IE790031L - Fatty acid amides - Google Patents

Fatty acid amides

Info

Publication number
IE790031L
IE790031L IE790031A IE3179A IE790031L IE 790031 L IE790031 L IE 790031L IE 790031 A IE790031 A IE 790031A IE 3179 A IE3179 A IE 3179A IE 790031 L IE790031 L IE 790031L
Authority
IE
Ireland
Prior art keywords
fatty acid
acid amides
compounds
group
gb2012261a
Prior art date
Application number
IE790031A
Other versions
IE48077B1 (en
Original Assignee
Sandoz Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/881,780 external-priority patent/US4229463A/en
Priority claimed from US05/891,298 external-priority patent/US4194002A/en
Application filed by Sandoz Ltd filed Critical Sandoz Ltd
Publication of IE790031L publication Critical patent/IE790031L/en
Publication of IE48077B1 publication Critical patent/IE48077B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B22/00—Use of inorganic materials as active ingredients for mortars, concrete or artificial stone, e.g. accelerators or shrinkage compensating agents
    • C04B22/0013—Boron compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/24—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
    • C07C243/26—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C243/28—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ceramic Engineering (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Materials Engineering (AREA)
  • Structural Engineering (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention provides novel anti- atherosclerotic compounds of the type <IMAGE> where A is the residue of a long chain, unsaturated fatty acid or cyclopropano analogues thereof; the -CO-N< moiety forms an amide or hydrazide group or the N atom may be part of a 4-optionally-substituted-styryl- hexahydro-4-indolinol-(1) group. The compounds are made by acylation of amines. [GB2012261A]
IE31/79A 1978-01-09 1979-01-08 Long-chain fatty acid amides and cyclopropano analogues thereof,their production and their use as anti-atherosclerotic agents IE48077B1 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US86781378A 1978-01-09 1978-01-09
US86782478A 1978-01-09 1978-01-09
US87283678A 1978-01-27 1978-01-27
US88178178A 1978-02-27 1978-02-27
US05/881,780 US4229463A (en) 1978-02-27 1978-02-27 Unsaturated fatty acid hydrazides
US05/891,298 US4194002A (en) 1978-03-29 1978-03-29 Cholesterol ester-reducing amides of hexahydroindolinols

Publications (2)

Publication Number Publication Date
IE790031L true IE790031L (en) 1979-07-09
IE48077B1 IE48077B1 (en) 1984-09-19

Family

ID=27560330

Family Applications (1)

Application Number Title Priority Date Filing Date
IE31/79A IE48077B1 (en) 1978-01-09 1979-01-08 Long-chain fatty acid amides and cyclopropano analogues thereof,their production and their use as anti-atherosclerotic agents

Country Status (20)

Country Link
JP (1) JPS54109930A (en)
AU (1) AU529328B2 (en)
CA (1) CA1101871A (en)
CH (1) CH644842A5 (en)
CY (1) CY1294A (en)
DE (1) DE2856856A1 (en)
DK (1) DK3079A (en)
FI (1) FI790025A7 (en)
FR (1) FR2416885A1 (en)
GB (1) GB2012261B (en)
HK (1) HK80985A (en)
IE (1) IE48077B1 (en)
IL (1) IL56393A (en)
IT (1) IT1110603B (en)
KE (1) KE3546A (en)
MY (1) MY8500133A (en)
NZ (1) NZ189331A (en)
PT (1) PT69052A (en)
SE (1) SE446093B (en)
SG (1) SG42985G (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2937175A1 (en) * 1978-09-18 1980-03-27 Sandoz Ag SECOND AMIDES OF 2-ALKYNOYL ACIDS, THEIR PRODUCTION AND THEIR PHARMACEUTICAL COMPOSITIONS
US4297349A (en) 1980-04-15 1981-10-27 Sandoz, Inc. Silicon-bearing carboxylic acids and amides
US4722927A (en) * 1986-04-28 1988-02-02 Warner-Lambert Company Pyrimidine amides of oleic or linoleic acid, composition containing them and their use as inhibitors of acyl-CoA cholesterol acyltransferase
FR2633617B1 (en) * 1988-07-04 1991-02-08 Adir NOVEL BENZOCYCLOHEPTENE DERIVATIVES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
US5290814A (en) * 1988-11-21 1994-03-01 Burroughs Wellcome Co. Anti-atherosclerotic diaryl compounds
CN102014897B (en) * 2008-04-21 2015-08-05 西格纳姆生物科学公司 Compound, compositions and its preparation method

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1814334B2 (en) * 1967-12-21 1973-04-19 Sumitomo Chemical Co Ltd , Osaka (Japan) FATTY ACID AMIDES AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
FR2000945A1 (en) * 1968-01-30 1969-09-19 Sumitomo Chemical Co
JPS5835505B2 (en) * 1976-01-09 1983-08-03 エーザイ株式会社 N-(α-methyl-benzyl)-fatty acid amide

Also Published As

Publication number Publication date
CH644842A5 (en) 1984-08-31
CA1101871A (en) 1981-05-26
DK3079A (en) 1979-07-10
SG42985G (en) 1985-12-13
FR2416885A1 (en) 1979-09-07
IL56393A0 (en) 1979-03-12
MY8500133A (en) 1985-12-31
NZ189331A (en) 1981-07-13
JPS6323987B2 (en) 1988-05-18
IE48077B1 (en) 1984-09-19
JPS54109930A (en) 1979-08-29
FI790025A7 (en) 1979-07-10
FR2416885B1 (en) 1983-04-22
IT7919059A0 (en) 1979-01-04
GB2012261A (en) 1979-07-25
IT1110603B (en) 1985-12-23
IL56393A (en) 1982-08-31
SE446093B (en) 1986-08-11
AU529328B2 (en) 1983-06-02
DE2856856A1 (en) 1979-07-12
CY1294A (en) 1985-10-18
HK80985A (en) 1985-10-25
GB2012261B (en) 1982-12-22
SE7900142L (en) 1979-07-10
AU4323379A (en) 1979-07-19
KE3546A (en) 1985-07-19
PT69052A (en) 1979-02-01

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