IE893481L - THE USE OF 4H-1-benzopyran-4-one derivatives, novel¹4H-1-benzopyran-4-one derivatives, and pharmaceuticals¹containing them - Google Patents

THE USE OF 4H-1-benzopyran-4-one derivatives, novel¹4H-1-benzopyran-4-one derivatives, and pharmaceuticals¹containing them

Info

Publication number
IE893481L
IE893481L IE893481A IE348189A IE893481L IE 893481 L IE893481 L IE 893481L IE 893481 A IE893481 A IE 893481A IE 348189 A IE348189 A IE 348189A IE 893481 L IE893481 L IE 893481L
Authority
IE
Ireland
Prior art keywords
benzopyran
derivatives
novel14h
compounds
formula
Prior art date
Application number
IE893481A
Other versions
IE69982B1 (en
Inventor
Ramchandra Ganapati Naik
Bansi Lal
Richard Helmut Rupp
Hans Harald Sedlacek
Gerhard Dickneite
Joerg Czech
Original Assignee
Timothy Gerard Vaughan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Timothy Gerard Vaughan filed Critical Timothy Gerard Vaughan
Publication of IE893481L publication Critical patent/IE893481L/en
Publication of IE69982B1 publication Critical patent/IE69982B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)

Abstract

Compounds of the formula I <IMAGE> in which the substituents R1-R5 and n and m have the said meanings, are suitable for controlling tumours. The present invention relates to the use of 4H-1-benzopyran-4-one derivatives, to 4H-1-benzopyran-4-one derivatives and to medicines containing same. Benzopyran derivatives have already been disclosed in European Patent No. 0137193 and German Offenlegungsschrift 36 12 337. In the latter, compounds of the formula a) are disclosed.
IE348189A 1988-10-28 1989-10-27 Use of 4H-1-benzopyran-4-one derivatives 4H-1-benzopyran-4-one derivatives and medicines containing same IE69982B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3836676A DE3836676A1 (en) 1988-10-28 1988-10-28 THE USE OF 4H-1-BENZOPYRAN-4-ON DERIVATIVES, NEW 4H-1-BENZOPYRAN-4-ON DERIVATIVES AND MEDICINAL PRODUCTS CONTAINING THEM

Publications (2)

Publication Number Publication Date
IE893481L true IE893481L (en) 1990-04-28
IE69982B1 IE69982B1 (en) 1996-10-16

Family

ID=6366059

Family Applications (1)

Application Number Title Priority Date Filing Date
IE348189A IE69982B1 (en) 1988-10-28 1989-10-27 Use of 4H-1-benzopyran-4-one derivatives 4H-1-benzopyran-4-one derivatives and medicines containing same

Country Status (14)

Country Link
EP (1) EP0366061B1 (en)
JP (1) JP2879910B2 (en)
KR (1) KR100194505B1 (en)
AT (1) ATE133170T1 (en)
AU (1) AU628409B2 (en)
CA (1) CA1336715C (en)
CY (1) CY2026A (en)
DE (2) DE3836676A1 (en)
DK (1) DK175228B1 (en)
ES (1) ES2084593T3 (en)
GR (1) GR3018739T3 (en)
HK (1) HK1006167A1 (en)
IE (1) IE69982B1 (en)
PT (1) PT92145B (en)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5284856A (en) * 1988-10-28 1994-02-08 Hoechst Aktiengesellschaft Oncogene-encoded kinases inhibition using 4-H-1-benzopyran-4-one derivatives
EP0508347A1 (en) * 1991-04-10 1992-10-14 Hoechst Aktiengesellschaft 5,7-Dihydroxy-2-methyl-8-[4-(3-hydroxy-1-(1-propyl)) piperidinyl]-4H-1-benzopyran-4-one, its preparation and its use
US5464871A (en) * 1993-05-12 1995-11-07 Octamer, Inc. Aromatic nitro and nitroso compounds and their metabolites useful as anti-viral and anti-tumor agents
US5733920A (en) * 1995-10-31 1998-03-31 Mitotix, Inc. Inhibitors of cyclin dependent kinases
DK0795334T3 (en) * 1996-03-12 2006-06-06 Sanofi Aventis Deutschland New prodrugs for the treatment of tumors and inflammatory diseases
DE19802449A1 (en) 1998-01-23 1999-07-29 Hoechst Marion Roussel De Gmbh Preparation of 3-hydroxy-1-methyl-4-phenyl-piperidine derivative isomer, for use as intermediate for antitumor agent flavopiridol
DE19959546A1 (en) * 1999-12-09 2001-06-21 Rhone Poulenc Rorer Gmbh Pharmaceutical preparation for the treatment of tumor diseases
US6821990B2 (en) 2000-01-18 2004-11-23 Aventis Pharma Deutschland Gmbh Ethanol solvate of (-)-cis-2-(2-chlorophenyl)-5, 7-dihydroxy-8 [4R-(3S-hydroxy-1-M ethyl) piperidinyl]-4H-1-benzopyran-4-one
ATE284400T1 (en) * 2000-01-18 2004-12-15 Aventis Pharma Inc ETHANOL SOLVATE OF (-)-CIS-2-(2-CHLORPHENYL)-5,7-DIHYDROXY-8-(4R-(3S-HYDROXY-1-METHYL)PIPERIDINYL)-4H-1-BENZOPYRAN-4-ONE
US6576647B2 (en) 2000-01-18 2003-06-10 Aventis Pharmaceuticals Inc. Pseudopolymorph of (—)-cis-2-(2-chlorophenyl)-5,7-dihydroxy-8[4R-(3S-hydroxy -1-methyl)piperidinyl]-4H-1-benzopyran-4-one
FR2805538B1 (en) * 2000-02-29 2006-08-04 Hoechst Marion Roussel Inc NOVEL FLAVON DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF, THEIR USE AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND NOVEL USE
KR100392468B1 (en) * 2000-09-18 2003-07-22 주식회사 엘지생명과학 3-Hydroxychromene-4-on derivatives useful as cyclin dependendent kinase inhibitors
DE10113513A1 (en) * 2001-03-20 2002-10-02 Medinnova Ges Med Innovationen Drug combination of kinase inhibitor and neurotropic factor, useful for treating and/or preventing nerve and/or glial cell damage, e.g. associated with neurodegenerative diseases
JP4448902B2 (en) * 2001-06-08 2010-04-14 株式会社医薬分子設計研究所 Sulfonamide derivatives
AU2003234733B2 (en) 2002-04-17 2009-01-29 Cytokinetics, Inc. Compounds, compositions, and methods
TWI331034B (en) * 2002-07-08 2010-10-01 Piramal Life Sciences Ltd Inhibitors of cyclin-dependent kinases and their use
JP2005533119A (en) 2002-07-17 2005-11-04 サイトキネティクス・インコーポレーテッド Compounds, compositions and methods
CN102438452B (en) * 2009-05-08 2015-02-25 乔治亚州大学研究基金会 Compounds and compositions comprising CDK inhibitors and methods for treating cancer
EP3399026B1 (en) 2010-06-14 2024-06-26 The Scripps Research Institute Reprogramming of cells to a new fate
WO2012007327A1 (en) 2010-07-12 2012-01-19 Dkfz Deutsches Krebsforschungszentrum Wogonin for the prevention and therapy of cardiac hypertrophy
WO2013113762A1 (en) 2012-01-31 2013-08-08 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and kits for predicting the risk of having a cutaneous melanoma in a subject
US9901574B2 (en) 2015-04-20 2018-02-27 Tolero Pharmaceuticals, Inc. Predicting response to alvocidib by mitochondrial profiling
ES2739749T3 (en) 2015-05-18 2020-02-03 Tolero Pharmaceuticals Inc Alvocidib prodrugs that have increased bioavailability
MX2018001289A (en) 2015-08-03 2018-04-30 Tolero Pharmaceuticals Inc Combination therapies for treatment of cancer.
WO2018094275A1 (en) 2016-11-18 2018-05-24 Tolero Pharmaceuticals, Inc. Alvocidib prodrugs and their use as protein kinase inhibitors
WO2019055579A1 (en) 2017-09-12 2019-03-21 Tolero Pharmaceuticals, Inc. Treatment regimen for cancers that are insensitive to bcl-2 inhibitors using the mcl-1 inhibitor alvocidib
US11034710B2 (en) 2018-12-04 2021-06-15 Sumitomo Dainippon Pharma Oncology, Inc. CDK9 inhibitors and polymorphs thereof for use as agents for treatment of cancer
US11793802B2 (en) 2019-03-20 2023-10-24 Sumitomo Pharma Oncology, Inc. Treatment of acute myeloid leukemia (AML) with venetoclax failure
CN110028475B (en) * 2019-05-13 2022-07-01 中国药科大学 Novel CDK9 inhibitor based on benzopyran structure, preparation method and application thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3329186A1 (en) * 1983-08-12 1985-02-21 Hoechst Ag, 6230 Frankfurt CHROMONAL CALALIDE, METHOD FOR ITS INSULATION FROM DYSOXYLUM BINECTARIFERUM, AND ITS USE AS A MEDICINAL PRODUCT
IN164232B (en) * 1986-04-11 1989-02-04 Hoechst India

Also Published As

Publication number Publication date
AU628409B2 (en) 1992-09-17
EP0366061A1 (en) 1990-05-02
KR900006325A (en) 1990-05-07
PT92145A (en) 1990-04-30
ATE133170T1 (en) 1996-02-15
IE69982B1 (en) 1996-10-16
JP2879910B2 (en) 1999-04-05
DK537289A (en) 1990-04-29
KR100194505B1 (en) 1999-06-15
DE3836676A1 (en) 1990-05-03
GR3018739T3 (en) 1996-04-30
PT92145B (en) 1995-06-30
ES2084593T3 (en) 1996-05-16
CA1336715C (en) 1995-08-15
CY2026A (en) 1998-02-20
DK175228B1 (en) 2004-07-19
EP0366061B1 (en) 1996-01-17
JPH02178225A (en) 1990-07-11
DK537289D0 (en) 1989-10-27
AU4384189A (en) 1990-05-03
HK1006167A1 (en) 1999-02-12
DE58909573D1 (en) 1996-02-29

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