IE780106L - Vincristine derivatives - Google Patents
Vincristine derivativesInfo
- Publication number
- IE780106L IE780106L IE780106A IE10678A IE780106L IE 780106 L IE780106 L IE 780106L IE 780106 A IE780106 A IE 780106A IE 10678 A IE10678 A IE 10678A IE 780106 L IE780106 L IE 780106L
- Authority
- IE
- Ireland
- Prior art keywords
- denotes
- group
- formula
- vincristine
- derivatives
- Prior art date
Links
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical class C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Dimeric indolodihydroindoles have the following formula <IMAGE> In this formula: R<1> denotes the group OH or <IMAGE>, R<2> denotes the group CHO or, if R<1> denotes the group OH, the group CH3, one of the radicals R<3> and R<4> denotes hydrogen and the other of these radicals denotes the group C2H5 and R<5> denotes hydrogen. As active compound, antitumour medicaments contain a compound of the formula I or a pharmaceutically acceptable salt thereof. Two processes for the preparation of the novel compounds are described.
[GB1593231A]
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76059577A | 1977-01-19 | 1977-01-19 | |
| US05/853,979 US4143041A (en) | 1977-01-19 | 1977-11-25 | 4'-Deoxyvincristine and related compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE780106L true IE780106L (en) | 1978-07-19 |
| IE46308B1 IE46308B1 (en) | 1983-05-04 |
Family
ID=27116837
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE106/78A IE46308B1 (en) | 1977-01-19 | 1978-01-18 | Vincristine derivatives |
Country Status (24)
| Country | Link |
|---|---|
| JP (1) | JPS5390299A (en) |
| AR (1) | AR217459A1 (en) |
| AT (1) | AT363620B (en) |
| BG (2) | BG33293A3 (en) |
| CA (2) | CA1088526A (en) |
| CH (1) | CH635106A5 (en) |
| CS (2) | CS194832B2 (en) |
| DD (1) | DD134527A5 (en) |
| DE (1) | DE2801748A1 (en) |
| DK (1) | DK144420C (en) |
| FR (1) | FR2378032A1 (en) |
| GB (1) | GB1593231A (en) |
| GR (1) | GR68940B (en) |
| IE (1) | IE46308B1 (en) |
| IL (1) | IL53813A (en) |
| IT (1) | IT1174356B (en) |
| MX (1) | MX5112E (en) |
| NL (1) | NL7800667A (en) |
| NZ (1) | NZ186232A (en) |
| PL (1) | PL109695B1 (en) |
| PT (1) | PT67535B (en) |
| RO (2) | RO78290A (en) |
| SE (2) | SE425852B (en) |
| YU (1) | YU7278A (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0649314U (en) * | 1992-12-11 | 1994-07-05 | ヒノマル株式会社 | Food packaging container |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2296418B1 (en) * | 1974-12-30 | 1978-07-21 | Anvar | |
| IL48685A (en) * | 1975-01-09 | 1980-03-31 | Lilly Co Eli | Amides of vincadioline and vinblastine |
-
1978
- 1978-01-16 GR GR55178A patent/GR68940B/el unknown
- 1978-01-16 CS CS78292A patent/CS194832B2/en unknown
- 1978-01-16 DE DE19782801748 patent/DE2801748A1/en not_active Withdrawn
- 1978-01-16 PT PT67535A patent/PT67535B/en unknown
- 1978-01-16 IL IL53813A patent/IL53813A/en unknown
- 1978-01-16 YU YU00072/78A patent/YU7278A/en unknown
- 1978-01-16 BG BG040832A patent/BG33293A3/en unknown
- 1978-01-16 GB GB1692/78A patent/GB1593231A/en not_active Expired
- 1978-01-16 CS CS785375A patent/CS194850B2/en unknown
- 1978-01-16 NZ NZ186232A patent/NZ186232A/en unknown
- 1978-01-16 BG BG038402A patent/BG33158A3/en unknown
- 1978-01-17 SE SE7800555A patent/SE425852B/en not_active IP Right Cessation
- 1978-01-17 CA CA295,086A patent/CA1088526A/en not_active Expired
- 1978-01-17 DK DK22478A patent/DK144420C/en not_active IP Right Cessation
- 1978-01-17 FR FR7801262A patent/FR2378032A1/en active Granted
- 1978-01-17 CA CA295,114A patent/CA1088527A/en not_active Expired
- 1978-01-17 AR AR270733A patent/AR217459A1/en active
- 1978-01-18 IT IT19388/78A patent/IT1174356B/en active
- 1978-01-18 AT AT0035478A patent/AT363620B/en not_active IP Right Cessation
- 1978-01-18 CH CH53578A patent/CH635106A5/en not_active IP Right Cessation
- 1978-01-18 MX MX786780U patent/MX5112E/en unknown
- 1978-01-18 IE IE106/78A patent/IE46308B1/en unknown
- 1978-01-19 JP JP479378A patent/JPS5390299A/en active Granted
- 1978-01-19 DD DD78203301A patent/DD134527A5/en unknown
- 1978-01-19 RO RO7899202A patent/RO78290A/en unknown
- 1978-01-19 NL NL7800667A patent/NL7800667A/en not_active Application Discontinuation
- 1978-01-19 PL PL1978204091A patent/PL109695B1/en unknown
- 1978-01-19 RO RO7892948A patent/RO73126A/en unknown
-
1982
- 1982-07-08 SE SE8204238A patent/SE444684B/en not_active IP Right Cessation
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