IE781800L - Improved erythrocyte o2-release - Google Patents

Improved erythrocyte o2-release

Info

Publication number
IE781800L
IE781800L IE781800A IE180078A IE781800L IE 781800 L IE781800 L IE 781800L IE 781800 A IE781800 A IE 781800A IE 180078 A IE180078 A IE 180078A IE 781800 L IE781800 L IE 781800L
Authority
IE
Ireland
Prior art keywords
release
erythrocytes
improved erythrocyte
erythrocyte
allosteric effectors
Prior art date
Application number
IE781800A
Other versions
IE47329B1 (en
Original Assignee
Klaus Gersonde Studiengesellsc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19772740053 external-priority patent/DE2740053A1/en
Priority claimed from DE19782820603 external-priority patent/DE2820603A1/en
Application filed by Klaus Gersonde Studiengesellsc filed Critical Klaus Gersonde Studiengesellsc
Publication of IE781800L publication Critical patent/IE781800L/en
Publication of IE47329B1 publication Critical patent/IE47329B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5063—Compounds of unknown constitution, e.g. material from plants or animals
    • A61K9/5068—Cell membranes or bacterial membranes enclosing drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/18—Erythrocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Virology (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Dispersion Chemistry (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Botany (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1. Modified intact erythrocytes ensuring improved oxygen release of the blood, characterized in that allosteric effectors are irreversibly incorporated into the erythrocytes by means of lipid vesicles and these allosteric effectors are bound to the haemoglobin in the erythrocytes. [EP0001104A2]
IE1800/78A 1977-09-06 1978-09-06 Controlled improvement of the o2-release by intact erythrocytes IE47329B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19772740053 DE2740053A1 (en) 1977-09-06 1977-09-06 USE OF ALLOSTERIC EFFECTORS WITH THE LIPID VESICLES WITH AN IRREVERSIBLE INCORPORATION FOR THE IMPROVED O DEEP 2 DISCHARGE OF THE HAEMOGLOBIN IN ERYTHROCYTES
DE19782820603 DE2820603A1 (en) 1978-05-11 1978-05-11 Erythrocytes modified with allo-steric effector(s) - using lipid vesicles, used for increasing oxygen supply to tissues

Publications (2)

Publication Number Publication Date
IE781800L true IE781800L (en) 1979-03-06
IE47329B1 IE47329B1 (en) 1984-02-22

Family

ID=25772674

Family Applications (1)

Application Number Title Priority Date Filing Date
IE1800/78A IE47329B1 (en) 1977-09-06 1978-09-06 Controlled improvement of the o2-release by intact erythrocytes

Country Status (12)

Country Link
EP (1) EP0001104B1 (en)
JP (1) JPS6022683B2 (en)
AT (1) AT364086B (en)
AU (1) AU524587B2 (en)
CA (1) CA1130724A (en)
DE (1) DE2860719D1 (en)
DK (1) DK393878A (en)
ES (1) ES473087A1 (en)
IE (1) IE47329B1 (en)
IN (1) IN149223B (en)
IT (1) IT1111675B (en)
YU (1) YU208078A (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3144705C2 (en) * 1981-11-11 1983-12-08 Biotest-Serum-Institut Gmbh, 6000 Frankfurt Process for the production of a storage-stable, cross-linked hemoglobin preparation with high oxygen transport capacity, as well as the hemoglobin preparation produced by this process
FR2529463B1 (en) * 1982-07-05 1986-01-10 Centre Nat Rech Scient METHOD AND DEVICE FOR THE ENCAPSULATION IN ERYTHROCYTES OF AT LEAST ONE BIOLOGICALLY ACTIVE SUBSTANCE, IN PARTICULAR ALLOSTERIC EFFECTORS OF HEMOGLOBIN AND ERYTHROCYTES OBTAINED THEREBY
NL8403425A (en) * 1984-11-09 1986-06-02 Stichting Gastransport STROMA-FREE HEMOGLOBINE SOLUTION, METHOD FOR PREPARING THE SAME AND USE THEREOF.
JPS6461426A (en) * 1987-08-31 1989-03-08 Terumo Corp Artificial erythrocyte
JPH01305033A (en) * 1988-06-01 1989-12-08 Sanwa Kagaku Kenkyusho Co Ltd Circulation improving agent, circulation improving functional food and tasteful food
JPH01305032A (en) * 1988-06-01 1989-12-08 Sanwa Kagaku Kenkyusho Co Ltd Remedy and preventive for hypofunctional exhaustion and food, drink and tasteful material
US4849416A (en) * 1988-07-25 1989-07-18 Rorer Pharmaceutical Corporation Treatment of conditions requiring enhanced oxygen availability to mammalian tissues
GB9225588D0 (en) 1992-12-08 1993-01-27 Univ Montfort Improving effectiveness of drugs
CA2928387A1 (en) * 2004-05-03 2005-11-17 Merrimack Pharmaceuticals, Inc. Drug delivery liposomes containing anionic polyols or anionic sugars

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2249552A1 (en) * 1971-10-12 1973-05-30 Inchema S A PROCESS FOR THE INCAPSULATION OF IN PARTICULAR WATER-SOLUBLE COMPOUNDS

Also Published As

Publication number Publication date
CA1130724A (en) 1982-08-31
IT1111675B (en) 1986-01-13
DK393878A (en) 1979-03-07
AT364086B (en) 1981-09-25
AU3955178A (en) 1980-03-13
EP0001104A3 (en) 1979-04-04
ATA642478A (en) 1981-02-15
JPS5449314A (en) 1979-04-18
EP0001104A2 (en) 1979-03-21
AU524587B2 (en) 1982-09-23
YU208078A (en) 1984-02-29
IT7827388A0 (en) 1978-09-06
IE47329B1 (en) 1984-02-22
EP0001104B1 (en) 1981-05-20
IN149223B (en) 1981-10-10
DE2860719D1 (en) 1981-08-27
JPS6022683B2 (en) 1985-06-03
ES473087A1 (en) 1979-04-16

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