IES80613B2 - Combined feed supplement and veterinary medicament composition - Google Patents
Combined feed supplement and veterinary medicament compositionInfo
- Publication number
- IES80613B2 IES80613B2 IES960801A IES80613B2 IE S80613 B2 IES80613 B2 IE S80613B2 IE S960801 A IES960801 A IE S960801A IE S80613 B2 IES80613 B2 IE S80613B2
- Authority
- IE
- Ireland
- Prior art keywords
- composition
- feed supplement
- combined feed
- sugar
- veterinary medicament
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 36
- 239000003814 drug Substances 0.000 title claims abstract description 11
- 239000006052 feed supplement Substances 0.000 title claims abstract description 11
- 235000015112 vegetable and seed oil Nutrition 0.000 claims abstract description 24
- 239000008158 vegetable oil Substances 0.000 claims abstract description 24
- 238000000034 method Methods 0.000 claims abstract description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 18
- 239000003792 electrolyte Substances 0.000 claims abstract description 11
- 206010012735 Diarrhoea Diseases 0.000 claims abstract description 9
- 238000002156 mixing Methods 0.000 claims abstract description 7
- 239000000546 pharmaceutical excipient Substances 0.000 claims abstract description 7
- 229920013821 hydroxy alkyl cellulose Polymers 0.000 claims abstract description 6
- 241001465754 Metazoa Species 0.000 claims abstract description 5
- 238000004090 dissolution Methods 0.000 claims abstract description 5
- 239000000725 suspension Substances 0.000 claims abstract description 5
- 230000015572 biosynthetic process Effects 0.000 claims abstract description 4
- 229940088594 vitamin Drugs 0.000 claims abstract description 4
- 235000013343 vitamin Nutrition 0.000 claims abstract description 4
- 239000011782 vitamin Substances 0.000 claims abstract description 4
- 229930003231 vitamin Natural products 0.000 claims abstract description 4
- 235000019156 vitamin B Nutrition 0.000 claims abstract description 3
- 239000011720 vitamin B Substances 0.000 claims abstract description 3
- 125000000217 alkyl group Chemical group 0.000 claims description 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 abstract 6
- 239000004166 Lanolin Substances 0.000 abstract 2
- 150000002191 fatty alcohols Chemical class 0.000 abstract 2
- 229940039717 lanolin Drugs 0.000 abstract 2
- 235000019388 lanolin Nutrition 0.000 abstract 2
- 239000007788 liquid Substances 0.000 abstract 2
- 239000008240 homogeneous mixture Substances 0.000 abstract 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 15
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 15
- 239000000047 product Substances 0.000 description 12
- 239000000843 powder Substances 0.000 description 10
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 8
- 239000004615 ingredient Substances 0.000 description 8
- 238000004519 manufacturing process Methods 0.000 description 5
- SPFMQWBKVUQXJV-BTVCFUMJSA-N (2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanal;hydrate Chemical compound O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O SPFMQWBKVUQXJV-BTVCFUMJSA-N 0.000 description 4
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 4
- 229920002678 cellulose Polymers 0.000 description 4
- 239000001913 cellulose Substances 0.000 description 4
- 229960000673 dextrose monohydrate Drugs 0.000 description 4
- 239000000428 dust Substances 0.000 description 4
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- XSTXAVWGXDQKEL-UHFFFAOYSA-N Trichloroethylene Chemical compound ClC=C(Cl)Cl XSTXAVWGXDQKEL-UHFFFAOYSA-N 0.000 description 3
- 244000309466 calf Species 0.000 description 3
- 230000007547 defect Effects 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 2
- 238000013019 agitation Methods 0.000 description 2
- FAPWYRCQGJNNSJ-UBKPKTQASA-L calcium D-pantothenic acid Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UBKPKTQASA-L 0.000 description 2
- 229960002079 calcium pantothenate Drugs 0.000 description 2
- 235000019864 coconut oil Nutrition 0.000 description 2
- 239000003240 coconut oil Substances 0.000 description 2
- 239000011888 foil Substances 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- TWNIBLMWSKIRAT-VFUOTHLCSA-N levoglucosan Chemical group O[C@@H]1[C@@H](O)[C@H](O)[C@H]2CO[C@@H]1O2 TWNIBLMWSKIRAT-VFUOTHLCSA-N 0.000 description 2
- 229910000402 monopotassium phosphate Inorganic materials 0.000 description 2
- 235000019796 monopotassium phosphate Nutrition 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 235000019198 oils Nutrition 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 description 2
- 239000001103 potassium chloride Substances 0.000 description 2
- 235000011164 potassium chloride Nutrition 0.000 description 2
- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 description 2
- 239000004172 quinoline yellow Substances 0.000 description 2
- 235000012752 quinoline yellow Nutrition 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 239000001509 sodium citrate Substances 0.000 description 2
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 229910002012 Aerosil® Inorganic materials 0.000 description 1
- 229910002016 Aerosil® 200 Inorganic materials 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 1
- 206010014418 Electrolyte imbalance Diseases 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 229920001131 Pulp (paper) Polymers 0.000 description 1
- 239000004231 Riboflavin-5-Sodium Phosphate Substances 0.000 description 1
- 229930003471 Vitamin B2 Natural products 0.000 description 1
- LXNHXLLTXMVWPM-UHFFFAOYSA-N Vitamin B6 Natural products CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 description 1
- 230000001142 anti-diarrhea Effects 0.000 description 1
- 229940124537 antidiarrhoeal agent Drugs 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 235000019577 caloric intake Nutrition 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 229940100060 combination of electrolytes Drugs 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical class OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229960001031 glucose Drugs 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 239000007970 homogeneous dispersion Substances 0.000 description 1
- 239000000644 isotonic solution Substances 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 235000019629 palatability Nutrition 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 description 1
- 235000019171 pyridoxine hydrochloride Nutrition 0.000 description 1
- 239000011764 pyridoxine hydrochloride Substances 0.000 description 1
- 229960004172 pyridoxine hydrochloride Drugs 0.000 description 1
- IZMJMCDDWKSTTK-UHFFFAOYSA-N quinoline yellow Chemical compound C1=CC=CC2=NC(C3C(C4=CC=CC=C4C3=O)=O)=CC=C21 IZMJMCDDWKSTTK-UHFFFAOYSA-N 0.000 description 1
- 229940051201 quinoline yellow Drugs 0.000 description 1
- 229960002477 riboflavin Drugs 0.000 description 1
- 235000019234 riboflavin-5-sodium phosphate Nutrition 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
- 229960000344 thiamine hydrochloride Drugs 0.000 description 1
- 235000019190 thiamine hydrochloride Nutrition 0.000 description 1
- 239000011747 thiamine hydrochloride Substances 0.000 description 1
- 235000019164 vitamin B2 Nutrition 0.000 description 1
- 239000011716 vitamin B2 Substances 0.000 description 1
- 239000011726 vitamin B6 Substances 0.000 description 1
- 235000019158 vitamin B6 Nutrition 0.000 description 1
- 229940011671 vitamin b6 Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/60—Feeding-stuffs specially adapted for particular animals for weanlings
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/163—Sugars; Polysaccharides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/174—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/26—Compounds containing phosphorus
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Polymers & Plastics (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Animal Husbandry (AREA)
- Birds (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The following are provided:- (a) a method for preparing a combined feed supplement and orally administrable veterinary medicament composition for the treatment of diarrhoea in domestic animals containing balanced proportions of electrolytes, sugar and vitamins of the B group, said composition being physically stable in sachets and multi-dose containers and being suitable for dissolution and suspension in water without appreciable formation of lumps, which method comprises dry blending the electrolytes, sugar and B vitamins with a commercially available hydroxyalkyl cellulose, together with at least one homogenising liquid excipient selected from the group comprising vegetable oils, fatty alcohols, lanolin derivatives, glycerol and propylene glycol; and (b) a combined feed supplement and orally administrable veterinary medicament composition for the treatment of diarrhoea or scour in domestic animals comprising 2% to 25% w/w of the composition hydroxyalkylcellulose, 40% to 90% w/w of the composition sugar and characterised in that it contains at least one homogenising liquid excipient selected from the group comprising vegetable oils, fatty alcohols, lanolin derivatives, glycerol and propylene glycol. The inclusion of the excipient enables a homogeneous mixture (with complete distribution of the low-quantity components) to be obtained which dissolves more satisfactorily in cold water.
Description
Combined feed supplement and veterinary medicament composition
This invention relates to a combined feed supplement and orally administrable veterinary medicament composition for the treatment of diarrhoea in domestic animals, especially calves and piglets, and a method for preparing it.
Several such combinations are known which comprise balanced proportions of electrolytes, sugar and vitamins of the B group, with polysaccharide employed for its capacity to absorb water and form a gel which helps in the absorption and replacement of electrolytes lost to the gut, as well as in water retention. Such combinations are hereinafter called compositions of the type described.
Known compositions of the type described have several drawbacks, including inadequate solubility in cold water, and unsuitably low viscosity in the solutions thus produced. There are other problems including a problem with palatability, and a problem with the speed of onset of the therapeutic effect due to defective absorption of electrolytes and energy sources from the composition. A major defect is the tendency of the composition, which is commonly supplied as a dry powder, to form lumps on being added to water despite all efforts to produce a homogenous solution or suspension by agitation. A further defect of these compositions is the generation and containment of dust during both the manufacturing processes (blending and filling) and during the dissolution in water prior to administration. Another serious defect of these compositions is that they absorb moisture from the atmosphere and so must be packed in foil sachets to prevent moisture uptake.
To overcome some at least of the above disadvantages is among the objects of the invention; it seeks to provide a method for preparing a powdered composition of the type described, which shall be adapted on contact with water to form a smooth solution or suspension with little requirement for agitation to make it do so; and a composition thus prepared.
The invention accordingly provides a method for preparing a combined feed supplement and orally administrable veterinary medicament composition for the treatment of diarrhoea in domestic animals, especially calves and piglets, containing balanced proportions of electrolytes, sugar and vitamins of the B group, said composition being physically stable in sachets and multi-dose containers and being suitable for dissolution and suspension in water without appreciable formation of lumps, which method comprises dry blending the electrolytes, sugar and B-vitamins with a commercially available hydroxyalkyl cellulose, together with excipients which include at least one vegetable oil.
In a preferred embodiment, the vegetable oil(s) is/are added as the final step in the method.
The invention also provides a composition prepared by said method.
Preferably the alkyl component of the hydroxyalkyl cellulose is selected from methyl, ethyl and propyl. A particularly preferred alkyl component is ethyl.
A preferred quality specification for hydroxyethyl cellulose for use in the invention is that of the European Pharmacopoeia, which specification is hereby incorporated in the present disclosure by reference.
In a specially advantageous embodiment of the invention, the hydroxyethyl cellulose is a product available from Aqualon, a division of Hercules Incorporated and marketed under the trade mark NATROSOL. A product variety designated NATROSOL 250 HX
Pharm is used for preference. The ratio of NATROSOL to salts and other solids ranges from 1:6.6 to 1:12.5.
In the commercial production of NATROSOL, high purity chemical cotton or wood pulp is treated with sodium hydroxide, which activates the three hydroxyl groups of each of the anhydroglucose units of the cellulose molecule. The activated groups are subsequently etherified with ethylene oxide to form hydroxyethyl ethers of cellulose. Moreover ethylene oxide, reacting with previously substituted hydroxyl groups, can cause polymerization to form a side chain. The reaction product is purified and ground to a fine powder.
The degree of molecular substitution (MS) of hydroxyethyl cellulose is defined as the average number of molecules of ethylene oxide that become attached to one anhydroglucose unit of the cellulose molecule. Complete and quick solubility in water is imparted to the product NATROSOL by selecting an appropriate MS and appropriate reaction conditions and controlling the uniformity of substitution. These procedures are employed by the manufacturers, of course, and do not form part of the invention.
Vegetable Oil(s)
In a preferred embodiment of the invention, the vegetable oil(s), are added after the dry ingredients have been thoroughly blended, and the vegetable oil is gradually blended into the dry blended ingredients.
All common vegetable oils are suitable for this process. Preferred vegetable oils include coconut oil and especially preferred are the commercially available fractionated vegetable oils known as Miglyol 812 and Triol 91. These fractionated coconut oils meet the quality specification of the British and European Pharmacopoeiae.
Preferably, the vegetable oil is added as a fine spray to the dry blended ingredients. The quantity of vegetable oil added is sufficient to form a cohesive, dust-free readily water dispersable powder. The quantity of vegetable oil is not limited in this invention as the quantity required depends on the variable physical characteristics (particle size, surface area, etc.) of the powder components. Usually, a quantity of vegetable oil corresponding to approximately 5% of the composition is found to be suitable.
The addition of the vegetable oil is found to eliminate ( the creation of powder dust during the blending and filling of the composition as well as eliminating the creation of powder dust during the reconstitution of the composition with water. In addition the employment of the vegetable oil serves both to greatly increase the flowability of the composition and ensure greater product homogeneity during manufacture. During storage the presence of the vegetable oil serves to minimise the absorption of moisture from the atmosphere, and hence eliminates the lumping effect due to moisture uptake. As a result this composition is suitable for both packing either in sachets or in multi-dose containers which are open to the atmosphere during use. On reconstitution the presence of the vegetable oil serves to ensure that the powder composition is readily dispersable in cold water and as a result is rapidly dissolved.
The techniques used effectively separate the particles of hydroxyethyl cellulose so that no lumping is encountered when the dry mix is added to water. The product is a balanced combination of electrolytes and nutrients, which, when made up as disclosed above, provides a nearly isotonic solution of salts and nutrients for use as an aid in the treatment of diarrhoea in calves and piglets. It is primarily designed for use at the onset of diarrhoea. The product incorporates more energy sources, such as dextrose arid citrate, than most commercial products of this type. It is therefore considered particularly useful in the early stages of diarrhoea and in the convalescent stage where energy intake is important.
The major objective of oral electrolyte therapy is to correct dehydration and/or correct electrolyte imbalance, and to provide energy in neonatal diarrhoea. The product is approximately isotonic (Total mosm.L'1 = 321, from all sources; isotonic - 300 mOsm.L1) and provides circa 400 kcal.day'1 from 2.27 litres (4 pints) twice daily or approximately 20-25% of maintenance feeding.
The product, as stated, incorporates NATROSOL, a proprietary hydroxyethyl cellulose, which has the properties of non-ionic, highly purified cellulose.
This polyaccharide is not metabolised in the body and is effective by its capacity to absorb water forming a viscous gel. The powdered product is specially formulated to reduce powder dust problems during manufacture and dissolution and to facilitate homogeneous dispersion in water prior to administration. Once administered, the product rapidly exhibits its gelling property and promotes absorption and replacement of lost electrolytes. It also has excellent water retention properties.
The invention will be appreciated in greater detail from the following examples of specific and preferred embodiments thereof.
Example 1
To make a sample quantity of a combined feed supplement and orally administrable veterinary medicament composition, the following ingredients are dry blended together:
Sodium chloride B.P 6.50 g Sodium citrate B.P 4.50 g Potassium chloride B.P. 2.50 g Potassium dihydrogen phosphate B.P. 1.30 g Hydroxyethyl cellulose 8.00 g Dextrose monohydrate B.P. 72.68 g Vitamin BI B.P. 75 mg Vitamin B2 B.P. 110 mg Vitamin B6 B.P. 40 mg Calcium pantothenate B.P. 150 mg Excipients to 100.00 g The excipients comprise vegetable oil(s) , aerosil
(powdered silica) and colouring matter, the presence of the latter two being optional. The hydroxyethyl cellulose used is NATROSOL 250 HX Pharm. The vegetable oil(s) used are Miglyol 812 or Triol 91 and are added last. The composition, on being added to cold water, readily dispenses and dissolves without lump formation.
Example 2
A batch of combined feed supplement and veterinary anti-diarrhoeal medicament composition is made up under manufacturing conditions from the following ingredients using the amounts given, by the method described:
1. Sodium chloride B.P. 38.350 Kg 2. Sodium citrate B.P 26.550 Kg 3. Potassium chloride B.P. 14.750 Kg 4. Potassium dihydrogen phosphate B.P. 7.670 Kg 5. Thiamine hydrochloride B.P. 442.5 g 6. Riboflavin 5-sodium phosphate B.P. 649.0 g 7. Pyridoxine hydrochloride (Lutavit B6) 236.0 g 8. Calcium pantothenate B.P. powder 885.0 g 9. Hydroxyethyl cellulose Pharm. Eur. 47.920 Kg 10. Aerosil 200 B.P. 590.0 g 11. Dextrose monohydrate B.P. 421.826 Kg 12. Ariavit Quinoline Yellow E 104 119.8 g 13. Triol - 91 - approx. 30.000 Kg Batch weight 590.000 Kg 1. load a suitable blender with half the formula
amount of Dextrose monohydrate (1.210Kg);
2. add, while mixing, ingredients numbered 1, 2, 3, 4, 9, 12, 5, 6, 7, 8 and 10 in that order, and
blend for five minutes;
3. add the remainder of the Dextrose monohydrate and blend for a further five minutes;
4. weigh and add very slowly ingredient 13 (vegetable oil) and continue mixing until all the oil is mixed in and homogeneously distributed;
. if the powder is dusty to the touch and does not come off cleanly from the surface of the blender, add a small amount of ingredient 13 (vegetable oil) and mix until homogeneous; record the additional quantity of oil used;
6. submit a sample from the batch to the lab for assay and dispersion test in water; and
7. fill the product into either foil/PVC sachets or multi-dose containers .
The invention is not limited by or to the details of the embodiment described, many of which can be widely varied without departing from the scope of the invention.
Claims (5)
1. A method for preparing a combined feed supplement and orally administrable veterinary medicament composition for the treatment of diarrhoea in domestic 5 animals containing balanced proportions of electrolytes, sugar and vitamins of the B group, said composition being physically stable in sachets and multi-dose containers and being suitable for dissolution and suspension in water without appreciable 10 formation of lumps, which method comprises dry blending the electrolytes, sugar and B vitamins with a commercially available hydroxyalkyl cellulose, together with excipients which include at least one vegetable oil. 15
2. A method as claimed in Claim 1 characterised in that the vegetable oil is added as the final step in the method.
3. A method as claimed in Claim 1 or Claim 2 characterised in that the alkyl component of the 20 hydroxyalkyl cellulose is selected from methyl, ethyl and propyl.
4. A method for preparing a combined feed supplement and orally administrable veterinary medicament composition substantially as hereinbefore described with reference to the examples.
5. A combined feed supplement and orally administrable veterinary medicament composition whenever prepared by a method as claimed in any of 5 Claims 1 to 4.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IE960801 IES80613B2 (en) | 1996-11-13 | 1996-11-13 | Combined feed supplement and veterinary medicament composition |
| IE970783A IE970783A1 (en) | 1996-11-13 | 1997-11-05 | Combined feed supplement and veterinary medicament¹composition |
| GB9723617A GB2319727B (en) | 1996-11-13 | 1997-11-10 | Combined feed supplement and veterinary medicament composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IE960801 IES80613B2 (en) | 1996-11-13 | 1996-11-13 | Combined feed supplement and veterinary medicament composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IES960801A2 IES960801A2 (en) | 1998-10-21 |
| IES80613B2 true IES80613B2 (en) | 1998-10-21 |
Family
ID=11041302
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE960801 IES80613B2 (en) | 1996-11-13 | 1996-11-13 | Combined feed supplement and veterinary medicament composition |
| IE970783A IE970783A1 (en) | 1996-11-13 | 1997-11-05 | Combined feed supplement and veterinary medicament¹composition |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE970783A IE970783A1 (en) | 1996-11-13 | 1997-11-05 | Combined feed supplement and veterinary medicament¹composition |
Country Status (2)
| Country | Link |
|---|---|
| GB (1) | GB2319727B (en) |
| IE (2) | IES80613B2 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2006320167C1 (en) * | 2005-12-02 | 2011-04-07 | Hill's Pet Nutrition, Inc. | Methods for altering stool quality and/or stool frequency |
| US8529965B2 (en) | 2007-07-09 | 2013-09-10 | Hill's Pet Nutrition, Inc. | Compositions and methods for altering stool quality in an animal |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1337176A (en) * | 1970-06-06 | 1973-11-14 | Yamanouchi Pharma Co Ltd | Syrup for treating diarrhoe in baby pigs |
-
1996
- 1996-11-13 IE IE960801 patent/IES80613B2/en not_active IP Right Cessation
-
1997
- 1997-11-05 IE IE970783A patent/IE970783A1/en not_active IP Right Cessation
- 1997-11-10 GB GB9723617A patent/GB2319727B/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| IES960801A2 (en) | 1998-10-21 |
| IE970783A1 (en) | 1998-05-20 |
| GB2319727A (en) | 1998-06-03 |
| GB2319727B (en) | 2000-05-03 |
| GB9723617D0 (en) | 1998-01-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD4E | Short term patents deemed void under section 64 |