IE802418L - ANTIALLERGIC AND ANTIULCER 1-OXO-1H-THIAZOLO (3,2-a)¹PYRIMIDINE-2-CARBOXAMIDES - Google Patents
ANTIALLERGIC AND ANTIULCER 1-OXO-1H-THIAZOLO (3,2-a)¹PYRIMIDINE-2-CARBOXAMIDESInfo
- Publication number
- IE802418L IE802418L IE802418A IE241880A IE802418L IE 802418 L IE802418 L IE 802418L IE 802418 A IE802418 A IE 802418A IE 241880 A IE241880 A IE 241880A IE 802418 L IE802418 L IE 802418L
- Authority
- IE
- Ireland
- Prior art keywords
- formula
- carbon atoms
- antiulcer
- thiazolo
- antiallergic
- Prior art date
Links
- 230000003266 anti-allergic effect Effects 0.000 title abstract 2
- 230000000767 anti-ulcer Effects 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 239000000543 intermediate Substances 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 239000000043 antiallergic agent Substances 0.000 abstract 1
- 239000003699 antiulcer agent Substances 0.000 abstract 1
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- -1 carbophenoxy Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/40—Unsubstituted amino or imino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
Antiallergy and antiulcer agents having the formula (I), <IMAGE> and their pharmaceutically acceptable salts, wherein R1 and R2 taken separately are each hydrogen or C1-5 alkyl; and R1 and R2 taken together are alkylene of 3 - 9 carbon atoms or phenylalkylene of 9 - 11 carbon atoms, with the proviso that the ring so formed is between 5- and 8-membered; acids of the formula (II), <IMAGE> wherein R1 and R2 are as defined above and R3 is hydrogen, which are useful as intermediates for compounds of the formula (I), but in many instances also possess the same useful biological activity as do formula I compounds; and intermediates of the formula II wherein R1 and R2 are defined as above, and R3 is alkyl of 1 to 4 carbon atoms, carbalkoxy of 2 to 5 carbon atoms, carbophenoxy or carbobenzoxy, are described.
[GB2063862A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9663179A | 1979-11-23 | 1979-11-23 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE802418L true IE802418L (en) | 1981-05-23 |
| IE50404B1 IE50404B1 (en) | 1986-04-16 |
Family
ID=22258306
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE2418/80A IE50404B1 (en) | 1979-11-23 | 1980-11-21 | Antiallergic and antiulcer 1-oxo-1h-thiazolo(3,2-a)pyrimidine-2-carboxamides and intermediates therefor |
Country Status (35)
| Country | Link |
|---|---|
| JP (1) | JPS5687586A (en) |
| KR (1) | KR830004322A (en) |
| AR (2) | AR228859A1 (en) |
| AT (1) | AT380883B (en) |
| AU (1) | AU520995B2 (en) |
| BE (1) | BE886319A (en) |
| CA (1) | CA1143731A (en) |
| CH (1) | CH649299A5 (en) |
| CS (1) | CS241476B2 (en) |
| DD (1) | DD154608A5 (en) |
| DE (2) | DE3043979C2 (en) |
| DK (1) | DK151811C (en) |
| EG (1) | EG14929A (en) |
| ES (1) | ES8203363A1 (en) |
| FI (1) | FI67706C (en) |
| FR (1) | FR2470132A1 (en) |
| GB (1) | GB2063862B (en) |
| GR (1) | GR72132B (en) |
| GT (1) | GT198066458A (en) |
| HU (1) | HU179091B (en) |
| IE (1) | IE50404B1 (en) |
| IL (1) | IL61535A (en) |
| IN (1) | IN154926B (en) |
| IT (1) | IT1209373B (en) |
| LU (1) | LU82950A1 (en) |
| NL (1) | NL182565C (en) |
| NO (1) | NO803521L (en) |
| NZ (1) | NZ195596A (en) |
| PH (1) | PH16666A (en) |
| PL (1) | PL132354B1 (en) |
| PT (1) | PT72090B (en) |
| SE (1) | SE448732B (en) |
| SU (1) | SU1042620A3 (en) |
| YU (1) | YU41953B (en) |
| ZA (1) | ZA807293B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8300728D0 (en) * | 1983-01-12 | 1983-02-16 | Erba Farmitalia | Substituted carboxy-thiazolo / 3 2 - a / pyrimidine derivatives |
| US4457932A (en) * | 1983-07-22 | 1984-07-03 | Bristol-Myers Company | Anti-ulcer agents |
| GB8422916D0 (en) * | 1984-09-11 | 1984-10-17 | May & Baker Ltd | Compositions of matter |
| JP2690742B2 (en) * | 1987-03-30 | 1997-12-17 | 第一製薬株式会社 | Heterocyclic amine derivative |
| DE68926473T2 (en) * | 1988-03-28 | 1996-10-02 | Janssen Pharmaceutica Nv | Means for preserving or restoring healthy skin |
| TWI500623B (en) * | 2009-10-13 | 2015-09-21 | Torrent Pharmaceuticals Ltd | Novel fused thiazole and oxazolidine |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1331059A (en) * | 1971-04-19 | 1973-09-19 | Lilly Industries Ltd | Pyrimidotriazinone compounds |
| US4041163A (en) * | 1976-03-29 | 1977-08-09 | Pfizer Inc. | N-(5-Tetrazolyl)-4-oxo-4H-pyrimido(2,1-b)benzothiazole-3-carboxamide antiallergy agents |
| DE2810863A1 (en) * | 1978-03-13 | 1979-09-27 | Boehringer Mannheim Gmbh | 1-OXO-1H-PYRIMIDO ANGLE CLAMP ON 6.1-B ANGLE CLAMP ON BENZTHIAZOLE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF |
| US4223031A (en) * | 1978-05-05 | 1980-09-16 | Mead Johnson & Company | Azolopyrimidinones |
-
1980
- 1980-09-30 DK DK413180A patent/DK151811C/en not_active IP Right Cessation
- 1980-10-15 IN IN760/DEL/80A patent/IN154926B/en unknown
- 1980-11-17 SU SU803212053A patent/SU1042620A3/en active
- 1980-11-18 AR AR283276A patent/AR228859A1/en active
- 1980-11-18 GB GB8036904A patent/GB2063862B/en not_active Expired
- 1980-11-18 CS CS807820A patent/CS241476B2/en unknown
- 1980-11-18 HU HU80802755A patent/HU179091B/en not_active IP Right Cessation
- 1980-11-19 EG EG723/80A patent/EG14929A/en active
- 1980-11-19 CH CH8567/80A patent/CH649299A5/en not_active IP Right Cessation
- 1980-11-20 GR GR63413A patent/GR72132B/el unknown
- 1980-11-20 YU YU2950/80A patent/YU41953B/en unknown
- 1980-11-20 NZ NZ195596A patent/NZ195596A/en unknown
- 1980-11-21 FR FR8024822A patent/FR2470132A1/en active Granted
- 1980-11-21 IT IT8026176A patent/IT1209373B/en active
- 1980-11-21 NO NO803521A patent/NO803521L/en unknown
- 1980-11-21 ES ES497066A patent/ES8203363A1/en not_active Expired
- 1980-11-21 CA CA000365258A patent/CA1143731A/en not_active Expired
- 1980-11-21 SE SE8008189A patent/SE448732B/en not_active IP Right Cessation
- 1980-11-21 IE IE2418/80A patent/IE50404B1/en unknown
- 1980-11-21 FI FI803628A patent/FI67706C/en not_active IP Right Cessation
- 1980-11-21 NL NLAANVRAGE8006362,A patent/NL182565C/en not_active IP Right Cessation
- 1980-11-21 DE DE3043979A patent/DE3043979C2/en not_active Expired
- 1980-11-21 IL IL61535A patent/IL61535A/en unknown
- 1980-11-21 LU LU82950A patent/LU82950A1/en unknown
- 1980-11-21 JP JP16450280A patent/JPS5687586A/en active Granted
- 1980-11-21 ZA ZA00807293A patent/ZA807293B/en unknown
- 1980-11-21 DE DE3050491A patent/DE3050491C2/en not_active Expired
- 1980-11-21 PT PT72090A patent/PT72090B/en not_active IP Right Cessation
- 1980-11-21 AU AU64595/80A patent/AU520995B2/en not_active Ceased
- 1980-11-21 AT AT0570780A patent/AT380883B/en not_active IP Right Cessation
- 1980-11-21 PH PH24891A patent/PH16666A/en unknown
- 1980-11-21 GT GT198066458A patent/GT198066458A/en unknown
- 1980-11-21 DD DD80225391A patent/DD154608A5/en not_active IP Right Cessation
- 1980-11-22 KR KR1019800004474A patent/KR830004322A/en not_active Ceased
- 1980-11-22 PL PL1980228008A patent/PL132354B1/en unknown
- 1980-11-24 BE BE0/202915A patent/BE886319A/en not_active IP Right Cessation
-
1982
- 1982-09-13 AR AR290628A patent/AR231296A1/en active
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