IE810967L - Enzyme inhibitor - Google Patents
Enzyme inhibitorInfo
- Publication number
- IE810967L IE810967L IE810967A IE96781A IE810967L IE 810967 L IE810967 L IE 810967L IE 810967 A IE810967 A IE 810967A IE 96781 A IE96781 A IE 96781A IE 810967 L IE810967 L IE 810967L
- Authority
- IE
- Ireland
- Prior art keywords
- lysyl
- hydrogen
- cyclopentanecarbonyl
- dehydroproline
- phenylalanyl
- Prior art date
Links
- 229940125532 enzyme inhibitor Drugs 0.000 title 1
- 239000002532 enzyme inhibitor Substances 0.000 title 1
- -1 phenylacetyl Chemical group 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- OMGHIGVFLOPEHJ-BYPYZUCNSA-N (2s)-2,5-dihydro-1h-pyrrole-2-carboxylic acid Chemical compound OC(=O)[C@H]1NCC=C1 OMGHIGVFLOPEHJ-BYPYZUCNSA-N 0.000 abstract 2
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 125000000405 phenylalanyl group Chemical group 0.000 abstract 2
- UUUHXMGGBIUAPW-UHFFFAOYSA-N 1-[1-[2-[[5-amino-2-[[1-[5-(diaminomethylideneamino)-2-[[1-[3-(1h-indol-3-yl)-2-[(5-oxopyrrolidine-2-carbonyl)amino]propanoyl]pyrrolidine-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbon Chemical compound C1CCC(C(=O)N2C(CCC2)C(O)=O)N1C(=O)C(C(C)CC)NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C1CCCN1C(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C1CCC(=O)N1 UUUHXMGGBIUAPW-UHFFFAOYSA-N 0.000 abstract 1
- ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical compound OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 abstract 1
- DZLNHFMRPBPULJ-GSVOUGTGSA-N D-thioproline Chemical compound OC(=O)[C@H]1CSCN1 DZLNHFMRPBPULJ-GSVOUGTGSA-N 0.000 abstract 1
- PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 abstract 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 abstract 1
- 125000002059 L-arginyl group Chemical group O=C([*])[C@](N([H])[H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H] 0.000 abstract 1
- 125000001176 L-lysyl group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C([H])([H])C([H])([H])C([H])([H])C(N([H])[H])([H])[H] 0.000 abstract 1
- 229930182821 L-proline Natural products 0.000 abstract 1
- 102000004270 Peptidyl-Dipeptidase A Human genes 0.000 abstract 1
- 108090000882 Peptidyl-Dipeptidase A Proteins 0.000 abstract 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
- 125000001980 alanyl group Chemical group 0.000 abstract 1
- 125000004063 butyryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 abstract 1
- 125000000487 histidyl group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 abstract 1
- 125000001841 imino group Chemical group [H]N=* 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 125000000741 isoleucyl group Chemical group [H]N([H])C(C(C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=O)O* 0.000 abstract 1
- 229950003188 isovaleryl diethylamide Drugs 0.000 abstract 1
- 125000001998 leucyl group Chemical group 0.000 abstract 1
- 229960002429 proline Drugs 0.000 abstract 1
- 125000001325 propanoyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
- 125000001982 tryptophyl group Chemical group 0.000 abstract 1
- 125000002233 tyrosyl group Chemical group 0.000 abstract 1
- 125000002114 valyl group Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/401—Proline; Derivatives thereof, e.g. captopril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
- A61K31/10—Sulfides; Sulfoxides; Sulfones
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Inhibitors of angiotensin converting enzyme which are physiologically tolerated salts of compounds of the general formula (I) in which R is hydrogen, formyl, acetyl, propanoyl, butanoyl, phenylacetyl, phenylpropanoyl, benzoyl, cyclopentanecarbonyl, tert- butyloxycarbonyl, cyclopentanecarbonyl-L-lysyl, pyro-L- glutamyl-L-lysyl, L-lysyl, L-arginyl or pyro-L-glutamyl, A is phenylalanyl, glycyl, alanyl, tryptophyl, tyrosyl, isoleucyl, leucyl, histidyl or valyl, where the alpha- amino group of these radicals is bonded in the form of an amide bond to the radical R having a meaning other than hydrogen, and phenylalanyl is racemic if R is benzoyl, R1 is hydrogen or methyl, R2 -COOH, L-proline, L-3,4- dehydroproline, D,L-3,4-dehydroproline, L-3- hydroxyproline, L-4-hydroxyproline, L-thiazolidine-4- carboxylic acid or L-5-oxoproline, where the imino group in these radicals is bonded to the adjacent group, Kat is the cation of a base, and n is zero or 1, where R1 is methyl if n is zero. <IMAGE>
[AT390796B]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/156,749 US4692437A (en) | 1978-09-11 | 1980-06-05 | Anti-hypertensive agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE810967L true IE810967L (en) | 1981-12-05 |
| IE51739B1 IE51739B1 (en) | 1987-03-18 |
Family
ID=22560916
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE967/81A IE51739B1 (en) | 1980-06-05 | 1981-04-30 | Anti-hypertensive agents |
Country Status (6)
| Country | Link |
|---|---|
| KR (1) | KR830005115A (en) |
| AT (1) | AT390796B (en) |
| DD (1) | DD159426A5 (en) |
| ES (1) | ES8203332A2 (en) |
| IE (1) | IE51739B1 (en) |
| PL (1) | PL231471A3 (en) |
-
1981
- 1981-04-28 ES ES501730A patent/ES8203332A2/en not_active Expired
- 1981-04-30 IE IE967/81A patent/IE51739B1/en not_active IP Right Cessation
- 1981-04-30 KR KR1019810001495A patent/KR830005115A/en active Pending
- 1981-05-08 AT AT0205181A patent/AT390796B/en not_active IP Right Cessation
- 1981-06-03 PL PL23147181A patent/PL231471A3/xx unknown
- 1981-06-04 DD DD81230574A patent/DD159426A5/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ATA205181A (en) | 1989-12-15 |
| DD159426A5 (en) | 1983-03-09 |
| KR830005115A (en) | 1983-07-23 |
| IE51739B1 (en) | 1987-03-18 |
| AT390796B (en) | 1990-06-25 |
| PL231471A3 (en) | 1982-03-01 |
| ES501730A0 (en) | 1982-04-01 |
| ES8203332A2 (en) | 1982-04-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Patent lapsed |