IE811074L - Sulphated polysaccharides - Google Patents
Sulphated polysaccharidesInfo
- Publication number
- IE811074L IE811074L IE811074A IE107481A IE811074L IE 811074 L IE811074 L IE 811074L IE 811074 A IE811074 A IE 811074A IE 107481 A IE107481 A IE 107481A IE 811074 L IE811074 L IE 811074L
- Authority
- IE
- Ireland
- Prior art keywords
- percentage
- mixtures
- degrees
- polysaccharides
- sulphated polysaccharides
- Prior art date
Links
- 150000004676 glycans Chemical class 0.000 title abstract 4
- 229920001282 polysaccharide Polymers 0.000 title abstract 4
- 239000005017 polysaccharide Substances 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 229920000669 heparin Polymers 0.000 abstract 1
- 229960002897 heparin Drugs 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 150000003839 salts Chemical group 0.000 abstract 1
- 159000000000 sodium salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Materials Engineering (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Polymers & Plastics (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compounds Of Unknown Constitution (AREA)
Abstract
1. Mixtures of sulphated polysaccharides having the general structure of the polysaccharides present in heparin, whose acid groups are in the free form or converted into a salt form, characterised in that the polysaccharides present in the said mixtures have an ethylenic double bond at one of the ends of their chain and in that, in the form of the sodium salt, the mixtures have the following characteristics : - percentage of sulphur : 9% to 13.5% - percentage of nitrogen : 1.8% to 2.5% - percentage of uronic acids : 20% to 30% - weight-average molecular weight : 2000 to 10 000 daltons - specific rotatory power in aqueous solution at 20 degrees C : [alpha]D-20 = + 25 degrees to + 55 degrees
[EP0040144A1]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8010791A FR2482611B1 (en) | 1980-05-14 | 1980-05-14 | NOVEL SULFATED POLYSACCHARIDES, METHODS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE811074L true IE811074L (en) | 1981-11-14 |
| IE51283B1 IE51283B1 (en) | 1986-11-26 |
Family
ID=9241965
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1074/81A IE51283B1 (en) | 1980-05-14 | 1981-05-13 | Sulphated polysaccharides,processes for their preparation and their use as medicaments |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP0040144B1 (en) |
| JP (1) | JPS6051482B2 (en) |
| KR (1) | KR840001753B1 (en) |
| AR (1) | AR229510A1 (en) |
| AT (1) | AT384428B (en) |
| AU (1) | AU535791B2 (en) |
| CA (1) | CA1181744A (en) |
| DE (1) | DE3165361D1 (en) |
| DK (1) | DK168824B1 (en) |
| DZ (1) | DZ294A1 (en) |
| ES (1) | ES502199A0 (en) |
| FI (1) | FI67865C (en) |
| FR (1) | FR2482611B1 (en) |
| GR (1) | GR82283B (en) |
| HU (1) | HU188667B (en) |
| IE (1) | IE51283B1 (en) |
| IL (1) | IL62866A (en) |
| IN (1) | IN152828B (en) |
| MA (1) | MA19143A1 (en) |
| NO (1) | NO156129C (en) |
| NZ (1) | NZ197081A (en) |
| PT (1) | PT73024B (en) |
| ZA (1) | ZA813176B (en) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2548672A1 (en) * | 1983-07-04 | 1985-01-11 | Pharmuka Lab | SULPHATE OLIGOSACCHARIDES AND THEIR USE AS MEDICAMENTS |
| DE3422407A1 (en) * | 1984-06-16 | 1986-03-06 | B. Braun Melsungen Ag, 3508 Melsungen | USE OF HEPARINE DERIVATIVES FOR SELECTIVE EXTRA-CORPORAL PRECIPITATION OF LOW-DENSITY-LIPOPROTEINS FROM FULL SERUM OR PLASMA |
| FR2584728B1 (en) * | 1985-07-12 | 1987-11-20 | Choay Sa | PROCESS FOR THE SULFATION OF GLYCOSAMINOGLYCANS AND THEIR FRAGMENTS |
| EP0209924A1 (en) * | 1985-07-12 | 1987-01-28 | Akzo N.V. | New anti-trombosis agent based on glycosaminoglycan, process for its preparation, and pharmaceutical compositions |
| ES2003197A6 (en) * | 1987-01-05 | 1988-10-16 | Rovi Lab Farmaceut Sa | Process for the depolymerization of heparin for obtaining heparin with a low molecular weight and having an antithrombotic activity. |
| EP0337327A1 (en) * | 1988-04-09 | 1989-10-18 | Bioiberica, S.A. | Process for the preparation of new oligosaccharide fractions by controlled chemical depolimerization of heparin |
| IT1230582B (en) | 1988-10-21 | 1991-10-28 | Opocrin S P A Lab Farmabiologi | DERMATAN SULPHATE AND HEPARIN OILGOSACCHARID WITH ANTI-THEROSCLEROTIC ACTIVITIES |
| IT1234826B (en) * | 1989-01-30 | 1992-05-29 | Alfa Wassermann Spa | HEPARIN DERIVATIVES AND PROCEDURE FOR THEIR PREPARATION |
| US5340932A (en) * | 1989-08-18 | 1994-08-23 | Ajorca S.A. | Substances with heparin-like structure and their method of production |
| DE4121115B9 (en) * | 1990-06-26 | 2005-09-29 | Aventis Pharma S.A. | Mixtures of sulfated polysaccharides with the basic structure of heparin-forming polysaccharides and low molecular weight, their method of preparation and use |
| FR2663639B1 (en) * | 1990-06-26 | 1994-03-18 | Rhone Poulenc Sante | LOW MOLECULAR WEIGHT POLYSACCHARIDE BLENDS PROCESS FOR PREPARATION AND USE. |
| USRE38743E1 (en) * | 1990-06-26 | 2005-06-14 | Aventis Pharma S.A. | Mixtures of particular LMW heparinic polysaccharides for the prophylaxis/treatment of acute thrombotic events |
| US5707973A (en) * | 1991-04-23 | 1998-01-13 | Rhone-Poulenc Rorer S.A. | Sulfated polysaccharids for treatment or prevention of thromboses |
| IT1256236B (en) * | 1992-12-23 | 1995-11-29 | Mediolanum Farmaceutici Srl | OLIGOSACCHARIDES WITH BIOLOGICAL ACTIVITY AND PROCEDURE FOR THEIR PREPARATION OF GLYCOSAMINOGLICANS |
| ES2077533B1 (en) * | 1994-02-28 | 1996-07-01 | Bioiberica | PROCEDURE FOR OBTAINING OLIGOSACCHARIDE FRACTIONS BY CHEMICAL DEPOLYMERIZATION OF HEPARIN. |
| UA63929C2 (en) * | 1996-11-27 | 2004-02-16 | Aventis Pharm Prod Inc | Pharmaceutical composition comprising compound having anti-xa activity and platelet aggregation antagonist compound |
| AUPO556297A0 (en) | 1997-03-11 | 1997-04-10 | Australian National University, The | Sulfated oligosaccharides having anticoagulant/ antithrombotic activity |
| JP4897991B2 (en) * | 1999-07-23 | 2012-03-14 | ラボラトリオス ファルマセウティコス ロビ ソシエダッド アノニマ | Ultra low molecular weight heparin composition |
| FR2811992B1 (en) * | 2000-07-21 | 2003-07-04 | Aventis Pharma Sa | MIXTURES OF HEPARIN-DERIVED POLYSACCHARIDES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| US6969705B2 (en) * | 2000-07-21 | 2005-11-29 | Aventis Pharma S.A. | Compositions of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them |
| ES2282368T3 (en) * | 2002-06-20 | 2007-10-16 | Chemi S.P.A. | PROCEDURE FOR THE PREPARATION OF ESTERES DE HEPARINA. |
| FR2845686B1 (en) * | 2002-10-10 | 2013-08-30 | Aventis Pharma Sa | MIXTURES OF HEPARIN-DERIVED POLYSACCHARIDES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| US20040171819A1 (en) | 2002-10-10 | 2004-09-02 | Aventis Pharma S.A. | Mixtures of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them |
| JP2006096668A (en) * | 2002-11-08 | 2006-04-13 | Ono Pharmaceut Co Ltd | A pharmaceutical comprising a combination of an elastase inhibitor and a blood coagulation system and / or fibrinolytic enzyme inhibitor |
| DE10260958A1 (en) * | 2002-12-20 | 2004-07-08 | Sustech Gmbh & Co. Kg | Composite materials made from calcium compounds and polysaccharides containing glucuronic acid and / or iduronic acid |
| US7956046B2 (en) | 2003-07-24 | 2011-06-07 | Aventis Pharma S.A. | Oligosaccharide mixtures derived from heparin, preparation thereof and pharmaceutical compositions containing them |
| ITMI20031679A1 (en) * | 2003-08-29 | 2005-02-28 | Opocrin Spa | PROCESS FOR THE PRODUCTION OF LOW WEIGHT EPARINES |
| EP1582531A1 (en) | 2004-03-24 | 2005-10-05 | Aventis Pharma S.A. | Process for oxidizing unfractionated heparins and detecting presence or absence of glycoserine in heparin and heparin products |
| US20050261241A1 (en) | 2004-05-19 | 2005-11-24 | Celsus Biopharmaceuticals, Inc. | Use of dermatan sulfates and/or desulfated heparins to treat or prevent heparinoid-induced autoimmune responses |
| ATE552004T1 (en) | 2005-11-30 | 2012-04-15 | Istituto G Ronzoni | ORAL HEPARINE DERIVATIVES |
| ES2340902B1 (en) * | 2008-07-01 | 2011-05-03 | Laboratorios Farmaceuticos Rovi, S.A. | PHARMACEUTICAL COMPOSITION WITH GLYCAMINOGLYGANS AND ITS USE IN THE TREATMENT OF CHRONIC ULCERAS. |
| EP2617737B1 (en) * | 2010-09-14 | 2017-03-01 | University Of Miyazaki | High purity heparin and production method therefor |
| BR112020011554B1 (en) | 2017-12-11 | 2023-10-17 | Biological E Limited | ENOXAPARIN SODIUM PREPARATION PROCESS |
| WO2022015794A1 (en) | 2020-07-14 | 2022-01-20 | Optimvia, Llc | Methods for synthesizing non-anticoagulant heparan sulfate |
| CA3144968A1 (en) | 2019-07-09 | 2021-01-14 | Optimvia Llc | Methods for synthesizing anticoagulant polysaccharides |
| ES2792298B2 (en) * | 2020-04-27 | 2022-04-20 | Farm Rovi Lab Sa | PROCEDURE FOR OBTAINING LOW MOLECULAR WEIGHT HEPARINS AND LOW MOLECULAR WEIGHT HEPARINS OBTAINED BY THE SAME |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3835112A (en) * | 1970-06-08 | 1974-09-10 | Etude Et D Exploit De Marques | Heparin esters |
| CA1136620A (en) * | 1979-01-08 | 1982-11-30 | Ulf P.F. Lindahl | Heparin fragments having selective anticoagulation activity |
-
1980
- 1980-05-14 FR FR8010791A patent/FR2482611B1/en not_active Expired
-
1981
- 1981-05-08 GR GR64889A patent/GR82283B/el unknown
- 1981-05-08 EP EP81400728A patent/EP0040144B1/en not_active Expired
- 1981-05-08 DE DE8181400728T patent/DE3165361D1/en not_active Expired
- 1981-05-11 MA MA19352A patent/MA19143A1/en unknown
- 1981-05-12 HU HU811300A patent/HU188667B/en unknown
- 1981-05-12 PT PT73024A patent/PT73024B/en unknown
- 1981-05-13 IL IL62866A patent/IL62866A/en not_active IP Right Cessation
- 1981-05-13 IE IE1074/81A patent/IE51283B1/en not_active IP Right Cessation
- 1981-05-13 ZA ZA00813176A patent/ZA813176B/en unknown
- 1981-05-13 KR KR1019810001640A patent/KR840001753B1/en not_active Expired
- 1981-05-13 NO NO811632A patent/NO156129C/en not_active IP Right Cessation
- 1981-05-13 FI FI811469A patent/FI67865C/en not_active IP Right Cessation
- 1981-05-13 NZ NZ197081A patent/NZ197081A/en unknown
- 1981-05-13 DK DK211981A patent/DK168824B1/en not_active IP Right Cessation
- 1981-05-13 ES ES502199A patent/ES502199A0/en active Granted
- 1981-05-13 AU AU70519/81A patent/AU535791B2/en not_active Expired
- 1981-05-13 AT AT0213681A patent/AT384428B/en not_active IP Right Cessation
- 1981-05-13 DZ DZ816189A patent/DZ294A1/en active
- 1981-05-14 JP JP56072858A patent/JPS6051482B2/en not_active Expired
- 1981-05-14 CA CA000377577A patent/CA1181744A/en not_active Expired
- 1981-05-14 AR AR285321A patent/AR229510A1/en active
- 1981-05-14 IN IN513/CAL/81A patent/IN152828B/en unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| SPCF | Request for grant of supplementary protection certificate |
Free format text: SPC 19/93:19930519 |
|
| SPCF | Request for grant of supplementary protection certificate |
Free format text: ERRATUM: SPC 15/93 19/93: THE WORD "ROBER" IN APPLICANTS NAME TO READ: "RORER". |
|
| SPCG | Supplementary protection certificate granted |
Free format text: SPC 19/93 EXPIRES:20020403 |
|
| MK9A | Patent expired |