IL101717A - WF11234 substance a method of preparation thereof and fungicidal and protozoicidal pharmaceutical compositions containing the same - Google Patents

WF11234 substance a method of preparation thereof and fungicidal and protozoicidal pharmaceutical compositions containing the same

Info

Publication number: IL101717A
Authority: IL; Israel
Prior art keywords: substance; salts; culture; protozoicide; salt
Prior art date: 1991-05-09

Application number

IL10171792A

Other languages

English (en)

Other versions

IL101717A0 (en

Original Assignee

Fujisawa Pharmaceutical Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-05-09

Filing date

1992-04-28

Publication date

1995-12-08

1991-05-09 Priority claimed from JP3132234A external-priority patent/JPH04335891A/ja

1991-10-21 Priority claimed from JP3299552A external-priority patent/JPH05112599A/ja

1992-04-28 Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co

1992-12-30 Publication of IL101717A0 publication Critical patent/IL101717A0/xx

1995-12-08 Publication of IL101717A publication Critical patent/IL101717A/en

Links

239000000126 substance Substances 0.000 title claims description 85
238000000034 method Methods 0.000 title claims description 17
230000000855 fungicidal effect Effects 0.000 title claims description 8
239000008194 pharmaceutical composition Substances 0.000 title description 4
238000002360 preparation method Methods 0.000 title description 4
150000003839 salts Chemical class 0.000 claims description 19
244000005700 microbiome Species 0.000 claims description 18
241000233866 Fungi Species 0.000 claims description 12
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 9
239000004480 active ingredient Substances 0.000 claims description 9
201000000317 pneumocystosis Diseases 0.000 claims description 9
208000015181 infectious disease Diseases 0.000 claims description 8
208000005384 Pneumocystis Pneumonia Diseases 0.000 claims description 7
206010073755 Pneumocystis jirovecii pneumonia Diseases 0.000 claims description 7
239000000843 powder Substances 0.000 claims description 7
OKKJLVBELUTLKV-MZCSYVLQSA-N Deuterated methanol Chemical compound [2H]OC([2H])([2H])[2H] OKKJLVBELUTLKV-MZCSYVLQSA-N 0.000 claims description 6
239000000417 fungicide Substances 0.000 claims description 5
238000000655 nuclear magnetic resonance spectrum Methods 0.000 claims description 5
239000003937 drug carrier Substances 0.000 claims description 3
238000004992 fast atom bombardment mass spectroscopy Methods 0.000 claims description 3
239000000546 pharmaceutical excipient Substances 0.000 claims description 3
241000233870 Pneumocystis Species 0.000 claims description 2
206010035660 Pneumocystis Infections Diseases 0.000 claims description 2
238000002844 melting Methods 0.000 claims description 2
230000008018 melting Effects 0.000 claims description 2
206010073756 Pneumocystis jirovecii infection Diseases 0.000 claims 1
238000012258 culturing Methods 0.000 claims 1
150000001875 compounds Chemical class 0.000 abstract description 6
230000000843 anti-fungal effect Effects 0.000 abstract 1
230000000842 anti-protozoal effect Effects 0.000 abstract 1
229940121375 antifungal agent Drugs 0.000 abstract 1
229920001184 polypeptide Polymers 0.000 abstract 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1
WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 42
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 30
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 18
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 14
239000000047 product Substances 0.000 description 13
239000002609 medium Substances 0.000 description 12
241000699670 Mus sp. Species 0.000 description 11
229920001817 Agar Polymers 0.000 description 9
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 9
239000008272 agar Substances 0.000 description 9
LFVGISIMTYGQHF-UHFFFAOYSA-N ammonium dihydrogen phosphate Chemical compound [NH4+].OP(O)([O-])=O LFVGISIMTYGQHF-UHFFFAOYSA-N 0.000 description 9
238000004519 manufacturing process Methods 0.000 description 9
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 8
LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 8
210000004276 hyalin Anatomy 0.000 description 8
230000003405 preventing effect Effects 0.000 description 8
230000002265 prevention Effects 0.000 description 7
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
239000000443 aerosol Substances 0.000 description 6
238000006243 chemical reaction Methods 0.000 description 6
239000000203 mixture Substances 0.000 description 6
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 5
241000282414 Homo sapiens Species 0.000 description 5
150000001413 amino acids Chemical class 0.000 description 5
230000000694 effects Effects 0.000 description 5
239000003960 organic solvent Substances 0.000 description 5
230000002829 reductive effect Effects 0.000 description 5
239000000243 solution Substances 0.000 description 5
238000012360 testing method Methods 0.000 description 5
241000222122 Candida albicans Species 0.000 description 4
UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 4
229940095731 candida albicans Drugs 0.000 description 4
238000001990 intravenous administration Methods 0.000 description 4
229910052757 nitrogen Inorganic materials 0.000 description 4
239000001965 potato dextrose agar Substances 0.000 description 4
239000002904 solvent Substances 0.000 description 4
238000003756 stirring Methods 0.000 description 4
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 3
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
239000001888 Peptone Substances 0.000 description 3
108010080698 Peptones Proteins 0.000 description 3
240000004808 Saccharomyces cerevisiae Species 0.000 description 3
239000013543 active substance Substances 0.000 description 3
239000002585 base Substances 0.000 description 3
229910052799 carbon Inorganic materials 0.000 description 3
238000001514 detection method Methods 0.000 description 3
201000010099 disease Diseases 0.000 description 3
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
229940079593 drug Drugs 0.000 description 3
239000003814 drug Substances 0.000 description 3
238000000855 fermentation Methods 0.000 description 3
230000004151 fermentation Effects 0.000 description 3
239000008103 glucose Substances 0.000 description 3
238000004128 high performance liquid chromatography Methods 0.000 description 3
238000011534 incubation Methods 0.000 description 3
238000007918 intramuscular administration Methods 0.000 description 3
230000001788 irregular Effects 0.000 description 3
235000012054 meals Nutrition 0.000 description 3
230000003641 microbiacidal effect Effects 0.000 description 3
230000007935 neutral effect Effects 0.000 description 3
235000019319 peptone Nutrition 0.000 description 3
NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 description 3
238000000746 purification Methods 0.000 description 3
230000002441 reversible effect Effects 0.000 description 3
FVAUCKIRQBBSSJ-UHFFFAOYSA-M sodium iodide Chemical compound [Na+].[I-] FVAUCKIRQBBSSJ-UHFFFAOYSA-M 0.000 description 3
239000000725 suspension Substances 0.000 description 3
229920000742 Cotton Polymers 0.000 description 2
108010068370 Glutens Proteins 0.000 description 2
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
229920000881 Modified starch Polymers 0.000 description 2
239000004368 Modified starch Substances 0.000 description 2
241000699666 Mus <mouse, genus> Species 0.000 description 2
241000233872 Pneumocystis carinii Species 0.000 description 2
WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 description 2
CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
229930006000 Sucrose Natural products 0.000 description 2
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 2
238000000862 absorption spectrum Methods 0.000 description 2
239000002253 acid Substances 0.000 description 2
-1 alkali metal salts Chemical class 0.000 description 2
239000003708 ampul Substances 0.000 description 2
238000004458 analytical method Methods 0.000 description 2
230000037396 body weight Effects 0.000 description 2
229940041514 candida albicans extract Drugs 0.000 description 2
239000006285 cell suspension Substances 0.000 description 2
239000002537 cosmetic Substances 0.000 description 2
235000012343 cottonseed oil Nutrition 0.000 description 2
239000002385 cottonseed oil Substances 0.000 description 2
238000011161 development Methods 0.000 description 2
239000008121 dextrose Substances 0.000 description 2
238000005516 engineering process Methods 0.000 description 2
239000000284 extract Substances 0.000 description 2
235000013305 food Nutrition 0.000 description 2
230000002538 fungal effect Effects 0.000 description 2
239000000499 gel Substances 0.000 description 2
235000021312 gluten Nutrition 0.000 description 2
239000001963 growth medium Substances 0.000 description 2
229930195733 hydrocarbon Natural products 0.000 description 2
150000002430 hydrocarbons Chemical class 0.000 description 2
238000001727 in vivo Methods 0.000 description 2
239000007924 injection Substances 0.000 description 2
238000002347 injection Methods 0.000 description 2
NNPPMTNAJDCUHE-UHFFFAOYSA-N isobutane Chemical compound CC(C)C NNPPMTNAJDCUHE-UHFFFAOYSA-N 0.000 description 2
239000007788 liquid Substances 0.000 description 2
159000000003 magnesium salts Chemical class 0.000 description 2
230000014759 maintenance of location Effects 0.000 description 2
239000012046 mixed solvent Substances 0.000 description 2
235000019426 modified starch Nutrition 0.000 description 2
229910000402 monopotassium phosphate Inorganic materials 0.000 description 2
VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 2
239000002504 physiological saline solution Substances 0.000 description 2
229920001296 polysiloxane Polymers 0.000 description 2
BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 2
239000003380 propellant Substances 0.000 description 2
238000011160 research Methods 0.000 description 2
239000011347 resin Substances 0.000 description 2
229920005989 resin Polymers 0.000 description 2
235000017557 sodium bicarbonate Nutrition 0.000 description 2
229910000030 sodium bicarbonate Inorganic materials 0.000 description 2
239000007787 solid Substances 0.000 description 2
239000005720 sucrose Substances 0.000 description 2
238000003786 synthesis reaction Methods 0.000 description 2
238000004809 thin layer chromatography Methods 0.000 description 2
LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 2
239000012138 yeast extract Substances 0.000 description 2
PAWQVTBBRAZDMG-UHFFFAOYSA-N 2-(3-bromo-2-fluorophenyl)acetic acid Chemical compound OC(=O)CC1=CC=CC(Br)=C1F PAWQVTBBRAZDMG-UHFFFAOYSA-N 0.000 description 1
MWBWWFOAEOYUST-UHFFFAOYSA-N 2-aminopurine Chemical compound NC1=NC=C2N=CNC2=N1 MWBWWFOAEOYUST-UHFFFAOYSA-N 0.000 description 1
ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
239000004254 Ammonium phosphate Substances 0.000 description 1
235000017060 Arachis glabrata Nutrition 0.000 description 1
244000105624 Arachis hypogaea Species 0.000 description 1
235000010777 Arachis hypogaea Nutrition 0.000 description 1
235000018262 Arachis monticola Nutrition 0.000 description 1
241000228212 Aspergillus Species 0.000 description 1
241001225321 Aspergillus fumigatus Species 0.000 description 1
241000228245 Aspergillus niger Species 0.000 description 1
241000222120 Candida <Saccharomycetales> Species 0.000 description 1
241000222178 Candida tropicalis Species 0.000 description 1
208000035473 Communicable disease Diseases 0.000 description 1
201000007336 Cryptococcosis Diseases 0.000 description 1
241001337994 Cryptococcus <scale insect> Species 0.000 description 1
241000221204 Cryptococcus neoformans Species 0.000 description 1
241000235646 Cyberlindnera jadinii Species 0.000 description 1
238000005033 Fourier transform infrared spectroscopy Methods 0.000 description 1
229930091371 Fructose Natural products 0.000 description 1
239000005715 Fructose Substances 0.000 description 1
RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
241000287828 Gallus gallus Species 0.000 description 1
244000137850 Marrubium vulgare Species 0.000 description 1
241001465754 Metazoa Species 0.000 description 1
241000235645 Pichia kudriavzevii Species 0.000 description 1
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
235000019764 Soybean Meal Nutrition 0.000 description 1
229920002472 Starch Polymers 0.000 description 1
241000209140 Triticum Species 0.000 description 1
235000021307 Triticum Nutrition 0.000 description 1
240000008042 Zea mays Species 0.000 description 1
235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
235000002017 Zea mays subsp mays Nutrition 0.000 description 1
150000007513 acids Chemical class 0.000 description 1
238000005273 aeration Methods 0.000 description 1
229910052783 alkali metal Inorganic materials 0.000 description 1
229910052784 alkaline earth metal Inorganic materials 0.000 description 1
229910000148 ammonium phosphate Inorganic materials 0.000 description 1
235000019289 ammonium phosphates Nutrition 0.000 description 1
150000003863 ammonium salts Chemical class 0.000 description 1
BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
229910052921 ammonium sulfate Inorganic materials 0.000 description 1
235000011130 ammonium sulphate Nutrition 0.000 description 1
239000010775 animal oil Substances 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
229940091771 aspergillus fumigatus Drugs 0.000 description 1
239000012752 auxiliary agent Substances 0.000 description 1
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
230000004071 biological effect Effects 0.000 description 1
238000007664 blowing Methods 0.000 description 1
229940036811 bone meal Drugs 0.000 description 1
239000002374 bone meal Substances 0.000 description 1
210000000621 bronchi Anatomy 0.000 description 1
229910000019 calcium carbonate Inorganic materials 0.000 description 1
159000000007 calcium salts Chemical class 0.000 description 1
239000002775 capsule Substances 0.000 description 1
235000013877 carbamide Nutrition 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
238000004587 chromatography analysis Methods 0.000 description 1
150000001868 cobalt Chemical class 0.000 description 1
239000003086 colorant Substances 0.000 description 1
239000012141 concentrate Substances 0.000 description 1
150000001879 copper Chemical class 0.000 description 1
235000005822 corn Nutrition 0.000 description 1
239000006783 corn meal agar Substances 0.000 description 1
239000006071 cream Substances 0.000 description 1
238000012364 cultivation method Methods 0.000 description 1
MNNHAPBLZZVQHP-UHFFFAOYSA-N diammonium hydrogen phosphate Chemical compound [NH4+].[NH4+].OP([O-])([O-])=O MNNHAPBLZZVQHP-UHFFFAOYSA-N 0.000 description 1
208000037765 diseases and disorders Diseases 0.000 description 1
239000012153 distilled water Substances 0.000 description 1
210000005069 ears Anatomy 0.000 description 1
238000000921 elemental analysis Methods 0.000 description 1
239000000839 emulsion Substances 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
238000000605 extraction Methods 0.000 description 1
239000000706 filtrate Substances 0.000 description 1
239000000796 flavoring agent Substances 0.000 description 1
235000019634 flavors Nutrition 0.000 description 1
235000013312 flour Nutrition 0.000 description 1
239000006260 foam Substances 0.000 description 1
208000024386 fungal infectious disease Diseases 0.000 description 1
235000011187 glycerol Nutrition 0.000 description 1
239000003102 growth factor Substances 0.000 description 1
230000007062 hydrolysis Effects 0.000 description 1
238000006460 hydrolysis reaction Methods 0.000 description 1
238000009776 industrial production Methods 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
230000002401 inhibitory effect Effects 0.000 description 1
230000005764 inhibitory process Effects 0.000 description 1
150000002484 inorganic compounds Chemical class 0.000 description 1
239000011630 iodine Substances 0.000 description 1
229910052740 iodine Inorganic materials 0.000 description 1
239000001282 iso-butane Substances 0.000 description 1
238000002955 isolation Methods 0.000 description 1
230000002147 killing effect Effects 0.000 description 1
238000009630 liquid culture Methods 0.000 description 1
229940057995 liquid paraffin Drugs 0.000 description 1
210000004072 lung Anatomy 0.000 description 1
244000000010 microbial pathogen Species 0.000 description 1
238000005142 microbroth dilution method Methods 0.000 description 1
239000011785 micronutrient Substances 0.000 description 1
235000013369 micronutrients Nutrition 0.000 description 1
239000002480 mineral oil Substances 0.000 description 1
235000010446 mineral oil Nutrition 0.000 description 1
238000012986 modification Methods 0.000 description 1
230000004048 modification Effects 0.000 description 1
230000035772 mutation Effects 0.000 description 1
239000005445 natural material Substances 0.000 description 1
FEMOMIGRRWSMCU-UHFFFAOYSA-N ninhydrin Chemical compound C1=CC=C2C(=O)C(O)(O)C(=O)C2=C1 FEMOMIGRRWSMCU-UHFFFAOYSA-N 0.000 description 1
231100000252 nontoxic Toxicity 0.000 description 1
230000003000 nontoxic effect Effects 0.000 description 1
235000015097 nutrients Nutrition 0.000 description 1
239000006877 oatmeal agar Substances 0.000 description 1
239000002674 ointment Substances 0.000 description 1
150000002897 organic nitrogen compounds Chemical class 0.000 description 1
238000007911 parenteral administration Methods 0.000 description 1
235000020232 peanut Nutrition 0.000 description 1
239000008188 pellet Substances 0.000 description 1
239000000825 pharmaceutical preparation Substances 0.000 description 1
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
229920000053 polysorbate 80 Polymers 0.000 description 1
229910000027 potassium carbonate Inorganic materials 0.000 description 1
239000001103 potassium chloride Substances 0.000 description 1
235000011164 potassium chloride Nutrition 0.000 description 1
229910000160 potassium phosphate Inorganic materials 0.000 description 1
235000011009 potassium phosphates Nutrition 0.000 description 1
159000000001 potassium salts Chemical class 0.000 description 1
239000001294 propane Substances 0.000 description 1
230000002685 pulmonary effect Effects 0.000 description 1
238000005086 pumping Methods 0.000 description 1
239000011541 reaction mixture Substances 0.000 description 1
238000001953 recrystallisation Methods 0.000 description 1
239000000741 silica gel Substances 0.000 description 1
229910002027 silica gel Inorganic materials 0.000 description 1
229910000029 sodium carbonate Inorganic materials 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
235000009518 sodium iodide Nutrition 0.000 description 1
239000001488 sodium phosphate Substances 0.000 description 1
229910000162 sodium phosphate Inorganic materials 0.000 description 1
159000000000 sodium salts Chemical class 0.000 description 1
238000000638 solvent extraction Methods 0.000 description 1
238000002336 sorption--desorption measurement Methods 0.000 description 1
239000004455 soybean meal Substances 0.000 description 1
239000007921 spray Substances 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
230000000087 stabilizing effect Effects 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1
238000010254 subcutaneous injection Methods 0.000 description 1
239000007929 subcutaneous injection Substances 0.000 description 1
239000000829 suppository Substances 0.000 description 1
230000008719 thickening Effects 0.000 description 1
239000002562 thickening agent Substances 0.000 description 1
230000000699 topical effect Effects 0.000 description 1
231100000820 toxicity test Toxicity 0.000 description 1
RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
150000003672 ureas Chemical class 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
210000003462 vein Anatomy 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/911—Microorganisms using fungi

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Genetics & Genomics (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Biochemistry (AREA)
Veterinary Medicine (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Polarising Elements (AREA)
Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
Peptides Or Proteins (AREA)
Thin Magnetic Films (AREA)
Led Devices (AREA)
Stereophonic System (AREA)
Secondary Cells (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
Sampling And Sample Adjustment (AREA)
Medicines Containing Plant Substances (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

IL10171792A 1991-05-09 1992-04-28 WF11234 substance a method of preparation thereof and fungicidal and protozoicidal pharmaceutical compositions containing the same IL101717A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP3132234A JPH04335891A (ja)	1991-05-09	1991-05-09	Ｗｆ１１２４３物質、その製法及び用途
JP3299552A JPH05112599A (ja)	1991-10-21	1991-10-21	Ｗｆ１１２４３物質、その製法及び生物学的利用

Publications (2)

Publication Number	Publication Date
IL101717A0 IL101717A0 (en)	1992-12-30
IL101717A true IL101717A (en)	1995-12-08

Family

ID=26466858

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL10171792A IL101717A (en)	1991-05-09	1992-04-28	WF11234 substance a method of preparation thereof and fungicidal and protozoicidal pharmaceutical compositions containing the same

Country Status (11)

Country	Link
US (2)	US5446022A (de)
EP (1)	EP0584360B1 (de)
AT (1)	ATE149521T1 (de)
AU (1)	AU652639B2 (de)
CA (1)	CA2102705A1 (de)
DE (1)	DE69217936T2 (de)
HU (1)	HUT69150A (de)
IL (1)	IL101717A (de)
MX (1)	MX9202145A (de)
TW (1)	TW199162B (de)
WO (1)	WO1992019648A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL101717A (en) *	1991-05-09	1995-12-08	Fujisawa Pharmaceutical Co	WF11234 substance a method of preparation thereof and fungicidal and protozoicidal pharmaceutical compositions containing the same
GB9506372D0 (en) *	1995-03-29	1995-05-17	Fujisawa Pharmaceutical Co	New peptide compounds
JP3123078B2 (ja)	1996-03-08	2001-01-09	藤沢薬品工業株式会社	環状リポペプチド物質の脱アシル化法
MA26663A1 (fr) *	1998-07-23	2004-12-20	Hoffmann La Roche	Nouvelles aerothricines et leurs applications antifongiques
WO2001053322A2 (en) *	2000-01-17	2001-07-26	Basilea Pharmaceutica Ag	Aerothricin analogs, their preparation and use
JP2013147429A (ja) *	2010-04-27	2013-08-01	Astellas Pharma Inc	デプシペプチド化合物

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4931352A (en) *	1987-10-07	1990-06-05	Merck & Co., Inc.	Antifungal fermentation product
US4968608A (en) *	1987-10-07	1990-11-06	Merck & Co., Inc.	Process for antifungal fermentation product
JPH01104097A (ja) *	1988-03-10	1989-04-21	Sankyo Co Ltd	マイコプラネシン誘導体
US5166135A (en) *	1988-09-12	1992-11-24	Merck & Company, Inc.	Method for the control of pneumocystis carinii
DK173802B1 (da) *	1988-09-12	2001-11-05	Merck & Co Inc	Præparat til behandling af Pneumocystis carinii infeksioner og anvendelse af et cyclohexapeptid til fremstilling af et lægemiddel mod Pneumocystis carinii infektioner
US5194377A (en) *	1989-06-30	1993-03-16	Merck & Co., Inc.	Antibiotic agent
US5021341A (en) *	1990-03-12	1991-06-04	Merck & Co., Inc.	Antibiotic agent produced by the cultivation of Zalerion microorganism in the presence of mannitol
CA2020063A1 (en) *	1989-06-30	1990-12-31	Robert A. Giacobbe	Antibiotic agent
US5021403A (en) *	1990-03-19	1991-06-04	Merck & Co., Inc.	Antibiotic agents
US5162211A (en) *	1990-03-19	1992-11-10	Merck & Co., Inc.	Process for producing a cyclic lipopeptide employing zalerion arboricola
US5137813A (en) *	1990-06-18	1992-08-11	Merck & Co., Inc.	Process for production of an antibiotic compound using zalerion arboricola
US5306708A (en) *	1990-12-19	1994-04-26	Merck & Co., Inc.	Antibiotic agent
US5229363A (en) *	1991-02-19	1993-07-20	Merck & Co., Inc.	Cyclic hexapeptide compounds
IL101717A (en) *	1991-05-09	1995-12-08	Fujisawa Pharmaceutical Co	WF11234 substance a method of preparation thereof and fungicidal and protozoicidal pharmaceutical compositions containing the same

1992
- 1992-04-28 IL IL10171792A patent/IL101717A/en not_active IP Right Cessation
- 1992-04-28 TW TW081103309A patent/TW199162B/zh active
- 1992-05-08 AT AT92909843T patent/ATE149521T1/de not_active IP Right Cessation
- 1992-05-08 CA CA002102705A patent/CA2102705A1/en not_active Abandoned
- 1992-05-08 DE DE69217936T patent/DE69217936T2/de not_active Expired - Fee Related
- 1992-05-08 HU HU9303165A patent/HUT69150A/hu active IP Right Revival
- 1992-05-08 MX MX9202145A patent/MX9202145A/es unknown
- 1992-05-08 WO PCT/JP1992/000586 patent/WO1992019648A1/ja not_active Ceased
- 1992-05-08 EP EP92909843A patent/EP0584360B1/de not_active Expired - Lifetime
- 1992-05-08 AU AU17404/92A patent/AU652639B2/en not_active Ceased
- 1992-05-08 US US08/140,074 patent/US5446022A/en not_active Expired - Fee Related
1995
- 1995-04-27 US US08/429,636 patent/US5547934A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0584360B1 (de)	1997-03-05
MX9202145A (es)	1992-11-01
ATE149521T1 (de)	1997-03-15
EP0584360A4 (en)	1994-08-17
US5446022A (en)	1995-08-29
CA2102705A1 (en)	1992-11-10
DE69217936T2 (de)	1997-06-19
EP0584360A1 (de)	1994-03-02
AU1740492A (en)	1992-12-21
IL101717A0 (en)	1992-12-30
AU652639B2 (en)	1994-09-01
HU9303165D0 (en)	1994-03-28
WO1992019648A1 (en)	1992-11-12
DE69217936D1 (de)	1997-04-10
US5547934A (en)	1996-08-20
HUT69150A (en)	1995-08-28
TW199162B (de)	1993-02-01

Legal Events

Date	Code	Title
1996-06-18	FF	Patent granted
1999-04-11	RH	Patent void
2006-02-21	HC	Change of name of proprietor(s)

Publication	Publication Date	Title
EP0431350B1 (de)	1995-07-26	Polypeptid und Verfahren zu dessen Herstellung
EP2261317A1 (de)	2010-12-15	Cyclische verbindung produzierender mikroorganismus
RU2482130C2 (ru)	2013-05-20	Циклическое соединение и его соль
US5547934A (en)	1996-08-20	WF11243 substance
US5854276A (en)	1998-12-29	Substance WF16616, process for production thereof, and use thereof
NO853396L (no)	1986-03-03	Nye saframycin a derivater og fremgangsmaate til fremstilling derav.
JP2661367B2 (ja)	1997-10-08	Ｗｆ１１２４３物質
JP2002510335A (ja)	2002-04-02	新規化合物ｗｆ００１４４
JP4095815B2 (ja)	2008-06-04	トリプシンの新規インヒビターｔｕ−５３５０物質とその製造法及び用途
KR100474161B1 (ko)	2005-03-10	에어로트리신 유도체, 이의 제조 방법 및 이를 함유하는 약학조성물
JPWO1992019648A1 (ja)	1993-05-13	Ｗｆ１１２４３物質
HU211527A9 (hu)	1995-11-28	Az átmeneti oltalom az 1. és 6-8. igénypontokra vonatkozik
JPH05112599A (ja)	1993-05-07	Ｗｆ１１２４３物質、その製法及び生物学的利用
KR0143769B1 (ko)	1998-07-01	항균성 폴리펩티드 화합물과 그 제조방법 및 이를 함유하는 약학 조성물
JPH1045617A (ja)	1998-02-17	抗原虫剤
JPH06145067A (ja)	1994-05-24	カリニ感染症予防治療剤
WO2001029182A1 (en)	2001-04-26	Novel compound, wf217
JPH04335891A (ja)	1992-11-24	Ｗｆ１１２４３物質、その製法及び用途
GB2293379A (en)	1996-03-27	WF17819 substance
WO2001000639A1 (en)	2001-01-04	Novel sordarin derivative as a therapeutic antimicrobial agent
WO1999063102A1 (en)	1999-12-09	ANTIDIABETIC ACTIVE COMPOUND(S) WF19353 AND PROCESS FOR THEIR FERMENTATIVE PREPARATION USING A FUNGUS OF THE GENUS $i(HELICOMYCES)
JPH08259585A (ja)	1996-10-08	生理活性物質ｆｒ１８３７８３