IL102385A - Vitamin D compounds and their preparation - Google Patents

Vitamin D compounds and their preparation

Info

Publication number: IL102385A
Authority: IL; Israel
Prior art keywords: vitamin; group; compound; compounds; preparation
Prior art date: 1991-07-05

Application number

IL10238592A

Other languages

English (en)

Other versions

IL102385A0 (en

Original Assignee

Duphar Int Res

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-07-05

Filing date

1992-07-02

Publication date

1996-09-12

1992-07-02 Application filed by Duphar Int Res filed Critical Duphar Int Res

1993-01-14 Publication of IL102385A0 publication Critical patent/IL102385A0/xx

1996-09-12 Publication of IL102385A publication Critical patent/IL102385A/xx

Links

229930003316 Vitamin D Natural products 0.000 title abstract 4
-1 Vitamin D compounds Chemical class 0.000 title abstract 4
QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 title abstract 4
235000019166 vitamin D Nutrition 0.000 title abstract 4
239000011710 vitamin D Substances 0.000 title abstract 4
229940046008 vitamin d Drugs 0.000 title abstract 4
125000003342 alkenyl group Chemical group 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
BNRNAKTVFSZAFA-UHFFFAOYSA-N hydrindane Chemical compound C1CCCC2CCCC21 BNRNAKTVFSZAFA-UHFFFAOYSA-N 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
150000002596 lactones Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/30—Compounds having groups
- C07C43/315—Compounds having groups containing oxygen atoms singly bound to carbon atoms not being acetal carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/20—Free hydroxyl or mercaptan
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/50—Organo-phosphines
- C07F9/53—Organo-phosphine oxides; Organo-phosphine thioxides
- C07F9/532—Cycloaliphatic phosphine oxides or thioxides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/24—All rings being cycloaliphatic the ring system containing nine carbon atoms, e.g. perhydroindane

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Obesity (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Hematology (AREA)
Nutrition Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Furan Compounds (AREA)
Epoxy Compounds (AREA)

IL10238592A 1991-07-05 1992-07-02 Vitamin D compounds and their preparation IL102385A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP91201746		1991-07-05
EP92200154		1992-01-20

Publications (2)

Publication Number	Publication Date
IL102385A0 IL102385A0 (en)	1993-01-14
IL102385A true IL102385A (en)	1996-09-12

Family

ID=26129316

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL10238592A IL102385A (en)	1991-07-05	1992-07-02	Vitamin D compounds and their preparation

Country Status (12)

Country	Link
US (3)	US5403940A (fr)
EP (1)	EP0521550B1 (fr)
JP (1)	JP3342047B2 (fr)
AT (1)	ATE143007T1 (fr)
AU (1)	AU650148B2 (fr)
CA (1)	CA2072915C (fr)
DE (1)	DE69213844T2 (fr)
DK (1)	DK0521550T3 (fr)
ES (1)	ES2093180T3 (fr)
GR (1)	GR3022053T3 (fr)
IL (1)	IL102385A (fr)
NZ (1)	NZ243409A (fr)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1333616C (fr) *	1989-03-09	1994-12-20	Hector F. Deluca	Composes de type 19-nor-vitamine d
US20040009958A1 (en) *	1991-01-08	2004-01-15	Bone Care International, Inc.	Methods for preparation and use of 1alpha,24(S)-dihydroxyvitamin D2
US5830885A (en) *	1992-03-12	1998-11-03	The Johns Hopkins University	Antiproliferative vitamin D3 hybrids
DE4220757A1 (de) *	1992-06-24	1994-01-05	Schering Ag	Derivate in der Vitamin D-Reihe mit Modifikationen in der 20-Position, Verfahren zu ihrer Herstellung, Zwischenprodukte für dieses Verfahren, diese Derivate enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln
GB9220272D0 (en) *	1992-09-25	1992-11-11	Leo Pharm Prod Ltd	Chemical compounds
GB9220439D0 (en) *	1992-09-28	1992-11-11	Leo Pharm Prod Ltd	Chemical compounds
TW267161B (fr) *	1992-11-20	1996-01-01	Hoffmann La Roche
US5449668A (en) *	1993-06-04	1995-09-12	Duphar International Research B.V.	Vitamin D compounds and method of preparing these compounds
US5763429A (en) *	1993-09-10	1998-06-09	Bone Care International, Inc.	Method of treating prostatic diseases using active vitamin D analogues
US5565589A (en) *	1993-11-03	1996-10-15	Wisconsin Alumni Research Foundation	17-formyl-5,6-trans-vitamin D compounds
US6121469A (en) *	1993-12-23	2000-09-19	The Regents Of The University Of California	Therapeutically effective 1α,25-dihydroxyvitamin D3 analogs
DK0717034T3 (da) *	1994-12-14	1999-10-18	Duphar Int Res	Vitamin D-forbindelser og fremgangsmåde til fremstilling af disse forbindelser
US20020183288A1 (en) *	1995-04-03	2002-12-05	Bone Care International, Inc.	Method for treating and preventing hyperparathyroidism
US20040043971A1 (en) *	1995-04-03	2004-03-04	Bone Care International, Inc.	Method of treating and preventing hyperparathyroidism with active vitamin D analogs
US6242434B1 (en) *	1997-08-08	2001-06-05	Bone Care International, Inc.	24-hydroxyvitamin D, analogs and uses thereof
CA2175881A1 (fr) *	1995-05-09	1996-11-10	Andrzej Kutner	Composes de type vitamine d et methodes pour les preparer
GB9607034D0 (en) *	1996-04-03	1996-06-05	Leo Pharm Prod Ltd	Chemical compounds
US6566353B2 (en) *	1996-12-30	2003-05-20	Bone Care International, Inc.	Method of treating malignancy associated hypercalcemia using active vitamin D analogues
US20020128240A1 (en) *	1996-12-30	2002-09-12	Bone Care International, Inc.	Treatment of hyperproliferative diseases using active vitamin D analogues
JP2001511811A (ja) *	1997-02-13	2001-08-14	ボーンケアインターナショナルインコーポレイテッド	ビタミンｄ化合物の標的治療放出
US20030129194A1 (en) *	1997-02-13	2003-07-10	Bone Care International, Inc.	Targeted therapeutic delivery of vitamin D compounds
US6359152B2 (en)	1997-07-21	2002-03-19	Wisconsin Alumni Research Foundation	18-substituted-19-nor-vitamin D compounds
US5939406A (en) *	1997-07-21	1999-08-17	Wisconsin Alumni Research Foundation	18-substituted-19-nor-vitamin D compounds
US6087350A (en) *	1997-08-29	2000-07-11	University Of Pittsburgh Of The Commonwealth System Of Higher Education	Use of pretreatment chemicals to enhance efficacy of cytotoxic agents
WO1999012894A1 (fr) *	1997-09-08	1999-03-18	F. Hoffmann-La Roche Ag	Analogues de vitamine d3 de 1,3-dihydroxy-20,20-dialkyle
ES2368824T3 (es) *	1998-03-27	2011-11-22	Oregon Health & Science University	Vitamina d y sus análogos en el tratamiento de tumores y otros desórdenes hiperproliferativos.
WO2006120681A2 (fr) *	2005-05-10	2006-11-16	Dermipsor Ltd.	Compositions et procedes de soin de la peau
AU7895601A (en) *	2000-07-18	2002-01-30	Bone Care Int Inc	Stabilized 1alpha-hydroxy vitamin d
DE10129108A1 (de) *	2001-06-16	2003-01-02	Harman Becker Automotive Sys	Verfahren und Schaltungsanordnung zur Datenübertragung
CA2461295A1 (fr) *	2001-09-27	2003-04-03	The Coca-Cola Company	Vitaminisation de produits alimentaires
US7148211B2 (en) *	2002-09-18	2006-12-12	Genzyme Corporation	Formulation for lipophilic agents
US20040053895A1 (en) *	2002-09-18	2004-03-18	Bone Care International, Inc.	Multi-use vessels for vitamin D formulations
US7094775B2 (en) *	2004-06-30	2006-08-22	Bone Care International, Llc	Method of treating breast cancer using a combination of vitamin D analogues and other agents
US20060003950A1 (en) *	2004-06-30	2006-01-05	Bone Care International, Inc.	Method of treating prostatic diseases using a combination of vitamin D analogues and other agents
US9173835B2 (en)	2005-05-10	2015-11-03	Dermipsor Ltd.	Compositions and methods for treating hyperproliferative epidermal diseases
CN101437440B (zh) *	2005-12-14	2011-09-07	数字信号公司	跟踪眼球运动的系统和方法
CA2981549A1 (fr) *	2009-01-27	2010-08-05	Berg Llc	Vitamines d3 et analogues de celles-ci pour soulagement des effets secondaires associes a une chimiotherapie
CN106265695B (zh)	2009-08-14	2021-05-07	博格有限责任公司	用于治疗脱发的维生素d3及其类似物
CN112156097A (zh)	2013-05-29	2021-01-01	博格有限责任公司	使用维生素d预防或减轻化疗诱发的脱发
US20190183908A1 (en)	2016-05-13	2019-06-20	Case Western Reserve University	Autophagy activators for treating or preventing skin injury
US9989699B2 (en)	2016-10-27	2018-06-05	Corning Incorporated	Low bend loss single mode optical fiber
US11787835B2 (en)	2018-09-07	2023-10-17	Trustees Of Dartmouth College	C19 scaffolds and steroids and methods of use and manufacture thereof
US11512107B2 (en)	2018-09-07	2022-11-29	Trustees Of Dartmouth College	Methods for assembly of tetracyclic compounds by stereoselective C9-C10 bond formation

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4617297A (en) *	1982-02-12	1986-10-14	Hoffmann-La Roche Inc.	Method of treating disease states by the administration of 1α,25,26-trihydroxycholecalciferol
US4508651A (en) *	1983-03-21	1985-04-02	Hoffmann-La Roche Inc.	Synthesis of 1α,25-dihydroxyergocalciferol
US4613594A (en) *	1984-11-16	1986-09-23	Hoffmann-La Roche Inc.	Fluorinated vitamin D3 compounds
US4612308A (en) *	1984-11-29	1986-09-16	Hoffmann-La Roche Inc.	25,26-Dehydro-1α,23(S,R)-dihydroxycholecalciferol and its epimers
EP0205025A1 (fr) *	1985-05-27	1986-12-17	Sumitomo Pharmaceuticals Company, Limited	Dérivés fluorés de vitamine D3 et agents inducteurs de différentiation cellulaire les contenant comme composé actif
US4755329A (en) *	1985-06-10	1988-07-05	Wisconsin Alumni Research Foundation	Process and intermediates for preparing 1α-hydroxyvitamin D compounds
JPH07100685B2 (ja) *	1985-08-02	1995-11-01	レオ・ファ−マシュ−ティカル・プロダクツ・リミテッド・エイ／エス（レ−ベンス・ケミスケ・ファブリック・プロデュクチオンスアクチ−セルスカブ）	新規ビタミンｄ類似体
IL77668A (en) *	1986-01-21	1989-03-31	Teva Pharma	Production of cholecalciferol derivatives and novel intermediates used therefor
US4804502A (en) *	1988-01-20	1989-02-14	Hoffmann-La Roche Inc.	Vitamin D compounds
NZ232734A (en) *	1989-03-09	1991-11-26	Wisconsin Alumni Res Found	19-nor vitamin d derivatives and pharmaceutical compositions
CA1333616C (fr) *	1989-03-09	1994-12-20	Hector F. Deluca	Composes de type 19-nor-vitamine d
US5246925A (en) *	1989-03-09	1993-09-21	Wisconsin Alumni Research Foundation	19-nor-vitamin D compounds for use in treating hyperparathyroidism
US5449668A (en) *	1993-06-04	1995-09-12	Duphar International Research B.V.	Vitamin D compounds and method of preparing these compounds
US5617297A (en) *	1995-09-25	1997-04-01	National Semiconductor Corporation	Encapsulation filler technology for molding active electronics components such as IC cards or PCMCIA cards

1992
- 1992-06-24 AT AT92201851T patent/ATE143007T1/de not_active IP Right Cessation
- 1992-06-24 DE DE69213844T patent/DE69213844T2/de not_active Expired - Fee Related
- 1992-06-24 EP EP92201851A patent/EP0521550B1/fr not_active Expired - Lifetime
- 1992-06-24 ES ES92201851T patent/ES2093180T3/es not_active Expired - Lifetime
- 1992-06-24 DK DK92201851.0T patent/DK0521550T3/da active
- 1992-06-29 AU AU18649/92A patent/AU650148B2/en not_active Ceased
- 1992-07-01 NZ NZ243409A patent/NZ243409A/en not_active IP Right Cessation
- 1992-07-02 CA CA002072915A patent/CA2072915C/fr not_active Expired - Fee Related
- 1992-07-02 IL IL10238592A patent/IL102385A/xx not_active IP Right Cessation
- 1992-07-02 JP JP19928792A patent/JP3342047B2/ja not_active Expired - Fee Related
1994
- 1994-01-12 US US08/180,463 patent/US5403940A/en not_active Expired - Lifetime
- 1994-11-01 US US08/333,305 patent/US5637742A/en not_active Expired - Fee Related
1996
- 1996-12-17 GR GR960403487T patent/GR3022053T3/el unknown
1997
- 1997-02-13 US US08/799,346 patent/US6072062A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
IL102385A0 (en)	1993-01-14
US5403940A (en)	1995-04-04
EP0521550A2 (fr)	1993-01-07
GR3022053T3 (en)	1997-03-31
EP0521550A3 (en)	1993-06-16
NZ243409A (en)	1995-02-24
AU650148B2 (en)	1994-06-09
US6072062A (en)	2000-06-06
CA2072915C (fr)	2005-11-01
DE69213844T2 (de)	1997-04-10
AU1864992A (en)	1993-01-07
CA2072915A1 (fr)	1993-01-06
EP0521550B1 (fr)	1996-09-18
ES2093180T3 (es)	1996-12-16
US5637742A (en)	1997-06-10
ATE143007T1 (de)	1996-10-15
DE69213844D1 (de)	1996-10-24
JP3342047B2 (ja)	2002-11-05
DK0521550T3 (da)	1996-11-04
JPH05221961A (ja)	1993-08-31

Legal Events

Date	Code	Title
1997-02-18	FF	Patent granted
1997-04-15	KB	Patent renewed
1998-12-27	KB	Patent renewed
2002-08-14	KB	Patent renewed
2006-09-05	KB	Patent renewed
2011-02-28	MM9K	Patent not in force due to non-payment of renewal fees

Publication	Publication Date	Title
IL102385A (en)	1996-09-12	Vitamin D compounds and their preparation
DE2964049D1 (en)	1982-12-23	2-aryl-1,3-cyclohexanedione compounds and alkali metal salts, ammonium salts and enol esters thereof, composition and method of controlling acarina ectoparasites on warmblooded animals
AU6347294A (en)	1994-12-08	Vitamin D compounds, intermediates in preparation thereof and method of preparing these compounds
EG19555A (en)	1995-09-30	Method for preparing of taxol
EP0703902A4 (fr)	1996-04-10
IL107551A0 (en)	1994-02-27	Novel compounds useful as sweetening agents and their method of preparation
GB2185252B (en)	1989-11-22	Triazole derivatives
ES2145003T3 (es)	2000-07-01	Composicion que contiene un derivado de dioxabiciclo(3.3.0)octano.
EP0423697A3 (en)	1992-08-05	Emulsion of lipid containing a prostaglandin analogue
KR100252404B1 (en)	2000-04-15	Azetidinone compound and process for preparation thereof
ZA858418B (en)	1986-07-30	5-alkyl-1-phenyl-2-piperazinoalkylpyrazoline-3-one compounds and methods for the preparation thereof,intermediates for use in the preparation of said compounds and medicaments containing said compounds
FR2479213B1 (fr)	1982-05-28
GR850734B (fr)	1985-07-19
GB9119281D0 (en)	1991-10-23	Compound use and preparation
FR2498607B1 (fr)	1983-07-29
HU9200629D0 (en)	1992-05-28	Method for producing alpha-methylene-cyclopentanonne derivatives and preparatives containing said compounds
IE810265L (en)	1981-08-13	Indane derivatives
GB8611762D0 (en)	1986-06-25	Polycyclic biocidal compounds
JPS57212137A (en)	1982-12-27	Preparation of phenyl aliphtic acid derivative
JPS5424888A (en)	1979-02-24	Novel 7alpha-methoxycephalosporins and their preparation
DE3772703D1 (de)	1991-10-10	Verfahren zur herstellung von penemen.
RO93389B (ro)	1988-01-01	Procedeu pentru prepararea unor derivati de 4-fluortiolcarbanilida
ES8606319A1 (es)	1986-04-16	Un metodo para producir un derivado de acido ascorbico
FR2608047B1 (fr)	1990-08-31	Compositions zootechniques renfermant un derive de la 6-amino 7-hydroxy 4,5,6,7-tetrahydroimidazo /4,5,1-j-k/ /1/ benzazepin-2-(1h)-one