IE821918L - Pyridine n-oxide compounds - Google Patents
Pyridine n-oxide compoundsInfo
- Publication number
- IE821918L IE821918L IE821918A IE191882A IE821918L IE 821918 L IE821918 L IE 821918L IE 821918 A IE821918 A IE 821918A IE 191882 A IE191882 A IE 191882A IE 821918 L IE821918 L IE 821918L
- Authority
- IE
- Ireland
- Prior art keywords
- aralkyl
- carbon atoms
- new compounds
- pyridine
- aryl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
The present invention relates to new compounds with the general formula I <IMAGE> or the tautomeric forms thereof in which R stands for a straight or branched, saturated or unsaturated, aliphatic hydrocarbon radical having from 1 to 8 carbon atoms, mono- or bicyclic, carbocyclic aryl or aralkyl, aryl meaning unsubstituted or substituted phenyl or naphthyl, and the alkyl moiety of aralkyl having from 1 to 6 carbon atoms. The new compounds are of low toxicity and have been shown to exert a strong and prolonged antihypertensive effect in various animal species when administered enterally or parenterally, without giving rise to other pharmacodynamic effect.
[GB2105331A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8127367 | 1981-09-10 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE821918L true IE821918L (en) | 1983-03-10 |
| IE54196B1 IE54196B1 (en) | 1989-07-19 |
Family
ID=10524416
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1918/82A IE54196B1 (en) | 1981-09-10 | 1982-08-09 | Chemical compounds |
Country Status (16)
| Country | Link |
|---|---|
| JP (1) | JPS5857363A (en) |
| BE (1) | BE894350A (en) |
| CA (1) | CA1177080A (en) |
| CH (1) | CH655500B (en) |
| DE (1) | DE3233380A1 (en) |
| DK (1) | DK157923C (en) |
| FR (1) | FR2512447B1 (en) |
| GB (1) | GB2105331B (en) |
| GR (1) | GR77009B (en) |
| IE (1) | IE54196B1 (en) |
| IT (1) | IT1156515B (en) |
| LU (1) | LU84375A1 (en) |
| NL (1) | NL8203214A (en) |
| PH (1) | PH18596A (en) |
| SE (1) | SE441357B (en) |
| ZA (1) | ZA825997B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5371086A (en) * | 1991-03-15 | 1994-12-06 | The Green Cross Corporation | Aminopyridine compounds |
| JPH05294935A (en) * | 1991-03-15 | 1993-11-09 | Green Cross Corp:The | Aminopyridine compound |
| WO2007022946A1 (en) | 2005-08-21 | 2007-03-01 | Abbott Gmbh & Co. Kg | Heterocyclic compounds and their use as binding partners for 5-ht5 receptors |
| EP1917244A2 (en) | 2005-08-24 | 2008-05-07 | Abbott GmbH & Co. KG | Hetaryl-substituted guanidine compounds and use thereof as binding partners for 5-ht5-receptors |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3074955A (en) * | 1960-11-30 | 1963-01-22 | Us Vitamin Pharm Corp | Pyridylalkyl dicyandiamides and guanylureas |
| US3329569A (en) * | 1962-07-31 | 1967-07-04 | Smith Kline French Lab | Hypotensive compositions and methods of producing hypotension |
| FR2043491A1 (en) * | 1969-05-30 | 1971-02-19 | Ugine Kuhlmann | Alpha-pyrid-4'-yl-benzylidene-aminoguani- - dines useful as hypotensives and spasmoly-tics |
| GB1489879A (en) * | 1974-12-20 | 1977-10-26 | Leo Pharm Prod Ltd | N'-cyano-n'-3-pyridylguanidines |
| US4287346A (en) * | 1979-02-16 | 1981-09-01 | Eisai Co., Ltd. | Cyanoguanidine derivatives |
-
1982
- 1982-08-09 IE IE1918/82A patent/IE54196B1/en unknown
- 1982-08-16 PH PH27732A patent/PH18596A/en unknown
- 1982-08-16 NL NL8203214A patent/NL8203214A/en not_active Application Discontinuation
- 1982-08-18 ZA ZA825997A patent/ZA825997B/en unknown
- 1982-08-31 GB GB08224808A patent/GB2105331B/en not_active Expired
- 1982-08-31 CH CH517782A patent/CH655500B/de not_active IP Right Cessation
- 1982-09-07 CA CA000410917A patent/CA1177080A/en not_active Expired
- 1982-09-07 DK DK398882A patent/DK157923C/en not_active IP Right Cessation
- 1982-09-08 SE SE8205107A patent/SE441357B/en not_active IP Right Cessation
- 1982-09-08 GR GR69232A patent/GR77009B/el unknown
- 1982-09-08 DE DE19823233380 patent/DE3233380A1/en not_active Withdrawn
- 1982-09-09 JP JP57157939A patent/JPS5857363A/en active Pending
- 1982-09-09 LU LU84375A patent/LU84375A1/en unknown
- 1982-09-09 FR FR8215312A patent/FR2512447B1/en not_active Expired
- 1982-09-09 BE BE0/208978A patent/BE894350A/en not_active IP Right Cessation
- 1982-11-16 IT IT68075/82A patent/IT1156515B/en active
Also Published As
| Publication number | Publication date |
|---|---|
| DK398882A (en) | 1983-03-11 |
| IE54196B1 (en) | 1989-07-19 |
| IT1156515B (en) | 1987-02-04 |
| SE8205107D0 (en) | 1982-09-08 |
| PH18596A (en) | 1985-08-15 |
| SE441357B (en) | 1985-09-30 |
| FR2512447B1 (en) | 1985-11-22 |
| LU84375A1 (en) | 1983-06-07 |
| DE3233380A1 (en) | 1983-03-17 |
| NL8203214A (en) | 1983-04-05 |
| CA1177080A (en) | 1984-10-30 |
| JPS5857363A (en) | 1983-04-05 |
| IT8268075A0 (en) | 1982-09-09 |
| IT8268075A1 (en) | 1984-05-16 |
| SE8205107L (en) | 1983-03-11 |
| GR77009B (en) | 1984-09-04 |
| FR2512447A1 (en) | 1983-03-11 |
| GB2105331A (en) | 1983-03-23 |
| ZA825997B (en) | 1983-07-27 |
| CH655500B (en) | 1986-04-30 |
| GB2105331B (en) | 1985-05-01 |
| BE894350A (en) | 1983-03-09 |
| DK157923B (en) | 1990-03-05 |
| DK157923C (en) | 1990-08-06 |
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