IE780678L - 4-(2-thienylmethylamino) benzoic acid compounds - Google Patents
4-(2-thienylmethylamino) benzoic acid compoundsInfo
- Publication number
- IE780678L IE780678L IE780678A IE67878A IE780678L IE 780678 L IE780678 L IE 780678L IE 780678 A IE780678 A IE 780678A IE 67878 A IE67878 A IE 67878A IE 780678 L IE780678 L IE 780678L
- Authority
- IE
- Ireland
- Prior art keywords
- compounds
- thienylmethylamino
- benzoic acid
- acid compounds
- gb1565936a
- Prior art date
Links
- SHTQXYWTNXSOLW-UHFFFAOYSA-N 4-(thiophen-2-ylmethylamino)benzoic acid Chemical class C1=CC(C(=O)O)=CC=C1NCC1=CC=CS1 SHTQXYWTNXSOLW-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000000055 hyoplipidemic effect Effects 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/28—Halogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Novel compounds of 4-(thienylmethylamino)benzoic acid and their pharmaceutically acceptable salts, a hypolipidaemic composition containing these compounds and a process for the preparation of these compounds are described. The compounds have the formula below where R is hydrogen or a C1 to C3 alkyl, and X, Y and Z, taken individually, represent H, Cl or Br provided that at least one of X, Y and Z is Cl or Br. These compounds can be used for reducing the lipids level in mammalian blood serum. <IMAGE>
[GB1565936A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78546777A | 1977-04-07 | 1977-04-07 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE780678L true IE780678L (en) | 1978-10-07 |
| IE46713B1 IE46713B1 (en) | 1983-09-07 |
Family
ID=25135597
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE678/78A IE46713B1 (en) | 1977-04-07 | 1978-04-05 | 4-(2-thienylmethylamino)benzoic acid compounds |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JPS53149968A (en) |
| BE (1) | BE865809A (en) |
| CA (1) | CA1108159A (en) |
| CH (1) | CH629796A5 (en) |
| DE (1) | DE2814798A1 (en) |
| DK (1) | DK153403C (en) |
| FR (1) | FR2386542A1 (en) |
| GB (1) | GB1565936A (en) |
| IE (1) | IE46713B1 (en) |
| IT (1) | IT1094318B (en) |
| NL (1) | NL7803669A (en) |
| NO (1) | NO149241C (en) |
| NZ (1) | NZ186886A (en) |
| SE (1) | SE446734B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4143151A (en) * | 1978-07-03 | 1979-03-06 | The Dow Chemical Company | Method for treating hyperglycemia in mammals using arylamino benzoic acids |
| JPS6421196A (en) * | 1987-07-15 | 1989-01-24 | Nippon Concrete Ind Co Ltd | Auger screw |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2983729A (en) * | 1958-04-30 | 1961-05-09 | Monsanto Chemicals | Preparation of 5-halothienyl amines |
| US3859440A (en) * | 1971-10-08 | 1975-01-07 | Ici Australia Ltd | Certain thienyl compounds used to control acarina |
| US4185115A (en) * | 1975-03-12 | 1980-01-22 | American Cyanamid Company | Antilipidemic para-[aryl(alkyl or alkenyl)amino]-benzoic acid derivatives |
-
1978
- 1978-04-03 CH CH355178A patent/CH629796A5/en not_active IP Right Cessation
- 1978-04-04 IT IT21941/78A patent/IT1094318B/en active
- 1978-04-05 FR FR7810111A patent/FR2386542A1/en active Granted
- 1978-04-05 IE IE678/78A patent/IE46713B1/en not_active IP Right Cessation
- 1978-04-05 DE DE19782814798 patent/DE2814798A1/en active Granted
- 1978-04-05 NZ NZ186886A patent/NZ186886A/en unknown
- 1978-04-06 DK DK153178A patent/DK153403C/en not_active IP Right Cessation
- 1978-04-06 NO NO781214A patent/NO149241C/en unknown
- 1978-04-06 JP JP4075978A patent/JPS53149968A/en active Granted
- 1978-04-06 GB GB13449/78A patent/GB1565936A/en not_active Expired
- 1978-04-06 NL NL7803669A patent/NL7803669A/en not_active Application Discontinuation
- 1978-04-06 SE SE7803910A patent/SE446734B/en not_active IP Right Cessation
- 1978-04-06 CA CA300,577A patent/CA1108159A/en not_active Expired
- 1978-04-07 BE BE186657A patent/BE865809A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| IT7821941A0 (en) | 1978-04-04 |
| IT1094318B (en) | 1985-07-26 |
| CH629796A5 (en) | 1982-05-14 |
| FR2386542A1 (en) | 1978-11-03 |
| FR2386542B1 (en) | 1981-07-10 |
| IE46713B1 (en) | 1983-09-07 |
| DK153178A (en) | 1978-10-08 |
| NL7803669A (en) | 1978-10-10 |
| DE2814798A1 (en) | 1978-10-19 |
| BE865809A (en) | 1978-10-09 |
| NO781214L (en) | 1978-10-10 |
| JPS53149968A (en) | 1978-12-27 |
| JPS6126790B2 (en) | 1986-06-21 |
| CA1108159A (en) | 1981-09-01 |
| NO149241B (en) | 1983-12-05 |
| SE7803910L (en) | 1978-10-08 |
| NO149241C (en) | 1984-03-14 |
| GB1565936A (en) | 1980-04-23 |
| DE2814798C2 (en) | 1988-05-26 |
| DK153403B (en) | 1988-07-11 |
| SE446734B (en) | 1986-10-06 |
| NZ186886A (en) | 1980-02-21 |
| DK153403C (en) | 1988-11-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Patent lapsed |