IE782146L - Immunologically active prp. - Google Patents
Immunologically active prp.Info
- Publication number
- IE782146L IE782146L IE782146A IE214678A IE782146L IE 782146 L IE782146 L IE 782146L IE 782146 A IE782146 A IE 782146A IE 214678 A IE214678 A IE 214678A IE 782146 L IE782146 L IE 782146L
- Authority
- IE
- Ireland
- Prior art keywords
- prp
- immunologically active
- antibody
- obtainable
- purification
- Prior art date
Links
- 238000000034 method Methods 0.000 abstract 4
- 241000588832 Bordetella pertussis Species 0.000 abstract 2
- 239000000427 antigen Substances 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 238000000746 purification Methods 0.000 abstract 2
- 229960005486 vaccine Drugs 0.000 abstract 2
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical class [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 abstract 1
- VJDOAZKNBQCAGE-LMVFSUKVSA-N D-ribitol 5-phosphate Chemical compound OC[C@H](O)[C@H](O)[C@H](O)COP(O)(O)=O VJDOAZKNBQCAGE-LMVFSUKVSA-N 0.000 abstract 1
- 241000606768 Haemophilus influenzae Species 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 239000003463 adsorbent Substances 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 238000010923 batch production Methods 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 229910000389 calcium phosphate Inorganic materials 0.000 abstract 1
- 239000001506 calcium phosphate Substances 0.000 abstract 1
- 235000011010 calcium phosphates Nutrition 0.000 abstract 1
- 239000000356 contaminant Substances 0.000 abstract 1
- 238000005755 formation reaction Methods 0.000 abstract 1
- 229940045808 haemophilus influenzae type b Drugs 0.000 abstract 1
- 229910052588 hydroxylapatite Inorganic materials 0.000 abstract 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 abstract 1
- 239000008363 phosphate buffer Substances 0.000 abstract 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/099—Bordetella
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Mycology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention provides methods for the purification of polyribosyl ribitol phosphate (PRP) from Haemophilus influenzae type b cultures, as well as novel forms of immunologically active PRP obtainable by such methods and combined vaccines containing immunologically active PRP and Bordetella pertussis antigens. The purification methods involve removing contaminants to a low level by treating the PRP in the form of a hexadecyltrimethyl ammonium bromide complex with a calcium phosphate adsorbent (hydroxylapatite) in a phosphate buffer, and may be practiced either as a batch process or as a column process. The purified PRP thus obtainable is immunologically active and may be used with B. pertussis antigens to form a combined vaccine which elicits anti-PRP antibody and antipercussis antibody formations in young animals. This sera with anti-PRP antibody exhibits a strong bactericidal activity.
[GB2007244A]
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/846,466 US4196192A (en) | 1977-10-28 | 1977-10-28 | Combined Haemophilus influenzae type b and pertussis vaccine |
| US05/846,488 US4220717A (en) | 1977-12-22 | 1977-12-22 | Isolation and purification of polyribosyl ribitol phosphate from Haemophilus influenzae type b. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE782146L true IE782146L (en) | 1979-04-28 |
| IE47474B1 IE47474B1 (en) | 1984-03-21 |
Family
ID=27126641
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE2146/78A IE47474B1 (en) | 1977-10-28 | 1978-10-27 | Purifying polyribosyl ribitol phosphate (prp) and vaccines containing immunologically active prp |
Country Status (25)
| Country | Link |
|---|---|
| JP (1) | JPS5480408A (en) |
| AR (1) | AR218932A1 (en) |
| AU (1) | AU520902B2 (en) |
| BE (1) | BE871586A (en) |
| CA (1) | CA1117866A (en) |
| CH (1) | CH649781A5 (en) |
| DD (1) | DD140701A5 (en) |
| DE (1) | DE2845745A1 (en) |
| DK (1) | DK154327C (en) |
| ES (1) | ES474611A1 (en) |
| FI (1) | FI63674C (en) |
| FR (1) | FR2407000B1 (en) |
| GB (1) | GB2007244B (en) |
| GR (1) | GR73991B (en) |
| HU (1) | HU178166B (en) |
| IE (1) | IE47474B1 (en) |
| IL (1) | IL55433A (en) |
| IT (1) | IT1107570B (en) |
| NL (1) | NL7810753A (en) |
| NO (1) | NO149611C (en) |
| NZ (1) | NZ188211A (en) |
| PH (1) | PH15882A (en) |
| PL (1) | PL210545A1 (en) |
| SE (1) | SE430753B (en) |
| YU (1) | YU250878A (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE889979A (en) * | 1981-08-14 | 1982-02-15 | Smith Kline Rit | PROCESS FOR THE PREPARATION OF PURIFIED ANTIGENIC CAPSULAR BACTERIAL POLYSACCHARIDES, PRODUCTS OBTAINED AND THEIR USE |
| CA1209036A (en) * | 1982-08-20 | 1986-08-05 | Joseph S.C. Kuo | Combined haemophilus influenzae and diphtheria, pertussis, tetanus vaccine |
| US4744982A (en) * | 1982-08-24 | 1988-05-17 | Hunter Kenneth W | Human monoclonal antibody reactive with polyribosylribitol phosphate |
| IL98715A0 (en) * | 1990-08-13 | 1992-07-15 | American Cyanamid Co | Filamentous hemaglutinin of bodetella pertussis as a carrier molecule for conjugate vaccines |
| CZ28694A3 (en) * | 1991-08-16 | 1994-05-18 | Merck & Co Inc | Process for preparing capsular polysaccharide free of lipid and endotoxin |
| DK0594950T3 (en) * | 1992-10-27 | 1999-09-13 | American Cyanamid Co | Pediatric combination vaccine with improved immunogenicity of each vaccine component |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3395219A (en) * | 1964-12-11 | 1968-07-30 | Merck & Co Inc | Process for production of pertussis antigen |
| IL24946A (en) * | 1965-01-19 | 1969-05-28 | Merck & Co Inc | Process for preparing b. pertussis antigens |
| US3465078A (en) * | 1965-10-21 | 1969-09-02 | Sydney Z Spiesel | Method of recovering antigens from bordetella pertussis cells |
| NL174267B (en) * | 1969-05-20 | Roussel Uclaf | IMPROVEMENT OF THE PROCESS FOR THE PREPARATION OF A SOMATIC ANTIGEN ACCORDING TO DUTCH PATENT 169754 AND PROCESS FOR PREPARING A PHARMACEUTICAL PREPARATION. | |
| US3636192A (en) * | 1970-01-13 | 1972-01-18 | Us Army | Meningococcal polysaccharide vaccines |
| FR2253499B1 (en) * | 1973-12-10 | 1977-11-04 | Fabre Sa Pierre | |
| DE2461439C3 (en) * | 1974-12-24 | 1980-03-20 | Behringwerke Ag, 3550 Marburg | Process for the preparation of a protective antigen from Bordetella pertussis and agent containing the same |
| US3978209A (en) * | 1975-03-24 | 1976-08-31 | Merck & Co., Inc. | Endotoxin free meningococcus polysaccharides |
-
1978
- 1978-08-22 NZ NZ188211A patent/NZ188211A/en unknown
- 1978-08-25 IL IL55433A patent/IL55433A/en unknown
- 1978-08-29 CA CA000310218A patent/CA1117866A/en not_active Expired
- 1978-08-30 AR AR273492A patent/AR218932A1/en active
- 1978-08-30 GR GR57127A patent/GR73991B/el unknown
- 1978-10-20 DE DE19782845745 patent/DE2845745A1/en active Granted
- 1978-10-24 IT IT51621/78A patent/IT1107570B/en active
- 1978-10-25 PH PH21738A patent/PH15882A/en unknown
- 1978-10-26 FR FR7830517A patent/FR2407000B1/fr not_active Expired
- 1978-10-26 AU AU41081/78A patent/AU520902B2/en not_active Expired
- 1978-10-26 FI FI783269A patent/FI63674C/en not_active IP Right Cessation
- 1978-10-27 NL NL7810753A patent/NL7810753A/en not_active Application Discontinuation
- 1978-10-27 YU YU02508/78A patent/YU250878A/en unknown
- 1978-10-27 PL PL21054578A patent/PL210545A1/xx unknown
- 1978-10-27 ES ES474611A patent/ES474611A1/en not_active Expired
- 1978-10-27 NO NO783635A patent/NO149611C/en unknown
- 1978-10-27 CH CH11125/78A patent/CH649781A5/en not_active IP Right Cessation
- 1978-10-27 GB GB7842230A patent/GB2007244B/en not_active Expired
- 1978-10-27 IE IE2146/78A patent/IE47474B1/en unknown
- 1978-10-27 HU HU78AE546A patent/HU178166B/en not_active IP Right Cessation
- 1978-10-27 BE BE191385A patent/BE871586A/en not_active IP Right Cessation
- 1978-10-27 SE SE7811192A patent/SE430753B/en not_active IP Right Cessation
- 1978-10-27 DD DD78208715A patent/DD140701A5/en unknown
- 1978-10-27 DK DK479578A patent/DK154327C/en not_active IP Right Cessation
- 1978-10-28 JP JP13310978A patent/JPS5480408A/en active Granted
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SE8305535D0 (en) | PHARMACEUTICAL PREPARATION WITH ANTINICOTIC EFFECTS AND PROCEDURES FOR PREPARING THEREOF | |
| NO169775C (en) | ANALOGUE PROCEDURE FOR THE PREPARATION OF NEW OLIGOSACCHARIDES | |
| ATE37196T1 (en) | BEER AND PROCESS FOR PRODUCTION. | |
| IE782146L (en) | Immunologically active prp. | |
| ATE119196T1 (en) | METHOD FOR PRODUCING A FACTOR-VIIA ENRICHED FRACTION AND USE THEREOF AS A MEDICINAL PRODUCT. | |
| ATE119135T1 (en) | METHOD FOR THE HYDROTHERMAL PRODUCTION OF POTASSIUM SILICATE SOLUTIONS WITH HIGH SI02:K20 MOLAR RATIO. | |
| ATE92335T1 (en) | PURIFICATION OF WHOOPING COUGH ANTIGENS. | |
| ATE96036T1 (en) | METHOD OF GROWING BORDETELLA PERTUSSIS, A PERTUSSIS TOXOID AND A PERTUSSIS VACCINE. | |
| IE891151L (en) | A pasteurella vaccine | |
| CY1935A (en) | Novel vaccine and method therefor | |
| ATE61230T1 (en) | PROCESS FOR THE MANUFACTURE OF A WHOOPING CAGE VACCINE COMPONENT AND COMBINED VACCINE CONSISTING OF WHOOPING CAGE ANTIGENS DIPHTERIA TOXOID AND TETANUS TOXOID. | |
| EP0316996A3 (en) | Method for preparing textile treatment compositions | |
| FR2597344B1 (en) | IMPROVEMENT IN THE PROCESS OF PURIFYING PROTEIN ANTIGENS FROM BACTERIA BELONGING TO THE GENUS BORDETELLA, WITH A VIEW TO OBTAINING A CELLULAR VACCINE. | |
| ATE420951T1 (en) | PROTECTIVE EPITOPES OF ADENYLATE CYCLASE-HEMOLYSIN (AC-HLY) AND THEIR USE FOR TREATING OR PREVENTING BORDETELLA INFECTIONS | |
| EP0101562A3 (en) | Combined haemophilus influenzae and diphtheria, pertussis, tetanus vaccine | |
| DE68917709D1 (en) | Process for the preparation of a pertussis toxin toxoid. | |
| DK0432841T3 (en) | Spiro-indoline-oxazine compounds with photochromatic and photosensitizing properties and process for their preparation | |
| JPS6456620A (en) | Production of hemorrhagic fever with renal syndrome virus antigen and vaccine and diagnostic agent using said antigen | |
| OA06223A (en) | Process for the preparation of novel oximes derived from 3-azidomethyl 7-amino thiazolyl acetamido cephalosporanic acid. | |
| GB1508922A (en) | Method for obtaining urokinase | |
| ATE106747T1 (en) | BORDETELLA PERTUSSIS VARIANTS. | |
| RO103684A2 (en) | PRODUCTION METHOD OF IMMUNO-GLOBULIN A1(IgA1) | |
| ATE212T1 (en) | INTRARESPIRATORY VACCINE, MODIFIED BACTERIAL STRAIN USED THEREIN, DOSAGE FORM OF THE VACCINE AND METHOD OF PRODUCTION. | |
| SU551894A2 (en) | METHOD OF CLEANING VIRUS-CONTAINING SUSPENSION | |
| GB1513984A (en) | Method for the purification of hydrofluoric acid |