IES62443B2 - 06-substituted guanine derivatives, a process for their preparation and their use in treating tumor cells - Google Patents
06-substituted guanine derivatives, a process for their preparation and their use in treating tumor cellsInfo
- Publication number
- IES62443B2 IES62443B2 IES940470A IES62443B2 IE S62443 B2 IES62443 B2 IE S62443B2 IE S940470 A IES940470 A IE S940470A IE S62443 B2 IES62443 B2 IE S62443B2
- Authority
- IE
- Ireland
- Prior art keywords
- compound according
- guanine
- cells
- host
- composition
- Prior art date
Links
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- GDBQQVLCIARPGH-ULQDDVLXSA-N leupeptin Chemical compound CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C=O)CCCN=C(N)N GDBQQVLCIARPGH-ULQDDVLXSA-N 0.000 description 1
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- JGJDORZNOSWWDS-UHFFFAOYSA-N methyl 1,3-oxazole-5-carboxylate Chemical compound COC(=O)C1=CN=CO1 JGJDORZNOSWWDS-UHFFFAOYSA-N 0.000 description 1
- GCVVHNKBMLQFCY-UHFFFAOYSA-N methyl 5-(hydroxymethyl)furan-2-carboxylate Chemical compound COC(=O)C1=CC=C(CO)O1 GCVVHNKBMLQFCY-UHFFFAOYSA-N 0.000 description 1
- 150000004702 methyl esters Chemical class 0.000 description 1
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- QXYYYPFGTSJXNS-UHFFFAOYSA-N mitozolomide Chemical compound N1=NN(CCCl)C(=O)N2C1=C(C(=O)N)N=C2 QXYYYPFGTSJXNS-UHFFFAOYSA-N 0.000 description 1
- 150000004682 monohydrates Chemical class 0.000 description 1
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- 230000003039 myelosuppressive effect Effects 0.000 description 1
- 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
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- 150000002923 oximes Chemical class 0.000 description 1
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- YBYRMVIVWMBXKQ-UHFFFAOYSA-N phenylmethanesulfonyl fluoride Chemical compound FS(=O)(=O)CC1=CC=CC=C1 YBYRMVIVWMBXKQ-UHFFFAOYSA-N 0.000 description 1
- 229940068918 polyethylene glycol 400 Drugs 0.000 description 1
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- 238000001556 precipitation Methods 0.000 description 1
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- CPTBDICYNRMXFX-UHFFFAOYSA-N procarbazine Chemical compound CNNCC1=CC=C(C(=O)NC(C)C)C=C1 CPTBDICYNRMXFX-UHFFFAOYSA-N 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
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- 230000000717 retained effect Effects 0.000 description 1
- 201000003708 skin melanoma Diseases 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- LFQULJPVXNYWAG-UHFFFAOYSA-N sodium;phenylmethanolate Chemical compound [Na]OCC1=CC=CC=C1 LFQULJPVXNYWAG-UHFFFAOYSA-N 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
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- 238000010561 standard procedure Methods 0.000 description 1
- 238000011272 standard treatment Methods 0.000 description 1
- 229960001052 streptozocin Drugs 0.000 description 1
- ZSJLQEPLLKMAKR-GKHCUFPYSA-N streptozocin Chemical compound O=NN(C)C(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O ZSJLQEPLLKMAKR-GKHCUFPYSA-N 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
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- 238000004114 suspension culture Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 125000005301 thienylmethyl group Chemical group [H]C1=C([H])C([H])=C(S1)C([H])([H])* 0.000 description 1
- 210000001541 thymus gland Anatomy 0.000 description 1
- CFOAUYCPAUGDFF-UHFFFAOYSA-N tosmic Chemical compound CC1=CC=C(S(=O)(=O)C[N+]#[C-])C=C1 CFOAUYCPAUGDFF-UHFFFAOYSA-N 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 238000010626 work up procedure Methods 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Resins (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IES940470 IES62443B2 (en) | 1993-06-08 | 1994-06-08 | 06-substituted guanine derivatives, a process for their preparation and their use in treating tumor cells |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IE930432 | 1993-06-08 | ||
| GB9410421A GB9410421D0 (en) | 1993-06-08 | 1994-05-23 | O (six)-substituted guanine derivatives |
| IES940470 IES62443B2 (en) | 1993-06-08 | 1994-06-08 | 06-substituted guanine derivatives, a process for their preparation and their use in treating tumor cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IES940470A2 IES940470A2 (en) | 1994-12-14 |
| IES62443B2 true IES62443B2 (en) | 1995-02-08 |
Family
ID=11039985
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IES940470 IES62443B2 (en) | 1993-06-08 | 1994-06-08 | 06-substituted guanine derivatives, a process for their preparation and their use in treating tumor cells |
Country Status (5)
| Country | Link |
|---|---|
| KR (1) | KR100333749B1 (uk) |
| GB (1) | GB9410421D0 (uk) |
| IE (1) | IES62443B2 (uk) |
| UA (1) | UA43336C2 (uk) |
| ZA (1) | ZA944026B (uk) |
-
1994
- 1994-05-23 GB GB9410421A patent/GB9410421D0/en active Pending
- 1994-06-08 ZA ZA944026A patent/ZA944026B/xx unknown
- 1994-06-08 KR KR1019950705556A patent/KR100333749B1/ko not_active Expired - Fee Related
- 1994-06-08 IE IES940470 patent/IES62443B2/en not_active IP Right Cessation
- 1994-08-06 UA UA95125190A patent/UA43336C2/uk unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GB9410421D0 (en) | 1994-07-13 |
| KR100333749B1 (ko) | 2002-10-04 |
| IES940470A2 (en) | 1994-12-14 |
| ZA944026B (en) | 1995-02-06 |
| UA43336C2 (uk) | 2001-12-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FK9A | Application deemed to have been withdrawn section 23(9) | ||
| MM4A | Patent lapsed |