IE782018L - Alkylthiopenoxypropanolamines - Google Patents

Alkylthiopenoxypropanolamines

Info

Publication number
IE782018L
IE782018L IE782018A IE201878A IE782018L IE 782018 L IE782018 L IE 782018L IE 782018 A IE782018 A IE 782018A IE 201878 A IE201878 A IE 201878A IE 782018 L IE782018 L IE 782018L
Authority
IE
Ireland
Prior art keywords
alkyl
gb2006197a
alkylthiophenoxypropanolamines
cycloalkyl
administered
Prior art date
Application number
IE782018A
Other versions
IE47449B1 (en
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of IE782018L publication Critical patent/IE782018L/en
Publication of IE47449B1 publication Critical patent/IE47449B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/32—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to an acyclic carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Alkylthiophenoxypropanolamines of the general formula:- <IMAGE> (A,B,R = H,C1-4 alkyl; R1=C1-8 alkyl R2 = C6-12 alkyl, (C5-8 cycloalkyl) - (C2-6 alkyl) ) and the pharmaceutically acceptable acid addition salts thereof increase peripheral blood flow, relax vascular smooth muscle, and inhibit platelet aggregation. They may be administered in the form of pharmaceutical preparations for the treatment of obstructive cerebrovascular deficiencies. [GB2006197A]
IE2018/78A 1977-10-11 1978-10-10 Alkylthiophenoxypropanolamines IE47449B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84116877A 1977-10-11 1977-10-11
US94222278A 1978-09-14 1978-09-14

Publications (2)

Publication Number Publication Date
IE782018L true IE782018L (en) 1979-04-11
IE47449B1 IE47449B1 (en) 1984-03-21

Family

ID=27126241

Family Applications (1)

Application Number Title Priority Date Filing Date
IE2018/78A IE47449B1 (en) 1977-10-11 1978-10-10 Alkylthiophenoxypropanolamines

Country Status (21)

Country Link
JP (1) JPS6049188B2 (en)
AR (2) AR224239A1 (en)
AU (1) AU520181B2 (en)
CA (1) CA1116636A (en)
CH (1) CH642349A5 (en)
DE (1) DE2844353C2 (en)
DK (1) DK146005C (en)
ES (1) ES474156A1 (en)
FI (1) FI70883C (en)
FR (1) FR2405932A1 (en)
GB (1) GB2006197B (en)
GR (1) GR73919B (en)
IE (1) IE47449B1 (en)
IL (1) IL55695A (en)
IT (1) IT1109310B (en)
LU (1) LU80345A1 (en)
NL (1) NL7810156A (en)
NO (1) NO146161C (en)
PH (1) PH15824A (en)
SE (1) SE443782B (en)
YU (1) YU41602B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4396629A (en) 1980-12-29 1983-08-02 Sterling Drug Inc. Compositions, processes and method

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6504268A (en) * 1965-04-03 1966-10-04
DE2551141A1 (en) * 1975-11-14 1977-05-18 Dolorgiet Arzneimittelfabrik (1)-Cyclododecylamino'(2)-hydroxy-propane derivs. - selective beta-receptor blockers
DE2552266A1 (en) * 1975-11-21 1977-05-26 Dolorgiet Arzneimittelfabrik (1)-Aryloxy or arylthio-(3)-cyclohexylamino-(2)-propanol derivs. - prepd. e.g. by reacting epoxy propane cpds. with (3,3,5)-trimethyl-cyclohexylamine

Also Published As

Publication number Publication date
ES474156A1 (en) 1979-10-16
AR223016A1 (en) 1981-07-15
DK146005C (en) 1989-05-29
FR2405932B1 (en) 1981-03-20
DK146005B (en) 1983-05-16
GB2006197B (en) 1982-01-27
PH15824A (en) 1983-04-08
DE2844353A1 (en) 1979-04-19
AR224239A1 (en) 1981-11-13
FI70883B (en) 1986-07-18
YU235278A (en) 1983-01-21
SE443782B (en) 1986-03-10
NL7810156A (en) 1979-04-17
SE7810574L (en) 1979-04-12
AU520181B2 (en) 1982-01-21
DK450978A (en) 1979-04-12
FI783068A7 (en) 1979-04-12
LU80345A1 (en) 1979-06-15
CH642349A5 (en) 1984-04-13
CA1116636A (en) 1982-01-19
FI70883C (en) 1986-10-27
JPS5488232A (en) 1979-07-13
AU4039378A (en) 1980-04-17
IL55695A0 (en) 1978-12-17
IL55695A (en) 1982-01-31
IT7851437A0 (en) 1978-10-10
GR73919B (en) 1984-05-22
NO783416L (en) 1979-05-25
IT1109310B (en) 1985-12-16
NO146161B (en) 1982-05-03
DE2844353C2 (en) 1984-01-26
YU41602B (en) 1987-12-31
FR2405932A1 (en) 1979-05-11
GB2006197A (en) 1979-05-02
JPS6049188B2 (en) 1985-10-31
NO146161C (en) 1982-08-11
IE47449B1 (en) 1984-03-21

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