IE782146L - Immunologically active prp. - Google Patents

Immunologically active prp.

Info

Publication number
IE782146L
IE782146L IE782146A IE214678A IE782146L IE 782146 L IE782146 L IE 782146L IE 782146 A IE782146 A IE 782146A IE 214678 A IE214678 A IE 214678A IE 782146 L IE782146 L IE 782146L
Authority
IE
Ireland
Prior art keywords
prp
immunologically active
antibody
obtainable
purification
Prior art date
Application number
IE782146A
Other versions
IE47474B1 (en
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/846,466 external-priority patent/US4196192A/en
Priority claimed from US05/846,488 external-priority patent/US4220717A/en
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of IE782146L publication Critical patent/IE782146L/en
Publication of IE47474B1 publication Critical patent/IE47474B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/099—Bordetella
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Mycology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention provides methods for the purification of polyribosyl ribitol phosphate (PRP) from Haemophilus influenzae type b cultures, as well as novel forms of immunologically active PRP obtainable by such methods and combined vaccines containing immunologically active PRP and Bordetella pertussis antigens. The purification methods involve removing contaminants to a low level by treating the PRP in the form of a hexadecyltrimethyl ammonium bromide complex with a calcium phosphate adsorbent (hydroxylapatite) in a phosphate buffer, and may be practiced either as a batch process or as a column process. The purified PRP thus obtainable is immunologically active and may be used with B. pertussis antigens to form a combined vaccine which elicits anti-PRP antibody and antipercussis antibody formations in young animals. This sera with anti-PRP antibody exhibits a strong bactericidal activity. [GB2007244A]
IE2146/78A 1977-10-28 1978-10-27 Purifying polyribosyl ribitol phosphate (prp) and vaccines containing immunologically active prp IE47474B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/846,466 US4196192A (en) 1977-10-28 1977-10-28 Combined Haemophilus influenzae type b and pertussis vaccine
US05/846,488 US4220717A (en) 1977-12-22 1977-12-22 Isolation and purification of polyribosyl ribitol phosphate from Haemophilus influenzae type b.

Publications (2)

Publication Number Publication Date
IE782146L true IE782146L (en) 1979-04-28
IE47474B1 IE47474B1 (en) 1984-03-21

Family

ID=27126641

Family Applications (1)

Application Number Title Priority Date Filing Date
IE2146/78A IE47474B1 (en) 1977-10-28 1978-10-27 Purifying polyribosyl ribitol phosphate (prp) and vaccines containing immunologically active prp

Country Status (25)

Country Link
JP (1) JPS5480408A (en)
AR (1) AR218932A1 (en)
AU (1) AU520902B2 (en)
BE (1) BE871586A (en)
CA (1) CA1117866A (en)
CH (1) CH649781A5 (en)
DD (1) DD140701A5 (en)
DE (1) DE2845745A1 (en)
DK (1) DK154327C (en)
ES (1) ES474611A1 (en)
FI (1) FI63674C (en)
FR (1) FR2407000B1 (en)
GB (1) GB2007244B (en)
GR (1) GR73991B (en)
HU (1) HU178166B (en)
IE (1) IE47474B1 (en)
IL (1) IL55433A (en)
IT (1) IT1107570B (en)
NL (1) NL7810753A (en)
NO (1) NO149611C (en)
NZ (1) NZ188211A (en)
PH (1) PH15882A (en)
PL (1) PL210545A1 (en)
SE (1) SE430753B (en)
YU (1) YU250878A (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE889979A (en) * 1981-08-14 1982-02-15 Smith Kline Rit PROCESS FOR THE PREPARATION OF PURIFIED ANTIGENIC CAPSULAR BACTERIAL POLYSACCHARIDES, PRODUCTS OBTAINED AND THEIR USE
CA1209036A (en) * 1982-08-20 1986-08-05 Joseph S.C. Kuo Combined haemophilus influenzae and diphtheria, pertussis, tetanus vaccine
US4744982A (en) * 1982-08-24 1988-05-17 Hunter Kenneth W Human monoclonal antibody reactive with polyribosylribitol phosphate
DE69113564T2 (en) * 1990-08-13 1996-05-30 American Cyanamid Co Bordetella pertussis fiber hemagglutinin as a carrier for conjugated vaccine.
WO1993004183A1 (en) * 1991-08-16 1993-03-04 Merck & Co., Inc. Process for converting lipid-containing bacterial capsular polysaccharide into lipid-free polysaccharide
ES2126616T3 (en) * 1992-10-27 1999-04-01 American Cyanamid Co COMBINED PEDIATRIC VACCINE, WITH INCREASED IMMUNOGENICITY OF EACH COMPONENT OF THE VACCINE.

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3395219A (en) * 1964-12-11 1968-07-30 Merck & Co Inc Process for production of pertussis antigen
IL24946A (en) * 1965-01-19 1969-05-28 Merck & Co Inc Process for preparing b. pertussis antigens
US3465078A (en) * 1965-10-21 1969-09-02 Sydney Z Spiesel Method of recovering antigens from bordetella pertussis cells
NL174267B (en) * 1969-05-20 Roussel Uclaf IMPROVEMENT OF THE PROCESS FOR THE PREPARATION OF A SOMATIC ANTIGEN ACCORDING TO DUTCH PATENT 169754 AND PROCESS FOR PREPARING A PHARMACEUTICAL PREPARATION.
US3636192A (en) * 1970-01-13 1972-01-18 Us Army Meningococcal polysaccharide vaccines
FR2253499B1 (en) * 1973-12-10 1977-11-04 Fabre Sa Pierre
DE2461439C3 (en) * 1974-12-24 1980-03-20 Behringwerke Ag, 3550 Marburg Process for the preparation of a protective antigen from Bordetella pertussis and agent containing the same
US3978209A (en) * 1975-03-24 1976-08-31 Merck & Co., Inc. Endotoxin free meningococcus polysaccharides

Also Published As

Publication number Publication date
YU250878A (en) 1983-12-31
FI783269A7 (en) 1979-04-29
JPS6231694B2 (en) 1987-07-09
JPS5480408A (en) 1979-06-27
FR2407000B1 (en) 1983-01-21
IL55433A (en) 1982-09-30
PL210545A1 (en) 1980-02-25
AR218932A1 (en) 1980-07-15
GR73991B (en) 1984-06-06
CA1117866A (en) 1982-02-09
SE7811192L (en) 1979-04-29
IE47474B1 (en) 1984-03-21
NL7810753A (en) 1979-05-02
PH15882A (en) 1983-04-13
DD140701A5 (en) 1980-03-26
NO783635L (en) 1979-05-02
GB2007244A (en) 1979-05-16
AU520902B2 (en) 1982-03-04
SE430753B (en) 1983-12-12
NZ188211A (en) 1984-09-28
BE871586A (en) 1979-04-27
DK479578A (en) 1979-04-29
FI63674C (en) 1983-08-10
IL55433A0 (en) 1978-10-31
DE2845745A1 (en) 1979-05-10
CH649781A5 (en) 1985-06-14
AU4108178A (en) 1980-05-01
DK154327B (en) 1988-11-07
ES474611A1 (en) 1980-01-16
NO149611B (en) 1984-02-13
IT1107570B (en) 1985-11-25
NO149611C (en) 1984-05-23
DK154327C (en) 1989-04-03
GB2007244B (en) 1982-03-31
FI63674B (en) 1983-04-29
HU178166B (en) 1982-03-28
FR2407000A1 (en) 1979-05-25
DE2845745C2 (en) 1987-10-01
IT7851621A0 (en) 1978-10-24

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