IL103203A0 - Increased expression of low molecular weight recombinant polypeptides - Google Patents
Increased expression of low molecular weight recombinant polypeptidesInfo
- Publication number
- IL103203A0 IL103203A0 IL103203A IL10320392A IL103203A0 IL 103203 A0 IL103203 A0 IL 103203A0 IL 103203 A IL103203 A IL 103203A IL 10320392 A IL10320392 A IL 10320392A IL 103203 A0 IL103203 A0 IL 103203A0
- Authority
- IL
- Israel
- Prior art keywords
- molecular weight
- low molecular
- increased expression
- recombinant polypeptides
- weight recombinant
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Plant Pathology (AREA)
- Diabetes (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/764,655 US5378613A (en) | 1991-09-24 | 1991-09-24 | Method for increased expression of low molecular weight recombinant polypeptides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL103203A0 true IL103203A0 (en) | 1993-02-21 |
Family
ID=25071354
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL103203A IL103203A0 (en) | 1991-09-24 | 1992-09-17 | Increased expression of low molecular weight recombinant polypeptides |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5378613A (de) |
| EP (1) | EP0534705A3 (de) |
| JP (1) | JPH05304978A (de) |
| AU (1) | AU655316B2 (de) |
| CA (1) | CA2079027A1 (de) |
| HU (1) | HUT62659A (de) |
| IL (1) | IL103203A0 (de) |
| MX (1) | MX9205312A (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3406244B2 (ja) * | 1999-04-30 | 2003-05-12 | 伊藤ハム株式会社 | 新規な融合蛋白質からの組み換えインスリンの製造方法 |
| EP1183357A2 (de) * | 1999-05-20 | 2002-03-06 | Scios Inc. | Vaskuläre endothelzellen wachstumsfaktordimere |
| AU5023300A (en) * | 1999-05-20 | 2000-12-12 | Scios Inc. | Vascular endothelial growth factor variants |
| DE60120372T2 (de) | 2000-03-24 | 2007-07-05 | Genentech Inc., San Francisco | Verwendung von insulin zur behandlung von knorpelkrankheiten |
| KR100847386B1 (ko) | 2000-12-26 | 2008-07-18 | 몬산토 테크놀로지 엘엘씨 | 소마토트로핀의 발현을 위한 재조합 ｄｎａ 벡터 |
| WO2012048856A1 (en) * | 2010-10-12 | 2012-04-19 | Glucometrix Pvs Gmbh | Proinsulin with helper sequence |
| EP2867250A2 (de) * | 2012-04-04 | 2015-05-06 | GlucoMetrix AG | Proinsulin mit verbesserter helfersequenz |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4782139A (en) * | 1985-10-28 | 1988-11-01 | Eli Lilly And Company | Selective chemical removal of a protein amino-terminal residue |
| EP0371041A1 (de) * | 1987-06-24 | 1990-06-06 | Novo Nordisk A/S | Verfahren für die herstellung eines proteins oder polypeptides, dns-sequenz, die dieses polypeptid kodiert, mikroorganismus, der diese dns-sequenz beinhaltet, sowie das polypeptid und seine verwendung als pharmazeutisches präparat |
| IL91771A0 (en) * | 1988-09-30 | 1990-06-10 | Lilly Co Eli | Increased expression of small molecular weight recombinant proteins |
| US5158875A (en) * | 1989-08-25 | 1992-10-27 | Amgen Inc. | Production of biologically active insulin-like growth factor i from high expression host cell systems |
| US5304473A (en) * | 1991-06-11 | 1994-04-19 | Eli Lilly And Company | A-C-B proinsulin, method of manufacturing and using same, and intermediates in insulin production |
-
1991
- 1991-09-24 US US07/764,655 patent/US5378613A/en not_active Expired - Fee Related
-
1992
- 1992-09-17 IL IL103203A patent/IL103203A0/xx unknown
- 1992-09-18 MX MX9205312A patent/MX9205312A/es unknown
- 1992-09-22 JP JP4252727A patent/JPH05304978A/ja not_active Withdrawn
- 1992-09-22 EP EP92308601A patent/EP0534705A3/en not_active Withdrawn
- 1992-09-22 AU AU25280/92A patent/AU655316B2/en not_active Ceased
- 1992-09-23 HU HU9203032A patent/HUT62659A/hu unknown
- 1992-09-24 CA CA002079027A patent/CA2079027A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP0534705A2 (de) | 1993-03-31 |
| HU9203032D0 (en) | 1992-11-30 |
| JPH05304978A (ja) | 1993-11-19 |
| AU2528092A (en) | 1993-03-25 |
| AU655316B2 (en) | 1994-12-15 |
| EP0534705A3 (en) | 1994-12-14 |
| MX9205312A (es) | 1993-07-01 |
| US5378613A (en) | 1995-01-03 |
| HUT62659A (en) | 1993-05-28 |
| CA2079027A1 (en) | 1993-03-25 |
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