IE791431L - Carboxy (phenyl or tolyl)-sulphonium salts - Google Patents
Carboxy (phenyl or tolyl)-sulphonium saltsInfo
- Publication number
- IE791431L IE791431L IE791431A IE143179A IE791431L IE 791431 L IE791431 L IE 791431L IE 791431 A IE791431 A IE 791431A IE 143179 A IE143179 A IE 143179A IE 791431 L IE791431 L IE 791431L
- Authority
- IE
- Ireland
- Prior art keywords
- alkyl
- phenyl
- compounds
- tolyl
- carboxy
- Prior art date
Links
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 title abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 title 1
- 125000003944 tolyl group Chemical group 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 150000001450 anions Chemical class 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- -1 phenylthio-phenyl compounds Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 150000001350 alkyl halides Chemical class 0.000 abstract 1
- 230000029936 alkylation Effects 0.000 abstract 1
- 238000005804 alkylation reaction Methods 0.000 abstract 1
- 238000005349 anion exchange Methods 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C381/00—Compounds containing carbon and sulfur and having functional groups not covered by groups C07C301/00 - C07C337/00
- C07C381/12—Sulfonium compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Novel compounds of formula <IMAGE> in which R1 = (C8-24) alkyl, R2 = (C1-6) or unsubstituted or substituted phenyl, R3 = H, halogen, (C1-3) alkyl or alkoxy, R4 = H or (C1-6) alkyl, n = 0 or 1, and Z<(-)>= anion forming a pharmaceutically acceptable non-toxic salt of the corresponding cation, provided that R2 is alkyl when R4 is H, are obtained by alkylation of corresponding alkylthio- or phenylthio-phenyl compounds with alkyl halides in the presence of a metal salt or with a trialkyloxonium tetrafluoroborate after which the resulting anion can be replaced by known anion exchange methods. The compounds are active against obesity and can be incorporated into pharmaceutical compositions.
[GB2028807A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US92942478A | 1978-07-31 | 1978-07-31 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE791431L true IE791431L (en) | 1980-01-31 |
| IE48604B1 IE48604B1 (en) | 1985-03-20 |
Family
ID=25457841
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1431/79A IE48604B1 (en) | 1978-07-31 | 1979-08-08 | Carboxy(phenyl or tolyl)-sulphonium salts,their preparation and use as anti-obesity agents |
Country Status (21)
| Country | Link |
|---|---|
| JP (1) | JPS5522679A (en) |
| AT (1) | AT376658B (en) |
| AU (1) | AU528588B2 (en) |
| BE (1) | BE877975A (en) |
| CA (1) | CA1137107A (en) |
| CH (1) | CH644844A5 (en) |
| DE (1) | DE2929692A1 (en) |
| DK (1) | DK310579A (en) |
| FI (1) | FI792314A7 (en) |
| FR (1) | FR2432507A1 (en) |
| GB (1) | GB2028807B (en) |
| IE (1) | IE48604B1 (en) |
| IL (1) | IL57921A (en) |
| IT (1) | IT7949744A0 (en) |
| MY (1) | MY8500132A (en) |
| NL (1) | NL7905821A (en) |
| NZ (1) | NZ191162A (en) |
| PH (1) | PH15716A (en) |
| PT (1) | PT69995A (en) |
| SE (1) | SE7906327L (en) |
| ZA (1) | ZA793908B (en) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1593541A (en) * | 1977-04-05 | 1981-07-15 | Boots Co Ltd | Carbamate esters of hydroxyaryl sulphonium salts and methods of regulating plant growth employing them |
-
1979
- 1979-07-13 IT IT7949744A patent/IT7949744A0/en unknown
- 1979-07-19 CH CH673279A patent/CH644844A5/en not_active IP Right Cessation
- 1979-07-21 DE DE19792929692 patent/DE2929692A1/en not_active Withdrawn
- 1979-07-23 DK DK310579A patent/DK310579A/en not_active Application Discontinuation
- 1979-07-24 FI FI792314A patent/FI792314A7/en not_active Application Discontinuation
- 1979-07-24 SE SE7906327A patent/SE7906327L/en not_active Application Discontinuation
- 1979-07-27 GB GB7926278A patent/GB2028807B/en not_active Expired
- 1979-07-27 NL NL7905821A patent/NL7905821A/en not_active Application Discontinuation
- 1979-07-27 CA CA000332672A patent/CA1137107A/en not_active Expired
- 1979-07-30 IL IL57921A patent/IL57921A/en unknown
- 1979-07-30 JP JP9618379A patent/JPS5522679A/en active Pending
- 1979-07-30 PT PT69995A patent/PT69995A/en unknown
- 1979-07-30 NZ NZ191162A patent/NZ191162A/en unknown
- 1979-07-30 AU AU49369/79A patent/AU528588B2/en not_active Ceased
- 1979-07-30 BE BE0/196525A patent/BE877975A/en not_active IP Right Cessation
- 1979-07-30 AT AT0522079A patent/AT376658B/en not_active IP Right Cessation
- 1979-07-30 PH PH22829A patent/PH15716A/en unknown
- 1979-07-31 ZA ZA00793908A patent/ZA793908B/en unknown
- 1979-07-31 FR FR7919658A patent/FR2432507A1/en active Granted
- 1979-08-08 IE IE1431/79A patent/IE48604B1/en unknown
-
1985
- 1985-12-30 MY MY132/85A patent/MY8500132A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT69995A (en) | 1979-08-01 |
| DK310579A (en) | 1980-02-01 |
| FR2432507B1 (en) | 1982-03-12 |
| AT376658B (en) | 1984-12-27 |
| FR2432507A1 (en) | 1980-02-29 |
| IL57921A (en) | 1983-06-15 |
| IL57921A0 (en) | 1979-11-30 |
| IT7949744A0 (en) | 1979-07-13 |
| CA1137107A (en) | 1982-12-07 |
| SE7906327L (en) | 1980-02-01 |
| BE877975A (en) | 1980-01-30 |
| NZ191162A (en) | 1984-05-31 |
| ATA522079A (en) | 1984-05-15 |
| NL7905821A (en) | 1980-02-04 |
| GB2028807B (en) | 1982-11-17 |
| IE48604B1 (en) | 1985-03-20 |
| FI792314A7 (en) | 1981-01-01 |
| PH15716A (en) | 1983-03-18 |
| AU4936979A (en) | 1980-02-07 |
| AU528588B2 (en) | 1983-05-05 |
| CH644844A5 (en) | 1984-08-31 |
| ZA793908B (en) | 1981-03-25 |
| MY8500132A (en) | 1985-12-31 |
| JPS5522679A (en) | 1980-02-18 |
| GB2028807A (en) | 1980-03-12 |
| DE2929692A1 (en) | 1980-02-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IE802347L (en) | 7-acylamino-3-vinylcephalosporanic acid derivatives | |
| ES8406485A1 (en) | Substituted azabicyclo compounds, process for their preparation and pharmaceutical compositions containing them. | |
| DE3060551D1 (en) | 2-alkoxyphenyl-imidazo(4,5-b)pyridines, their preparation, their use in the production of medicaments and medicaments containing these compounds | |
| ZA793150B (en) | 2-(2-alkoxyethyl)-2'-hydroxy-6,7-benzomorphanes,processes for their preparation,and pharmaceutical compositions thereof | |
| EP0057422A3 (en) | New cephem compounds, processes for preparation thereof and pharmaceutical composition containing them | |
| IE46278L (en) | Tri-phenyl-substituted-piperazine derivatives | |
| ES8107240A1 (en) | Salts of cationic brighteners, their preparation and their use on organic materials as well as their concentrated aqueous solutions. | |
| IE820401L (en) | N-£4-(indolyl)-piperidino-alkyl|-benzimidazolines | |
| IE40511L (en) | Pyridyl piperidine derivatives | |
| JPS5777689A (en) | Novel cephen compound, or its salt, its preparation, and preventive it as active ingredient | |
| ES2001341A6 (en) | Novel guanidinomethylbenzoic acid derivatives. | |
| IE801861L (en) | Oxiranecarboxylic acid derivatives | |
| ES8200643A1 (en) | Cyclohexane carboxylic acid derivatives | |
| JPS55115892A (en) | 3-phosphonocephalosporanic acid derivative, its preparation, and medicine containing the same | |
| AU575400B2 (en) | Piperidine and imidazole and amino salt derivatives as plant growth regulators | |
| IE45222L (en) | 2-loweralkyl-2- or -3-cephem-4-carboxylic acids. | |
| ES459903A1 (en) | Quinoline derivatives | |
| SE7906327L (en) | CARBOXY (PHENYL OR TOLYL) -SULPHONIUM SALTS, THEIR PREPARATION AND THEIR USE AS AN OBJECTS AGENT | |
| IL58999A0 (en) | Pharmaceutical compositions comprising certain imidazolinederivatives | |
| PL246418A1 (en) | Process for preparing n-/3-trifluoromethylphenyl/-n'-propargylpiperazine | |
| JPS56142282A (en) | Penem-3-carboxylic acid derivative and its preparation | |
| DE3661829D1 (en) | 0-substituted 3-oxy-pyridinium salts, process for their preparation and their use as fungicides in crop protection | |
| ES8106147A1 (en) | 1,2,4-Triazole-3-thiols as antisecretory agents | |
| IE820684L (en) | Hydroxamic acid derivatives. | |
| ES2005748A6 (en) | 3,7-disubstituted-3-cephem compound and production thereof |