IL102573A - Hypoglycemic thiazolidinediones - Google Patents

Hypoglycemic thiazolidinediones

Info

Publication number: IL102573A
Authority: IL; Israel
Prior art keywords: phenyl; thiazolidine; enantiomer; dione; hydroxypropyl
Prior art date: 1991-07-22

Application number

IL102573A

Other languages

English (en)

Other versions

IL102573A0 (en

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-07-22

Filing date

1992-07-21

Publication date

1997-04-15

1992-07-21 Application filed by Pfizer filed Critical Pfizer

1992-07-21 Priority to IL114828A priority Critical patent/IL114828A/xx

1993-01-14 Publication of IL102573A0 publication Critical patent/IL102573A0/xx

1997-04-15 Publication of IL102573A publication Critical patent/IL102573A/xx

Links

229940123464 Thiazolidinedione Drugs 0.000 title 1
230000002218 hypoglycaemic effect Effects 0.000 title 1
150000001467 thiazolidinediones Chemical class 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
ZOBPZXTWZATXDG-UHFFFAOYSA-N 1,3-thiazolidine-2,4-dione Chemical compound O=C1CSC(=O)N1 ZOBPZXTWZATXDG-UHFFFAOYSA-N 0.000 abstract 2
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 1
125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
125000002091 cationic group Chemical group 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000003884 phenylalkyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Diabetes (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Hematology (AREA)
Obesity (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Plant Substances (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Thiazole And Isothizaole Compounds (AREA)

IL102573A 1991-07-22 1992-07-21 Hypoglycemic thiazolidinediones IL102573A (en)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
IL114828A IL114828A (en)	1991-07-22	1992-07-21	Thiazole compounds that are intermediates for hypoglycemic thiazolidinediones

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US73377191A	1991-07-22	1991-07-22

Publications (2)

Publication Number	Publication Date
IL102573A0 IL102573A0 (en)	1993-01-14
IL102573A true IL102573A (en)	1997-04-15

Family

ID=24949048

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL102573A IL102573A (en)	1991-07-22	1992-07-21	Hypoglycemic thiazolidinediones

Country Status (19)

Country	Link
US (1)	US6329408B1 (2)
EP (1)	EP0641338A1 (2)
JP (1)	JPH08823B2 (2)
CN (1)	CN1030195C (2)
AU (1)	AU665775B2 (2)
BR (1)	BR9206293A (2)
CA (1)	CA2111447C (2)
CZ (1)	CZ282831B6 (2)
HU (1)	HUT69692A (2)
IE (1)	IE922357A1 (2)
IL (1)	IL102573A (2)
MX (1)	MX9204279A (2)
NO (1)	NO301226B1 (2)
NZ (1)	NZ243653A (2)
PT (1)	PT100711B (2)
RU (1)	RU2079497C1 (2)
TW (1)	TW222626B (2)
WO (1)	WO1993002079A1 (2)
ZA (1)	ZA925468B (2)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FI940306A0 (fi) *	1991-07-22	1994-01-21	Pfizer	Menetelmä kiraalisten tiatsolidiini-2,4-dionijohdannaisten synteesissä tarvittavien välituotteiden valmistamiseksi
GB9308487D0 (en) *	1993-04-23	1993-06-09	Smithkline Beecham Plc	Novel compounds
PL337510A1 (en)	1997-06-18	2000-08-28	Smithkline Beecham Plc	Treatment of diabetes by means of derivatives of thiazolydinone and sulphonylurea
OA11677A (en)	1998-11-12	2005-01-12	Smithkline Beecham Plc	Pharmaceutical composition for modified release ofan insulin sensitiser and another antidiabetic agent.
AR023699A1 (es)	1998-11-12	2002-09-04	Smithkline Beecham Corp	Una composicion farmaceutica que comprende un estabilizador de insulina y un procedimiento para preparar una composicion farmaceutica
RU2267484C2 (ru) *	1999-04-28	2006-01-10	Авентис Фарма Дойчланд Гмбх	Производные диариловой кислоты и фармацевтическая композиция на их основе
TWI302149B (en) *	1999-09-22	2008-10-21	Bristol Myers Squibb Co	Substituted acid derivatives useful as antiodiabetic and antiobesity agents and method
KR100518142B1 (ko) *	1999-11-10	2005-10-04	다케다 야쿠힌 고교 가부시키가이샤	혈당저하 및 지질혈저하 활성을 갖는 5-원ｎ-헤테로고리형 화합물
KR100545507B1 (ko) *	2000-05-26	2006-01-24	니뽄 신야쿠 가부시키가이샤	복소환 유도체
GB0014969D0 (en)	2000-06-19	2000-08-09	Smithkline Beecham Plc	Novel method of treatment
JP2003040877A (ja) *	2001-07-24	2003-02-13	Sumika Fine Chemicals Co Ltd	５−［６−（２−フルオロベンジルオキシ）−２−ナフチル］メチル−２，４−チアゾリジンジオンの製造方法及びその精製方法
KR20050012771A (ko) *	2002-06-03	2005-02-02	노파르티스 아게	치환된 시아노피롤리딘의 용도 및 이들을 함유하는고지혈증 및 관련 질환의 치료를 위한 조합 제제
AU2003249879B2 (en) *	2002-07-03	2008-12-18	F. Hoffmann-La Roche Ag	Oxazole derivatives and their use as insulin sensitizers
US8268352B2 (en)	2002-08-05	2012-09-18	Torrent Pharmaceuticals Limited	Modified release composition for highly soluble drugs
US8216609B2 (en)	2002-08-05	2012-07-10	Torrent Pharmaceuticals Limited	Modified release composition of highly soluble drugs
KR20060121884A (ko) *	2003-09-22	2006-11-29	오노 야꾸힝 고교 가부시키가이샤	페닐초산 유도체, 그 제조 방법 및 용도
DE602004004631D1 (de) *	2004-04-01	2007-03-22	Sanofi Aventis Deutschland	Oxadiazolone, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Pharmazeutika
US20120094959A1 (en)	2010-10-19	2012-04-19	Bonnie Blazer-Yost	Treatment of cystic diseases
WO2016071727A1 (en)	2014-11-04	2016-05-12	INSERM (Institut National de la Santé et de la Recherche Médicale)	Methods for the prevention and the treatment of rapidly progressive glomerulonephritis
CN109867765A (zh) *	2019-02-28	2019-06-11	中山大学惠州研究院	一种长效缓释可降解防污聚氨酯及其制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5522636A (en)	1978-08-04	1980-02-18	Takeda Chem Ind Ltd	Thiazoliding derivative
US4367234A (en)	1980-07-28	1983-01-04	Pfizer Inc.	Hypoglycemic 5-substituted oxazolidine-2,4-diones
US4342771A (en)	1981-01-02	1982-08-03	Pfizer Inc.	Hypoglycemic 5-substituted oxazolidine-2,4-diones
US4617312A (en)	1983-01-17	1986-10-14	Pfizer Inc.	Aldose reductase inhibiting 5-(2-alkoxyphenyl) thiazolidinediones
CN1003445B (zh)	1984-10-03	1989-03-01	武田药品工业株式会社	噻唑烷二酮衍生物，其制备方法和用途
WO1986007056A1 (en)	1985-05-21	1986-12-04	Pfizer Inc.	Hypoglycemic thiazolidinediones
FI91869C (fi) *	1987-03-18	1994-08-25	Tanabe Seiyaku Co	Menetelmä antidiabeettisena aineena käytettävien bensoksatsolijohdannaisten valmistamiseksi
GB8713861D0 (en) *	1987-06-13	1987-07-15	Beecham Group Plc	Compounds
WO1989008651A1 (en) *	1988-03-08	1989-09-21	Pfizer Inc.	Hypoglycemic thiazolidinedione derivatives
US5036079A (en)	1989-12-07	1991-07-30	Pfizer Inc.	Hypoglycemic thiazolidinedione derivatives
US5089514A (en)	1990-06-14	1992-02-18	Pfizer Inc.	3-coxazolyl [phenyl, chromanyl or benzofuranyl]-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents

1992
- 1992-06-30 TW TW081105174A patent/TW222626B/zh active
- 1992-07-01 WO PCT/US1992/005436 patent/WO1993002079A1/en not_active Ceased
- 1992-07-01 JP JP5502812A patent/JPH08823B2/ja not_active Expired - Fee Related
- 1992-07-01 CA CA002111447A patent/CA2111447C/en not_active Expired - Fee Related
- 1992-07-01 RU RU94012853/04A patent/RU2079497C1/ru not_active IP Right Cessation
- 1992-07-01 HU HU9400181A patent/HUT69692A/hu unknown
- 1992-07-01 BR BR9206293A patent/BR9206293A/pt not_active Application Discontinuation
- 1992-07-01 CZ CS94124A patent/CZ282831B6/cs not_active IP Right Cessation
- 1992-07-01 AU AU22973/92A patent/AU665775B2/en not_active Ceased
- 1992-07-01 EP EP92915346A patent/EP0641338A1/en not_active Withdrawn
- 1992-07-20 PT PT100711A patent/PT100711B/pt active IP Right Grant
- 1992-07-21 MX MX9204279A patent/MX9204279A/es not_active IP Right Cessation
- 1992-07-21 ZA ZA925468A patent/ZA925468B/xx unknown
- 1992-07-21 NZ NZ243653A patent/NZ243653A/en unknown
- 1992-07-21 IE IE235792A patent/IE922357A1/en not_active Application Discontinuation
- 1992-07-21 IL IL102573A patent/IL102573A/xx not_active IP Right Cessation
- 1992-07-21 CN CN92108662A patent/CN1030195C/zh not_active Expired - Fee Related
1994
- 1994-01-21 NO NO940225A patent/NO301226B1/no unknown
1995
- 1995-06-01 US US08/458,071 patent/US6329408B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
RU2079497C1 (ru)	1997-05-20
IE922357A1 (en)	1993-01-27
CA2111447C (en)	2002-08-13
CA2111447A1 (en)	1993-02-04
NO301226B1 (no)	1997-09-29
HUT69692A (en)	1995-09-28
EP0641338A1 (en)	1995-03-08
CZ12494A3 (en)	1994-07-13
AU665775B2 (en)	1996-01-18
JPH07502487A (ja)	1995-03-16
HU9400181D0 (en)	1994-05-30
CZ282831B6 (cs)	1997-10-15
CN1068823A (zh)	1993-02-10
IL102573A0 (en)	1993-01-14
WO1993002079A1 (en)	1993-02-04
NZ243653A (en)	1995-02-24
PT100711B (pt)	1999-07-30
US6329408B1 (en)	2001-12-11
MX9204279A (es)	1994-03-31
TW222626B (2)	1994-04-21
BR9206293A (pt)	1994-11-08
NO940225D0 (no)	1994-01-21
PT100711A (pt)	1993-09-30
NO940225L (no)	1994-01-21
JPH08823B2 (ja)	1996-01-10
ZA925468B (en)	1994-01-21
CN1030195C (zh)	1995-11-01
AU2297392A (en)	1993-02-23

Legal Events

Date	Code	Title
1997-11-20	FF	Patent granted
1998-02-22	KB	Patent renewed
1998-12-27	KB	Patent renewed
2002-08-14	KB	Patent renewed
2007-05-21	MM9K	Patent not in force due to non-payment of renewal fees

Publication	Publication Date	Title
IL102573A (en)	1997-04-15	Hypoglycemic thiazolidinediones
AU3107889A (en)	1989-09-14	Hypoglycemic thiazolidinedione derivatives
NO903862D0 (no)	1990-09-05	Fremgangsmaate for fremstilling av en tiazolidindionhypoglykemisk aktiv forbindelse.
AU2001277723A1 (en)	2002-02-25	Ppardelta activators
CA2039056A1 (en)	1991-09-28	3,5-di-tertiarybutyl-4-hydroxyphenylmethylene derivatives of 2-substituted thiazolidinones, oxazolidinones, and imidazolidinones as antiinflammatory agents
CA2163028A1 (en)	1994-12-08	New thiazolidinediones and pharmaceutical agents containing them
ES2132135T3 (es)	1999-08-16	Procedimiento para la preparacion de compuestos de tiazolidina u oxazolidina farmaceuticamente activos mediante una reductasa de levadura.
MY103837A (en)	1993-09-30	Thiazolidinedione derivatives as hypoglycemic agents.
CA2321188A1 (en)	1999-09-02	Derivatives of azetidine and pyrrolidine
GR890100162A (en)	1990-01-19	7-(2-(s-amino1,2,4-thiadiazol-3yl)-2-(substituted-iminoacetamido)-3-(3-(quaternaryammonio)-1-propen-1-y)-3-cephem-4-carboxy-lates of the formula
RU92016545A (ru)	1995-05-20	Гетероциклические соединения, способ их получения и фармацевтическая композиция
ES2045067T3 (es)	1994-01-16	Procedimiento para preparar nuevos compuestos de tiazol.
IE791478L (en)	1980-02-03	N-substituted aziridine 2-carboxylic acid derivatives.
AU639672B2 (en)	1993-08-05	Acyloxypropanolamines
AU7244287A (en)	1987-11-05	Fungicidal pyridyl cyclopropane carboxamides
CA2111096A1 (en)	1993-01-07	Thiazolidinedione Hypoglycemic Agents
DK0534655T3 (da)	1995-08-28	Thiazolidin-2,4-dioner til behandling af hypertension
HU9500871D0 (en)	1995-05-29	Renin inhibiting n-(2-amino-2-oxo-ethyl)butanediamide derivatives
YU48914B (sh)	2002-11-15	Hipoglikemski tiazolidindioni i intermedijari
AU532634B2 (en)	1983-10-06	Thiazolyl derivatives
DE69623943D1 (de)	2002-10-31	Wasserfreie kristalle
AU3634489A (en)	1989-12-21	Aminomethylphenols and fungicides containing these compounds
IL114828A (en)	1997-04-15	Thiazole compounds that are intermediates for hypoglycemic thiazolidinediones
DK561389D0 (da)	1989-11-09	Hukommelsesforbedrende midler indeholdende dioxopiperidinderivater