IE47698B1 - Oral formulations for treating diarrhoea in humans - Google Patents

Oral formulations for treating diarrhoea in humans

Info

Publication number: IE47698B1
Authority: IE; Ireland
Prior art keywords: composition; composition according; ingredients; monosaccharide; citric acid
Prior art date: 1977-12-23

Application number

IE2515/78A

Other languages

English (en)

Other versions

IE782515L (en

Original Assignee

Beecham Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-12-23

Filing date

1978-12-20

Publication date

1984-05-30

1978-12-20 Application filed by Beecham Group Ltd filed Critical Beecham Group Ltd

1979-06-23 Publication of IE782515L publication Critical patent/IE782515L/xx

1984-05-30 Publication of IE47698B1 publication Critical patent/IE47698B1/en

Links

239000000203 mixture Substances 0.000 title claims description 86
206010012735 Diarrhoea Diseases 0.000 title abstract description 15
238000009472 formulation Methods 0.000 title 1
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 52
150000002772 monosaccharides Chemical class 0.000 claims abstract description 24
150000003839 salts Chemical class 0.000 claims abstract description 19
150000001413 amino acids Chemical class 0.000 claims abstract description 18
239000008194 pharmaceutical composition Substances 0.000 claims abstract description 8
239000004615 ingredient Substances 0.000 claims description 24
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 20
239000008121 dextrose Substances 0.000 claims description 19
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 17
239000000796 flavoring agent Substances 0.000 claims description 15
235000019634 flavors Nutrition 0.000 claims description 15
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical group [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 10
239000003792 electrolyte Substances 0.000 claims description 9
239000004471 Glycine Substances 0.000 claims description 8
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
239000002245 particle Substances 0.000 claims description 7
238000000034 method Methods 0.000 claims description 5
239000011780 sodium chloride Substances 0.000 claims description 5
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 4
239000001508 potassium citrate Substances 0.000 claims description 4
QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 claims description 4
239000011734 sodium Substances 0.000 claims description 4
229910052708 sodium Inorganic materials 0.000 claims description 4
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 3
235000015870 tripotassium citrate Nutrition 0.000 claims description 3
238000002360 preparation method Methods 0.000 claims description 2
150000001860 citric acid derivatives Chemical class 0.000 claims 1
229960001031 glucose Drugs 0.000 description 18
235000001014 amino acid Nutrition 0.000 description 13
241000282412 Homo Species 0.000 description 6
239000000843 powder Substances 0.000 description 5
239000002253 acid Substances 0.000 description 4
229910000402 monopotassium phosphate Inorganic materials 0.000 description 4
235000019796 monopotassium phosphate Nutrition 0.000 description 4
BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 description 4
PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 description 4
238000002560 therapeutic procedure Methods 0.000 description 4
244000248349 Citrus limon Species 0.000 description 3
235000005979 Citrus limon Nutrition 0.000 description 3
241000282414 Homo sapiens Species 0.000 description 3
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
229930182830 galactose Natural products 0.000 description 3
239000000463 material Substances 0.000 description 3
239000000243 solution Substances 0.000 description 3
SPFMQWBKVUQXJV-BTVCFUMJSA-N (2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanal;hydrate Chemical compound O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O SPFMQWBKVUQXJV-BTVCFUMJSA-N 0.000 description 2
PNNNRSAQSRJVSB-UHFFFAOYSA-N 2,3,4,5-tetrahydroxyhexanal Chemical compound CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 description 2
239000005995 Aluminium silicate Substances 0.000 description 2
239000004475 Arginine Substances 0.000 description 2
QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 2
WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
229920002472 Starch Polymers 0.000 description 2
239000004480 active ingredient Substances 0.000 description 2
235000004279 alanine Nutrition 0.000 description 2
235000012211 aluminium silicate Nutrition 0.000 description 2
239000007864 aqueous solution Substances 0.000 description 2
ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 2
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
229940075614 colloidal silicon dioxide Drugs 0.000 description 2
229960000673 dextrose monohydrate Drugs 0.000 description 2
NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 2
-1 mono Chemical class 0.000 description 2
150000004682 monohydrates Chemical group 0.000 description 2
229960005181 morphine Drugs 0.000 description 2
239000007787 solid Substances 0.000 description 2
239000008107 starch Substances 0.000 description 2
235000019698 starch Nutrition 0.000 description 2
LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 2
229910002012 Aerosil® Inorganic materials 0.000 description 1
229930003347 Atropine Natural products 0.000 description 1
BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
206010008631 Cholera Diseases 0.000 description 1
241000207199 Citrus Species 0.000 description 1
RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 description 1
SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 description 1
RKUNBYITZUJHSG-UHFFFAOYSA-N Hyosciamin-hydrochlorid Natural products CN1C(C2)CCC1CC2OC(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-UHFFFAOYSA-N 0.000 description 1
ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
241001465754 Metazoa Species 0.000 description 1
229930193140 Neomycin Natural products 0.000 description 1
239000008896 Opium Substances 0.000 description 1
229910019142 PO4 Inorganic materials 0.000 description 1
241001516739 Platonia insignis Species 0.000 description 1
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
VVWYOYDLCMFIEM-UHFFFAOYSA-N Propantheline Chemical compound C1=CC=C2C(C(=O)OCC[N+](C)(C(C)C)C(C)C)C3=CC=CC=C3OC2=C1 VVWYOYDLCMFIEM-UHFFFAOYSA-N 0.000 description 1
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 description 1
230000009056 active transport Effects 0.000 description 1
WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 1
239000003242 anti bacterial agent Substances 0.000 description 1
230000001078 anti-cholinergic effect Effects 0.000 description 1
230000001142 anti-diarrhea Effects 0.000 description 1
229940088710 antibiotic agent Drugs 0.000 description 1
229940124537 antidiarrhoeal agent Drugs 0.000 description 1
RKUNBYITZUJHSG-SPUOUPEWSA-N atropine Chemical compound O([C@H]1C[C@H]2CC[C@@H](C1)N2C)C(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-SPUOUPEWSA-N 0.000 description 1
229960000396 atropine Drugs 0.000 description 1
230000037396 body weight Effects 0.000 description 1
238000009835 boiling Methods 0.000 description 1
239000000872 buffer Substances 0.000 description 1
239000011575 calcium Substances 0.000 description 1
229910052791 calcium Inorganic materials 0.000 description 1
229910052799 carbon Inorganic materials 0.000 description 1
125000004432 carbon atom Chemical group C* 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
235000020971 citrus fruits Nutrition 0.000 description 1
230000003247 decreasing effect Effects 0.000 description 1
230000018044 dehydration Effects 0.000 description 1
238000006297 dehydration reaction Methods 0.000 description 1
ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 description 1
238000004090 dissolution Methods 0.000 description 1
229940079593 drug Drugs 0.000 description 1
239000003814 drug Substances 0.000 description 1
230000000694 effects Effects 0.000 description 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
239000012530 fluid Substances 0.000 description 1
230000005176 gastrointestinal motility Effects 0.000 description 1
229940050410 gluconate Drugs 0.000 description 1
239000008103 glucose Substances 0.000 description 1
239000008187 granular material Substances 0.000 description 1
125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
208000037951 infantile gastroenteritis Diseases 0.000 description 1
229910052500 inorganic mineral Inorganic materials 0.000 description 1
230000031891 intestinal absorption Effects 0.000 description 1
150000002500 ions Chemical class 0.000 description 1
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
239000007788 liquid Substances 0.000 description 1
HOVAGTYPODGVJG-ZFYZTMLRSA-N methyl alpha-D-glucopyranoside Chemical compound CO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HOVAGTYPODGVJG-ZFYZTMLRSA-N 0.000 description 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
235000010755 mineral Nutrition 0.000 description 1
239000011707 mineral Substances 0.000 description 1
125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
229960004927 neomycin Drugs 0.000 description 1
230000007935 neutral effect Effects 0.000 description 1
229960001027 opium Drugs 0.000 description 1
239000007968 orange flavor Substances 0.000 description 1
238000004806 packaging method and process Methods 0.000 description 1
239000001814 pectin Substances 0.000 description 1
229920001277 pectin Polymers 0.000 description 1
235000010987 pectin Nutrition 0.000 description 1
230000008855 peristalsis Effects 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
230000035479 physiological effects, processes and functions Effects 0.000 description 1
229960003975 potassium Drugs 0.000 description 1
239000011591 potassium Substances 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
239000001103 potassium chloride Substances 0.000 description 1
235000011164 potassium chloride Nutrition 0.000 description 1
229960002635 potassium citrate Drugs 0.000 description 1
235000011082 potassium citrates Nutrition 0.000 description 1
GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 description 1
159000000001 potassium salts Chemical class 0.000 description 1
230000002035 prolonged effect Effects 0.000 description 1
229960000697 propantheline Drugs 0.000 description 1
ZFEKVFJKFDZSHE-UHFFFAOYSA-M sodium;2-aminoacetic acid;chloride Chemical compound [Na+].[Cl-].NCC(O)=O ZFEKVFJKFDZSHE-UHFFFAOYSA-M 0.000 description 1
239000000126 substance Substances 0.000 description 1
150000003456 sulfonamides Chemical class 0.000 description 1
229910021653 sulphate ion Inorganic materials 0.000 description 1
208000024891 symptom Diseases 0.000 description 1
229910000404 tripotassium phosphate Inorganic materials 0.000 description 1
235000019798 tripotassium phosphate Nutrition 0.000 description 1
SOBHUZYZLFQYFK-UHFFFAOYSA-K trisodium;hydroxy-[[phosphonatomethyl(phosphonomethyl)amino]methyl]phosphinate Chemical compound [Na+].[Na+].[Na+].OP(O)(=O)CN(CP(O)([O-])=O)CP([O-])([O-])=O SOBHUZYZLFQYFK-UHFFFAOYSA-K 0.000 description 1
235000013343 vitamin Nutrition 0.000 description 1
239000011782 vitamin Substances 0.000 description 1
229940088594 vitamin Drugs 0.000 description 1
229930003231 vitamin Natural products 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Inorganic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

IE2515/78A 1977-12-23 1978-12-20 Oral formulations for treating diarrhoea in humans IE47698B1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB5387577		1977-12-23

Publications (2)

Publication Number	Publication Date
IE782515L IE782515L (en)	1979-06-23
IE47698B1 true IE47698B1 (en)	1984-05-30

Family

ID=10469271

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IE2515/78A IE47698B1 (en)	1977-12-23	1978-12-20	Oral formulations for treating diarrhoea in humans

Country Status (15)

Country	Link
JP (1)	JPS54101437A (de)
AU (1)	AU4282278A (de)
BE (1)	BE872647A (de)
CA (1)	CA1119517A (de)
CH (1)	CH644017A5 (de)
DE (1)	DE2854281A1 (de)
FR (1)	FR2412313A1 (de)
GB (1)	GB2012163B (de)
IE (1)	IE47698B1 (de)
IT (1)	IT1111383B (de)
NL (1)	NL7812403A (de)
NZ (1)	NZ189122A (de)
OA (1)	OA06135A (de)
PH (1)	PH14262A (de)
ZA (1)	ZA786856B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0059057A1 (de) *	1981-02-20	1982-09-01	Beecham Group Plc	Behandlung der Diarrhee
US4542123A (en) *	1982-01-11	1985-09-17	Massachusetts Institute Of Technology	Composition and method for increasing brain tyrosine levels
EP0112061A3 (de) *	1982-11-20	1985-08-14	Beecham Group Plc	Pharmazeutische und tierärztliche Guanoxabenz enthaltende Zusammensetzung
CA1217723A (en) *	1983-01-13	1987-02-10	Robert W. Phillips	Oral energy rich therapy for diarrhea in mammals
GB8528307D0 (en) *	1985-11-18	1985-12-24	Beecham Group Plc	Veterinary compositions

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ183492A (en) *	1976-03-27	1980-04-28	Beecham Group Ltd	Veterinary rehydration compositions containing monosaccharide amino acid and citric acid or citrate

1978
- 1978-12-06 ZA ZA00786856A patent/ZA786856B/xx unknown
- 1978-12-07 NZ NZ189122A patent/NZ189122A/xx unknown
- 1978-12-08 BE BE192233A patent/BE872647A/xx unknown
- 1978-12-13 PH PH21944A patent/PH14262A/en unknown
- 1978-12-15 DE DE19782854281 patent/DE2854281A1/de not_active Withdrawn
- 1978-12-15 FR FR7835352A patent/FR2412313A1/fr active Granted
- 1978-12-20 JP JP15908578A patent/JPS54101437A/ja active Pending
- 1978-12-20 IE IE2515/78A patent/IE47698B1/en unknown
- 1978-12-21 AU AU42822/78A patent/AU4282278A/en active Pending
- 1978-12-21 NL NL7812403A patent/NL7812403A/xx not_active Application Discontinuation
- 1978-12-21 IT IT52414/78A patent/IT1111383B/it active
- 1978-12-21 GB GB7849575A patent/GB2012163B/en not_active Expired
- 1978-12-21 CH CH1304478A patent/CH644017A5/de not_active IP Right Cessation
- 1978-12-22 CA CA000318507A patent/CA1119517A/en not_active Expired
- 1978-12-22 OA OA56691A patent/OA06135A/xx unknown

Also Published As

Publication number	Publication date
IT1111383B (it)	1986-01-13
ZA786856B (en)	1979-11-28
IE782515L (en)	1979-06-23
DE2854281A1 (de)	1979-07-05
CA1119517A (en)	1982-03-09
AU4282278A (en)	1979-06-28
OA06135A (fr)	1981-06-30
NL7812403A (nl)	1979-06-26
NZ189122A (en)	1980-12-19
IT7852414A0 (it)	1978-12-21
PH14262A (en)	1981-04-23
BE872647A (fr)	1979-06-08
JPS54101437A (en)	1979-08-10
FR2412313B1 (de)	1982-06-25
GB2012163A (en)	1979-07-25
CH644017A5 (de)	1984-07-13
GB2012163B (en)	1982-09-22
FR2412313A1 (fr)	1979-07-20

Publication	Publication Date	Title
US4942042A (en)	1990-07-17	Anti-diarrhea compositions
CA1275933C (en)	1990-11-06	Therapeutic composition containing ibuprofen
CA2148071C (en)	2000-10-17	Method of administering azithromycin
RU2089193C1 (ru)	1997-09-10	Фармацевтическая композиция для орального применения на основе дезоксипуринового нуклеозида, обладающая антивирусной активностью
NL194749C (nl)	2003-02-04	Stabiel calciumhoudend farmaceutisch preparaat.
JP3480939B2 (ja)	2003-12-22	アモキシシリンおよびクラブラン酸含有の組成物
TW492875B (en)	2002-07-01	Pharmaceutical formulations of cefaclor
JPH05505193A (ja)	1993-08-05	薬剤製剤
US20090176877A1 (en)	2009-07-09	Oseltamivir phoshate granule and preparation method thereof
CA1119517A (en)	1982-03-09	Oral formulations for human use
JPH01125319A (ja)	1989-05-17	全腸管洗浄液用投与組成物
SK4982000A3 (en)	2001-10-08	Pharmaceutical composition with a content of calcium or mixture of calcium and vitamin d or mixture of calcium and magnesium in a new formulation
US3243347A (en)	1966-03-29	Instantly assimilable vitamin product
JP2922456B2 (ja)	1999-07-26	トリメブチンを含む新規医薬組成物及びその調製法
SU1755780A1 (ru)	1992-08-23	"Сухой безалкогольный напиток "Стимул"
AU704541B2 (en)	1999-04-29	Pulverulent and water-soluble compositions and their applications
US20020099044A1 (en)	2002-07-25	Composition comprising amoxycillin and clavulanic acid
US4515805A (en)	1985-05-07	Soluble sodium cromoglycate compositions
IE970899A1 (en)	1998-10-07	Formulation and use
CA1252045A (en)	1989-04-04	Fluidized magaldrate suspension
GB2086227A (en)	1982-05-12	Sodium cromoglycate reconstitutable powders
GB2285923A (en)	1995-08-02	Pharmaceutical powder containing N-acetyl-cysteine
CZ11407U1 (cs)	2001-07-31	Farmaceutický prostředek uzpůsobený pro pediatrické podávání