IE782404L - Detoxified pharmaceutical product - Google Patents
Detoxified pharmaceutical productInfo
- Publication number
- IE782404L IE782404L IE782404A IE240478A IE782404L IE 782404 L IE782404 L IE 782404L IE 782404 A IE782404 A IE 782404A IE 240478 A IE240478 A IE 240478A IE 782404 L IE782404 L IE 782404L
- Authority
- IE
- Ireland
- Prior art keywords
- detoxified
- pharmaceutical product
- alk
- alkylating agent
- ca1117015a
- Prior art date
Links
- 239000000825 pharmaceutical preparation Substances 0.000 title abstract 2
- 229940127557 pharmaceutical product Drugs 0.000 title 1
- 229940100198 alkylating agent Drugs 0.000 abstract 2
- 239000002168 alkylating agent Substances 0.000 abstract 2
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 abstract 1
- 229910006069 SO3H Inorganic materials 0.000 abstract 1
- 150000001335 aliphatic alkanes Chemical class 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000003396 thiol group Chemical class [H]S* 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The present invention is related to a process for producing a pharmaceutical preparation containing a cytostatically active alkylating agent which has been detoxified by adding thereto a a pharmacologically acceptable salt of a mercapto alkane sulfonic acid of the general formula HS-alk-SO3H wherein alk is an alkylene group having from 2 to 6 carbon atoms, in an amount of at least 20 % of the weight of the alkylating agent thereby substantially improving the properties thereof.
[CA1117015A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2756018A DE2756018C2 (en) | 1977-12-14 | 1977-12-14 | Use of salts of mercaptoalkanesulfonic acids |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE782404L true IE782404L (en) | 1979-06-14 |
| IE47609B1 IE47609B1 (en) | 1984-05-02 |
Family
ID=6026256
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE2404/78A IE47609B1 (en) | 1977-12-14 | 1978-12-05 | Process for producing detoxified pharmaceutical products containing a cytostatically active alkylating agent |
Country Status (15)
| Country | Link |
|---|---|
| AR (1) | AR216563A1 (en) |
| AT (1) | AT358162B (en) |
| CA (1) | CA1117015A (en) |
| DD (1) | DD140420B5 (en) |
| DE (1) | DE2756018C2 (en) |
| EG (1) | EG14057A (en) |
| GR (1) | GR68356B (en) |
| HU (1) | HU179915B (en) |
| IE (1) | IE47609B1 (en) |
| IL (1) | IL56097A (en) |
| MC (1) | MC1229A1 (en) |
| PL (1) | PL211758A1 (en) |
| PT (1) | PT68904A (en) |
| YU (1) | YU291978A (en) |
| ZA (1) | ZA786662B (en) |
-
1977
- 1977-12-14 DE DE2756018A patent/DE2756018C2/en not_active Expired
-
1978
- 1978-11-27 ZA ZA00786662A patent/ZA786662B/en unknown
- 1978-11-29 GR GR57769A patent/GR68356B/el unknown
- 1978-11-30 IL IL56097A patent/IL56097A/en unknown
- 1978-12-05 IE IE2404/78A patent/IE47609B1/en unknown
- 1978-12-06 AR AR274705A patent/AR216563A1/en active
- 1978-12-06 AT AT871078A patent/AT358162B/en not_active IP Right Cessation
- 1978-12-12 PT PT68904A patent/PT68904A/en unknown
- 1978-12-12 DD DD20969178A patent/DD140420B5/en active IP Right Maintenance
- 1978-12-12 MC MC781346A patent/MC1229A1/en unknown
- 1978-12-12 CA CA000317744A patent/CA1117015A/en not_active Expired
- 1978-12-13 EG EG702/78A patent/EG14057A/en active
- 1978-12-13 HU HU78AA913A patent/HU179915B/en unknown
- 1978-12-14 PL PL21175878A patent/PL211758A1/xx unknown
- 1978-12-16 YU YU02919/78A patent/YU291978A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MC1229A1 (en) | 1979-10-26 |
| IL56097A (en) | 1981-09-13 |
| AT358162B (en) | 1980-08-25 |
| YU291978A (en) | 1984-02-29 |
| EG14057A (en) | 1982-09-30 |
| PL211758A1 (en) | 1980-02-11 |
| CA1117015A (en) | 1982-01-26 |
| AR216563A1 (en) | 1979-12-28 |
| IE47609B1 (en) | 1984-05-02 |
| ATA871078A (en) | 1980-01-15 |
| DD140420B5 (en) | 1995-06-14 |
| HU179915B (en) | 1983-01-28 |
| ZA786662B (en) | 1979-10-31 |
| DD140420A5 (en) | 1980-03-05 |
| DE2756018C2 (en) | 1979-11-22 |
| IL56097A0 (en) | 1979-01-31 |
| DE2756018B1 (en) | 1979-03-29 |
| GR68356B (en) | 1981-12-23 |
| PT68904A (en) | 1979-01-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE3170245D1 (en) | Indane derivatives, methods of their preparation and compositions containing them | |
| ES8403858A1 (en) | PROCEDURE FOR THE PREPARATION OF CARBOXIALKYL DIPEPTIDES. | |
| ES8204739A1 (en) | their starting compounds and their preparation. | |
| IE39898B1 (en) | 1-or 7-oxoalkyl xanthine derivatives | |
| KR880003958A (en) | Novel cefem compound and preparation method thereof | |
| GB1363506A (en) | Process for the preparation of alpha-amino-penicillins and such penicillins and intermediates and pharmaceutical preparations | |
| ATE36859T1 (en) | 4'-DEMETHYL-4-EPIPODOPHYLLOTOXIN DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS. | |
| FR2374334A1 (en) | NEW NUCLEOSIDES USEFUL AS MEDICINAL PRODUCTS AND PROCESS FOR THEIR PREPARATION | |
| IE810275L (en) | Substituted imidazoles | |
| ES483289A1 (en) | 1,2,3,5-Tetrahydroimidazothienopyrimidin-2-ones, a process for their preparation and pharmaceutical compositions. | |
| ATE50575T1 (en) | 2-OXIMINO-2-AMINOTHIAZOLYLACETIC ACID DERIVATIVES AND PROCESS FOR THEIR PRODUCTION. | |
| ES8504682A1 (en) | New nitro aliphatic compounds, process for preparation thereof and use thereof. | |
| PL249964A1 (en) | Process for preparing novel derivatives of 7-//z/-2-/2-aminothiazolyl-4/-2-oxyiminoacetamide/-3-cephemo-4-carboxylic acid | |
| ES484718A1 (en) | Chromanol derivatives, a process for their preparation and pharmaceutical compositions comprising them. | |
| ES474367A1 (en) | New benzo [d] thiazole derivatives, process for their preparation and their therapeutic applications | |
| EP0123962A3 (en) | Novel benzimidazole derivative, process for the preparation thereof and pharmaceutical composition | |
| ES480041A1 (en) | Pharmaceutically active cyclohexyl compounds and their preparation | |
| ES470383A1 (en) | 99hydroxyethoxymethylguanine derivative and process for preparing same | |
| ES8502689A1 (en) | Benzazepine derivatives, process for their preparation and their use as pharmaceutical compounds. | |
| IE44414L (en) | Furan and thiophene compounds | |
| ES485333A1 (en) | 5,6,7,8-Tetrahydro-4(3H)- quinazolinone derivatives useful as spasmolytics | |
| IE781718L (en) | Imidazole derivatives | |
| SE8303565D0 (en) | PROCESS FOR THE PREPARATION OF 1-ALKYL OR 1,4-DIALKYL-1H-PYRROLE-2-ACETIC ACID ESTERS | |
| PT81066A (en) | Arphamine derivatives a process for their preparation and the pharmaceutical compositions therewith | |
| IE780190L (en) | Triazolothienodiazepines |