IE781382L - Indole derivatives - Google Patents
Indole derivativesInfo
- Publication number
- IE781382L IE781382L IE781382A IE138278A IE781382L IE 781382 L IE781382 L IE 781382L IE 781382 A IE781382 A IE 781382A IE 138278 A IE138278 A IE 138278A IE 781382 L IE781382 L IE 781382L
- Authority
- IE
- Ireland
- Prior art keywords
- alkyl
- chem
- formula
- hydrogen
- compound
- Prior art date
Links
- 150000002475 indoles Chemical class 0.000 title abstract 2
- 229940054051 antipsychotic indole derivative Drugs 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- -1 4-piperidyl Chemical group 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000002490 anilino group Chemical group [H]N(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Chemical group 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000005344 pyridylmethyl group Chemical group [H]C1=C([H])C([H])=C([H])C(=N1)C([H])([H])* 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
- 125000003258 trimethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])[*:1] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Indole compounds useful for the treatment of hypertension, of formula <CHEM> wherein n is 2 or 3, A is 1,4-cyclohexylidene or trimethylene and R1 is H or alkyl, or A together with NR1 is 4-piperidyl, R2 is hydrogen or alkyl, R3 is alkyl, cycloalkyl, amino, alkylamino, dialkylamino, phenylamino, unsubstituted or substituted phenyl or benzyl, pyridylmethyl or an heterocycle, R4 is hydrogen, chlorine, bromine or alkyl, R5 is hydrogen, alkyl, alkoxy or alkylthio, and X is -CO- or -CS, a process for their production which comprises a) acylating a compound of formula II <CHEM> wherein n, A and R1 to R5 are as defined above, or b) condensing a compound of formula III <CHEM> wherein n, R4 and R5 are as defined above, and Y is a leaving group, with a compound of formula IV <CHEM> wherein A, R1 to R3 and X are as defined above. n
[EP0000355A1]
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH858977 | 1977-07-12 | ||
| CH300878 | 1978-03-20 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE781382L true IE781382L (en) | 1979-01-12 |
| IE47209B1 IE47209B1 (en) | 1984-01-11 |
Family
ID=25691930
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1382/78A IE47209B1 (en) | 1977-07-12 | 1978-07-10 | Improvements in or relating to organic compounds |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0000355B1 (en) |
| JP (1) | JPS5436259A (en) |
| AU (1) | AU521641B2 (en) |
| CA (1) | CA1114381A (en) |
| DE (1) | DE2861502D1 (en) |
| DK (1) | DK300978A (en) |
| ES (1) | ES471593A1 (en) |
| FI (1) | FI782138A7 (en) |
| IE (1) | IE47209B1 (en) |
| IL (1) | IL55116A (en) |
| IT (1) | IT7850140A0 (en) |
| NZ (1) | NZ187813A (en) |
| PH (1) | PH14993A (en) |
| PT (1) | PT68270A (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2960547D1 (en) * | 1978-02-24 | 1981-11-05 | Pfizer Ltd | 3-(imidazol-1-ylalkyl)indoles as selective inhibitors of thromboxane synthetase,pharmaceutical compositions thereof, and methods for preparing them |
| US4634713A (en) * | 1982-05-28 | 1987-01-06 | Ciba-Geigy Corporation | Antihypertensive 3-(ureidocyclohexyleneamino)propane-1,2-diol derivatives |
| JPH0283380A (en) * | 1988-09-21 | 1990-03-23 | Kotobuki Seiyaku Kk | Novel diamine derivative, antiarrhythmic agent and production thereof |
| FR2642422A1 (en) * | 1988-12-22 | 1990-08-03 | Roussel Uclaf | NOVEL ACYLATED POLYAMINES, PROCESS FOR PREPARING THEM AND THEIR APPLICATION AS FUNGICIDES |
| CN1052224C (en) * | 1993-04-07 | 2000-05-10 | 大塚制药株式会社 | Peripheral Vasodilating agent containing N-acylated 4-amino piperidine derivatives as active ingredients |
| MY142362A (en) | 2004-01-29 | 2010-11-30 | Otsuka Pharma Co Ltd | Pharmaceutical composition for promoting angiogenesis |
| US11764679B2 (en) | 2020-01-15 | 2023-09-19 | Solaredge Technologies Ltd. | Power device |
| CN116478134B (en) * | 2022-01-17 | 2025-07-25 | 上海医药工业研究院有限公司 | SSRI/5-HT1ADouble-target antidepressant formylpiperidine compound and preparation method and application thereof |
| CN115433164B (en) * | 2022-09-14 | 2023-12-12 | 南京师范大学 | Nicotinamide derivative, preparation method thereof and application thereof in resisting aging and prolonging life |
-
1978
- 1978-06-12 PH PH21359A patent/PH14993A/en unknown
- 1978-06-29 DE DE7878100274T patent/DE2861502D1/en not_active Expired
- 1978-06-29 EP EP78100274A patent/EP0000355B1/en not_active Expired
- 1978-07-03 FI FI782138A patent/FI782138A7/en not_active Application Discontinuation
- 1978-07-03 DK DK783009A patent/DK300978A/en not_active Application Discontinuation
- 1978-07-03 IT IT7850140A patent/IT7850140A0/en unknown
- 1978-07-10 NZ NZ187813A patent/NZ187813A/en unknown
- 1978-07-10 IE IE1382/78A patent/IE47209B1/en unknown
- 1978-07-10 IL IL55116A patent/IL55116A/en unknown
- 1978-07-10 PT PT68270A patent/PT68270A/en unknown
- 1978-07-10 ES ES471593A patent/ES471593A1/en not_active Expired
- 1978-07-11 JP JP8363778A patent/JPS5436259A/en active Pending
- 1978-07-11 CA CA307,174A patent/CA1114381A/en not_active Expired
- 1978-07-11 AU AU37939/78A patent/AU521641B2/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| AU3793978A (en) | 1980-01-17 |
| IL55116A0 (en) | 1978-09-29 |
| DK300978A (en) | 1979-01-13 |
| JPS5436259A (en) | 1979-03-16 |
| NZ187813A (en) | 1981-03-16 |
| DE2861502D1 (en) | 1982-02-25 |
| CA1114381A (en) | 1981-12-15 |
| ES471593A1 (en) | 1979-10-01 |
| AU521641B2 (en) | 1982-04-22 |
| IL55116A (en) | 1982-02-28 |
| IT7850140A0 (en) | 1978-07-03 |
| PT68270A (en) | 1978-08-01 |
| EP0000355A1 (en) | 1979-01-24 |
| PH14993A (en) | 1982-03-22 |
| FI782138A7 (en) | 1979-01-13 |
| EP0000355B1 (en) | 1982-01-06 |
| IE47209B1 (en) | 1984-01-11 |
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