IE800115L - Pharmaceutical compositions, containing a benzo £c| £1,6|¹naphthyridine - Google Patents
Pharmaceutical compositions, containing a benzo £c| £1,6|¹naphthyridineInfo
- Publication number
- IE800115L IE800115L IE800115A IE11580A IE800115L IE 800115 L IE800115 L IE 800115L IE 800115 A IE800115 A IE 800115A IE 11580 A IE11580 A IE 11580A IE 800115 L IE800115 L IE 800115L
- Authority
- IE
- Ireland
- Prior art keywords
- carbon atoms
- hydrogen
- chlorine
- alkoxy
- alkyl
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 125000005605 benzo group Chemical group 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 13
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 229910052801 chlorine Inorganic materials 0.000 abstract 4
- 239000000460 chlorine Substances 0.000 abstract 4
- -1 cinnamoyl Chemical group 0.000 abstract 3
- 150000002431 hydrogen Chemical group 0.000 abstract 3
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 2
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 2
- 229910052794 bromium Inorganic materials 0.000 abstract 2
- 229910052731 fluorine Inorganic materials 0.000 abstract 2
- 239000011737 fluorine Substances 0.000 abstract 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 239000002876 beta blocker Substances 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000029078 coronary artery disease Diseases 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000004772 dichloromethyl group Chemical group [H]C(Cl)(Cl)* 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 208000010125 myocardial infarction Diseases 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000000168 pyrrolyl group Chemical group 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Pharmaceutical compositions containing A) a compound of formula I, <IMAGE> wherein either i) R1 is hydrogen, alkyl of 1 to 3 carbon atoms, alkoxy of 1 to 3 carbon atoms or alkylthio of 1 to 3 carbon atoms, fluorine, bromine, chlorine, nitro, trifluoromethyl, amino or -NHCOR, wherein -COR is alkanoyl of 1 to 18 carbon atoms; benzoyl; benzoyl wherein the benzene ring is substituted by one X and one Y, X being alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, fluorine, chlorine or bromine, and Y being hydrogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, or chlorine; phenylalkanoyl, wherein the alkylene section has 1 to 3 carbon atoms; cinnamoyl; phenylalkanoyl as defined above or cinnamoyl which are substitute in the benzene ring by one X and one Y which are as defined above; or -COA, A being thienyl, furyl, pyrrolyl or pyridyl; R2 is hydrogen, chlorine, alkyl of 1 to 3 carbon atoms or alkoxy of 1 to 3 carbon atoms and either R3 and R4 are both hydrogen or both methoxy or R3 and R4 together are methylene-dioxy, or ii) R1 is -NHCOR min , wherein R min is dichloromethyl, cycloalkyl of 3 to 6 carbon atoms or alkenyl of 2 to 5 carbon atoms, R2 is hydrogen and R3 and R4 are both methoxy and B) a beta -adrenoceptor blocking agent, are used in the treatment of coronary heart disease and myocardial infarction.
[GB2040682A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7902147 | 1979-01-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IE800115L true IE800115L (en) | 1980-07-22 |
Family
ID=10502644
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE800115A IE800115L (en) | 1979-01-22 | 1980-01-21 | Pharmaceutical compositions, containing a benzo £c| £1,6|¹naphthyridine |
Country Status (12)
| Country | Link |
|---|---|
| AU (1) | AU5478180A (en) |
| BE (1) | BE880455A (en) |
| DE (1) | DE3001016A1 (en) |
| ES (1) | ES487881A0 (en) |
| FR (1) | FR2446636A1 (en) |
| GB (1) | GB2040682A (en) |
| IE (1) | IE800115L (en) |
| IL (1) | IL59176A0 (en) |
| NL (1) | NL8000332A (en) |
| PT (1) | PT70715A (en) |
| SE (1) | SE8000268L (en) |
| ZA (1) | ZA80369B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3423003A1 (en) * | 1984-06-22 | 1986-01-02 | Beiersdorf Ag, 2000 Hamburg | BENZO (C) (1,8) NAPHTHYRIDINE, METHOD FOR THE PRODUCTION AND USE THEREOF, AND PREPARATIONS CONTAINING THESE COMPOUNDS |
| US4652567A (en) * | 1985-03-13 | 1987-03-24 | Hoechst-Roussel Pharmaceuticals Inc. | Benzo(c)-1,5-naphthyridines useful for treating a patient having drug induced memory impairment in need of memory enhancement |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1361441A (en) * | 1970-05-13 | 1974-07-24 | Sandoz Ltd | Benzonaphthyridine derivatives |
| JPS5585519A (en) * | 1978-12-11 | 1980-06-27 | Sandoz Ag | Novel use of benzo*c**1*6*naphthyridine and medical composition containing same and betaablocking agent |
-
1979
- 1979-12-06 BE BE1/9634A patent/BE880455A/en unknown
-
1980
- 1980-01-12 DE DE19803001016 patent/DE3001016A1/en not_active Withdrawn
- 1980-01-14 SE SE8000268A patent/SE8000268L/en unknown
- 1980-01-17 GB GB8001667A patent/GB2040682A/en not_active Withdrawn
- 1980-01-18 NL NL8000332A patent/NL8000332A/en not_active Application Discontinuation
- 1980-01-21 IE IE800115A patent/IE800115L/en unknown
- 1980-01-21 AU AU54781/80A patent/AU5478180A/en not_active Abandoned
- 1980-01-21 ES ES487881A patent/ES487881A0/en active Granted
- 1980-01-21 PT PT70715A patent/PT70715A/en unknown
- 1980-01-21 IL IL59176A patent/IL59176A0/en unknown
- 1980-01-22 ZA ZA00800369A patent/ZA80369B/en unknown
- 1980-01-22 FR FR8001329A patent/FR2446636A1/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| DE3001016A1 (en) | 1980-07-31 |
| AU5478180A (en) | 1980-07-31 |
| IL59176A0 (en) | 1980-05-30 |
| FR2446636A1 (en) | 1980-08-14 |
| PT70715A (en) | 1980-02-01 |
| ES8102126A1 (en) | 1980-12-16 |
| GB2040682A (en) | 1980-09-03 |
| ES487881A0 (en) | 1980-12-16 |
| ZA80369B (en) | 1981-08-26 |
| NL8000332A (en) | 1980-07-24 |
| BE880455A (en) | 1980-06-06 |
| SE8000268L (en) | 1980-07-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU652981B2 (en) | Condensed benzoxa ring compound, production thereof, and pharmaceutical composition containing the same | |
| SE9002206D0 (en) | NEW COMPOUNDS | |
| DE69505968D1 (en) | AZOLIDINDION DERIVATIVES AND THEIR USE AS ANTI-HYPERGLYCEMAS | |
| FI855117A0 (en) | Block polymers and similar compounds useful as soil release agents in detergent compositions | |
| MY110142A (en) | Thiazolidinedione derivatives, their production and use | |
| IE45574L (en) | Piperidyl-indole derivatives | |
| AU6700590A (en) | 1-aryl-1-hydroxy-1-substituted-3-(4-substituted-1- piperazinyl-2-propanones and their use in treatment of neurogenic bladder disorders | |
| SE8503415L (en) | NEW ISOINDOLINYLALKYL PIPERAZINES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | |
| ES466143A1 (en) | Novel imidazoquinolines | |
| SE8500107D0 (en) | NEW 8ALFA-ACYLAMINOERGOLINE | |
| NO960441L (en) | Benzopyrans and pharmaceutical compounds containing them | |
| AU7733491A (en) | Isochromane derivatives | |
| DK37580A (en) | 4,5-DIHYDRO-4-OXOFURAN-2-CARBOXYLIC ACID DERIVATIVES AND THEIR PREPARATION AND USE | |
| ATE133672T1 (en) | THIENOPYRIDINE DERIVATIVES, THEIR PREPARATION AND USE | |
| ATE88467T1 (en) | PHARMACOLOGICALLY ACTIVE ALKYLENE DERIVATIVES. | |
| MY104955A (en) | Pyrroloquinoline and pyrrolophemothiazine carboxamides and related compounds. | |
| MY102440A (en) | Fungicidal pyridyl cyclopropane carboxamides. | |
| IL67564A (en) | 7-heteroaryl-(1,2)-fused 1,4-benzodiazepine compounds,their preparation and pharmaceutical compositions containing them | |
| SE7905051L (en) | NEW SULPHONAMIDES | |
| MY105057A (en) | A process for preparing naphthalene derivatives | |
| IE40722B1 (en) | Indolopiperdino-alkylthiazines | |
| DE69111311D1 (en) | 2-tetrahydrofuran enantiomer derivatives, intermediates thereof and their preparation. | |
| HK77191A (en) | Aminoacylates of glycerol acetal | |
| RU92016560A (en) | SUBSTITUTED BENZOIMIDAZOLES, PHARMACEUTICAL COMPOSITION, METHOD OF INHIBITION OR TREATMENT AND METHOD OF THEIR RECEIVING AND APPLICATION | |
| TW360630B (en) | A secoaporphine compounds on arrhythmia |