IE810698L - Pyranone derivatives - Google Patents

Pyranone derivatives

Info

Publication number
IE810698L
IE810698L IE810698A IE69881A IE810698L IE 810698 L IE810698 L IE 810698L IE 810698 A IE810698 A IE 810698A IE 69881 A IE69881 A IE 69881A IE 810698 L IE810698 L IE 810698L
Authority
IE
Ireland
Prior art keywords
hydrogen atom
compounds
prepared
group
pyranone derivatives
Prior art date
Application number
IE810698A
Other languages
Unknown language ( )
Other versions
IE52367B1 (en
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=12604367&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IE810698(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sankyo Co filed Critical Sankyo Co
Publication of IE810698L publication Critical patent/IE810698L/en
Publication of IE52367B1 publication Critical patent/IE52367B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Compounds of formula (I): (in which R<1> and R<2>, which may be the same or different, each represents a hydrogen atom or an acyl group and R<3> represents a hydrogen atom or a methyl group, provided that, where R<1> represents a hydrogen atom, R<2> and R<3> cannot simultaneously be hydrogen atoms and R<2> cannot be a a- methylbutyryl group) inhibit the biosynthesis of cholesterol and hence can be used for the treatment of disorders resulting from high cholesterol levels. The compounds of the invention can be prepared by acylation of corresponding compounds where one or both of R<1> and R<2> represents a hydrogen atom and these may, in turn, be prepared by cultivation of microoorganisms of the genus Monascus.
IE698/81A 1980-03-31 1981-03-27 Inhibitors of cholesterol biosynthesis,their preparation and use IE52367B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP55041292A JPH0692381B2 (en) 1980-03-31 1980-03-31 MB-530A derivative

Publications (2)

Publication Number Publication Date
IE810698L true IE810698L (en) 1981-09-30
IE52367B1 IE52367B1 (en) 1987-09-30

Family

ID=12604367

Family Applications (1)

Application Number Title Priority Date Filing Date
IE698/81A IE52367B1 (en) 1980-03-31 1981-03-27 Inhibitors of cholesterol biosynthesis,their preparation and use

Country Status (15)

Country Link
JP (1) JPH0692381B2 (en)
AT (1) ATA150781A (en)
AU (1) AU6893281A (en)
BE (1) BE888214A (en)
CH (1) CH646966A5 (en)
DE (2) DE3112566A1 (en)
DK (3) DK151273C (en)
FI (1) FI810991L (en)
FR (1) FR2479222A1 (en)
GB (1) GB2073193A (en)
IE (1) IE52367B1 (en)
IT (1) IT1144325B (en)
MX (1) MX9203567A (en)
NL (1) NL8101592A (en)
SE (1) SE461590B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4472426A (en) * 1982-12-22 1984-09-18 Merck & Co., Inc. Antihypercholesterolemic compounds
ATE69602T1 (en) * 1985-09-13 1991-12-15 Sankyo Co HYDROXY-ML-236B DERIVATIVES, THEIR PREPARATION AND USE.
US4997848A (en) * 1987-10-27 1991-03-05 Sankyo Company, Limited Octahydronaphthalene oxime derivatives for cholesterol synthesis inhibition
US5075327A (en) * 1988-08-10 1991-12-24 Hoffmann-La Roche Inc. Antipsoriatic agents
US5073568A (en) * 1988-11-14 1991-12-17 Hoffmann-La Roche Inc. Antipsoriatic agents
US5200549A (en) * 1988-11-14 1993-04-06 Hoffman-La Roche Inc. Antipsoriatic agents
US5021451A (en) * 1988-11-14 1991-06-04 Hoffman-La Roche Inc. Method for inhibiting hyperproliferative diseases
US5159104A (en) * 1991-05-01 1992-10-27 Merck & Co., Inc. Process to simvastatin ester
FR2937537A1 (en) 2008-10-29 2010-04-30 Centre Nat Rech Scient NANOPARTICLES OF STATIN
KR101820099B1 (en) 2013-01-18 2018-01-18 에스프린팅솔루션 주식회사 resistive heat generating material, heating member and fusing device adopting the same
WO2019139919A1 (en) 2018-01-09 2019-07-18 Ligand Pharmaceuticals, Inc. Acetal compounds and therapeutic uses thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5612114B2 (en) * 1974-06-07 1981-03-18
JPS5925599B2 (en) * 1979-02-20 1984-06-19 三共株式会社 New physiologically active substance monacolin K and its production method
AU535944B2 (en) * 1979-06-15 1984-04-12 Merck & Co., Inc. Hypocholestermic fermentation products from aspergillus
US4231938A (en) * 1979-06-15 1980-11-04 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
AU548996B2 (en) * 1980-02-04 1986-01-09 Merck & Co., Inc. Tetrahydro-2h-pyran-2-one derivatives
ZA81703B (en) * 1980-02-04 1982-09-29 Merck & Co Inc New antihypercholesterolemic compounds,intermediates and processes
PT72394B (en) * 1980-02-04 1982-09-06 Merck & Co Inc Process for preparing dihydro and tetrahydromevinoline hypocholesterolimics
US4282155A (en) * 1980-02-04 1981-08-04 Merck & Co., Inc. Antihypercholesterolemic compounds

Also Published As

Publication number Publication date
DK167805B1 (en) 1993-12-20
DE3112566C2 (en) 1990-04-05
DE3153666C2 (en) 1993-11-11
JPH0692381B2 (en) 1994-11-16
IT8167438A0 (en) 1981-03-30
AU6893281A (en) 1981-10-08
FR2479222A1 (en) 1981-10-02
GB2073193A (en) 1981-10-14
IE52367B1 (en) 1987-09-30
FI810991A7 (en) 1981-10-01
FR2479222B1 (en) 1983-08-26
DK32290A (en) 1990-02-07
IT1144325B (en) 1986-10-29
DK151273B (en) 1987-11-16
BE888214A (en) 1981-09-30
SE8102047L (en) 1981-10-01
CH646966A5 (en) 1984-12-28
MX9203567A (en) 1992-09-01
DE3112566A1 (en) 1982-03-11
DK151273C (en) 1988-07-04
ATA150781A (en) 1983-03-15
DK32190D0 (en) 1990-02-07
DK145481A (en) 1981-10-01
FI810991L (en) 1981-10-01
DK32190A (en) 1990-02-07
NL8101592A (en) 1981-10-16
DK32290D0 (en) 1990-02-07
JPS56138181A (en) 1981-10-28
SE461590B (en) 1990-03-05

Similar Documents

Publication Publication Date Title
JPS5412381A (en) N-alkylpiperidine derivative
CA2266016A1 (en) Tricyclic inhibitors of farnesyl protein transferase
MY129994A (en) Novel siloxane derivatives, producing method thereof and agents including siloxane derivative
IE810167L (en) Tetrahydropyran-2-ones.
EP0037486A3 (en) Metal chelates of 1,4-bis(substituted-amino)-5,8-dihydroxy-anthraquinones
AU4223696A (en) Preventive or alleviative agent for hypertension or medical symptoms caused thereby
SE8102047L (en) INHIBITORS OF CHOLESTEROL BIOSYNTHESIS, THEIR PREPARATION AND USE
WO1990011823A1 (en) Surfactant and process for producing the same
AU575342B2 (en) Gamma - butyrolactone derivatives
EP0374838A3 (en) Electrophotographic elements containing certain anthraquinone derivatives as electron-transport agents
WO1998011091A3 (en) Tricyclic compounds useful for inhibition of farnesyl protein transferase
ES8301928A1 (en) Herbicidal 4-benzoyl-5-phenacyloxy-pyrazole derivatives, composition and method
CA2264513A1 (en) Substituted benzocycloheptapyridine derivatives useful for inhibition of farnesyl protein transferase
WO1996031208A3 (en) Use of substituted piperidine or pyrrolidine compounds for treating sigma-receptor modulated disorders
AU665648B2 (en) Azacycloalkane derivatives
IE810760L (en) Thiazoles
AU653854B2 (en) Process for the preparation of 4-hydroxy-3(2H)furanones
JPS52125168A (en) Triazoline derivatives, method of preparing the same, and herbicides
IE780890L (en) Pyranoquinolinones
EP0386258A4 (en) Tetrahydropyridine derivatives
ES8206419A1 (en) A PROCEDURE FOR THE PREPARATION OF BIS-HYDROXYBENCIL DERIVATIVE.
AU1099688A (en) Substituted 3-phenyl-7h-thiazolo(2,2-b)(1,2,4)triazin-7-ones, a process for the preparation thereof, medicaments containing same and the use thereof, and also some intermediates formed in the preparation of the compounds mentioned
JPS549258A (en) Epidesmosterol derivatives
EP0048532A3 (en) Sultines; a process for producing these; a process for producing sulfoxides; a process for producing sparsomycin and related compounds
AU4771090A (en) Methyl-3,3-dialkoxy-1-propylphosphinic acid esters, the corresponding 3-oxo compounds, and a process for their preparation

Legal Events

Date Code Title Description
MK9A Patent expired