IE800209L - Dextrorotatory 9, 10-ethanoanthracene derivative. - Google Patents

Dextrorotatory 9, 10-ethanoanthracene derivative.

Info

Publication number
IE800209L
IE800209L IE800209A IE20980A IE800209L IE 800209 L IE800209 L IE 800209L IE 800209 A IE800209 A IE 800209A IE 20980 A IE20980 A IE 20980A IE 800209 L IE800209 L IE 800209L
Authority
IE
Ireland
Prior art keywords
methylamino
methyl
alpha
compound
formula
Prior art date
Application number
IE800209A
Other versions
IE49741B1 (en
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of IE800209L publication Critical patent/IE800209L/en
Publication of IE49741B1 publication Critical patent/IE49741B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/24—Preparation of compounds containing amino groups bound to a carbon skeleton by reductive alkylation of ammonia, amines or compounds having groups reducible to amino groups, with carbonyl compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
    • B29D30/00—Producing pneumatic or solid tyres or parts thereof
    • B29D30/06—Pneumatic tyres or parts thereof (e.g. produced by casting, moulding, compression moulding, injection moulding, centrifugal casting)
    • B29D30/08—Building tyres
    • B29D30/20—Building tyres by the flat-tyre method, i.e. building on cylindrical drums
    • B29D30/32—Fitting the bead-rings or bead-cores; Folding the textile layers around the rings or cores
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
    • B29D30/00—Producing pneumatic or solid tyres or parts thereof
    • B29D30/06—Pneumatic tyres or parts thereof (e.g. produced by casting, moulding, compression moulding, injection moulding, centrifugal casting)
    • B29D30/08—Building tyres
    • B29D30/20—Building tyres by the flat-tyre method, i.e. building on cylindrical drums
    • B29D30/32—Fitting the bead-rings or bead-cores; Folding the textile layers around the rings or cores
    • B29D2030/3207—Positioning the beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
    • B29D30/00—Producing pneumatic or solid tyres or parts thereof
    • B29D30/06—Pneumatic tyres or parts thereof (e.g. produced by casting, moulding, compression moulding, injection moulding, centrifugal casting)
    • B29D30/08—Building tyres
    • B29D30/20—Building tyres by the flat-tyre method, i.e. building on cylindrical drums
    • B29D30/32—Fitting the bead-rings or bead-cores; Folding the textile layers around the rings or cores
    • B29D2030/3214—Locking the beads on the drum; details of the drum in the bead locking areas, e.g. drum shoulders
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
    • B29D30/00—Producing pneumatic or solid tyres or parts thereof
    • B29D30/06—Pneumatic tyres or parts thereof (e.g. produced by casting, moulding, compression moulding, injection moulding, centrifugal casting)
    • B29D30/08—Building tyres
    • B29D30/20—Building tyres by the flat-tyre method, i.e. building on cylindrical drums
    • B29D30/32—Fitting the bead-rings or bead-cores; Folding the textile layers around the rings or cores
    • B29D2030/3221—Folding over means, e.g. bladders or rigid arms
    • B29D2030/3228—Folding over means, e.g. bladders or rigid arms using one bladder acting on each side of the drum
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
    • B29D30/00—Producing pneumatic or solid tyres or parts thereof
    • B29D30/06—Pneumatic tyres or parts thereof (e.g. produced by casting, moulding, compression moulding, injection moulding, centrifugal casting)
    • B29D30/08—Building tyres
    • B29D30/20—Building tyres by the flat-tyre method, i.e. building on cylindrical drums
    • B29D30/32—Fitting the bead-rings or bead-cores; Folding the textile layers around the rings or cores
    • B29D2030/3221—Folding over means, e.g. bladders or rigid arms
    • B29D2030/3235—Folding over means, e.g. bladders or rigid arms using two or more bladders acting on each side of the drum
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
    • B29D30/00—Producing pneumatic or solid tyres or parts thereof
    • B29D30/06—Pneumatic tyres or parts thereof (e.g. produced by casting, moulding, compression moulding, injection moulding, centrifugal casting)
    • B29D30/08—Building tyres
    • B29D30/20—Building tyres by the flat-tyre method, i.e. building on cylindrical drums
    • B29D30/32—Fitting the bead-rings or bead-cores; Folding the textile layers around the rings or cores
    • B29D2030/3221—Folding over means, e.g. bladders or rigid arms
    • B29D2030/3242—Folding over means, e.g. bladders or rigid arms and with means for pressing the bladder against the ply material, e.g. bladder guide shoes, cages, arms

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Mechanical Engineering (AREA)
  • Pain & Pain Management (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Steroid Compounds (AREA)

Abstract

For all designated states : BE, CH, DE, FR, GB, IT, LU, NL, SE 1. S-(+)-alpha-[methylamino)methyl]-9-10-ethano anthracene-9(10H)-ethanol of the formula I see diagramm : EP0014434,P11,F1 or an acid addition salt thereof. For the contracting state : AT 1. A process for the production of S-(+)-alpha-([methylamino)methyl]-9-10-ethano anthracene-9(10H)-ethanol of the formula I ad indicated in claim 1, or of an acid addition salt thereof, which process comprises a) resolving the racemic alpha-[(methylamino)-methyl]-9-10-ethanoanthracene- 9(10H)-ethanol and isolating S-(+)-alpha-[(methylamino)-methyl]-9-10-ethano anthracene-9(10H)-ethanol, if desired in the form of an acid addition salt, or b) reacting a compound of the formula II see diagramm : EP0014434,P12,F1 with a compound of the formula III X2 -CH3 wherein one of X1 and X2 is the amino group and the other is a reactive esterified hydroxyl group, and Y1 is a free hydroxyl group, and X1 together with Y1 can also be an epoxy group, and A is the 9,10-ethanoanthracen-9(10H)-yl radical, or c) in a compound of the formula IV see diagramm : EP0014434,P12,F2 in which at least one of Z1 and Z2 is a removable radical and the other may be hydrogen, or Z1 and Z2 together are a divalent removable radical, and A is the 9,10-ethanoanthracen-9(10H)-yl radical, removing Z1 and/or Z2 , d) reducing a compound which differs from the compound of the formula I only in that, in said compound, a carbon atom adjacent to the nitrogen atom is attached to this latter through a double bond or is substituted by a hydroxyl group or an oxo radical, optionally together with lower alkoxy, or e) adding ethylene to S-alpha-[(methylamino)-methyl]-9(10H)-anthracene, or hydrolyzing the intermediate obtained, and, if desired, converting the resultant S-(+)-alpha-[(methylamino)methyl]-9,10-ethanoanthracen- e-9(10H)-ethanol into an acid addition salt and/or liberating the base from a resultant acid addition salt. [EP0014434A1]
IE209/80A 1979-02-02 1980-02-01 New dextrorotatory basic derivative of 9,10-ethanoanthracene,process for the manufacture thereof,pharmaceutical compositions containing this compound and their use IE49741B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH104779 1979-02-02
CH9480 1980-01-08

Publications (2)

Publication Number Publication Date
IE800209L true IE800209L (en) 1980-08-02
IE49741B1 IE49741B1 (en) 1985-12-11

Family

ID=25683498

Family Applications (1)

Application Number Title Priority Date Filing Date
IE209/80A IE49741B1 (en) 1979-02-02 1980-02-01 New dextrorotatory basic derivative of 9,10-ethanoanthracene,process for the manufacture thereof,pharmaceutical compositions containing this compound and their use

Country Status (19)

Country Link
EP (1) EP0014434B1 (en)
KR (1) KR830001858A (en)
AT (1) ATE3414T1 (en)
AU (1) AU538114B2 (en)
CA (1) CA1140596A (en)
CS (1) CS215042B2 (en)
DD (1) DD148950A5 (en)
DE (1) DE3063221D1 (en)
DK (1) DK149102C (en)
ES (1) ES488191A0 (en)
FI (1) FI800269A7 (en)
GR (1) GR73703B (en)
HU (1) HU181019B (en)
IE (1) IE49741B1 (en)
IL (1) IL59284A (en)
NO (1) NO146952C (en)
NZ (1) NZ192780A (en)
PL (1) PL221743A1 (en)
PT (1) PT70765A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8313571D0 (en) * 1983-05-17 1983-06-22 Wellcome Found Chemical compounds

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4017542A (en) * 1971-02-23 1977-04-12 Ciba-Geigy Corporation 9-(2-Hydroxy-3-amino-propyl)-9,10-dihydro-9,10-ethano-anthracenes and salts thereof

Also Published As

Publication number Publication date
ES8102078A1 (en) 1980-12-16
CS215042B2 (en) 1982-06-25
DD148950A5 (en) 1981-06-17
NO146952B (en) 1982-09-27
HU181019B (en) 1983-05-30
KR830001858A (en) 1983-05-19
NO800271L (en) 1980-08-04
PT70765A (en) 1980-03-01
IE49741B1 (en) 1985-12-11
ES488191A0 (en) 1980-12-16
DK149102C (en) 1986-06-09
EP0014434A1 (en) 1980-08-20
PL221743A1 (en) 1980-12-15
CA1140596A (en) 1983-02-01
NZ192780A (en) 1982-06-29
FI800269A7 (en) 1981-01-01
IL59284A0 (en) 1980-05-30
AU538114B2 (en) 1984-08-02
ATE3414T1 (en) 1983-06-15
DE3063221D1 (en) 1983-07-07
DK149102B (en) 1986-01-27
AU5511980A (en) 1980-08-07
GR73703B (en) 1984-04-03
DK44480A (en) 1980-08-03
EP0014434B1 (en) 1983-05-18
NO146952C (en) 1983-01-05
IL59284A (en) 1983-05-15

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