IES950206A2 - Process for the separation of the optical antipodes of racemic phenyl-(2-Pyridyl)-dimethylpropylamines - Google Patents
Process for the separation of the optical antipodes of racemic phenyl-(2-Pyridyl)-dimethylpropylaminesInfo
- Publication number
- IES950206A2 IES950206A2 IES950206A IES950206A2 IE S950206 A2 IES950206 A2 IE S950206A2 IE S950206 A IES950206 A IE S950206A IE S950206 A2 IES950206 A2 IE S950206A2
- Authority
- IE
- Ireland
- Prior art keywords
- dimethylpropylamines
- pyridyl
- separation
- compound
- optical antipodes
- Prior art date
Links
- NSAGKCVHEKTUFT-UHFFFAOYSA-N N,N-dimethyl-1-phenyl-1-pyridin-2-ylpropan-1-amine Chemical class C1(=CC=CC=C1)C(CC)(N(C)C)C1=NC=CC=C1 NSAGKCVHEKTUFT-UHFFFAOYSA-N 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 230000003287 optical effect Effects 0.000 title 1
- 238000000926 separation method Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 150000003839 salts Chemical class 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- 230000001387 anti-histamine Effects 0.000 abstract 1
- 235000003704 aspartic acid Nutrition 0.000 abstract 1
- -1 benzenesulphonyl aspartic acid Chemical class 0.000 abstract 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Chemical group 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
Landscapes
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A process for preparing in substantially pure form the d-isor of a compound of the formula I <CHEM 1> wherein X is chlorine or bromine and n is 0 or 1, or a pharmaceutically acceptable acid addition salt thereof, comprises reacting the d1-form of a compound of the formula I with a D-substituted benzenesulphonyl aspartic acid or a salt thereof as resolving agent and, if desired, converting the compound thus obtained into a pharmaceutically acceptable acid addition salt thereof. These compounds have strong anti-histaminic activity.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IES950206 IES65748B2 (en) | 1995-03-23 | 1995-03-23 | Process for the separation of the optical antipodes of racemic phenyl-(2-Pyridyl)-dimethylpropylamines |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IES950206 IES65748B2 (en) | 1995-03-23 | 1995-03-23 | Process for the separation of the optical antipodes of racemic phenyl-(2-Pyridyl)-dimethylpropylamines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IES950206A2 true IES950206A2 (en) | 1995-11-01 |
| IES65748B2 IES65748B2 (en) | 1995-11-01 |
Family
ID=11040689
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IES950206 IES65748B2 (en) | 1995-03-23 | 1995-03-23 | Process for the separation of the optical antipodes of racemic phenyl-(2-Pyridyl)-dimethylpropylamines |
Country Status (1)
| Country | Link |
|---|---|
| IE (1) | IES65748B2 (en) |
-
1995
- 1995-03-23 IE IES950206 patent/IES65748B2/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| IES65748B2 (en) | 1995-11-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Patent lapsed |