IE55801B1 - Novel vitamin d analogs - Google Patents

Novel vitamin d analogs

Info

Publication number
IE55801B1
IE55801B1 IE1745/83A IE174583A IE55801B1 IE 55801 B1 IE55801 B1 IE 55801B1 IE 1745/83 A IE1745/83 A IE 1745/83A IE 174583 A IE174583 A IE 174583A IE 55801 B1 IE55801 B1 IE 55801B1
Authority
IE
Ireland
Prior art keywords
analogs
novel vitamin
vitamin
fluoro
alpha
Prior art date
Application number
IE1745/83A
Other versions
IE831745L (en
Original Assignee
Wisconsin Alumni Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/401,996 external-priority patent/US4428946A/en
Application filed by Wisconsin Alumni Res Found filed Critical Wisconsin Alumni Res Found
Publication of IE831745L publication Critical patent/IE831745L/en
Publication of IE55801B1 publication Critical patent/IE55801B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/24—All rings being cycloaliphatic the ring system containing nine carbon atoms, e.g. perhydroindane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

This invention provides 24-fluoro-1 alpha ,25-dihydroxyvitamin D3 and 24- fluoro-1 alpha ,25-dihydroxy-5,6-trans- vitamin D3 of formulae <IMAGE> where R1, R2 and R3 are hydrogen or acyl.o [GB2126234A]
IE1745/83A 1982-07-26 1983-07-25 Novel vitamin d analogs IE55801B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40199782A 1982-07-26 1982-07-26
US06/401,996 US4428946A (en) 1982-07-26 1982-07-26 Method of preventing milk fever in dairy cattle

Publications (2)

Publication Number Publication Date
IE831745L IE831745L (en) 1984-01-26
IE55801B1 true IE55801B1 (en) 1991-01-16

Family

ID=27017681

Family Applications (1)

Application Number Title Priority Date Filing Date
IE1745/83A IE55801B1 (en) 1982-07-26 1983-07-25 Novel vitamin d analogs

Country Status (4)

Country Link
FR (1) FR2530624B1 (en)
GB (1) GB2126234B (en)
IE (1) IE55801B1 (en)
IT (1) IT1163846B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1272953A (en) * 1984-10-08 1990-08-21 Yuji Makino Pharmaceutical composition for external use containing active-type vitamin d.sub.3
US4853378A (en) * 1986-10-20 1989-08-01 Sumitomo Chemical Company, Limited Fluorine derivatives of vitamin D3 and process for producing the same
CA2042369A1 (en) * 1989-09-11 1991-03-12 Charles D. Pauza Use of vitamin d compounds to inhibit replication of the aids virus
EP1021401A1 (en) * 1995-09-21 2000-07-26 Wisconsin Alumni Research Foundation Calcitriol derivatives and their uses
US5952317A (en) * 1995-09-21 1999-09-14 Wisconsin Alumni Research Foundation Calcitriol derivatives and their uses
US5976784A (en) * 1996-09-20 1999-11-02 Wisconsin Alumni Research Foundation Calcitriol derivatives and their uses

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5576858A (en) * 1978-12-04 1980-06-10 Teijin Ltd 24-fluoro-25-hydroxyvitamin d3 or its oh-protected derivative, and their preparation
US4305880A (en) * 1980-09-22 1981-12-15 Wisconsin Alumni Research Foundation Process for preparing 24-fluoro-25-hydroxycholecalciferol
NZ201702A (en) * 1981-08-28 1985-08-16 Hoffmann La Roche 1 alpha,25-dihydroxy-(24r or 24s)-fluorocholecal-ciferol and intermediates;pharmaceutical compositions

Also Published As

Publication number Publication date
GB8319932D0 (en) 1983-08-24
IE831745L (en) 1984-01-26
FR2530624A1 (en) 1984-01-27
IT1163846B (en) 1987-04-08
IT8322218A0 (en) 1983-07-25
FR2530624B1 (en) 1987-08-07
GB2126234B (en) 1986-05-21
GB2126234A (en) 1984-03-21

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