IES20180094A2 - Drug intermediates o-aminobenzaldehyde synthesis method - Google Patents
Drug intermediates o-aminobenzaldehyde synthesis methodInfo
- Publication number
- IES20180094A2 IES20180094A2 IES20180094A IES20180094A IES20180094A2 IE S20180094 A2 IES20180094 A2 IE S20180094A2 IE S20180094 A IES20180094 A IE S20180094A IE S20180094 A IES20180094 A IE S20180094A IE S20180094 A2 IES20180094 A2 IE S20180094A2
- Authority
- IE
- Ireland
- Prior art keywords
- solution
- mol
- aminobenzaldehyde
- synthesis method
- drug intermediates
- Prior art date
Links
- FXWFZIRWWNPPOV-UHFFFAOYSA-N 2-aminobenzaldehyde Chemical compound NC1=CC=CC=C1C=O FXWFZIRWWNPPOV-UHFFFAOYSA-N 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title abstract 2
- 239000000543 intermediate Substances 0.000 title abstract 2
- 238000001308 synthesis method Methods 0.000 title abstract 2
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- IOLCXVTUBQKXJR-UHFFFAOYSA-M potassium bromide Chemical compound [K+].[Br-] IOLCXVTUBQKXJR-UHFFFAOYSA-M 0.000 abstract 2
- CMWKITSNTDAEDT-UHFFFAOYSA-N 2-nitrobenzaldehyde Chemical compound [O-][N+](=O)C1=CC=CC=C1C=O CMWKITSNTDAEDT-UHFFFAOYSA-N 0.000 abstract 1
- 229910021591 Copper(I) chloride Inorganic materials 0.000 abstract 1
- OTMSDBZUPAUEDD-UHFFFAOYSA-N Ethane Chemical compound CC OTMSDBZUPAUEDD-UHFFFAOYSA-N 0.000 abstract 1
- OXBLHERUFWYNTN-UHFFFAOYSA-M copper(I) chloride Chemical compound [Cu]Cl OXBLHERUFWYNTN-UHFFFAOYSA-M 0.000 abstract 1
- 239000013078 crystal Substances 0.000 abstract 1
- 229940045803 cuprous chloride Drugs 0.000 abstract 1
- 239000012024 dehydrating agents Substances 0.000 abstract 1
- RNVCVTLRINQCPJ-UHFFFAOYSA-N o-toluidine Chemical compound CC1=CC=CC=C1N RNVCVTLRINQCPJ-UHFFFAOYSA-N 0.000 abstract 1
- 238000003756 stirring Methods 0.000 abstract 1
- 238000005292 vacuum distillation Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Drug intermediates o-aminobenzaldehyde synthesis method, comprises the following steps: the reaction vessel was added 2 mol o-nitrobenzaldehyde, 50 L water, 3-4 mol cuprous chloride, 5-6 mol 2-aminotoluene, the stirring rate was controlled at 90-130 rpm, and the temperature of the solution was raised to 70-75°C, reaction for 70-90min, vacuum distillation, collecting fraction of 80-86°C, collecting distillate, add 1-2kg potassium bromide, reduce the solution temperature to 5-8°C, after the crystal precipitated, filter it, washed with the dimethylmine solution and with trifluoroaceticacid solution, dehydrating with the dehydrating agent and recrystallized in the ethane solution to obtain the finished product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IES20180094A IES86950B2 (en) | 2018-04-03 | 2018-04-03 | Drug intermediates o-aminobenzaldehyde synthesis method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IES20180094A IES86950B2 (en) | 2018-04-03 | 2018-04-03 | Drug intermediates o-aminobenzaldehyde synthesis method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IES20180094A2 true IES20180094A2 (en) | 2019-01-09 |
| IES86950B2 IES86950B2 (en) | 2019-01-09 |
Family
ID=65009472
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IES20180094A IES86950B2 (en) | 2018-04-03 | 2018-04-03 | Drug intermediates o-aminobenzaldehyde synthesis method |
Country Status (1)
| Country | Link |
|---|---|
| IE (1) | IES86950B2 (en) |
-
2018
- 2018-04-03 IE IES20180094A patent/IES86950B2/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IES86950B2 (en) | 2019-01-09 |
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