IE820741L - Oligosaccharide compositions - Google Patents
Oligosaccharide compositionsInfo
- Publication number
- IE820741L IE820741L IE820741A IE74182A IE820741L IE 820741 L IE820741 L IE 820741L IE 820741 A IE820741 A IE 820741A IE 74182 A IE74182 A IE 74182A IE 820741 L IE820741 L IE 820741L
- Authority
- IE
- Ireland
- Prior art keywords
- octasaccharides
- abreviation
- see diagramm
- denoted below
- sequence
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 5
- 229920001542 oligosaccharide Polymers 0.000 title abstract 3
- 150000002482 oligosaccharides Chemical class 0.000 title abstract 3
- 230000002255 enzymatic effect Effects 0.000 abstract 3
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 230000015556 catabolic process Effects 0.000 abstract 1
- 238000006731 degradation reaction Methods 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y402/00—Carbon-oxygen lyases (4.2)
- C12Y402/02—Carbon-oxygen lyases (4.2) acting on polysaccharides (4.2.2)
- C12Y402/02007—Heparin lyase (4.2.2.7), i.e. heparinase I
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Materials Engineering (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Polymers & Plastics (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
1. Claims for the Contracting States : BE, CH, DE, GB, IT, LI, LU, NL, SE Short chained oligosaccharide compositions, characterized in that they are formed essentially of hexasaccharides having the sequence denoted below by the abreviation C'-H : see diagramm : EP0064452,P18,F1 in which R represents a hydrogen atom or the -SO3 - group and their physiologically acceptable salts. 1. Claims for the Contracting State : AT A process for the preparation of short chained oligosaccharide compositions, having the sequence denoted below by the abreviation C'-H : see diagramm : EP0064452,P19,F1 in which R represents a hydrogen atom or the -SO3 - group and their physiologically acceptable salts, characterized in that octasaccharides corresponding to the sequence ABCDEFGH (denoted below by the abreviation A-H), of the formula see diagramm : EP0064452,P20,F1 or octasaccharide compositions formed to a large extent of these octasaccharides, having a high ratio of their Yin-Wessler titer to their APTT or USP titer, are contacted, in a calcium containing buffer medium, with an enzymatic agent, said enzymatic agent having an enzymatic activity of at least 90 000 units and being applied at 0,25 to 1 mg per mg of octasaccharides treated, preferably of the order of 0.5 mg of enzymes per mg of octasaccharides, which enables to specifically fragment these octasaccharides in order to eliminate A-B units, and the major part of the active hexasaccharides C'-H are separated from the degradation mixture.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8108604A FR2504928A1 (en) | 1981-04-29 | 1981-04-29 | SHORT CHAIN OLIGOSACCHARIDES HAVING BIOLOGICAL PROPERTIES, PREPARATION THEREOF AND APPLICATIONS THEREOF AS MEDICAMENTS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE820741L true IE820741L (en) | 1982-10-29 |
| IE52906B1 IE52906B1 (en) | 1988-04-13 |
Family
ID=9257922
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE741/82A IE52906B1 (en) | 1981-04-29 | 1982-03-29 | Short chain oligosaccharides having biological properties, a process for making the same and the use thereof as drugs |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0064452B1 (en) |
| JP (1) | JPS57190001A (en) |
| AT (1) | ATE12791T1 (en) |
| CA (1) | CA1180292A (en) |
| DE (1) | DE3263083D1 (en) |
| DK (1) | DK189982A (en) |
| ES (1) | ES511470A0 (en) |
| FR (1) | FR2504928A1 (en) |
| IE (1) | IE52906B1 (en) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2584728B1 (en) * | 1985-07-12 | 1987-11-20 | Choay Sa | PROCESS FOR THE SULFATION OF GLYCOSAMINOGLYCANS AND THEIR FRAGMENTS |
| EP0209924A1 (en) * | 1985-07-12 | 1987-01-28 | Akzo N.V. | New anti-trombosis agent based on glycosaminoglycan, process for its preparation, and pharmaceutical compositions |
| US5106734A (en) * | 1986-04-30 | 1992-04-21 | Novo Nordisk A/S | Process of using light absorption to control enzymatic depolymerization of heparin to produce low molecular weight heparin |
| US5707973A (en) * | 1991-04-23 | 1998-01-13 | Rhone-Poulenc Rorer S.A. | Sulfated polysaccharids for treatment or prevention of thromboses |
| EP0861903A1 (en) * | 1997-02-22 | 1998-09-02 | Lansing, Manfred | Method for reversible immobilizing oligo and/or polysaccharides |
| US5985582A (en) * | 1997-12-09 | 1999-11-16 | Sigma-Aldrich Co. | Thrombin-based assay for antithrombin III |
| FR2845686B1 (en) * | 2002-10-10 | 2013-08-30 | Aventis Pharma Sa | MIXTURES OF HEPARIN-DERIVED POLYSACCHARIDES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| FR2857971B1 (en) * | 2003-07-24 | 2005-08-26 | Aventis Pharma Sa | MIXTURES OF HEPARIN DERIVED OLIGOSACCHARIDES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| EP1582531A1 (en) | 2004-03-24 | 2005-10-05 | Aventis Pharma S.A. | Process for oxidizing unfractionated heparins and detecting presence or absence of glycoserine in heparin and heparin products |
| EP1792621B1 (en) | 2005-11-30 | 2012-04-04 | Istituto di Ricerche Chimiche e Biochimiche "G. Ronzoni" | Orally administrable heparin derivatives |
| WO2009155108A1 (en) | 2008-05-30 | 2009-12-23 | Momenta Pharmaceuticals, Inc. | Saccharide structures and methods of making and using such structures |
| EP3398971A4 (en) * | 2015-12-30 | 2019-09-25 | Shenzhen Hepalink Pharmaceutical Group Co., Ltd. | OLIGOSACCHARIDE OF SULPHATED HEPARIN AND PREPARATION METHOD AND APPLICATION THEREOF |
| WO2022015794A1 (en) | 2020-07-14 | 2022-01-20 | Optimvia, Llc | Methods for synthesizing non-anticoagulant heparan sulfate |
| JP2022540849A (en) | 2019-07-09 | 2022-09-20 | オプティムヴィア、エルエルシー | Method for synthesizing anticoagulant polysaccharide |
| JP7611465B2 (en) * | 2019-10-10 | 2025-01-10 | ジェイ・アイ・サイエンス有限会社 | Eluent-based fraction collector |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3766167A (en) * | 1971-03-26 | 1973-10-16 | Research Corp | Orally active anticoagulant |
| IL61201A (en) * | 1979-10-05 | 1984-09-30 | Choay Sa | Oligosaccharides having no more than 8 saccharide moieties,their obtention from heparin and pharmaceutical compositions containing them |
| JPH0231721A (en) * | 1988-07-20 | 1990-02-01 | Matsushita Electric Ind Co Ltd | Charging type cleaner |
-
1981
- 1981-04-29 FR FR8108604A patent/FR2504928A1/en active Granted
-
1982
- 1982-03-29 IE IE741/82A patent/IE52906B1/en not_active IP Right Cessation
- 1982-03-31 CA CA000399961A patent/CA1180292A/en not_active Expired
- 1982-04-16 ES ES511470A patent/ES511470A0/en active Granted
- 1982-04-26 AT AT82400739T patent/ATE12791T1/en active
- 1982-04-26 DE DE8282400739T patent/DE3263083D1/en not_active Expired
- 1982-04-26 EP EP82400739A patent/EP0064452B1/en not_active Expired
- 1982-04-27 JP JP57071124A patent/JPS57190001A/en active Pending
- 1982-04-28 DK DK189982A patent/DK189982A/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0064452A1 (en) | 1982-11-10 |
| ES8302094A1 (en) | 1983-02-01 |
| EP0064452B1 (en) | 1985-04-17 |
| CA1180292A (en) | 1985-01-02 |
| ES511470A0 (en) | 1983-02-01 |
| DE3263083D1 (en) | 1985-05-23 |
| FR2504928B1 (en) | 1984-02-24 |
| ATE12791T1 (en) | 1985-05-15 |
| JPS57190001A (en) | 1982-11-22 |
| DK189982A (en) | 1982-10-30 |
| IE52906B1 (en) | 1988-04-13 |
| FR2504928A1 (en) | 1982-11-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| FR2504928B1 (en) | ||
| ES312813A1 (en) | Certain 6-substituted-imidazo[2, 1-b] thiazole compounds | |
| IE64635B1 (en) | Pharmaceutical combination preparations for use in anti-neoplastic therapy | |
| CA2283280A1 (en) | Reovirus for the treatment of neoplasia | |
| AU1446388A (en) | Preparation of serine-n, n-diacetic acid and derivatives as complexing agents and detergents containing same | |
| TR200000673T2 (en) | Aromatic C16-C20-substituted tetrahydro prostaglandins useful as FP agonists. | |
| DE3267039D1 (en) | Stable s-adenosylmethionine salts, the process for their preparation and therapeutic compositions which contain them as active principle | |
| PT85591A (en) | Process for the preparation of multiple unit dosage pharmaceutical compositions comprising as a pharmaceutilly active compound l-dopa | |
| ATE82681T1 (en) | 2',3'-DIDEOXY-3'-FLUOROTHYMIDINE AND RELATED COMPOUNDS FOR THE TREATMENT OF ADENOVIRUS INFECTIONS. | |
| EP0293751A3 (en) | Taurohyodeoxycholic acid for the therapy of calculosis of the biliary tract and of biliary dyspepsia | |
| TNSN90021A1 (en) | PROCESS FOR THE PREPARATION OF TETRAHYDROIMIDAZO (1,4) BENZODIAZEPIN -2- ANTIVIRAL THIONES | |
| DE3166084D1 (en) | Tricyclic cytosine derivatives for use in pharmaceutical preparations and process for their preparation | |
| BR0008778A (en) | Prostaglandin analogs selective for unsaturated fpc16 | |
| ES8700054A1 (en) | Improved germicide composition. | |
| BR0109617A (en) | Pharmaceutical composition, oligosaccharide, process for preparing oligosaccharides, and use of oligosaccharides | |
| GR74443B (en) | ||
| Heitlinger et al. | Transport of glucose polymer-derived glucose by rabbit jejunum | |
| DE3062300D1 (en) | Piperidine derivatives of 4,5-dialkyl-3-hydroxy-pyrrole-2-carboxylic acid esters, their preparation and pharmaceutical compositions containing them | |
| PE43995A1 (en) | PROCEDURE FOR THE PREVENTION OF THE DEGRADATION OF PROTEIN C | |
| ES8506338A1 (en) | Composition and process for the intensification of plant cultivation. | |
| US4205081A (en) | Composition and method for preventing or treating swine dysentery | |
| CA2508238A1 (en) | Reovirus for the treatment of neoplasia | |
| ES2044534T3 (en) | A METHOD FOR THE PREPARATION OF A THROMBOLITICALLY ACTIVE COMPOSITION. | |
| DE3464601D1 (en) | 2-alkylthio-1-aminoalkyl-2-pyrroline-3-carbonitriles, process for their preparation and medicines with anti-thrombotic effects containing them | |
| Djajapranata et al. | Gastrozepin in gastritis. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Patent lapsed |