/IE45604L/en
Publication of IE45604B1 publication Critical patent/IE45604B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0041—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C07D307/937—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
    • C07F3/10—Mercury compounds

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Analogues of 5,6-dihydroprostacyclin of the formula <IMAGE> in which the substituents are defined in claim 1, are prepared. These compounds are obtained by halogenating and cyclising a compound of the formula <IMAGE> and subsequently reductively dehalogenating the reaction product, with the formation of the desired ether, or by converting the said compound LXII into a corresponding mercury compound and then subjecting the reaction product to the removal of mercury by reduction. The compounds which are obtained may be used for the same pharmacological purposes as the known prostaglandins. [GB1554048A]
IE1133/77A 1976-06-01 1977-06-01 Prostacyclin derivatives IE45604B1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US69140076A 1976-06-01 1976-06-01
US69139976A 1976-06-01 1976-06-01
US78814777A 1977-04-19 1977-04-19
US78814677A 1977-04-19 1977-04-19

Publications (2)

Publication Number Publication Date
IE45604L true IE45604L (en) 1977-12-01
IE45604B1 IE45604B1 (en) 1982-10-06

Family

ID=27505431

Family Applications (1)

Application Number Title Priority Date Filing Date
IE1133/77A IE45604B1 (en) 1976-06-01 1977-06-01 Prostacyclin derivatives

Country Status (13)

Country Link
JP (1) JPS5936912B2 (en)
AU (1) AU508891B2 (en)
BE (1) BE855224A (en)
CA (1) CA1196632A (en)
CH (1) CH640847A5 (en)
DE (1) DE2724555A1 (en)
FR (1) FR2353543B1 (en)
GB (1) GB1554048A (en)
IE (1) IE45604B1 (en)
IL (1) IL52099A (en)
MX (1) MX4813E (en)
NL (1) NL7705991A (en)
SE (3) SE436744B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL51189A (en) * 1976-02-04 1985-08-30 Upjohn Co Prostaglandin analogs
FI71138C (en) 1976-12-31 1986-11-24 Erba Farmitalia FOERFARANDE FOER FRAMSTAELLNING AV TERAPEUTISKT ACTIVE BISYCLISKA PROSTAGLANDINER
AU524786B2 (en) * 1977-03-07 1982-10-07 The Upjohn Company Prostacyclins
DE2743283A1 (en) * 1977-09-27 1979-04-05 Hoechst Ag NEW PROSTACYCLIN ANALOG
DE2811950A1 (en) * 1978-03-18 1979-12-13 Hoechst Ag NEW PROSTACYCLIN ANALOGS
US4237060A (en) 1979-03-23 1980-12-02 Hoffmann-La Roche Inc. Prostacyclin analogs
DE60023144T2 (en) 1999-08-05 2006-07-06 Teijin Ltd. MEANS FOR IMPROVING NEUROPATHY, CONTAINING NITROGEN-CONTAINING COMPOUNDS AS ACTIVE INGREDIENTS

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1079025B (en) * 1976-05-11 1985-05-08 Wellcome Found IMPROVEMENT IN THE PREPARATION OF ETERI

Also Published As

Publication number Publication date
FR2353543A1 (en) 1977-12-30
GB1554048A (en) 1979-10-17
CA1196632A (en) 1985-11-12
SE8201649L (en) 1982-03-16
IL52099A0 (en) 1977-07-31
SE7811142L (en) 1978-11-28
BE855224A (en) 1977-11-30
MX4813E (en) 1982-10-19
NL7705991A (en) 1977-12-05
SE436744B (en) 1985-01-21
JPS52156854A (en) 1977-12-27
IE45604B1 (en) 1982-10-06
JPS5936912B2 (en) 1984-09-06
SE432101B (en) 1984-03-19
IL52099A (en) 1985-03-31
SE7706245L (en) 1977-12-16
AU508891B2 (en) 1980-04-03
FR2353543B1 (en) 1986-02-21
CH640847A5 (en) 1984-01-31
AU2508677A (en) 1978-11-16
DE2724555A1 (en) 1977-12-15

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