IE811302L - IMIDAZO £2,1-b| £1,3,5| BENZOTHIADIAZEPINES - Google Patents
IMIDAZO £2,1-b| £1,3,5| BENZOTHIADIAZEPINESInfo
- Publication number
- IE811302L IE811302L IE811302A IE130281A IE811302L IE 811302 L IE811302 L IE 811302L IE 811302 A IE811302 A IE 811302A IE 130281 A IE130281 A IE 130281A IE 811302 L IE811302 L IE 811302L
- Authority
- IE
- Ireland
- Prior art keywords
- alkyl
- halogeno
- sulfamoyl
- hydrogen
- compounds
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000004414 alkyl thio group Chemical group 0.000 abstract 2
- 125000001589 carboacyl group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- -1 cyano, carboxy Chemical group 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000002030 1,2-phenylene group Chemical group [H]C1=C([H])C([*:1])=C([*:2])C([H])=C1[H] 0.000 abstract 1
- 229910052783 alkali metal Chemical group 0.000 abstract 1
- 150000001340 alkali metals Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000001651 cyanato group Chemical group [*]OC#N 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 230000000701 neuroleptic effect Effects 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000000858 thiocyanato group Chemical group *SC#N 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Polymerisation Methods In General (AREA)
Abstract
The invention concerns the compounds of the Formula I <IMAGE> wherein each of R1 and R2 is hydrogen, alkyl, alkanoyl, halogeno, cyano, carboxy, carbalkoxy, carbamoyl, sulfamoyl, mono- or di-alkyl-(carbamoyl or sulfamoyl); Ph is 1,2-phenylene, unsubstituted or substituted by up to two identical or different members selected from alkyl, alkoxy, alkylthio, halogeno, trifluoromethyl, sulfamoyl, mono- or di-alkylsulfamoyl; each of CmH2m and CnH2n is alkylene separating both nitrogen atoms by 2 or 3 carbon atoms, and R3 is hydrogen, alkyl, alkanoyl, alkoxycarbonyl, phenyl-alkoxycarbonyl or hydroxyalkyl, wherein the hydroxy group is separated from the nitrogen atom by at least 2 carbon atoms; their N- and/or S-oxides, and alkyl quaternary derivatives thereof salts of all these compounds. The compounds exhibit neuroleptic activity. They are prepared by condensing a compound of the general Formula III or a salt thereof with a compound of the general Formula IV <IMAGE> wherein X is halogeno, alkoxy, alkylthio, cyanato or thiocyanato; Y is hydrogen or an alkali metal; p is an integer from 0 to 2, and the remaining symbols have the meaning given for formula I.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15867180A | 1980-06-12 | 1980-06-12 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE811302L true IE811302L (en) | 1981-12-12 |
| IE52043B1 IE52043B1 (en) | 1987-05-27 |
Family
ID=22569177
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1302/81A IE52043B1 (en) | 1980-06-12 | 1981-06-11 | Imidazobenzothiadiazepines process for their manufacture pharmaceutical preparations containing these compounds and their therapeutic application |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP0042354B1 (en) |
| JP (1) | JPS57118589A (en) |
| KR (2) | KR840002145B1 (en) |
| AT (1) | ATE16935T1 (en) |
| AU (1) | AU538864B2 (en) |
| CA (1) | CA1163630A (en) |
| DD (1) | DD160535A5 (en) |
| DE (1) | DE3173184D1 (en) |
| DK (1) | DK255281A (en) |
| ES (2) | ES502949A0 (en) |
| FI (1) | FI69310C (en) |
| GB (1) | GB2077727B (en) |
| GR (1) | GR78222B (en) |
| HU (1) | HU185128B (en) |
| IE (1) | IE52043B1 (en) |
| IL (1) | IL63079A (en) |
| NO (1) | NO811977L (en) |
| NZ (1) | NZ197392A (en) |
| PT (1) | PT73173B (en) |
| ZA (1) | ZA813930B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4460508A (en) * | 1981-12-07 | 1984-07-17 | Ciba-Geigy Corporation | 5-Diazacycloalkylimidazo[1,2-c][1,3]benzodiazepines |
| US4460587A (en) * | 1981-12-07 | 1984-07-17 | Ciba-Geigy Corporation | 5-Diazacycloalkyl imidazo[1,2-c][1,3]benzodiazepines |
| US4507311A (en) * | 1981-12-07 | 1985-03-26 | Ciba-Geigy Corporation | Imidazo[1,2-c][1,3]benzodiazepines |
| FI824170A7 (en) * | 1981-12-07 | 1983-06-08 | Ciba Geigy Ag | Imidazobenzodiazepines, a process for their preparation, pharmaceutical compositions containing these compounds and their therapeutic use. |
| US4459232A (en) * | 1981-12-07 | 1984-07-10 | Ciba-Geigy Corporation | Imidazo[1,2-c][1,3]benzodiazepines |
| US4595535A (en) * | 1983-06-06 | 1986-06-17 | Ciba-Geigy Corporation | Diazacycloalkyl-1,2,4-triazolo[2,3-c][1,3]benzodiazepines useful as neuroleptic and/or antihistaminic agents |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2349064A1 (en) * | 1973-09-29 | 1975-04-10 | Basf Ag | 1,3-DIAZACYCLOALKENO- SQUARE BRACKET ON 1,2-SQUARE BRACKET TO -BENZO- SQUARE BRACKET ON SQUARE BRACKET TO -1,3,4- THIADIAZEPINE |
| IT7851496A0 (en) * | 1977-10-31 | 1978-10-13 | Sandoz Ag | PYRAZINOBENZOXAZEPINES THEIR PREPARATION AND THEIR MEDICAL USE |
-
1981
- 1981-05-30 JP JP56083705A patent/JPS57118589A/en active Pending
- 1981-06-08 FI FI811771A patent/FI69310C/en not_active IP Right Cessation
- 1981-06-09 GB GB8117623A patent/GB2077727B/en not_active Expired
- 1981-06-09 EP EP81810228A patent/EP0042354B1/en not_active Expired
- 1981-06-09 AT AT81810228T patent/ATE16935T1/en not_active IP Right Cessation
- 1981-06-09 DE DE8181810228T patent/DE3173184D1/en not_active Expired
- 1981-06-10 GR GR65189A patent/GR78222B/el unknown
- 1981-06-10 CA CA000379490A patent/CA1163630A/en not_active Expired
- 1981-06-11 NZ NZ197392A patent/NZ197392A/en unknown
- 1981-06-11 NO NO811977A patent/NO811977L/en unknown
- 1981-06-11 DD DD81230728A patent/DD160535A5/en unknown
- 1981-06-11 DK DK255281A patent/DK255281A/en not_active Application Discontinuation
- 1981-06-11 HU HU811736A patent/HU185128B/en unknown
- 1981-06-11 IL IL63079A patent/IL63079A/en unknown
- 1981-06-11 AU AU71641/81A patent/AU538864B2/en not_active Ceased
- 1981-06-11 ZA ZA813930A patent/ZA813930B/en unknown
- 1981-06-11 PT PT73173A patent/PT73173B/en unknown
- 1981-06-11 ES ES502949A patent/ES502949A0/en active Granted
- 1981-06-11 IE IE1302/81A patent/IE52043B1/en unknown
- 1981-06-12 KR KR1019810002117A patent/KR840002145B1/en not_active Expired
-
1982
- 1982-07-01 ES ES513638A patent/ES8304570A1/en not_active Expired
-
1984
- 1984-07-26 KR KR1019840004435A patent/KR850000614B1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| NZ197392A (en) | 1984-03-30 |
| GB2077727B (en) | 1984-03-07 |
| KR850000614B1 (en) | 1985-05-01 |
| IE52043B1 (en) | 1987-05-27 |
| GR78222B (en) | 1984-09-26 |
| JPS57118589A (en) | 1982-07-23 |
| GB2077727A (en) | 1981-12-23 |
| CA1163630A (en) | 1984-03-13 |
| DK255281A (en) | 1981-12-13 |
| IL63079A0 (en) | 1981-09-13 |
| EP0042354A2 (en) | 1981-12-23 |
| ES8304570A1 (en) | 1983-05-16 |
| KR840002145B1 (en) | 1984-11-23 |
| ATE16935T1 (en) | 1985-12-15 |
| PT73173A (en) | 1981-07-01 |
| AU7164181A (en) | 1981-12-17 |
| FI811771L (en) | 1981-12-13 |
| NO811977L (en) | 1981-12-14 |
| ZA813930B (en) | 1982-06-30 |
| ES513638A0 (en) | 1983-03-01 |
| EP0042354A3 (en) | 1982-02-24 |
| PT73173B (en) | 1983-04-29 |
| HU185128B (en) | 1984-12-28 |
| FI69310B (en) | 1985-09-30 |
| DD160535A5 (en) | 1983-09-07 |
| IL63079A (en) | 1985-06-30 |
| AU538864B2 (en) | 1984-08-30 |
| EP0042354B1 (en) | 1985-12-11 |
| KR850001467A (en) | 1985-03-18 |
| ES8300761A1 (en) | 1982-11-01 |
| KR830006313A (en) | 1983-09-20 |
| ES502949A0 (en) | 1982-11-01 |
| DE3173184D1 (en) | 1986-01-23 |
| FI69310C (en) | 1986-01-10 |
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