IL102731A - תהליך תסיסה לייצור נטאמיצין - Google Patents

תהליך תסיסה לייצור נטאמיצין

Info

Publication number: IL102731A
Authority: IL; Israel
Prior art keywords: natamycin; fermentation; medium; inoculum; streptomyces
Prior art date: 1991-08-05

Application number

IL10273192A

Other languages

English (en)

Other versions

IL102731A0 (en

Original Assignee

Bio Tech Resources

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-08-05

Filing date

1992-08-05

Publication date

1996-01-31

1992-08-05 Application filed by Bio Tech Resources filed Critical Bio Tech Resources

1993-01-31 Publication of IL102731A0 publication Critical patent/IL102731A0/xx

1996-01-31 Publication of IL102731A publication Critical patent/IL102731A/he

Links

NCXMLFZGDNKEPB-FFPOYIOWSA-N natamycin Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C[C@@H](C)OC(=O)/C=C/[C@H]2O[C@@H]2C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 NCXMLFZGDNKEPB-FFPOYIOWSA-N 0.000 title claims abstract description 74
229960003255 natamycin Drugs 0.000 title claims abstract description 74
235000010298 natamycin Nutrition 0.000 title claims abstract description 74
239000004311 natamycin Substances 0.000 title claims abstract description 74
238000000855 fermentation Methods 0.000 title claims description 87
230000004151 fermentation Effects 0.000 title claims description 87
241000187747 Streptomyces Species 0.000 claims abstract description 35
239000002054 inoculum Substances 0.000 claims description 75
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 58
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 31
229910052799 carbon Inorganic materials 0.000 claims description 31
229910052757 nitrogen Inorganic materials 0.000 claims description 29
238000000034 method Methods 0.000 claims description 18
235000018102 proteins Nutrition 0.000 claims description 16
108090000623 proteins and genes Proteins 0.000 claims description 16
102000004169 proteins and genes Human genes 0.000 claims description 16
108010058643 Fungal Proteins Proteins 0.000 claims description 8
240000004808 Saccharomyces cerevisiae Species 0.000 claims description 4
241000493924 Streptomyces gilvosporeus Species 0.000 claims description 4
108010073771 Soybean Proteins Proteins 0.000 claims description 3
229940001941 soy protein Drugs 0.000 claims description 3
235000004252 protein component Nutrition 0.000 claims 1
239000002609 medium Substances 0.000 abstract description 48
239000013587 production medium Substances 0.000 abstract description 21
239000000725 suspension Substances 0.000 abstract description 18
230000000644 propagated effect Effects 0.000 abstract description 2
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 17
229920001817 Agar Polymers 0.000 description 16
239000008272 agar Substances 0.000 description 16
239000008103 glucose Substances 0.000 description 16
238000004519 manufacturing process Methods 0.000 description 16
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
238000012360 testing method Methods 0.000 description 9
239000000203 mixture Substances 0.000 description 8
239000001888 Peptone Substances 0.000 description 7
108010080698 Peptones Proteins 0.000 description 7
239000012153 distilled water Substances 0.000 description 7
230000002503 metabolic effect Effects 0.000 description 7
235000019319 peptone Nutrition 0.000 description 7
KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 6
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 5
229940041514 candida albicans extract Drugs 0.000 description 5
229910052760 oxygen Inorganic materials 0.000 description 5
239000001301 oxygen Substances 0.000 description 5
239000008188 pellet Substances 0.000 description 5
239000012138 yeast extract Substances 0.000 description 5
XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 4
240000008042 Zea mays Species 0.000 description 4
235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 4
235000002017 Zea mays subsp mays Nutrition 0.000 description 4
238000013019 agitation Methods 0.000 description 4
235000005822 corn Nutrition 0.000 description 4
235000015097 nutrients Nutrition 0.000 description 4
230000001954 sterilising effect Effects 0.000 description 4
238000004659 sterilization and disinfection Methods 0.000 description 4
241001602876 Nata Species 0.000 description 3
238000005273 aeration Methods 0.000 description 3
239000000284 extract Substances 0.000 description 3
239000011780 sodium chloride Substances 0.000 description 3
230000028070 sporulation Effects 0.000 description 3
ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 description 2
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 2
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 2
235000015278 beef Nutrition 0.000 description 2
229910052796 boron Inorganic materials 0.000 description 2
239000011575 calcium Substances 0.000 description 2
229910052791 calcium Inorganic materials 0.000 description 2
239000010941 cobalt Substances 0.000 description 2
229910017052 cobalt Inorganic materials 0.000 description 2
GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 2
238000007796 conventional method Methods 0.000 description 2
229910052802 copper Inorganic materials 0.000 description 2
239000010949 copper Substances 0.000 description 2
-1 etc. ) Substances 0.000 description 2
239000003102 growth factor Substances 0.000 description 2
239000004615 ingredient Substances 0.000 description 2
229910052500 inorganic mineral Inorganic materials 0.000 description 2
229910052742 iron Inorganic materials 0.000 description 2
239000007788 liquid Substances 0.000 description 2
239000011707 mineral Substances 0.000 description 2
235000010755 mineral Nutrition 0.000 description 2
239000011591 potassium Substances 0.000 description 2
229910052700 potassium Inorganic materials 0.000 description 2
230000001902 propagating effect Effects 0.000 description 2
235000019624 protein content Nutrition 0.000 description 2
239000011734 sodium Substances 0.000 description 2
229910052708 sodium Inorganic materials 0.000 description 2
229940071440 soy protein isolate Drugs 0.000 description 2
241000894007 species Species 0.000 description 2
239000011573 trace mineral Substances 0.000 description 2
235000013619 trace mineral Nutrition 0.000 description 2
238000012546 transfer Methods 0.000 description 2
235000013343 vitamin Nutrition 0.000 description 2
239000011782 vitamin Substances 0.000 description 2
229940088594 vitamin Drugs 0.000 description 2
229930003231 vitamin Natural products 0.000 description 2
229910052725 zinc Inorganic materials 0.000 description 2
239000011701 zinc Substances 0.000 description 2
DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 description 1
229920002261 Corn starch Polymers 0.000 description 1
XZMCDFZZKTWFGF-UHFFFAOYSA-N Cyanamide Chemical compound NC#N XZMCDFZZKTWFGF-UHFFFAOYSA-N 0.000 description 1
ZIIJJOPLRSCQNX-UHFFFAOYSA-N Flurazepam hydrochloride Chemical compound Cl.Cl.N=1CC(=O)N(CCN(CC)CC)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1F ZIIJJOPLRSCQNX-UHFFFAOYSA-N 0.000 description 1
DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 description 1
GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 description 1
108010009736 Protein Hydrolysates Proteins 0.000 description 1
244000061456 Solanum tuberosum Species 0.000 description 1
235000002595 Solanum tuberosum Nutrition 0.000 description 1
230000002411 adverse Effects 0.000 description 1
230000000843 anti-fungal effect Effects 0.000 description 1
230000001857 anti-mycotic effect Effects 0.000 description 1
239000002518 antifoaming agent Substances 0.000 description 1
239000002543 antimycotic Substances 0.000 description 1
239000012736 aqueous medium Substances 0.000 description 1
229960001230 asparagine Drugs 0.000 description 1
235000009582 asparagine Nutrition 0.000 description 1
239000007613 bennett's agar Substances 0.000 description 1
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
150000001720 carbohydrates Chemical group 0.000 description 1
239000003153 chemical reaction reagent Substances 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
238000011109 contamination Methods 0.000 description 1
230000007423 decrease Effects 0.000 description 1
239000013530 defoamer Substances 0.000 description 1
239000008121 dextrose Substances 0.000 description 1
238000010586 diagram Methods 0.000 description 1
229940111685 dibasic potassium phosphate Drugs 0.000 description 1
AIUDWMLXCFRVDR-UHFFFAOYSA-N dimethyl 2-(3-ethyl-3-methylpentyl)propanedioate Chemical class CCC(C)(CC)CCC(C(=O)OC)C(=O)OC AIUDWMLXCFRVDR-UHFFFAOYSA-N 0.000 description 1
ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 description 1
235000013312 flour Nutrition 0.000 description 1
238000005187 foaming Methods 0.000 description 1
150000004676 glycans Chemical class 0.000 description 1
238000011534 incubation Methods 0.000 description 1
238000011081 inoculation Methods 0.000 description 1
239000000463 material Substances 0.000 description 1
238000002156 mixing Methods 0.000 description 1
DTSSDPFTHGBSDX-KVTDHHQDSA-N mycosamine Chemical compound C[C@@H](O)[C@@H](O)[C@H](N)[C@H](O)C=O DTSSDPFTHGBSDX-KVTDHHQDSA-N 0.000 description 1
235000021049 nutrient content Nutrition 0.000 description 1
229940066779 peptones Drugs 0.000 description 1
150000004291 polyenes Chemical class 0.000 description 1
229920001282 polysaccharide Polymers 0.000 description 1
239000005017 polysaccharide Substances 0.000 description 1
229920001296 polysiloxane Polymers 0.000 description 1
229920001592 potato starch Polymers 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
VXPLXMJHHKHSOA-UHFFFAOYSA-N propham Chemical compound CC(C)OC(=O)NC1=CC=CC=C1 VXPLXMJHHKHSOA-UHFFFAOYSA-N 0.000 description 1
239000003531 protein hydrolysate Substances 0.000 description 1
238000011084 recovery Methods 0.000 description 1
238000012552 review Methods 0.000 description 1
239000008399 tap water Substances 0.000 description 1
235000020679 tap water Nutrition 0.000 description 1
150000005672 tetraenes Chemical class 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
- C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
- C12P19/626—Natamycin; Pimaricin; Tennecetin

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Life Sciences & Earth Sciences (AREA)
Wood Science & Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
Microbiology (AREA)
General Chemical & Material Sciences (AREA)
Biotechnology (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

IL10273192A 1991-08-05 1992-08-05 תהליך תסיסה לייצור נטאמיצין IL102731A (he)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US74054591A	1991-08-05	1991-08-05

Publications (2)

Publication Number	Publication Date
IL102731A0 IL102731A0 (en)	1993-01-31
IL102731A true IL102731A (he)	1996-01-31

Family

ID=24976976

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL10273192A IL102731A (he)	1991-08-05	1992-08-05	תהליך תסיסה לייצור נטאמיצין

Country Status (11)

Country	Link
EP (1)	EP0600983B1 (he)
CN (1)	CN1043659C (he)
AU (1)	AU2427992A (he)
CA (1)	CA2115038C (he)
DE (1)	DE69209510T2 (he)
ES (1)	ES2085031T3 (he)
IL (1)	IL102731A (he)
MX (1)	MX9204546A (he)
NZ (1)	NZ243848A (he)
WO (1)	WO1993003170A1 (he)
ZA (1)	ZA925876B (he)

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5591438A (en) *	1990-12-07	1997-01-07	Bio-Technical Resources L.P.	Natamycin recovery
WO2007039572A1 (en) *	2005-10-04	2007-04-12	Dsm Ip Assets B.V.	Improved anti-fungal composition
CN101062934B (zh) *	2007-05-31	2010-05-19	山东鲁抗医药股份有限公司	从发酵技术培养物中提取纳他霉素的方法
AU2009281457A1 (en)	2008-08-14	2010-02-18	Bayer Cropscience Ag	Insecticidal 4-phenyl-1H-pyrazoles
EP2204094A1 (en)	2008-12-29	2010-07-07	Bayer CropScience AG	Method for improved utilization of the production potential of transgenic plants Introduction
EP2227951A1 (de)	2009-01-23	2010-09-15	Bayer CropScience AG	Verwendung von Enaminocarbonylverbindungen zur Bekämpfung von durch Insekten übertragenen Viren
JP2013523795A (ja)	2010-04-06	2013-06-17	バイエル・インテレクチユアル・プロパテイー・ゲー・エム・ベー・ハー	植物のストレス耐性を増強させるための４−フェニル酪酸及び／又はその塩の使用
BR112012025848A2 (pt)	2010-04-09	2015-09-08	Bayer Ip Gmbh	uso de derivados do ácido (1-cianociclopropil) fenilfosfínico, os ésteres do mesmo e/ou os sais do mesmo para aumentar a tolerância de plantas a estresse abiótico.
WO2011151370A1 (en)	2010-06-03	2011-12-08	Bayer Cropscience Ag	N-[(het)arylalkyl)] pyrazole (thio)carboxamides and their heterosubstituted analogues
UA110703C2 (uk)	2010-06-03	2016-02-10	Байєр Кропсайнс Аг	Фунгіцидні похідні n-[(тризаміщений силіл)метил]-карбоксаміду
EP2474542A1 (en)	2010-12-29	2012-07-11	Bayer CropScience AG	Fungicide hydroximoyl-tetrazole derivatives
AR090010A1 (es)	2011-04-15	2014-10-15	Bayer Cropscience Ag	5-(ciclohex-2-en-1-il)-penta-2,4-dienos y 5-(ciclohex-2-en-1-il)-pent-2-en-4-inos sustituidos como principios activos contra el estres abiotico de las plantas, usos y metodos de tratamiento
AR085585A1 (es)	2011-04-15	2013-10-09	Bayer Cropscience Ag	Vinil- y alquinilciclohexanoles sustituidos como principios activos contra estres abiotico de plantas
US20140173770A1 (en)	2011-06-06	2014-06-19	Bayer Cropscience Nv	Methods and means to modify a plant genome at a preselected site
JP2014520776A (ja)	2011-07-04	2014-08-25	バイエル・インテレクチユアル・プロパテイー・ゲー・エム・ベー・ハー	植物における非生物的ストレスに対する活性薬剤としての置換されているイソキノリノン類、イソキノリンジオン類、イソキノリントリオン類およびジヒドロイソキノリノン類または各場合でのそれらの塩の使用
IN2014DN00156A (he)	2011-08-10	2015-05-22	Bayer Ip Gmbh
BR112014002988A2 (pt)	2011-08-12	2017-03-01	Bayer Cropscience Nv	expressão específica de célula de proteção de transgenes em algodão
AR087873A1 (es)	2011-09-16	2014-04-23	Bayer Ip Gmbh	Uso de fenilpirazolin-3-carboxilatos para mejorar el rendimiento de las plantas
EP2755484A1 (en)	2011-09-16	2014-07-23	Bayer Intellectual Property GmbH	Use of 5-phenyl- or 5-benzyl-2 isoxazoline-3 carboxylates for improving plant yield
UA115971C2 (uk)	2011-09-16	2018-01-25	Байєр Інтеллектуал Проперті Гмбх	Застосування ацилсульфонамідів для покращення врожайності рослин
BR112014006940A2 (pt)	2011-09-23	2017-04-04	Bayer Ip Gmbh	uso de derivados de ácido 1-fenilpirazol-3-carboxílico 4-substituído como agentes contra estresse abiótico em plantas
US9408386B2 (en)	2012-02-22	2016-08-09	Bayer Intellectual Property Gmbh	Use of succinate dehydrogenase inhibitors (SDHIs) for controlling wood diseases in grape
CN104611283B (zh) *	2012-12-27	2018-09-21	北京市农林科学院	一种重组利迪链霉菌及其应用
CN115323020B (zh) *	2022-07-21	2025-08-05	河北圣雪大成制药有限责任公司	一种用于生产纳他霉素的发酵培养基
CN115505615A (zh) *	2022-11-09	2022-12-23	淮北师范大学	一种基于链霉菌混菌发酵合成纳他霉素的方法
CN119776231A (zh) *	2025-01-23	2025-04-08	淮北师范大学	一种褐黄孢链霉菌zy8及其发酵种子和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH359517A (de) *	1956-03-13	1962-01-15	Koninklijke Gist Spiritus	Verfahren zur Herstellung von Pimaricin
GB846933A (en) *	1956-07-23	1960-09-07	American Cyanamid Co	New antifungal substance, pimaricin, and method of producing same

1992
- 1992-08-05 NZ NZ243848A patent/NZ243848A/en unknown
- 1992-08-05 EP EP92917836A patent/EP0600983B1/en not_active Expired - Lifetime
- 1992-08-05 AU AU24279/92A patent/AU2427992A/en not_active Abandoned
- 1992-08-05 CN CN92110469A patent/CN1043659C/zh not_active Expired - Lifetime
- 1992-08-05 ZA ZA925876A patent/ZA925876B/xx unknown
- 1992-08-05 MX MX9204546A patent/MX9204546A/es unknown
- 1992-08-05 ES ES92917836T patent/ES2085031T3/es not_active Expired - Lifetime
- 1992-08-05 IL IL10273192A patent/IL102731A/he not_active IP Right Cessation
- 1992-08-05 DE DE69209510T patent/DE69209510T2/de not_active Expired - Lifetime
- 1992-08-05 CA CA002115038A patent/CA2115038C/en not_active Expired - Lifetime
- 1992-08-05 WO PCT/US1992/006323 patent/WO1993003170A1/en not_active Ceased

Also Published As

Publication number	Publication date
CN1043659C (zh)	1999-06-16
DE69209510D1 (de)	1996-05-02
EP0600983A1 (en)	1994-06-15
MX9204546A (es)	1993-02-01
ES2085031T3 (es)	1996-05-16
DE69209510T2 (de)	1996-10-10
CN1071460A (zh)	1993-04-28
CA2115038A1 (en)	1993-02-18
ZA925876B (en)	1994-02-07
CA2115038C (en)	2002-10-22
IL102731A0 (en)	1993-01-31
AU2427992A (en)	1993-03-02
EP0600983B1 (en)	1996-03-27
NZ243848A (en)	1995-07-26
WO1993003170A1 (en)	1993-02-18

Legal Events

Date	Code	Title
1996-07-23	FF	Patent granted
1999-01-26	KB	Patent renewed
2002-09-12	KB	Patent renewed
2006-10-04	KB	Patent renewed
2010-11-30	KB	Patent renewed
2013-03-24	EXP	Patent expired

Publication	Publication Date	Title
EP0600983B1 (en)	1996-03-27	A fermentation process for producing natamycin
El‐Enshasy et al.	2000	Influence of inoculum type and cultivation conditions on natamycin production by Streptomyces natalensis
Srinivasan et al.	1991	Physiology and nutritional aspects of actinomycetes: an overview
US5231014A (en)	1993-07-27	Fermentation process for producing natamycin
US5686273A (en)	1997-11-11	Fermentation process for producing natamycin with additional carbon and nitrogen
SU695565A3 (ru)	1979-10-30	Способ получени клавулановой кислоты и ее солей
JPH0698010B2 (ja)	1994-12-07	免疫抑制剤の新規な製造方法
CA1316477C (en)	1993-04-20	Xylose isomerase, a method for production of such xylose isomerase, immobilized xylose isomerase and a method for isomerization of glucose to fructose
CA2115036C (en)	2002-11-12	Continuous natamycin production
US5902579A (en)	1999-05-11	Natamycin-containing streptomyces biomass and its use in animal feed
WO2007145602A1 (en)	2007-12-21	Process for the preparation of polymyxin b employing ( paeni ) bacillus polymyxa
El-Enshasy et al.	2003	Improvement of rifemycins production by Amycolatopsis mediterranei in batch and fed-batch cultures
EP1613759B1 (en)	2012-08-01	Fermentation processes with low concentrations of carbon- and nitrogen-containing nutrients
Lee	1997	Ammonium ion affecting tylosin production by Streptomyces fradiae NRRL 2702 in continuous culture
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