IE902276L - Serpin variants - Google Patents

Serpin variants

Info

Publication number
IE902276L
IE902276L IE902276A IE227690A IE902276L IE 902276 L IE902276 L IE 902276L IE 902276 A IE902276 A IE 902276A IE 227690 A IE227690 A IE 227690A IE 902276 L IE902276 L IE 902276L
Authority
IE
Ireland
Prior art keywords
amino acid
factor
vis
region
acid substitutions
Prior art date
Application number
IE902276A
Other versions
IE902276A1 (en
Original Assignee
Akzo Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nv filed Critical Akzo Nv
Publication of IE902276L publication Critical patent/IE902276L/en
Publication of IE902276A1 publication Critical patent/IE902276A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8128—Antithrombin III

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Modified antithrombin III variants are developed which contain amino acid substitutions in the region comprising amino acids 384-396. In this region one or more amino acids are replaced by the corresponding amino acid(s) grouped around the factor Xa cleavage site in factor II related to the formation of meizothrombin. These amino acid substitutions result in altered heparin-dependent inhibitory effect of the modified antithrombin III vis-à-vis the factors IIa and Xa, respectively. [WO9100291A1]
IE227690A 1989-06-26 1990-06-22 Serpin variants IE902276A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP89201675 1989-06-26

Publications (2)

Publication Number Publication Date
IE902276L true IE902276L (en) 1990-12-26
IE902276A1 IE902276A1 (en) 1991-01-16

Family

ID=8202416

Family Applications (1)

Application Number Title Priority Date Filing Date
IE227690A IE902276A1 (en) 1989-06-26 1990-06-22 Serpin variants

Country Status (4)

Country Link
AU (1) AU5939390A (en)
IE (1) IE902276A1 (en)
WO (1) WO1991000291A1 (en)
ZA (1) ZA904930B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3901917A1 (en) * 1989-01-24 1990-07-26 Behringwerke Ag MUTANTS OF HUMAN ANTITHROMBIN III
JP3479539B2 (en) * 1992-04-10 2003-12-15 エーザイ株式会社 Human antithrombin III mutant
AU3479495A (en) * 1994-09-30 1996-04-26 Ppl Therapeutics (Scotland) Ltd Alpha-1-antitrypsin and antithrombine-iii variants
JP4441116B2 (en) 1998-05-12 2010-03-31 スーザン シー． ボック， Human antithrombin III and methods related thereto
JP4339962B2 (en) 1999-06-23 2009-10-07 武比古 小出 Human antithrombin mutant
CA2487901A1 (en) 2002-05-31 2003-12-11 University Of Utah Research Foundation Variants of antithrombin iii
ES2374054B1 (en) * 2010-07-03 2012-12-26 Instituto De Salud Carlos Iii NEW SERINA PROTEASA INHIBITOR AND ITS USE.
GB201322091D0 (en) 2013-12-13 2014-01-29 Cambridge Entpr Ltd Modified serpins for the treatment of bleeding disorders

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0238473A3 (en) * 1986-03-18 1989-06-07 Monsanto Company Serine protease inhibitors

Also Published As

Publication number Publication date
IE902276A1 (en) 1991-01-16
WO1991000291A1 (en) 1991-01-10
ZA904930B (en) 1991-04-24
AU5939390A (en) 1991-01-17

Similar Documents

Publication Publication Date Title
EP1319669A3 (en) Tissue inhibitor of metalloproteinase type three (TIMP-3) composition and methods
FI922434A0 (en) PRODUKTION AV REKOMBINANT HUMAN INTERLEUKIN-1-INHIBITOR.
DE68910279D1 (en) Hydroxy-functional monomers, their preparation and their use for the production of polyurethanes.
WO1996004378A3 (en) Chimeric proteins and muteins of tissue factor pathway inhibitors tfpi and tfpi-2
EP0404489A3 (en) Well treatment process
IT1230055B (en) PROCESS FOR THE PRODUCTION OF BOEMITICAL ALUMINES.
IT1221776B (en) PROCESS FOR THE PREPARATION OF 1,2 DIFLUOROETHANE AND 1,1,2 TRIFLUOROETHANE
EP1231274A3 (en) Modified porteinase inhibitors
EP0183159A3 (en) 1-heteroaryl-4-aryl-pyrazolin-5-ones for use as medicaments
HU9303314D0 (en) Process for producing elasteze- and catepsin-d-inhibitors
ES2062345T3 (en) SUBSTITUTED CHROMANES IN THE TREATMENT OF ASTHMA, ARTHRITIS AND RELATED DISEASES.
AU2209500A (en) Inhibitors of alpha4beta1 mediated cell adhesion
DE59404321D1 (en) Process for the production of purified ethylene glycol carbonate (EGC)
DE68914236D1 (en) Process for the production of sodium hyaluronate by fermentation.
WO1995015391A3 (en) Aspergillus expression system
TW369541B (en) Thrombin inhibitors
DE59000045D1 (en) PRESSLINGS BASED ON PYROGEN-MADE TITANIUM DIOXIDE, PROCESS FOR THEIR PRODUCTION AND THEIR USE.
ITRM940433A0 (en) "MULTIPLE FABRICS PRODUCTION PROCEDURE".
DE69314056D1 (en) DETERGENTS AND THEIR PRODUCTION PROCESS
AU4516989A (en) Improved hypochlorous acid process
DE59408443D1 (en) Fleece card, as well as processes for fleece production
FI900991A0 (en) APROTINHOMOLOGER OCH ETT FOERFARANDE FOER PRODUCERING AV APROTIN OCH APROTINHOMOLOGER I JAEST.
WO1999058098A3 (en) HUMAN ANTITHROMBIN IIIs AND METHODS RELATED THERETO
ES2176349T3 (en) SILILATION PROCESS.
DE69331094D1 (en) Process for the production of ready-to-eat cereal flakes