IE790126L - Heterocycle-substituted guanidine derivatives - Google Patents
Heterocycle-substituted guanidine derivativesInfo
- Publication number
- IE790126L IE790126L IE790126A IE12679A IE790126L IE 790126 L IE790126 L IE 790126L IE 790126 A IE790126 A IE 790126A IE 12679 A IE12679 A IE 12679A IE 790126 L IE790126 L IE 790126L
- Authority
- IE
- Ireland
- Prior art keywords
- carbon atoms
- heterocycle
- alkyl
- guanidine derivatives
- hydrogen
- Prior art date
Links
- 150000002357 guanidines Chemical class 0.000 title 1
- 229940083094 guanine derivative acting on arteriolar smooth muscle Drugs 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- GXGJIOMUZAGVEH-UHFFFAOYSA-N Chamazulene Chemical group CCC1=CC=C(C)C2=CC=C(C)C2=C1 GXGJIOMUZAGVEH-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Substances 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000005277 alkyl imino group Chemical group 0.000 abstract 1
- 229940030600 antihypertensive agent Drugs 0.000 abstract 1
- 239000002220 antihypertensive agent Substances 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 125000001841 imino group Chemical group [H]N=* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Chemical group 0.000 abstract 1
- 125000003258 trimethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])[*:1] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/42—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms with nitro or nitroso radicals directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/28—Halogen atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Furan Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
Compounds of formula I, <IMAGE> wherein R1, R2 and R3 are, independently, hydrogen, halogen or alkyl of 1 to 4 carbon atoms, and either R4 and R6 are independently hydrogen, alkyl or hydroxyalkyl, each of 1 to 4 carbon atoms, or alkoxyalkyl with a maximum of 6 carbon atoms, or R4 and R6 together signify dimethylene or trimethylene, R5 and R7 are, independently, hydrogen or alkyl of 1 to 4 carbon atoms, and X is sulphur, oxygen, imino, or (C1-4) alkylimino, are useful as antihypertensive agents.
[GB2013192A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH79978 | 1978-01-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IE790126L true IE790126L (en) | 1979-07-25 |
Family
ID=4195448
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE790126A IE790126L (en) | 1978-01-25 | 1979-01-30 | Heterocycle-substituted guanidine derivatives |
Country Status (12)
| Country | Link |
|---|---|
| JP (1) | JPS54112859A (en) |
| AU (1) | AU4359279A (en) |
| BE (1) | BE873658A (en) |
| DE (1) | DE2901362A1 (en) |
| FR (1) | FR2415636A1 (en) |
| GB (1) | GB2013192A (en) |
| IE (1) | IE790126L (en) |
| IL (1) | IL56486A0 (en) |
| IT (1) | IT7947732A0 (en) |
| NL (1) | NL7900444A (en) |
| SE (1) | SE7900459L (en) |
| ZA (1) | ZA79315B (en) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE423121T1 (en) | 2004-06-16 | 2009-03-15 | Wyeth Corp | DIPHENYLIMIDAZOPYRIMIDINE AND IMIDAZOLAMINE AS B-SECRETASE INHIBITORS |
| ES2332659T3 (en) | 2004-06-16 | 2010-02-10 | Wyeth | DERIVATIVES OF AMINO-5,5-DIFENYLIMIDAZOLONE FOR THE INHIBITION OF BETA-SECRETASA. |
| CN101103034A (en) | 2005-01-14 | 2008-01-09 | 惠氏公司 | Amino-imidazolones that inhibit β-secretase |
| MX2007009313A (en) | 2005-02-01 | 2007-09-12 | Wyeth Corp | Amino-pyridines as inhibitors of ????-secretase. |
| BRPI0606902A2 (en) | 2005-02-14 | 2009-07-28 | Wyeth Corp | compound; method for treating a disease or disorder associated with excessive baceous activity in a patient in need thereof; method for modulating bace activity; pharmaceutical composition |
| WO2006088694A1 (en) | 2005-02-14 | 2006-08-24 | Wyeth | SUBSTITUTED THIENYL AND FURYL ACYLGUANIDINES AS β-SECRETASE MODULATORS |
| TW200738683A (en) | 2005-06-30 | 2007-10-16 | Wyeth Corp | Amino-5-(5-membered)heteroarylimidazolone compounds and the use thereof for β-secretase modulation |
| EP1896448A1 (en) | 2005-06-30 | 2008-03-12 | Wyeth | AMINO-5-(6-MEMBERED)HETEROARYLIMIDAZOLONE COMPOUNDS AND THE USE THEREOF FOR ß-SECRETASE MODULATION |
| KR20080050430A (en) | 2005-09-26 | 2008-06-05 | 와이어쓰 | Amino-5- [4- (difluoromethoxy) phenyl] -5-phenylimidazolone compounds as beta-secretase (CAC) inhibitors |
| WO2007100536A1 (en) | 2006-02-24 | 2007-09-07 | Wyeth | DIHYDROSPIRO[DIBENZO[A,D][7]ANNULENE-5,4'-IMIDAZOL] COMPOUNDS FOR THE INHIBITION OF β-SECRETASE |
| US7700606B2 (en) | 2006-08-17 | 2010-04-20 | Wyeth Llc | Imidazole amines as inhibitors of β-secretase |
| CL2008000791A1 (en) | 2007-03-23 | 2008-05-30 | Wyeth Corp | COMPOUNDS DERIVED FROM 2-AMINO-5- (4-DIFLUOROMETOXI-FENIL) -5-FENIL-IMIDAZOLIDIN-4-ONA; PHARMACEUTICAL COMPOSITION THAT INCLUDES SUCH COMPOUNDS; AND ITS USE IN THE TREATMENT OF A DISEASE ASSOCIATED WITH EXCESSIVE BACE ACTIVITY, SUCH AS ILLNESS |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1298112A (en) * | 1969-02-20 | 1972-11-29 | Wander Ag Dr A | Phenyl acetyl guanidine derivatives |
-
1979
- 1979-01-15 DE DE19792901362 patent/DE2901362A1/en not_active Withdrawn
- 1979-01-18 SE SE7900459A patent/SE7900459L/en unknown
- 1979-01-19 NL NL7900444A patent/NL7900444A/en not_active Application Discontinuation
- 1979-01-22 GB GB7902149A patent/GB2013192A/en not_active Withdrawn
- 1979-01-23 AU AU43592/79A patent/AU4359279A/en not_active Abandoned
- 1979-01-23 IT IT7947732A patent/IT7947732A0/en unknown
- 1979-01-23 FR FR7901657A patent/FR2415636A1/en not_active Withdrawn
- 1979-01-23 BE BE0/193042A patent/BE873658A/en unknown
- 1979-01-23 IL IL56486A patent/IL56486A0/en unknown
- 1979-01-24 JP JP621579A patent/JPS54112859A/en active Pending
- 1979-01-25 ZA ZA79315A patent/ZA79315B/en unknown
- 1979-01-30 IE IE790126A patent/IE790126L/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SE7900459L (en) | 1979-07-26 |
| GB2013192A (en) | 1979-08-08 |
| BE873658A (en) | 1979-07-23 |
| JPS54112859A (en) | 1979-09-04 |
| ZA79315B (en) | 1980-09-24 |
| AU4359279A (en) | 1979-08-02 |
| IL56486A0 (en) | 1979-03-12 |
| FR2415636A1 (en) | 1979-08-24 |
| NL7900444A (en) | 1979-07-27 |
| DE2901362A1 (en) | 1979-07-26 |
| IT7947732A0 (en) | 1979-01-23 |
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