IE870410L - Amphoteric surfactant for contact lenses - Google Patents

Abstract

Aq. self-preserving cleaning and conservation solns. for soft contact lenses contain as sole active ingredient a water-soluble amphoteric surfactant of formula R-A-R1-N(R2)(R3)+-R4-COO-(I), or its ophthalmologically-acceptable salt. In the formula R = 6-18C-alkyl, -alkenyl, or -alkadienyl (opt. substd. with Hal, OH, or amino); A = -O-, -S-, -C(O)O-, or C(O)NR'- (with R' = H or lower alkyl); R1 = 2-6C alkylene (opt. OH-substd.); R2, R3 = H or lower alkyl (opt. substd. with carboxy or with 1 or 2 OH, one of which can be esterified with phosphoric or sulphuric acid); R4 = (opt. OH-substd.) up to 3C alkylene. Soft contact lenses are cleaned or preserved by bringing into intense contact with the soln.. The soln. is mfd. by conventional mixing of the components. Pref., R = 11-17C alkyl or alkenyl; A = -O- or (esp.) -CONH-(CO bound to R); R1 = (esp. unsubstd.) 2 or 3C alkylene; R2, R3 = lower alkyl (opt. substd. with carboxy or, esp., one OH, which can be esterified to form the corresp. triorganophosphate); R4 = up to 3C alkylene. Alternatively, R = 8-12C alkyl; A = -CONH- (CO bound to R); R1 = 2 or 3C alkylene; R2, R3 = lower alkyl; R4 = up to 3C alkylene. Specific (I) are N-lauroylaminopropyl- or N-cocoylaminopropyl-N,N-dimethylglycine, and tris-(3-(N-cocoylaminoethyl) -N-hydroxyethyl-N-carboxymethyl)amino -2-hydroxypropanol) phosphate. The soln. also contains a soluble salt which is compatible with eye tissue, such that the salt content corresp. to a tonicity of 0.5-2 wt.% NaCl. Pref. soln. contains 0.005-2 wt.% (I), 0-5 wt.% non-ionic surfactant, 0-5 wt.% thickening agent, 0-1 wt.% chelating agent; 0-2 wt.% buffer, and 0-2 wt.% additional salt. Aqueous, self-preserving cleaning and preserving solutions for soft contact lenses which contain, as the only preservative, a water- soluble and amphoteric surfactant of the formula I <IMAGE> where R is alkyl, alkenyl or alkanedienyl having 6 to 18 carbon atoms, each of these radicals is unsubstituted or substituted by halogen, hydroxyl or amino, A is -O-, -S-, -C(O)O- or -C(O)NR'- in which R' is hydrogen or lower alkyl, R<1> is unsubstituted or hydroxy-substituted alkylene having 2 to 6 carbon atoms, R<2> and R<3>, independently of one another, are hydrogen or lower alkyl which is unsubstituted or substituted by carboxyl or by one or two hydroxyl groups, of which one may be esterified using phosphoric acid or sulphuric acid, and R<4> is unsubstituted or hydroxy-substituted alkylene having up to 3 carbon atoms, or an ophthalmologically acceptable salt thereof, in an amount which is effective with respect to the desired properties as a surfactant and preservative. [EP0233842A2]