IE922401L - An injectable pharmaceutical composition for the¹protectionof tissue damaged by ischemia - Google Patents
An injectable pharmaceutical composition for the¹protectionof tissue damaged by ischemiaInfo
- Publication number
- IE922401L IE922401L IE922401A IE922401A IE922401L IE 922401 L IE922401 L IE 922401L IE 922401 A IE922401 A IE 922401A IE 922401 A IE922401 A IE 922401A IE 922401 L IE922401 L IE 922401L
- Authority
- IE
- Ireland
- Prior art keywords
- c2h4o
- composition
- approximately
- fibrinolytic
- ischemia
- Prior art date
Links
- 208000028867 ischemia Diseases 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 3
- 229920001577 copolymer Polymers 0.000 abstract 2
- 239000003527 fibrinolytic agent Substances 0.000 abstract 2
- 230000003480 fibrinolytic effect Effects 0.000 abstract 2
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 101710196208 Fibrinolytic enzyme Proteins 0.000 abstract 1
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 abstract 1
- 108010023197 Streptokinase Proteins 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 108090000373 Tissue Plasminogen Activator Proteins 0.000 abstract 1
- 102000003978 Tissue Plasminogen Activator Human genes 0.000 abstract 1
- 108090000435 Urokinase-type plasminogen activator Proteins 0.000 abstract 1
- 102000003990 Urokinase-type plasminogen activator Human genes 0.000 abstract 1
- 230000017531 blood circulation Effects 0.000 abstract 1
- 210000004204 blood vessel Anatomy 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000007859 condensation product Substances 0.000 abstract 1
- 229940088598 enzyme Drugs 0.000 abstract 1
- 125000000963 oxybis(methylene) group Chemical group [H]C([H])(*)OC([H])([H])* 0.000 abstract 1
- 229960005202 streptokinase Drugs 0.000 abstract 1
- 229960000187 tissue plasminogen activator Drugs 0.000 abstract 1
- 229960005356 urokinase Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/44—Oxidoreductases (1)
- A61K38/446—Superoxide dismutase (1.15)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/12—Chemical aspects of preservation
- A01N1/122—Preservation or perfusion media
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/12—Chemical aspects of preservation
- A01N1/122—Preservation or perfusion media
- A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- A61K38/166—Streptokinase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/49—Urokinase; Tissue plasminogen activator
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Environmental Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Dentistry (AREA)
- Biomedical Technology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
"IMPROVED FIBRINOLYTIC COMPOSITION" of the Invention In accordance with the present invention, a composition is provided that is effective in dissolving blood clots and reestablishing and maintaining blood flow through thrombosed coronary or other blood vessels. The fibrinolytic composition of the present invention comprises an enzyme, such as streptokinase, urokinase, tissue plasminogen activator or other fibrinolytic enzyme, and a surface-active copolymer. The surface-active copolymer can be an ethylene oxide-propylene oxide condensation product with the following general formula: HO(C2H4O)b(C3H6O)a(C2H4O)bH wherein a is an integer such that the hydrophobe represented by (C3H6O) has a molecular weight of approximately 950 to 4000, preferably approximately 1750 to 3500, and b is an integer such that the hydrophile portion represented by (C2H4O) constitutes approximately 50% to 90% by weight of the compound.
[CA1297792C]
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86358286A | 1986-05-15 | 1986-05-15 | |
| US07/045,459 US4801452A (en) | 1986-05-15 | 1987-05-07 | Fibrinolytic composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IE922401L true IE922401L (en) | 1987-11-15 |
Family
ID=26722792
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE922400A IE922400L (en) | 1986-05-15 | 1987-05-14 | Composition comprising an oxygen radical scavenger and a¹surface-active copolymer |
| IE922401A IE922401L (en) | 1986-05-15 | 1987-05-14 | An injectable pharmaceutical composition for the¹protectionof tissue damaged by ischemia |
| IE922399A IE922399L (en) | 1986-05-15 | 1987-05-14 | An ex vivo tissue perfusion composition and the use thereof |
| IE126187A IE62088B1 (en) | 1986-05-15 | 1987-05-14 | Fibrinolytic composition |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE922400A IE922400L (en) | 1986-05-15 | 1987-05-14 | Composition comprising an oxygen radical scavenger and a¹surface-active copolymer |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE922399A IE922399L (en) | 1986-05-15 | 1987-05-14 | An ex vivo tissue perfusion composition and the use thereof |
| IE126187A IE62088B1 (en) | 1986-05-15 | 1987-05-14 | Fibrinolytic composition |
Country Status (6)
| Country | Link |
|---|---|
| CA (1) | CA1297792C (en) |
| GR (1) | GR870758B (en) |
| IE (4) | IE922400L (en) |
| NZ (1) | NZ220288A (en) |
| PH (1) | PH25909A (en) |
| PT (1) | PT84880B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2678873C (en) | 2007-02-19 | 2016-10-25 | Plurogen Therapeutics, Inc. | Compositions for treating biofilms and methods for using same |
| WO2016118644A1 (en) | 2015-01-20 | 2016-07-28 | Plurogen Therapeutics, Llc | Compositions and methods of treating microbes |
-
1987
- 1987-05-13 NZ NZ220288A patent/NZ220288A/en unknown
- 1987-05-13 CA CA000537052A patent/CA1297792C/en not_active Expired - Lifetime
- 1987-05-14 IE IE922400A patent/IE922400L/en not_active Application Discontinuation
- 1987-05-14 IE IE922401A patent/IE922401L/en not_active Application Discontinuation
- 1987-05-14 IE IE922399A patent/IE922399L/en not_active Application Discontinuation
- 1987-05-14 IE IE126187A patent/IE62088B1/en not_active IP Right Cessation
- 1987-05-15 GR GR870758A patent/GR870758B/en unknown
- 1987-05-15 PH PH35259A patent/PH25909A/en unknown
- 1987-05-15 PT PT84880A patent/PT84880B/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA1297792C (en) | 1992-03-24 |
| IE922399L (en) | 1987-11-15 |
| PT84880B (en) | 1990-02-08 |
| IE871261L (en) | 1987-11-15 |
| IE62088B1 (en) | 1994-12-14 |
| IE922400L (en) | 1987-11-15 |
| NZ220288A (en) | 1989-08-29 |
| PT84880A (en) | 1987-06-01 |
| PH25909A (en) | 1991-12-19 |
| GR870758B (en) | 1988-05-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA9A | Application withdrawn section 33(1) |