IES20180089A2 - Drugs intermediates 2,5-dichlorobenzoic acid synthesis method - Google Patents
Drugs intermediates 2,5-dichlorobenzoic acid synthesis methodInfo
- Publication number
- IES20180089A2 IES20180089A2 IES20180089A IES20180089A IES20180089A2 IE S20180089 A2 IES20180089 A2 IE S20180089A2 IE S20180089 A IES20180089 A IE S20180089A IE S20180089 A IES20180089 A IE S20180089A IE S20180089 A2 IES20180089 A2 IE S20180089A2
- Authority
- IE
- Ireland
- Prior art keywords
- solution
- added
- washed
- mol
- dichlorobenzoic acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/16—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Drugs intermediates 2,5-dichlorobenzoic acid synthesis method, comprises the following steps: 2 mol 2,5-dichloro-6-aminobenzoic acid, 3-5 mol diisobutyl adipate solution were added to the reaction vessel, the temperature of the solution was raised to 70-78 and the stirring speed was controlled at 130-160 rpm, 3-4 mol cobalt naphthenate was added by 3-5 times, each time the interval was about 30-40 min, continued to react for 90-120 min, added 1200 ml potassium chloride solution, after the solution layered, reduced the solution temperature to 10-15 °C, added oxalic acid solution to adjust the pH to 4-5, washed with potassium sulfate solution, washed with methyl tert-butyl ether solution, and washed with 2-methyl tetrahydrofuran solution, vacuum distillation, collected fractions of 110-120 °C, dehydrated with dehydrating agent, finally obtained 2,5-dichlorobenzoic acid.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710218741.0A CN108238900A (en) | 2017-04-05 | 2017-04-05 | A kind of synthetic method of pharmaceutical intermediate 2,5- dichlorobenzoic acids |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IES20180089A2 true IES20180089A2 (en) | 2019-04-03 |
| IES86994B2 IES86994B2 (en) | 2019-05-01 |
Family
ID=59220646
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IES20180089A IES86994B2 (en) | 2017-04-05 | 2018-04-03 | Drugs intermediates 2,5-dichlorobenzoic acid synthesis method |
Country Status (4)
| Country | Link |
|---|---|
| CN (1) | CN108238900A (en) |
| AU (1) | AU2018100423A4 (en) |
| GB (1) | GB201708119D0 (en) |
| IE (1) | IES86994B2 (en) |
-
2017
- 2017-04-05 CN CN201710218741.0A patent/CN108238900A/en active Pending
- 2017-05-22 GB GBGB1708119.1A patent/GB201708119D0/en not_active Ceased
-
2018
- 2018-04-01 AU AU2018100423A patent/AU2018100423A4/en not_active Ceased
- 2018-04-03 IE IES20180089A patent/IES86994B2/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN108238900A (en) | 2018-07-03 |
| AU2018100423A4 (en) | 2018-05-17 |
| IES86994B2 (en) | 2019-05-01 |
| GB201708119D0 (en) | 2017-07-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP4279535A3 (en) | Method for preparing polyols | |
| MX2010005230A (en) | Terephthalic acid composition and process for the production thereof. | |
| JP2014528927A5 (en) | ||
| MY165103A (en) | Recombinant microorganisms and methods of use thereof | |
| EP4296365A3 (en) | Processes for conversion of biologically derived mevalonic acid | |
| EA201891400A1 (en) | OXIDATIVE METHOD FOR OBTAINING POTASSIUM TYOSULPHATE | |
| WO2017004349A3 (en) | Methods for production of terephthalic acid from ethylene oxide | |
| WO2012068284A3 (en) | Efficient method for preparing functionalized benzosuberenes | |
| BR112015031669A2 (en) | PRODUCTION PROCESS OF A FERMENTATION PRODUCT, AND USE OF A PROTEASE | |
| MY173237A (en) | Process for the fermentative production of lactic acid from a plant extract in the presence of a caustic magnesium salt | |
| EA201201666A1 (en) | INTERMEDIATE COMPOUNDS AGOMELATIN AND METHOD OF THEIR OBTAINING | |
| IES20180089A2 (en) | Drugs intermediates 2,5-dichlorobenzoic acid synthesis method | |
| WO2017024229A8 (en) | Stereospecific process for 3-heterocyclylcycloaliphatic-1,2-diols | |
| US9309181B2 (en) | Method of producing unsaturated acid from salt of hydroxycarboxylic acid | |
| AU2018100416A4 (en) | Pharmaceutical raw materials hexafluoroacetone synthesis method | |
| AU2018100422A4 (en) | Drugs intermediates 2-ethylhexanoic acid synthesis method | |
| Sreelakshmi et al. | Chemoenzymatic total synthesis of paecilocin A and 3-butyl-7-hydroxyphthalide | |
| AU2018100387A4 (en) | Organic synthesis intermediates m-aminobenzenesulfonic acid synthesis method | |
| PH12018501918A1 (en) | Glucose composition, microbial fermentation raw material, and method for producing chemical product | |
| PL412983A1 (en) | Method for producing natural 2-phenylethanol | |
| AU2018100394A4 (en) | Drugs intermediates 2-formylcarbonylbenzoic acid synthesis method | |
| AU2018100411A4 (en) | Medicine intermediates terephthalic acid synthesis method | |
| AU2018100532A4 (en) | Anti-arrhythmic drug intermediate 1-(2,6-dimethoxy)-2-acetone synthesis method | |
| AU2018100829A4 (en) | Organic synthesis intermediates 2-octanal aldehyde synthesis method | |
| IES20180085A2 (en) | Drugs intermediates 1,4-dibromo-2,3-butanediol synthesis method |