IE45922L - Improved morphine/apomorphine rearrangement process - Google Patents
Improved morphine/apomorphine rearrangement processInfo
- Publication number
- IE45922L IE45922L IE237377A IE237377A IE45922L IE 45922 L IE45922 L IE 45922L IE 237377 A IE237377 A IE 237377A IE 237377 A IE237377 A IE 237377A IE 45922 L IE45922 L IE 45922L
- Authority
- IE
- Ireland
- Prior art keywords
- apomorphine
- rearrangement process
- improved
- morphine
- improved morphine
- Prior art date
Links
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 title abstract 3
- VMWNQDUVQKEIOC-CYBMUJFWSA-N apomorphine Chemical compound C([C@H]1N(C)CC2)C3=CC=C(O)C(O)=C3C3=C1C2=CC=C3 VMWNQDUVQKEIOC-CYBMUJFWSA-N 0.000 title abstract 2
- 229960004046 apomorphine Drugs 0.000 title 1
- 229960005181 morphine Drugs 0.000 title 1
- 230000008707 rearrangement Effects 0.000 title 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 abstract 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 abstract 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 abstract 1
- 229910052753 mercury Inorganic materials 0.000 abstract 1
- 230000017105 transposition Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/18—Ring systems of four or more rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
Apomorphine derivatives are prepared with an improved yield by transposition of the corresponding morphine derivative in the presence of anhydrous phosphoric acid under a partial vacuum, generally between 9 and 20 mm of mercury and at a temperature between 125 DEG C and 140 DEG C.
[GB1566049A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75788877A | 1977-01-10 | 1977-01-10 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE45922L true IE45922L (en) | 1978-07-10 |
| IE45922B1 IE45922B1 (en) | 1982-12-29 |
Family
ID=25049636
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE237377A IE45922B1 (en) | 1977-01-10 | 1977-11-23 | Improved morphine/apomorphine rearrangement process |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JPS5387359A (en) |
| AU (1) | AU510976B2 (en) |
| BE (1) | BE862389A (en) |
| CA (1) | CA1092122A (en) |
| CH (1) | CH624674A5 (en) |
| DE (1) | DE2758954A1 (en) |
| DK (1) | DK584077A (en) |
| FR (1) | FR2376847A1 (en) |
| GB (1) | GB1566049A (en) |
| IE (1) | IE45922B1 (en) |
| LU (1) | LU78790A1 (en) |
| NL (1) | NL7714227A (en) |
| NZ (1) | NZ185799A (en) |
| SE (1) | SE7713456L (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3171561D1 (en) * | 1980-05-08 | 1985-09-05 | Univ Northeastern | N-substituted aporphines, a method of inducing emesis and a method of controlling psychosis utilising the same |
| WO1990012574A1 (en) * | 1989-04-25 | 1990-11-01 | Northeastern University | Dopamine agonist compounds |
| GB201915911D0 (en) * | 2019-11-01 | 2019-12-18 | Johnson Matthey Plc | Process |
-
1977
- 1977-11-22 CA CA291,508A patent/CA1092122A/en not_active Expired
- 1977-11-22 GB GB4862177A patent/GB1566049A/en not_active Expired
- 1977-11-23 IE IE237377A patent/IE45922B1/en unknown
- 1977-11-28 AU AU31013/77A patent/AU510976B2/en not_active Expired
- 1977-11-28 NZ NZ18579977A patent/NZ185799A/en unknown
- 1977-11-28 SE SE7713456A patent/SE7713456L/en not_active Application Discontinuation
- 1977-12-21 NL NL7714227A patent/NL7714227A/en not_active Application Discontinuation
- 1977-12-28 FR FR7739473A patent/FR2376847A1/en active Granted
- 1977-12-28 BE BE1008611A patent/BE862389A/en unknown
- 1977-12-29 CH CH1622177A patent/CH624674A5/en not_active IP Right Cessation
- 1977-12-29 JP JP15869177A patent/JPS5387359A/en active Pending
- 1977-12-29 LU LU78790A patent/LU78790A1/xx unknown
- 1977-12-29 DK DK584077A patent/DK584077A/en unknown
- 1977-12-30 DE DE19772758954 patent/DE2758954A1/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| AU510976B2 (en) | 1980-07-24 |
| JPS5387359A (en) | 1978-08-01 |
| FR2376847A1 (en) | 1978-08-04 |
| IE45922B1 (en) | 1982-12-29 |
| FR2376847B1 (en) | 1980-08-22 |
| DK584077A (en) | 1978-07-11 |
| BE862389A (en) | 1978-06-28 |
| NZ185799A (en) | 1979-12-11 |
| AU3101377A (en) | 1979-06-07 |
| LU78790A1 (en) | 1978-07-11 |
| CH624674A5 (en) | 1981-08-14 |
| DE2758954A1 (en) | 1978-07-13 |
| CA1092122A (en) | 1980-12-23 |
| GB1566049A (en) | 1980-04-30 |
| SE7713456L (en) | 1978-07-11 |
| NL7714227A (en) | 1978-07-12 |
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