IE67152B1 - Low toxicity drug-lipid systems - Google Patents

Low toxicity drug-lipid systems

Info

Publication number: IE67152B1
Authority: IE; Ireland
Prior art keywords: lipid; drug; amphotericin; composition; mole percent
Prior art date: 1987-03-05

Application number

IE60088A

Other languages

English (en)

Other versions

IE880600L (en

Inventor

Joel Portnoff

John J Kearns

Lawrence Boni

Anthony G Durning

Robert P Lenk

Andrew S Janoff

Robert Klimchak

Thomas Madden

Pieter R Cullis

Original Assignee

Liposome Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-03-05

Filing date

1988-03-03

Publication date

1996-03-06

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27361805&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IE67152(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1988-03-03 Application filed by Liposome Co Inc filed Critical Liposome Co Inc

1988-09-05 Publication of IE880600L publication Critical patent/IE880600L/xx

1996-03-06 Publication of IE67152B1 publication Critical patent/IE67152B1/en

Links

231100000053 low toxicity Toxicity 0.000 title description 4
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150000002632 lipids Chemical class 0.000 claims abstract description 149
APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 claims abstract description 148
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230000036961 partial effect Effects 0.000 description 1
235000021110 pickles Nutrition 0.000 description 1
229960001416 pilocarpine Drugs 0.000 description 1
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229920000642 polymer Polymers 0.000 description 1
102000040430 polynucleotide Human genes 0.000 description 1
108091033319 polynucleotide Proteins 0.000 description 1
239000002157 polynucleotide Substances 0.000 description 1
229920001155 polypropylene Polymers 0.000 description 1
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239000005017 polysaccharide Substances 0.000 description 1
239000001294 propane Substances 0.000 description 1
239000003380 propellant Substances 0.000 description 1
150000003180 prostaglandins Chemical class 0.000 description 1
230000001681 protective effect Effects 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
230000002285 radioactive effect Effects 0.000 description 1
102000005962 receptors Human genes 0.000 description 1
108020003175 receptors Proteins 0.000 description 1
230000009467 reduction Effects 0.000 description 1
230000010076 replication Effects 0.000 description 1
230000003362 replicative effect Effects 0.000 description 1
125000006853 reporter group Chemical group 0.000 description 1
210000002345 respiratory system Anatomy 0.000 description 1
230000004044 response Effects 0.000 description 1
230000002441 reversible effect Effects 0.000 description 1
238000012552 review Methods 0.000 description 1
235000003441 saturated fatty acids Nutrition 0.000 description 1
238000004513 sizing Methods 0.000 description 1
SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical class [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 description 1
239000011877 solvent mixture Substances 0.000 description 1
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238000003860 storage Methods 0.000 description 1
235000000346 sugar Nutrition 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
MLKXDPUZXIRXEP-MFOYZWKCSA-N sulindac Chemical compound CC1=C(CC(O)=O)C2=CC(F)=CC=C2\C1=C/C1=CC=C(S(C)=O)C=C1 MLKXDPUZXIRXEP-MFOYZWKCSA-N 0.000 description 1
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230000004083 survival effect Effects 0.000 description 1
230000002459 sustained effect Effects 0.000 description 1
208000024891 symptom Diseases 0.000 description 1
208000011580 syndromic disease Diseases 0.000 description 1
IMCGHZIGRANKHV-AJNGGQMLSA-N tert-butyl (3s,5s)-2-oxo-5-[(2s,4s)-5-oxo-4-propan-2-yloxolan-2-yl]-3-propan-2-ylpyrrolidine-1-carboxylate Chemical compound O1C(=O)[C@H](C(C)C)C[C@H]1[C@H]1N(C(=O)OC(C)(C)C)C(=O)[C@H](C(C)C)C1 IMCGHZIGRANKHV-AJNGGQMLSA-N 0.000 description 1
210000001550 testis Anatomy 0.000 description 1
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229940113082 thymine Drugs 0.000 description 1
229960004605 timolol Drugs 0.000 description 1
229930003799 tocopherol Natural products 0.000 description 1
239000011732 tocopherol Substances 0.000 description 1
125000002640 tocopherol group Chemical class 0.000 description 1
235000019149 tocopherols Nutrition 0.000 description 1
241001529453 unidentified herpesvirus Species 0.000 description 1
241001430294 unidentified retrovirus Species 0.000 description 1
229960003048 vinblastine Drugs 0.000 description 1
JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 description 1
OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 description 1
229960004528 vincristine Drugs 0.000 description 1
OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 1
238000005406 washing Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
- A61K47/544—Phospholipids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1277—Preparation processes; Proliposomes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- G—PHYSICS
- G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
- G03B—APPARATUS OR ARRANGEMENTS FOR TAKING PHOTOGRAPHS OR FOR PROJECTING OR VIEWING THEM; APPARATUS OR ARRANGEMENTS EMPLOYING ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ACCESSORIES THEREFOR
- G03B2227/00—Photographic printing apparatus
- G03B2227/32—Projection printing apparatus, e.g. enlarging apparatus, copying camera
- G03B2227/325—Microcapsule copiers

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Dispersion Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Saccharide Compounds (AREA)
Vehicle Step Arrangements And Article Storage (AREA)
Catalysts (AREA)
Vehicle Interior And Exterior Ornaments, Soundproofing, And Insulation (AREA)

IE60088A 1987-03-05 1988-03-03 Low toxicity drug-lipid systems IE67152B1 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date
US2215787A	1987-03-05	1987-03-05
US6990887A	1987-07-06	1987-07-06
US7930987A	1987-07-29	1987-07-29

Publications (2)

Publication Number	Publication Date
IE880600L IE880600L (en)	1988-09-05
IE67152B1 true IE67152B1 (en)	1996-03-06

Family

ID=27361805

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IE60088A IE67152B1 (en)	1987-03-05	1988-03-03	Low toxicity drug-lipid systems

Country Status (20)

Country	Link
EP (1)	EP0282405B2 (fr)
KR (1)	KR970002870B1 (fr)
CN (1)	CN1044093C (fr)
AT (1)	ATE118169T1 (fr)
AU (1)	AU622405B2 (fr)
CA (1)	CA1338701C (fr)
DE (1)	DE3852961T3 (fr)
DK (1)	DK176010B1 (fr)
ES (1)	ES2070131T5 (fr)
FI (1)	FI102724B (fr)
GR (1)	GR3015916T3 (fr)
HK (1)	HK1007495A1 (fr)
IE (1)	IE67152B1 (fr)
IL (1)	IL85607A (fr)
LU (1)	LU88684I2 (fr)
NL (1)	NL990004I1 (fr)
NO (4)	NO179995C (fr)
NZ (1)	NZ223660A (fr)
PT (1)	PT86913B (fr)
WO (1)	WO1988006443A1 (fr)

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5178875A (en) *	1991-01-14	1993-01-12	The Board Of Regents, The University Of Texas System	Liposomal-polyene preliposomal powder and method for its preparation
US5830498A (en) *	1987-10-16	1998-11-03	Board Of Regents, The University Of Texas System	Liposomal-polyene preliposomal powder and method for its preparation
AU598958B2 (en)	1987-11-12	1990-07-05	Vestar, Inc.	Improved amphotericin b liposome preparation
ES2087151T3 (es) *	1989-03-31	1996-07-16	Univ California	Preparacion de composiciones complejas de liposomas y lipidos.
US5188951A (en) *	1990-04-17	1993-02-23	The Liposome Company, Inc.	Enzymatic synthesis of soluble phosphatides from phospholipids
DE4108903A1 (de) *	1990-08-06	1992-02-13	Nattermann A & Cie	Pharmazeutisches produkt
US5556637A (en) *	1990-08-06	1996-09-17	A. Nattermann & Cie. Gmbh	Water containing liposome system
US5534502A (en) *	1990-11-06	1996-07-09	Nippon Shinyaku Co. Ltd.	Process for producing fat emulsion
EP0556392A4 (fr) *	1990-11-06	1994-03-17	Nippon Shinyaku Co Ltd	Procede de production d'une emulsion grasse.
EP0599977A1 (fr) *	1991-08-14	1994-06-08	SEQUUS PHARMACEUTICALS, INC. (a Delaware Corporation)	Procede de traitement contre le vih avec de l'amphotericine b a faible toxicite
DE69429511T2 (de) *	1993-05-21	2002-05-16	The Liposome Co., Inc.	Reduzierung von durch liposome induzierte physiologischen gegenreaktionen
US5716526A (en) *	1994-01-14	1998-02-10	The Liposome Company, Inc.	Method of separating materials from liposomes or lipid complexes
US5902604A (en) *	1995-06-06	1999-05-11	Board Of Regents, The University Of Texas System	Submicron liposome suspensions obtained from preliposome lyophilizates
GB2326337A (en) *	1997-06-20	1998-12-23	Phares Pharma Holland	Homogeneous lipid compositions for drug delivery
US6165997A (en) *	1997-11-20	2000-12-26	Statens Serum Institut	Phospholipids having antimicrobial activity with or without the presence of antimicrobials
EP2007355A2 (fr) *	2005-12-08	2008-12-31	Wyeth a Corporation of the State of Delaware	Compositions liposomales
KR101132626B1 (ko) *	2009-10-12	2012-04-02	주식회사 녹십자	난용성 약물의 전달을 위한 고밀도지단백 나노입자의 제조방법
CA2809022C (fr)	2010-08-20	2017-01-03	Dr. Reddy`S Laboratories, Inc.	Depot phospholipidique
JP5877843B2 (ja)	2010-10-22	2016-03-08	ドクターレディズラボラトリーズ，インコーポレイテッド	創傷を処置するための保存に安定した粘性リン脂質デポーの使用
CA2871821C (fr)	2012-05-10	2021-01-12	Painreform Ltd.	Preparations de depot d'un anesthesiant local et procedes de preparation associes
US10799456B2 (en)	2015-06-15	2020-10-13	University Of Washington	Multiple drug lipid nanoparticle composition and related methods for extended drug levels in blood and lymph tissue

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4310506A (en) *	1979-02-22	1982-01-12	California Institute Of Technology	Means of preparation and applications of liposomes containing high concentrations of entrapped ionic species
FR2521565B1 (fr) *	1982-02-17	1985-07-05	Dior Sa Parfums Christian	Melange pulverulent de constituants lipidiques et de constituants hydrophobes, procede pour le preparer, phases lamellaires lipidiques hydratees et procede de fabrication, compositions pharmaceutiques ou cosmetiques comportant des phases lamellaires lipidiques hydratees
US4604376A (en) *	1982-04-21	1986-08-05	Research Corporation	Enteric compounds and complexes
US4436746A (en) *	1982-09-30	1984-03-13	Ciba-Geigy Corporation	Thromboxane synthetase inhibitory N-substituted-2-(1-imidazolyl)indoles
US4622219A (en) *	1983-06-17	1986-11-11	Haynes Duncan H	Method of inducing local anesthesia using microdroplets of a general anesthetic
IL78930A0 (en) *	1985-07-29	1986-09-30	Abbott Lab	Lyophilized emulsion compositions for parenteral administration
IL78929A0 (en) *	1985-07-29	1986-09-30	Abbott Lab	Microemulsion compositions for parenteral administration

1988
- 1988-02-26 NZ NZ223660A patent/NZ223660A/en unknown
- 1988-02-29 CA CA000560121A patent/CA1338701C/fr not_active Expired - Lifetime
- 1988-03-02 IL IL85607A patent/IL85607A/xx not_active IP Right Cessation
- 1988-03-03 WO PCT/US1988/000647 patent/WO1988006443A1/fr not_active Ceased
- 1988-03-03 KR KR1019880701402A patent/KR970002870B1/ko not_active Expired - Lifetime
- 1988-03-03 AU AU17990/88A patent/AU622405B2/en not_active Expired
- 1988-03-03 IE IE60088A patent/IE67152B1/en not_active IP Right Cessation
- 1988-03-04 AT AT88400520T patent/ATE118169T1/de active
- 1988-03-04 PT PT86913A patent/PT86913B/pt not_active IP Right Cessation
- 1988-03-04 LU LU88684C patent/LU88684I2/fr unknown
- 1988-03-04 ES ES88400520T patent/ES2070131T5/es not_active Expired - Lifetime
- 1988-03-04 EP EP88400520A patent/EP0282405B2/fr not_active Expired - Lifetime
- 1988-03-04 DE DE3852961T patent/DE3852961T3/de not_active Expired - Lifetime
- 1988-03-05 CN CN88101864A patent/CN1044093C/zh not_active Expired - Lifetime
- 1988-10-04 NO NO884391A patent/NO179995C/no not_active IP Right Cessation
1989
- 1989-03-01 DK DK198900980A patent/DK176010B1/da not_active IP Right Cessation
- 1989-09-04 FI FI894161A patent/FI102724B/fi not_active IP Right Cessation
1994
- 1994-10-26 NO NO944071A patent/NO180147C/no not_active IP Right Cessation
1995
- 1995-04-25 GR GR950401037T patent/GR3015916T3/el unknown
1998
- 1998-03-25 NO NO1998013C patent/NO1998013I1/no unknown
- 1998-03-25 NO NO1998012C patent/NO1998012I1/no unknown
- 1998-06-25 HK HK98106740A patent/HK1007495A1/en not_active IP Right Cessation
1999
- 1999-01-26 NL NL990004C patent/NL990004I1/nl unknown

Also Published As

Publication number	Publication date
NO1998012I1 (no)	1998-03-25
IE880600L (en)	1988-09-05
EP0282405B2 (fr)	1998-07-22
FI102724B1 (fi)	1999-02-15
IL85607A (en)	1992-08-18
IL85607A0 (en)	1988-08-31
NO884391D0 (no)	1988-10-04
KR890700341A (ko)	1989-04-24
NO1998013I1 (no)	1998-03-25
GR3015916T3 (en)	1995-07-31
NL990004I1 (nl)	1999-04-01
NO180147C (no)	1997-02-26
ES2070131T5 (es)	1998-10-01
CN1044093C (zh)	1999-07-14
CN88101864A (zh)	1988-09-28
AU622405B2 (en)	1992-04-09
AU1799088A (en)	1988-09-26
NO944071D0 (no)	1994-10-26
KR970002870B1 (ko)	1997-03-12
DK98089A (da)	1989-03-01
EP0282405A2 (fr)	1988-09-14
WO1988006443A1 (fr)	1988-09-07
NO179995C (no)	1997-01-29
NO180147B (no)	1996-11-18
FI102724B (fi)	1999-02-15
DK176010B1 (da)	2005-11-28
ES2070131T3 (es)	1995-06-01
PT86913A (pt)	1989-03-30
LU88684I2 (fr)	1996-04-29
PT86913B (pt)	1993-07-30
NO944071L (no)	1988-11-24
ATE118169T1 (de)	1995-02-15
DK98089D0 (da)	1989-03-01
CA1338701C (fr)	1996-11-12
NO179995B (no)	1996-10-21
EP0282405A3 (en)	1989-01-04
DE3852961T3 (de)	1998-12-24
EP0282405B1 (fr)	1995-02-08
DE3852961T2 (de)	1995-07-06
NZ223660A (en)	1990-11-27
HK1007495A1 (en)	1999-04-16
FI894161A0 (fi)	1989-09-04
DE3852961D1 (de)	1995-03-23
NO884391L (no)	1988-11-24

Legal Events

Date	Code	Title	Description
1996-10-02	SPCF	Request for grant of supplementary protection certificate	Free format text: SPC 19/96 19960814
1997-05-07	SPCG	Supplementary protection certificate granted	Free format text: SPC 19/96 EXPIRES:20100209
2008-04-30	MK9A	Patent expired

Publication	Publication Date	Title
US5616334A (en)	1997-04-01	Low toxicity drug-lipid systems
US6406713B1 (en)	2002-06-18	Methods of preparing low-toxicity drug-lipid complexes
EP0282405B2 (fr)	1998-07-22	Systèmes médicament-lipide à basse toxicité
EP0191824B1 (fr)	1993-10-27	Encapsulement d'agents antineoplastiques dans des liposomes
HK1007495B (en)	1999-04-16	Low toxicity drug-lipid systems
Vemuri et al.	1995	Preparation and characterization of liposomes as therapeutic delivery systems: a review
JP2882607B2 (ja)	1999-04-12	リポソーム性抗腫瘍剤の高薬剤：脂質調剤
EP0231261B1 (fr)	1994-04-06	Liposomes multilamellaires presentant une efficacite de capture amelioree
US5380531A (en)	1995-01-10	Accumulations of amino acids and peptides into liposomes
HK1007494B (en)	1999-04-16	Encapsulation of antineoplastic agents in liposomes
US5783210A (en)	1998-07-21	Phospholipid composition
US20020119170A1 (en)	2002-08-29	Low toxicity drug-lipid systems
JP2705175B2 (ja)	1998-01-26	低毒性薬剤‐脂質系
US20060030578A1 (en)	2006-02-09	Pharmaceutically active lipid based formulation of irinotecan
HU209647B (en)	1994-09-28	Process for production of low toxicity composition containing bioactive agent and lipid
HK1007497B (en)	1999-04-16	Accumulations of amino acids and peptides into liposomes