IE880127L - Polymercomplexes of metals - Google Patents

Polymercomplexes of metals

Info

Publication number
IE880127L
IE880127L IE880127A IE12788A IE880127L IE 880127 L IE880127 L IE 880127L IE 880127 A IE880127 A IE 880127A IE 12788 A IE12788 A IE 12788A IE 880127 L IE880127 L IE 880127L
Authority
IE
Ireland
Prior art keywords
polymercomplexes
metals
phosphonyl
cations
inorganic
Prior art date
Application number
IE880127A
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of IE880127L publication Critical patent/IE880127L/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins
    • A61K49/16—Antibodies; Immunoglobulins; Fragments thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6887—Antibody-chelate conjugates using chelates for therapeutic purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/12—Macromolecular compounds
    • A61K49/126—Linear polymers, e.g. dextran, inulin, PEG
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C08G73/0206—Polyalkylene(poly)amines

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Radiology & Medical Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)

Abstract

Polymer complexes comprising a ligand containing carboxyl, phosphonyl and/or phenol groups and alkylated amine units, at least one ion of an element having an atomic number of 21 - 29, 31, 32, 38, 39, 42 - 44, 49 or 57 - 83, and, if desired, cations of inorganic and/or organic bases, amino acids or amino acid amides, are valuable diagnostic and therapeutic agents. [EP0277088A2]
IE880127A 1987-01-19 1988-01-19 Polymercomplexes of metals IE880127L (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19873701665 DE3701665A1 (en) 1987-01-19 1987-01-19 POLYMER COMPLEXES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL AGENTS CONTAINING THEM

Publications (1)

Publication Number Publication Date
IE880127L true IE880127L (en) 1988-07-19

Family

ID=6319226

Family Applications (1)

Application Number Title Priority Date Filing Date
IE880127A IE880127L (en) 1987-01-19 1988-01-19 Polymercomplexes of metals

Country Status (10)

Country Link
EP (1) EP0277088A2 (en)
JP (1) JPS6454028A (en)
AU (1) AU1064988A (en)
DE (1) DE3701665A1 (en)
DK (1) DK22688A (en)
IE (1) IE880127L (en)
IL (1) IL85139A0 (en)
NO (1) NO880179L (en)
PT (1) PT86572B (en)
ZA (1) ZA88342B (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3806795A1 (en) * 1988-02-29 1989-09-07 Schering Ag POLYMER-TIED COMPLEX IMAGERS, THEIR COMPLEXES AND CONJUGATES, METHOD FOR THEIR PRODUCTION AND PHARMACEUTICAL AGENTS CONTAINING THEM
US5681543A (en) * 1988-02-29 1997-10-28 Shering Aktiengesellschaft Polymer-bonded complexing agents and pharmaceutical agents containing them for MRI
GB8900719D0 (en) * 1989-01-13 1989-03-08 Nycomed As Compounds
FR2645862B1 (en) * 1989-04-18 1991-07-12 Esteve Labor Dr SUBSTITUTED ISOTHIAZOLO-PYRYDONE AZETIDINYL DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION AS MEDICAMENTS
US5384108A (en) * 1989-04-24 1995-01-24 Mallinckrodt Medical, Inc. Magnetic resonance imaging agents
GB8916781D0 (en) * 1989-07-21 1989-09-06 Nycomed As Compositions
DE3938992A1 (en) 1989-11-21 1991-05-23 Schering Ag Cascade polymer-bound complex formers, their complexes and conjugates, process for their preparation and pharmaceutical compositions containing them
DE4017439C2 (en) * 1990-05-30 1994-06-23 Deutsches Krebsforsch Polyether-substituted tumor agents
DE4039920A1 (en) * 1990-12-14 1992-06-17 Basf Ag NEW POLYETHYLENIMINE AND POLYVINYLAMINE DERIVATIVES, CARRIER MATERIALS COATED WITH THESE DERIVATIVES ON THE BASIS OF ALUMINUM AND THE USE THEREOF FOR THE PRODUCTION OF OFFSET PRINTING PLATES
JP2901787B2 (en) * 1991-07-15 1999-06-07 日本メジフィジックス株式会社 Nuclear magnetic resonance contrast agent
JP2894879B2 (en) * 1991-10-04 1999-05-24 日本メジフィジックス株式会社 Diagnostic contrast agent
US5324503A (en) * 1992-02-06 1994-06-28 Mallinckrodt Medical, Inc. Iodo-phenylated chelates for x-ray contrast
CA2147151A1 (en) * 1992-10-14 1994-04-28 Robert A. Snow Therapeutic and diagnostic imaging compositions and methods
EP1419786A1 (en) 2002-11-13 2004-05-19 Bracco Imaging S.p.A. Method for the selective and quantitative functionalization of immunoglobulin fab fragments, conjugate compounds obtained with the same and compositions thereof
ITPD20030174A1 (en) * 2003-07-31 2003-10-29 Univ Padova POLYMERIC CONJUGATES FOR DIAGNOSTICS AND THERAPY
DE102005039154A1 (en) * 2005-08-17 2007-03-01 GÖPFERICH, Achim, Prof. Dr. Biodegradable polymers for the transport of nucleic acids into cells
JP2023525544A (en) 2020-05-12 2023-06-16 ビーエーエスエフ ソシエタス・ヨーロピア Use of carboxymethylated polymers of lysine as dispersants and compositions containing same
CN112940157B (en) * 2021-03-22 2023-01-10 南方医科大学 Gadolinium chelate and preparation method and application thereof

Also Published As

Publication number Publication date
NO880179D0 (en) 1988-01-18
EP0277088A2 (en) 1988-08-03
DK22688A (en) 1988-07-20
DE3701665A1 (en) 1988-07-28
NO880179L (en) 1988-07-20
AU1064988A (en) 1988-07-21
JPS6454028A (en) 1989-03-01
IL85139A0 (en) 1988-06-30
ZA88342B (en) 1988-07-04
PT86572A (en) 1988-02-01
DK22688D0 (en) 1988-01-19
PT86572B (en) 1991-12-31

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